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Activated immune-inflammatory pathways are associated with long-standing depressive symptoms: Evidence from gene-set enrichment analyses in the Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature275217
Source
J Psychiatr Res. 2015 Dec;71:120-5
Publication Type
Article
Date
Dec-2015
Author
Marko Elovainio
Tuukka Taipale
Ilkka Seppälä
Nina Mononen
Emma Raitoharju
Markus Jokela
Laura Pulkki-Råback
Thomas Illig
Melanie Waldenberger
Christian Hakulinen
Taina Hintsa
Mika Kivimäki
Mika Kähönen
Liisa Keltikangas-Järvinen
Olli Raitakari
Terho Lehtimäki
Source
J Psychiatr Res. 2015 Dec;71:120-5
Date
Dec-2015
Language
English
Publication Type
Article
Keywords
Adult
Depressive Disorder - epidemiology - immunology
Female
Finland - epidemiology
Gene Expression Profiling
Humans
Male
Prospective Studies
Psychiatric Status Rating Scales
Severity of Illness Index
Abstract
We used genome wide expression (GWE) data of circulating blood cells and pathway analysis to investigate the inflammatory and other molecular pathways that may be associated with long-standing depressive symptoms. Participants were 607 women and 316 men (mean age 42 years) from the Young Finns Study who participated in three consecutive study phases in 2001, 2007 and 2012. Using Gene-set enrichment analyses (GSEA) we focused our analyses to pathways (available in MSigDB database) that are likely to affect immunological and inflammatory processes. GSEA were performed for blood cell GWE data in 2012. Depressive symptoms were assessed using a modified 21-item Beck Depression Inventory in each of the three study phases. Participants who scored in the top quartile of depressive symptoms in each of the three measurement points (n = 191) differed from other participants (n = 732) in several gene-set pathways related to inflammatory processes or immune-inflammatory signaling including interleukin (IL-1) pathway, and pathways related to various immuno-inflammatory processes, such as toll-like, the NEF protein, the nuclear factor kB, the kinase AKT and the mature B cell antigen receptor pathway (false discovery rates, FDRs
PubMed ID
26473696 View in PubMed
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[Adjusting for studied districts can be useful]

https://arctichealth.org/en/permalink/ahliterature24068
Source
Lakartidningen. 1993 Apr 28;90(17):1636-7
Publication Type
Article
Date
Apr-28-1993
Author
G. Steineck
T. Hakulinen
Source
Lakartidningen. 1993 Apr 28;90(17):1636-7
Date
Apr-28-1993
Language
Swedish
Publication Type
Article
Keywords
Breast Neoplasms - mortality - prevention & control
Data Interpretation, Statistical
Female
Humans
Mammography - statistics & numerical data
Mass Screening - statistics & numerical data
Models, Statistical
Sweden - epidemiology
Notes
Comment On: Lakartidningen. 1993 Feb 17;90(7):608-10; discussion 6117786323
Comment On: Lakartidningen. 1993 Feb 24;90(8):6848437487
PubMed ID
8487602 View in PubMed
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Advanced detection of time trends in long-term cancer patient survival: experience from 50 years of cancer registration in Finland.

https://arctichealth.org/en/permalink/ahliterature188602
Source
Am J Epidemiol. 2002 Sep 15;156(6):566-77
Publication Type
Article
Date
Sep-15-2002
Author
Hermann Brenner
Timo Hakulinen
Author Affiliation
Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany. brenner@dzfa.uni-heidelberg.de
Source
Am J Epidemiol. 2002 Sep 15;156(6):566-77
Date
Sep-15-2002
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Child
Child, Preschool
Cohort Studies
Databases, Factual
Female
Finland - epidemiology
Humans
Infant
Infant, Newborn
Male
Middle Aged
Neoplasms - mortality - pathology
Prognosis
Registries
Survival Analysis
Abstract
Timely monitoring of trends in long-term patient survival is an important task of cancer registries. Recently, a new method, denoted period analysis, has been proposed to enhance up-to-date monitoring of survival. The authors assessed the use of period analysis for advanced detection of time trends in long-term cancer patient survival based on data from the nationwide Finnish Cancer Registry by comparing estimates of 10-, 15-, and 20-year relative survival rates obtained by period analysis and by traditional (cohort) analysis of survival at various points of time between 1953 and 1997. Time trends are graphically displayed for the 15 most common forms of cancer. Long-term survival rates strongly improved over time for most forms of cancer. The slope and shape of trend curves obtained by period analysis are very similar to those obtained by traditional survival analysis. However, detection of progress in 10-, 15-, and 20-year survival rates of newly diagnosed patients could have been advanced by 5-10 years, 10-15 years, and 15-20 years, respectively, with the use of period analysis rather than traditional cohort survival analysis. The authors conclude that period analysis should be routinely used to advance detection of progress in long-term cancer patient survival.
PubMed ID
12226004 View in PubMed
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Age dependence of the west/east gradient in cardiovascular mortality of Finnish males.

