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Radiation-epidemiological studies of thyroid cancer incidence among children and adolescents in the Bryansk oblast of Russia after the Chernobyl accident (1991-2001 follow-up period).

https://arctichealth.org/en/permalink/ahliterature82622
Source
Radiat Environ Biophys. 2006 May;45(1):9-16
Publication Type
Article
Date
May-2006
Author
Ivanov V K
Gorski A I
Tsyb A F
Maksioutov M A
Tumanov K A
Vlasov O K
Author Affiliation
Medical Radiological Research Centre of Russian Academy of Medical Sciences, 4 Korolyov street, 249036 Obninsk, Kaluga Region, Russia. nrer@obninsk.com
Source
Radiat Environ Biophys. 2006 May;45(1):9-16
Date
May-2006
Language
English
Publication Type
Article
Keywords
Accidents, Radiation
Adolescent
Age Factors
Chernobyl Nuclear Accident
Child
Child, Preschool
Female
Follow-Up Studies
Humans
Incidence
Infant
Infant, Newborn
Male
Neoplasms, Radiation-Induced - epidemiology
Power Plants
Russia
Sex Factors
Thyroid Neoplasms - epidemiology
Ukraine
Abstract
In this study, thyroid cancer incidence (follow-up period: 1991-2001) has been analyzed, including persons who were exposed as children at an age between 0 and 17 years and who are living in the Bryansk oblast, the worst contaminated area of Russia after the Chernobyl accident. According to the census of 1989, the population of this oblast comprises 375 thousand people. Thyroid doses from incorporated radioiodine isotopes -- both for the thyroid cancer cases and the study population -- were determined based on the official methodology approved by the Russian Scientific Commission on Radiation Protection. Between 1991 and 2001, a total of 199 thyroid cancer cases were diagnosed at cancer centers (the so-called oncological dispensaries) of the investigated regions. The performed analysis relies on medical and dosimetric information available from the Russian National Medical and Dosimetric Registry which was established after the Chernobyl accident. Diagnoses were confirmed histologically for 95% of the cases. The analysis described revealed statistically significant radiation risk only for those exposed as children at an age of 0-9 years. In this group, the standardized incidence ratio (the national incidence rate was used as a reference) in the considered time period is estimated to be 6.7 (5.1, 8.6 95%CI) and 14.6 (10.3, 20.2 95%CI) for girls and boys, respectively. The risk dependence on age at exposure has also been studied. It has been shown that the smaller the age the higher the risk. For girls whose age at exposure was 0-4 years, the excess relative risk per 1 Gy for the period 1991-2001 was 45.3 (5.2, 9,953 95%CI; with internal control) and 28.8 (4.3, 2,238 95%CI; with external control), respectively. For boys whose age at exposure was 0-9 years the corresponding excess relative risk per 1 Gy was 68.6 (10.0, 4,520 95%CI) and 177.4 (-276, 10(6) 95%CI), respectively. Dependence of radiation risk on time was studied, with the focus on two follow-up periods 1991-1996 and 1997-2001, respectively. In 1997-2001 the radiation risk is shown to decrease among girls, and increase among boys.
PubMed ID
16544150 View in PubMed
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Risk of thyroid cancer among Chernobyl emergency workers of Russia.

https://arctichealth.org/en/permalink/ahliterature92997
Source
Radiat Environ Biophys. 2008 Nov;47(4):463-7
Publication Type
Article
Date
Nov-2008
Author
Ivanov V K
Chekin S Yu
Kashcheev V V
Maksioutov M A
Tumanov K A
Author Affiliation
Medical Radiological Research Centre, Russian Academy of Medical Sciences, 4 Korolyov street, Obninsk, Kaluga region 249036, Russia. nrer@obninsk.com
Source
Radiat Environ Biophys. 2008 Nov;47(4):463-7
Date
Nov-2008
Language
English
Publication Type
Article
Keywords
Adult
Aged
Chernobyl Nuclear Accident
Emergency Medical Services - manpower
Humans
Incidence
Male
Middle Aged
Neoplasms, Radiation-Induced - epidemiology
Occupational Diseases - epidemiology
Occupational Exposure - statistics & numerical data
Power Plants
Radioactive Hazard Release
Risk Assessment - methods
Risk factors
Russia - epidemiology
Thyroid Neoplasms - epidemiology
Ukraine
Abstract
The presented paper deals with the thyroid cancer incidence in selected cohorts of emergency workers of Russia. In 1986-2003, a total of 87 cases of thyroid cancer were observed. Based on these data, a statistically significant increase in thyroid cancer incidence was found above the reference level for the male population of Russia, corresponding to a standardized incidence rate (SIR) of SIR = 3.47 [95% confidence interval (CI): 2.80; 4.25]. The highest incidence rate (SIR = 6.62, 95% CI: 4.63; 9.09) was shown for those emergency workers who took part in the early recovery operations in April-July 1986. The estimated SIR value increases to 7.97 (95% CI: 5.24; 11.52) after allowing for a 10 years latent period of Chernobyl-related thyroid cancers. These results indicate that the exposure to incorporated (131)I was the major risk factor of thyroid cancer among Chernobyl emergency workers. No statistically significant relationship was found for the thyroid cancer incidence and external radiation dose.
PubMed ID
18551301 View in PubMed
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