Skip header and navigation

Refine By

1 records – page 1 of 1.

Initiation and long-term use of benzodiazepines and Z-drugs in bipolar disorder.

https://arctichealth.org/en/permalink/ahliterature299924
Source
Bipolar Disord. 2018 11; 20(7):634-646
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
11-2018
Author
Louise Wingård
Heidi Taipale
Johan Reutfors
Anna Westerlund
Robert Bodén
Jari Tiihonen
Antti Tanskanen
Morten Andersen
Author Affiliation
Centre for Pharmacoepidemiology (CPE), Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Source
Bipolar Disord. 2018 11; 20(7):634-646
Date
11-2018
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Accidental Falls - prevention & control
Adult
Aged
Benzodiazepines - administration & dosage - adverse effects
Bipolar Disorder - diagnosis - drug therapy - epidemiology - psychology
Cognition - drug effects
Cohort Studies
Female
Humans
Inappropriate Prescribing - adverse effects - prevention & control - statistics & numerical data
Logistic Models
Long Term Adverse Effects - chemically induced - diagnosis - prevention & control
Male
Middle Aged
Risk assessment
Sleep Aids, Pharmaceutical - administration & dosage - adverse effects
Sweden - epidemiology
Abstract
Increasing evidence points to the harmful effects of long-term benzodiazepine treatment. Our objective was to study the incidence of, and predictors for, long-term use of benzodiazepines and Z-drugs in bipolar disorder.
We conducted a population-based cohort study, using data from Swedish national registers. Swedish residents aged 18-75 years with a recorded diagnosis of bipolar disorder or mania between July 2006 and December 2012, and no history of benzodiazepine/Z-drug use in the past year, were included. Patients were followed for 1 year with regard to prescription fills of benzodiazepines/Z-drugs. Initiators were followed for another year during which continuous use for >6 months was defined as "long-term". Patient and prescription characteristics were investigated as potential predictors for long-term use in multivariate logistic regression models.
Out of the 21 883 patients included, 29% started benzodiazepine/Z-drug treatment, of whom one in five became long-term users. Patients who were prescribed clonazepam or alprazolam had high odds for subsequent long-term use (adjusted odds ratios [aORs] 3.78 [95% confidence interval (CI) 2.24-6.38] and 2.03 [95% CI 1.30-3.18], respectively), compared to those prescribed diazepam. Polytherapy with benzodiazepines/Z-drugs also predicted long-term use (aOR 2.46, 95% CI 1.79-3.38), as did age =60 years (aOR 1.93, 95% CI 1.46-2.53, compared to age
PubMed ID
29450954 View in PubMed
Less detail