https://arctichealth.org/en/permalink/ahliterature239310
Source
Acta Med Scand. 1985;218(5):463-71
Publication Type
Article
Date
1985
Author
L. Tenkanen
L. Teppo
T. Hakulinen
E. Läärä
Source
Acta Med Scand. 1985;218(5):463-71
Date
1985
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Aged
Cardiovascular Diseases - mortality
Coronary Disease - mortality
Finland
Follow-Up Studies
Humans
Male
Middle Aged
Risk
Sex Factors
Smoking
Abstract
A cohort of 4 475 Finnish men was followed up during 1964-80 in order to study regional differences in mortality from cardiovascular diseases, especially ischaemic heart disease (IHD). The west/east gradient in cardiovascular mortality recorded in several previous studies was greatly age-dependent. The excess eastern risk was a feature of younger age groups; with increasing age the risk pattern was reversed. The risk factors in IHD in eastern Finland have an element which somehow accelerates the process of this disease.
PubMed ID
4091046 View in PubMed
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Age-standardisation of relative survival ratios of cancer patients in a comparison between countries, genders and time periods.

https://arctichealth.org/en/permalink/ahliterature153684
Source
Eur J Cancer. 2009 Mar;45(4):642-7
Publication Type
Article
Date
Mar-2009
Author
Arun Pokhrel
Timo Hakulinen
Author Affiliation
Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Pieni Roobertinkatu 9, FI-00130 Helsinki, Finland. arun.pokhrel@cancer.fi
Source
Eur J Cancer. 2009 Mar;45(4):642-7
Date
Mar-2009
Language
English
Publication Type
Article
Keywords
Adult
Age Distribution
Aged
Aged, 80 and over
Child
Child, Preschool
Epidemiologic Methods
Europe - epidemiology
Female
Finland - epidemiology
Humans
Infant
Infant, Newborn
Male
Middle Aged
Neoplasms - mortality
Prognosis
Sex Distribution
United States - epidemiology
Young Adult
Abstract
A recent method of age-standardisation of relative survival ratios for cancer patients does not require calculation of age-specific relative survival ratios, as ratios of age-specific proportions between the standard population and study group at the beginning of the follow-up are used to substitute the original individual observations. This method, however, leads to direct age-standardisation with weights that are different for each patient group if the general population mortality patterns for the groups are different. This is the case in international comparisons, and in comparisons between genders and time periods. The magnitude of the bias caused by the differences in general population mortality is investigated for comparisons involving European countries and the USA. Patients in each country are assumed to have exactly the same age-specific relative survival ratios as those diagnosed in Finland in 1985-2004. An application of a properly functioning age-standardisation method should then give exactly equal age-standardised relative survival ratios for each country. However, the recent method shows substantial differences between countries, with highest relative survival for populations, where the general population mortality in the oldest ages is the highest. This source of error can thus be a serious limitation for the use of the method, and other methods that are available should then be employed.
PubMed ID
19081246 View in PubMed
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Alcohol, smoking and human papillomavirus in laryngeal carcinoma: a Nordic prospective multicenter study.

