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Clinical and Instrumental Characteristics of Newly Diagnosed Patients with Various Forms of Pulmonary Hypertension according to the Russian National Registry.

https://arctichealth.org/en/permalink/ahliterature311275
Source
Biomed Res Int. 2020; 2020:6836973
Publication Type
Journal Article
Date
2020
Author
Irina Yev Chazova
Tamila V Martynyuk
Zarina S Valieva
Svetlana Yev Gratsianskaya
Anna M Aleevskaya
Andrey V Zorin
Sergey N Nakonechnikov
Author Affiliation
Federal State Budgetary Institution, National Medical Research Center of Cardiology of the Ministry of Healthcare of Russian Federation, Russia.
Source
Biomed Res Int. 2020; 2020:6836973
Date
2020
Language
English
Publication Type
Journal Article
Keywords
Adolescent
Adult
Aged
Chronic Disease
Female
Humans
Hypertension, Pulmonary - complications - diagnosis - epidemiology - physiopathology
Male
Middle Aged
Peptic ulcer
Registries
Russia
Venous Thrombosis
Young Adult
Abstract
To study demographic and clinical characteristics and to give a comparative description of the functional and hemodynamic status, profile of concomitant pathology in patients with various forms of pulmonary arterial hypertension (PAH), and chronic thromboembolic pulmonary hypertension (CTEPH) according to the Russian National Registry.
During the period from January 01, 2012, till January 01, 2019, 1105 patients aged >18 years with verified diagnosis of PAH and CTEPH, who were subsequently observed at 15 PH expert centers of the Russian Federation in the 52 provinces, are included in the Russian registry on the basis of the Federal State Budgetary Institution of Cardiology of the Ministry of Healthcare of Russia. All newly diagnosed patients (n = 727) were entered into the registry database (NCT03707561). A comparative analysis of demographic and clinical characteristics, profile of concomitant pathology, and parameters of a comprehensive examination of patients was performed.
Among newly diagnosed patients, 67% had PAH and 28.3% had CTEPH. In the PAH group, 40.9% of patients had idiopathic arterial PAH (IPAH), 36.6% had PAH associated with simple congenital heart disease (PAH-CHD), 19.3% had PAH associated with systemic connective tissue disease (PAH-CTD), 1.8% had portal pulmonary hypertension (PoPH), 0.6% had PAH associated with HIV infection (PAH-HIV), 0.4% had heritable PAH (HPAH), and 0.4% had drug/toxin-induced PAH. At the time of diagnosis, PAH patients were younger than patients with CTEPH (45.2 ± 14.9; 52.6 ± 15.3 years, respectively) (p
PubMed ID
32626754 View in PubMed
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