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Fertility treatment and reproductive health of male offspring: a study of 1,925 young men from the general population.

https://arctichealth.org/en/permalink/ahliterature79349
Source
Am J Epidemiol. 2007 Mar 1;165(5):583-90
Publication Type
Article
Date
Mar-1-2007
Author
Jensen Tina Kold
Jørgensen Niels
Asklund Camilla
Carlsen Elisabeth
Holm Mette
Skakkebaek Niels E
Author Affiliation
Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark. tkjensen@health.sdu.dk
Source
Am J Epidemiol. 2007 Mar 1;165(5):583-90
Date
Mar-1-2007
Language
English
Publication Type
Article
Keywords
Adult
Androgens - blood
Denmark - epidemiology
Female
Humans
Infertility, Female - therapy
Linear Models
Male
Physical Examination
Questionnaires
Sperm Count
Sperm Motility
Testis - anatomy & histology
Testosterone - blood
Abstract
Little is known the about the reproductive health of offspring after fertility treatment. In 2001-2005, the authors approached young Danish men attending a compulsory physical examination to determine their fitness for military service. A total of 1,925 men volunteered, delivered a semen sample, had a physical examination performed and a blood sample drawn, and responded to a questionnaire. Their mothers were questioned about whether they had received fertility treatment in order to conceive their sons. Forty-seven mothers reported having received fertility treatment to conceive the index subject. After control for confounders, men whose mothers had received fertility treatment to conceive them had a 46% lower sperm concentration (95% confidence interval (CI): -63, -20) and a 45% lower total sperm count (95% CI: -64, -16). They had a smaller testis size (-0.9 ml, 95% CI: -2.2, 0.4), fewer motile sperm (-4.0%, 95% CI: -8.0, -0.1), and fewer morphologically normal spermatozoa (-2.0%, 95% CI: -4.1, 0.0). They also had a lower serum testosterone level and free androgen index (results not statistically significant). These findings should be viewed in light of the increasing use of fertility treatments. Although the cause of these findings is unknown, they raise concern about possible late effects of fertility treatment. Larger-scale studies of children born after fertility treatment should be performed.
PubMed ID
17182980 View in PubMed
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Self-rated health and semen quality among 3,457 young Danish men.

https://arctichealth.org/en/permalink/ahliterature84776
Source
Fertil Steril. 2007 Nov;88(5):1366-73
Publication Type
Article
Date
Nov-2007
Author
Jensen Tina K
Jørgensen Niels
Asklund Camilla
Carlsen Elisabeth
Kristensen Tage S
Holm Mette
Skakkebaek Niels Erik
Author Affiliation
Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark. tkjensen@health.sdu.dk
Source
Fertil Steril. 2007 Nov;88(5):1366-73
Date
Nov-2007
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Cross-Sectional Studies
Denmark
Health status
Humans
Male
Questionnaires
Self Concept
Semen - cytology - physiology
Sperm Count - methods
Testis - anatomy & histology - physiology
Abstract
OBJECTIVE: To study the relationship between self-rated health (SRH) and semen quality. DESIGN: Cross-sectional study of men attending a compulsory physical examination to determine their fitness for military service from 1996 to 2005. SETTING: Young men were approached when they were summoned for a compulsory physical examination to determine their fitness for military service in two major Danish cities. PATIENT(S): A total of 3,457 Danish young men delivered a semen sample, had a physical examination performed, and responded to a questionnaire including a question about SRH. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Semen quality and testis size. RESULT(S): After control for confounders, men with good and poor SRH had, respectively, 0.5 mL (95% CI: -0.8, -0.1) and 0.8 mL (95% CI: -2.4, 0.8) smaller testes size compared to men with very good SRH, the trend was statistically significant. Men with good and poor SRH had, respectively, 12.2% (95% CI: -21.2%, -2.2%) and 26.9% (95% CI: -55.7%, 20.8%) lower total sperm count compared to men with very good SRH, the trend was statistically significant, and had +0.4% (-1.4%, 2.2%) and 1.4% (-3.5%, 0.7%) fewer morphologically normal sperms (trend statistically significant). Percentages of motile spermatozoa and semen volume were not significantly associated with SRH. CONCLUSION(S): We found significant associations between SRH and semen quality and testicular size. Given the cross-sectional study design, we cannot establish a causal relationship but argue that SRH may be associated with semen quality. Our findings need to be validated and confirmed with other study designs (preferably prospective) and in populations of different age structure and fertility status.
PubMed ID
17588567 View in PubMed
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