https://arctichealth.org/en/permalink/ahliterature77781
Source
J Cancer Res Clin Oncol. 2007 Sep;133(9):673-8
Publication Type
Article
Date
Sep-2007
Author
Koskinen Walter J
Brøndbo Kjell
Mellin Dahlstrand Hanna
Luostarinen Tapio
Hakulinen Timo
Leivo Ilmo
Molijn Anco
Quint Wim G
Røysland Tov
Munck-Wikland Eva
Mäkitie Antti A
Pyykkö Ilmari
Dillner Joakim
Vaheri Antti
Aaltonen Leena-Maija
Author Affiliation
Department of Virology, Haartman Institute, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, 00014, Helsinki, Finland.
Source
J Cancer Res Clin Oncol. 2007 Sep;133(9):673-8
Date
Sep-2007
Language
English
Publication Type
Article
Abstract
PURPOSE: Human papillomavirus (HPV) has been linked to oropharyngeal carcinomas, but its role in laryngeal squamous cell carcinoma (LSCC) is not clear. A prospective multicenter study based on known tumor-cell percentage of fresh frozen carcinoma biopsies was established to determine the HPV prevalence. Moreover risk factors such as smoking, alcohol abuse, chronic laryngitis and gastroesophageal reflux disease (GERD) were evaluated METHODS: Fresh-frozen laryngeal cancer biopsies from 108 patients in Finland, Norway, and Sweden were investigated. Patients whose biopsy samples contained at least 20% tumor tissue (N = 69) entered the study. HPV DNA was determined with MY09/11 and GP5+/6+ nested PCR and SPF10 PCR hybridization assay. Patients were examined by an ENT specialist and an extensive questionnaire concerning risk factors was filled in. RESULTS: Only three patients (4.4%) harbored HPV DNA in their carcinoma sample. Heavy alcohol drinking was associated with an increased risk of death, advanced-stage disease, and younger age at diagnosis. Chronic laryngitis, GERD, and orogenital sex contacts were rare. Poor oral hygiene was not associated with survival, although it correlated with heavy drinking. CONCLUSION: In our series HPV was not important in LSCC. Heavy drinking led to major mortality in LSCC and promoted early carcinogenesis.
PubMed ID
17486368 View in PubMed
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Are patients diagnosed with breast cancer before age 50 years ever cured?

https://arctichealth.org/en/permalink/ahliterature182272
Source
J Clin Oncol. 2004 Feb 1;22(3):432-8
Publication Type
Article
Date
Feb-1-2004
Author
Hermann Brenner
Timo Hakulinen
Author Affiliation
Department of Epidemiology, German Centre for Research on Aging, Bergheimer Strasse 20, D-69115 Heidelberg, Germany. Brenner@dzfa-uni-heidelberg.de
Source
J Clin Oncol. 2004 Feb 1;22(3):432-8
Date
Feb-1-2004
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Breast Neoplasms - diagnosis - mortality
Cohort Studies
Female
Finland - epidemiology
Follow-Up Studies
Humans
Middle Aged
Neoplasm Staging
Prognosis
Registries
Risk factors
Survival Rate
Time Factors
Abstract
Breast cancer diagnosed before the age of 50 years has become a common disease in many developed countries. Although average remaining life expectancy in the affected age groups is usually several decades, data regarding survival perspectives beyond 10 to 20 years after diagnosis are sparse. The aim of this study was to assess long-term survival in a large population-based sample of patients diagnosed with breast cancer before age 50 years.
Relative survival within up to 40 years after diagnosis was assessed for cohorts of women diagnosed with breast cancer before age 50 years and notified to the nationwide Finnish Cancer Registry within various time intervals since 1953. In addition, up-to-date estimates of 40-year relative survival were obtained by exclusively looking at the survival experience of breast cancer patients in recent years (1993 to 1999) using period analysis, a new method of survival analysis.
Prognosis of patients diagnosed with breast cancer before age 50 years has considerably improved during the past decades. According to the latest estimates from period analysis, cumulative 40-year relative survival is now approximately 43% for all cancers combined, 57% for localized cancers, and 24% for cancers with regional tumor spread. Nevertheless, patients diagnosed with breast cancer before age 50 years continue to have increased mortality throughout at least four decades after diagnosis. This applies even if breast cancer is diagnosed in a localized stage and in the absence of a second primary breast cancer.
Despite major improvement in prognosis over time, breast cancer occurring among patients who are younger than 50 years remains a chronic disease that affects prognosis for decades.
Notes
Comment In: J Clin Oncol. 2004 Feb 1;22(3):392-414691128
PubMed ID
14691121 View in PubMed
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[Association between cancer and exposure to chlorophenols in a county located in southern Finland].

https://arctichealth.org/en/permalink/ahliterature227775
Source
Duodecim. 1991;107(9):702-10
Publication Type
Article
Date
1991

The association between early-onset schizophrenia with employment, income, education, and cohabitation status: nationwide study with 35 years of follow-up.

