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A population-based retrospective assessment of the disease burden resulting from invasive Haemophilus influenzae in infants and young children in Santiago, Chile.

https://arctichealth.org/en/permalink/ahliterature6906
Source
Pediatr Infect Dis J. 1990 Jul;9(7):488-94
Publication Type
Article
Date
Jul-1990
Author
C. Ferreccio
E. Ortiz
L. Astroza
C. Rivera
J. Clemens
M M Levine
Author Affiliation
Ministry of Health, Santiago, Chile.
Source
Pediatr Infect Dis J. 1990 Jul;9(7):488-94
Date
Jul-1990
Language
English
Publication Type
Article
Keywords
Age Factors
Child, Preschool
Chile - epidemiology
Comparative Study
Disease Outbreaks
Finland - epidemiology
Haemophilus Infections - epidemiology - mortality
Haemophilus influenzae - isolation & purification
Humans
Incidence
Indians, North American
Infant
Infant, Newborn
Inuits
Meningitis, Haemophilus - epidemiology - mortality
Retrospective Studies
United States - epidemiology
Abstract
Clinical discharge and laboratory records were reviewed in the seven government hospitals that provide care for 93% of the pediatric population of Santiago, Chile, to detect cases of meningitis and other invasive (bacteremia-associated) infections caused by Haemophilus influenzae. infections that occurred in children less than five years of age from January, 1985, through December, 1987, were recorded and matched with census data to calculate incidence rates. The incidence of meningitis and non-meningitis syndromes peaked in the 6- to 11-month age group and tapered sharply after 12 months of age. The city-wide incidence (ca. 21.6 cases/10(5) children less than 5 years of age) is one-third to one-half that reported for the general pediatric population in the United States. However, there is much evidence for under-reporting in Santiago. In Area Norte, served by Roberto del Rio Children's Hospital where H. influenzae has been a subject of research by pediatricians for years, the incidence of invasive H. influenzae infections (42.5/105) is approximately two-fold higher than the rest of Santiago. The cumulative proportions of episodes of H. influenzae disease occurring in successively older age groups closely parallel the pattern seen in the general United States pediatric population. Although only ca. 20% of all episodes occur during the first 6 months of life, nearly 80% of episodes are seen by 18 months of age. Based on the observed incidence rates, the apparent underreporting and the high city-wide case fatality of Hib meningitis (16%), invasive H. influenzae infections represent an important public health problem in Santiago, Chile.
PubMed ID
2371082 View in PubMed
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