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Identification of gymnodimine D and presence of gymnodimine variants in the dinoflagellate Alexandrium ostenfeldii from the Baltic Sea.

https://arctichealth.org/en/permalink/ahliterature278360
Source
Toxicon. 2016 Mar 15;112:68-76
Publication Type
Article
Date
Mar-15-2016
Author
Kirsi Harju
Harri Koskela
Anke Kremp
Sanna Suikkanen
Pablo de la Iglesia
Christopher O Miles
Bernd Krock
Paula Vanninen
Source
Toxicon. 2016 Mar 15;112:68-76
Date
Mar-15-2016
Language
English
Publication Type
Article
Keywords
Atlantic Ocean
Cells, Cultured
Chromatography, High Pressure Liquid
Clone Cells
Dinoflagellida - chemistry - cytology - growth & development - metabolism
Harmful Algal Bloom
Heterocyclic Compounds, 3-Ring - chemistry - isolation & purification - metabolism
Heterocyclic Compounds, 4 or More Rings - chemistry - isolation & purification - metabolism
Hydrocarbons, Cyclic - chemistry - isolation & purification - metabolism
Imines - chemistry - isolation & purification - metabolism
Marine Toxins - chemistry - isolation & purification - metabolism
Methylation
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Spectrometry, Mass, Electrospray Ionization
Stereoisomerism
Sweden
Tandem Mass Spectrometry
Abstract
Gymnodimines are lipophilic toxins produced by the marine dinoflagellates Karenia selliformis and Alexandrium ostenfeldii. Currently four gymnodimine analogues are known and characterized. Here we describe a novel gymnodimine and a range of gymnodimine related compounds found in an A. ostenfeldii isolate from the northern Baltic Sea. Gymnodimine D (1) was extracted and purified from clonal cultures, and characterized by liquid chromatography-tandem mass spectrometry (LC-MS/MS), nuclear magnetic resonance (NMR) spectroscopy, and liquid chromatography-high resolution mass spectrometry (LC-HRMS) experiments. The structure of 1 is related to known gymnodimines (2-5) with a six-membered cyclic imine ring and several other fragments typical of gymnodimines. However, the carbon chain in the gymnodimine macrocyclic ring differs from the known gymnodimines in having two tetrahydrofuran rings in the macrocyclic ring.
PubMed ID
26829651 View in PubMed
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One-year Results of Health-related and Vision-related Quality of Life after Clear Lens Extraction and Multifocal IOL Implantation.

https://arctichealth.org/en/permalink/ahliterature311331
Source
Am J Ophthalmol. 2021 Apr 03; :
Publication Type
Journal Article
Date
Apr-03-2021
Author
Antti Viljanen
Kimmo Koskela
Harri Koskela
Raimo Tuuminen
Hannu Uusitalo
Author Affiliation
Medilaser Coronaria, Silmaasema Silmasairaala, CorGroup, Oulu, Finland. Electronic address: antti.viljanen@coronaria.fi.
Source
Am J Ophthalmol. 2021 Apr 03; :
Date
Apr-03-2021
Language
English
Publication Type
Journal Article
Abstract
Multifocal intraocular lenses (MIOLs) are effective in treating presbyopia before cataracts develop. This study measured health-related quality of life (HRQoL) and vision-related quality of life (VRQoL) after clear lens extraction (CLE) and MIOL implantation.
Before-and-After study.
Patients were treated in Medilaser Coronaria, CorGroup, Oulu, Finland. HRQoL was measured by a generic 15 dimension (15D) instrument. VRQoL was measured with VF-14 questionnaire.
CLE and MIOL implantation was performed in 137 patients. The patient age was 57 ± 6.2 years (mean±standard deviation), and 58% were women. The near add was 2.1±0.3 diopters. The overall HRQoL 15D score increased from 0.938±0.058 to 0.955±0.057 at 6 months (p
PubMed ID
33823159 View in PubMed
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