Skip header and navigation

1 records – page 1 of 1.

Chloracne caused by ingestion of olive oil contaminated with PCDDs and PCDFs.

https://arctichealth.org/en/permalink/ahliterature37044
Source
Hum Exp Toxicol. 1991 Sep;10(5):311-22
Publication Type
Article
Date
Sep-1991
Author
A. Rodriguez-Pichardo
F. Camacho
C. Rappe
M. Hansson
A G Smith
J B Greig
Author Affiliation
Departmento de Dermatologia, Universidad de Sevilla, Spain.
Source
Hum Exp Toxicol. 1991 Sep;10(5):311-22
Date
Sep-1991
Language
English
Publication Type
Article
Keywords
Acne Vulgaris - chemically induced
Adult
Animals
Benzofurans - poisoning
Chickens
Child
Child, Preschool
Female
Food contamination - analysis
Humans
Infant, Newborn
Male
Mice
Plant Oils - analysis
Polymers - poisoning
Spain
Tetrachlorodibenzodioxin - analogs & derivatives - poisoning
Abstract
1. All members of a Spanish family (father, mother and six children) developed chloracne. 2. The causative agent was found to be the family's stock of olive oil, which had become contaminated with polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), pentachlorophenol, and hexachlorobenzene. 3. The more highly chlorinated PCDDs, in particular octachlorodibenzo-p-dioxin, were the predominant congeners in the oil. 4. Three members of the family exhibited either an overt or a sub-clinical disturbance of kidney function. The father also had a chronic respiratory problem. These changes could not be unequivocally attributed to the PCDDs. 5. Experimental toxicity of the oil was limited to the development of an hepatic porphyria in mice. 6. A serum sample, taken 5 years after consumption of the oil ceased, contained high levels of the PCDDs and PCDFs. Extrapolation back to ingested dose was used to validate dosage estimates. 7. The use of toxicity equivalence factors (TEFs) provided estimates of cumulative dosage to produce chloracne as 0.13-0.31 micrograms 2378-TCDD kg-1 (using EPA TEFs) or 6.7-16 micrograms 2378-TCDD kg-1 (using Nordic/NATO TEFs). 8. This is the first incident in which human toxicity is related primarily to ingestion of PCDDs and for which estimates of dosage can be made.
PubMed ID
1683543 View in PubMed
Less detail