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Correspondence with a pioneer, J├╝rgen Lehmann (1898-1989), producer of the first effective antituberculosis specific.

https://arctichealth.org/en/permalink/ahliterature69644
Source
S Afr Med J. 1991 Jan 5;79(1):48-50
Publication Type
Article
Date
Jan-5-1991
Author
H. Dubovsky
Source
S Afr Med J. 1991 Jan 5;79(1):48-50
Date
Jan-5-1991
Language
English
Publication Type
Article
Keywords
History, 20th Century
Portraits
Sweden
p-Aminosalicylic Acid - history
Abstract
Correspondence between the author and Lehmann provided evidence that the latter evolved the first effective antituberculosis drug, para-aminosalicylic acid (PAS), contrary to accepted belief that this honour belonged to Nobel Prize-winner Selman A. Waksman for his production of streptomycin. While both drugs appeared in 1943, successful animal and clinical trials of PAS preceded those of streptomycin. PAS has been discarded in modern treatment regimens because of gastric side-effects, but was available at a critical time to demonstrate the principle of multiple therapy in prevention of bacterial resistance in tuberculosis therapy. It probably saved streptomycin, which causes bacterial resistance and clinical regression within 3 months when used alone, from being discarded as an unsuitable drug of temporary benefit and a public health hazard.
PubMed ID
1986452 View in PubMed
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The history of para-aminosalicylic acid (pas), the first tuberculosis anti-microbial agent, and streptomycin (sm): a comparative study.

https://arctichealth.org/en/permalink/ahliterature69733
Source
Adler Mus Bull. 1988 Jun;14(1):7-11
Publication Type
Article
Date
Jun-1988
Author
H. Dubovsky
Source
Adler Mus Bull. 1988 Jun;14(1):7-11
Date
Jun-1988
Language
English
Publication Type
Article
Keywords
History, Modern 1601-
Microbiology - history
Pharmaceutical Preparations - history
Sweden
Tuberculosis - history
PubMed ID
11621575 View in PubMed
Less detail