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Quantification of metabolites from single-voxel in vivo 1H NMR data of normal human brain by means of time-domain data analysis.
MAGMA. 1995 Sep-Dec;3(3-4):129-36
Publication Type
M. Ala-Korpela
J P Usenius
J. Keisala
A. van den Boogaart
P. Vainio
J. Jokisaari
S. Soimakallio
R. Kauppinen
Author Affiliation
Department of Physical Sciences, University of Oulu, Finland.
MAGMA. 1995 Sep-Dec;3(3-4):129-36
Publication Type
Aspartic Acid - analogs & derivatives - metabolism
Brain - anatomy & histology - metabolism
Choline - metabolism
Comparative Study
Creatine - metabolism
Magnetic Resonance Spectroscopy - methods
Research Support, Non-U.S. Gov't
Signal Processing, Computer-Assisted
We present here a combination of time-domain signal analysis procedures for quantification of human brain in vivo 1H NMR spectroscopy (MRS) data. The method is based on a separate removal of a residual water resonance followed by a frequency-selective time-domain line-shape fitting analysis of metabolite signals. Calculation of absolute metabolite concentrations was based on the internal water concentration as a reference. The estimated average metabolite concentrations acquired from six regions of normal human brain with a single-voxel spin-echo technique for the N-acetylaspartate, creatine, and choline-containing compounds were 11.4 +/- 1.0, 6.5 +/- 0.5, and 1.7 +/- 0.2 mumol kg-1 wet weight, respectively. The time-domain analyses of in vivo 1H MRS data from different brain regions with their specific characteristics demonstrate a case in which the use of frequency-domain methods pose serious difficulties.
PubMed ID
8749730 View in PubMed
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