https://arctichealth.org/en/permalink/ahliterature309253
Source
Soc Psychiatry Psychiatr Epidemiol. 2019 Nov; 54(11):1343-1351
Publication Type
Journal Article
Date
Nov-2019
Author
Christian Hakulinen
John J McGrath
Allan Timmerman
Niels Skipper
Preben Bo Mortensen
Carsten Bøcker Pedersen
Esben Agerbo
Author Affiliation
Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, P.O. Box 21, 00014, Helsinki, Finland. christian.hakulinen@helsinki.fi.
Source
Soc Psychiatry Psychiatr Epidemiol. 2019 Nov; 54(11):1343-1351
Date
Nov-2019
Language
English
Publication Type
Journal Article
Keywords
Adolescent
Adult
Cohort Studies
Denmark - epidemiology
Educational Status
Employment - psychology - statistics & numerical data
Female
Follow-Up Studies
Humans
Income - statistics & numerical data
Male
Middle Aged
Residence Characteristics - statistics & numerical data
Schizophrenia - epidemiology
Young Adult
Abstract
Individuals with schizophrenia have been reported to have low employment rates. We examined the associations of schizophrenia with employment, income, and status of cohabitation from a work life course perspective.
Nationwide cohort study including all individuals (n?=?2,390,127) born in Denmark between 1955 and 1991, who were alive at their 25th birthday. Diagnosis of schizophrenia (yes/no) between ages 15 and 25 was used as an exposure. Employment status, annual wage or self-employment earnings, level of education, and cohabitant status from the age of 25-61 (years 1980-2016) were used as outcomes.
Schizophrenia diagnosis between ages 15 and 25 (n?=?9448) was associated with higher odds of not being employed (at the age of 30: OR 39.4, 95% CI 36.5-42.6), having no secondary or higher education (7.4, 7.0-7.8), and living alone (7.6, 7.2-8.1). These odds ratios were two-to-three times lower and decreasing over time for those individuals who did not receive treatment in a psychiatric inpatient or outpatient clinic for schizophrenia after the age of 25. Between ages 25-61, individuals with schizophrenia have cumulative earning of $224,000, which is 14% of the amount that the individuals who have not been diagnosed with schizophrenia earn.
Individuals with schizophrenia are at high risk of being outside the labour market and living alone throughout their entire life, resulting in an enormous societal loss in earnings. Individuals with less chronic course of schizophrenia had a gradual but substantial improvement throughout their work life.
PubMed ID
31456027 View in PubMed
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Association between influenza during pregnancy and childhood leukaemia.

https://arctichealth.org/en/permalink/ahliterature254198
Source
Br Med J. 1973 Nov 3;4(5887):265-7
Publication Type
Article
Date
Nov-3-1973
Author
T. Hakulinen
L. Hovi
Karkinen-Jääskeläinen
K. Penttinen
L. Saxén
Source
Br Med J. 1973 Nov 3;4(5887):265-7
Date
Nov-3-1973
Language
English
Publication Type
Article
Keywords
Absenteeism
Child
Child, Preschool
Disease Outbreaks - epidemiology
Female
Finland
Humans
Infant
Infant, Newborn
Influenza, Human - complications - epidemiology - microbiology
Leukemia - epidemiology - etiology
Orthomyxoviridae - isolation & purification
Pregnancy
Pregnancy Complications, Infectious
Abstract
This report based on the data available from the Finnish Cancer Registry and from virus isolations gives further support to the association (P=0.04) between maternal influenza of the 1957 "Asian" type and subsequent later leukaemia in the infants. No such association was found from other influenza epidemics.
Notes
Cites: Ann Clin Res. 1969 Dec;1(4):291-3005371916
Cites: Lancet. 1971 Dec 18;2(7738):1346-74108264
Cites: Br Med J. 1972 May 27;2(5812):485-84337948
Cites: Am J Obstet Gynecol. 1972 Sep 15;114(2):239-424628993
Cites: Br Med J. 1972 Dec 16;4(5841):631-44674941
Cites: Br Med J. 1973 Mar 24;1(5855):706-84348514
Cites: Bull World Health Organ. 1972;47(4):449-524540994
Cites: Acta Pathol Microbiol Scand. 1960;49:114-2614442130
PubMed ID
4753239 View in PubMed
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281 records – page 1 of 29.