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Global trends in resistance to antituberculosis drugs. World Health Organization-International Union against Tuberculosis and Lung Disease Working Group on Anti-Tuberculosis Drug Resistance Surveillance.

https://arctichealth.org/en/permalink/ahliterature69418
Source
N Engl J Med. 2001 Apr 26;344(17):1294-303
Publication Type
Article
Date
Apr-26-2001
Author
M A Espinal
A. Laszlo
L. Simonsen
F. Boulahbal
S J Kim
A. Reniero
S. Hoffner
H L Rieder
N. Binkin
C. Dye
R. Williams
M C Raviglione
Author Affiliation
Communicable Diseases Cluster, World Health Organization, Geneva, Switzerland. espinalm@who.int
Source
N Engl J Med. 2001 Apr 26;344(17):1294-303
Date
Apr-26-2001
Language
English
Publication Type
Article
Keywords
Antitubercular Agents - pharmacology - therapeutic use
Data Collection
Drug Resistance, Multiple
Humans
Mycobacterium tuberculosis - drug effects
Prevalence
Research Support, U.S. Gov't, Non-P.H.S.
Sampling Studies
Tuberculosis - drug therapy
World Health
Abstract
BACKGROUND: Data on global trends in resistance to antituberculosis drugs are lacking. METHODS: We expanded the survey conducted by the World Health Organization and the International Union against Tuberculosis and Lung Disease to assess trends in resistance to antituberculosis drugs in countries on six continents. We obtained data using standard protocols from ongoing surveillance or from surveys of representative samples of all patients with tuberculosis. The standard sampling techniques distinguished between new and previously treated patients, and laboratory performance was checked by means of an international program of quality assurance. RESULTS: Between 1996 and 1999, patients in 58 geographic sites were surveyed; 28 sites provided data for at least two years. For patients with newly diagnosed tuberculosis, the frequency of resistance to at least one antituberculosis drug ranged from 1.7 percent in Uruguay to 36.9 percent in Estonia (median, 10.7 percent). The prevalence increased in Estonia, from 28.2 percent in 1994 to 36.9 percent in 1998 (P=0.01), and in Denmark, from 9.9 percent in 1995 to 13.1 percent in 1998 (P=0.04). The median prevalence of multidrug resistance among new cases of tuberculosis was only 1.0 percent, but the prevalence was much higherin Estonia (14.1 percent), Henan Province in China (10.8 percent), Latvia (9.0 percent), the Russian oblasts of Ivanovo (9.0 percent) and Tomsk (6.5 percent), Iran (5.0 percent), and Zhejiang Province in China (4.5 percent). There were significant decreases in multidrug resistance in France and the United States. In Estonia, the prevalence in all cases increased from 11.7 percent in 1994 to 18.1 percent in 1998 (P
PubMed ID
11320389 View in PubMed
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Secular trends of tuberculosis in western Europe.

https://arctichealth.org/en/permalink/ahliterature8129
Source
Bull World Health Organ. 1993;71(3-4):297-306
Publication Type
Article
Date
1993
Author
M C Raviglione
P. Sudre
H L Rieder
S. Spinaci
A. Kochi
Author Affiliation
Tuberculosis Programme, World Health Organization, Geneva, Switzerland.
Source
Bull World Health Organ. 1993;71(3-4):297-306
Date
1993
Language
English
Publication Type
Article
Keywords
AIDS-Related Opportunistic Infections - epidemiology - etiology
Aged
Child
Child, Preschool
Emigration and Immigration
Europe - epidemiology
Humans
Infant
Population Dynamics
Population Surveillance
Transients and Migrants
Tuberculosis - complications - epidemiology - mortality
Abstract
Deaths due to tuberculosis have decreased uniformly in all countries in Western Europe, and most have occurred among those aged > or = 65 years. In recent years, tuberculosis case notifications have continued to decline in Belgium, Finland, France, Germany, and Spain, and have levelled off in Sweden and the United Kingdom; increases have, however, been recorded in Austria, Denmark, Ireland, Italy, Netherlands, Norway, and Switzerland. In Denmark, Netherlands, Norway, Sweden, and Switzerland an increasing number of cases of tuberculosis among foreign-born residents has resulted in a change from the expected downward trend. Human immunodeficiency virus (HIV) infection appears to contribute only marginally to the overall tuberculosis morbidity; however, it appears to be important in Paris and its surrounding areas, and tuberculosis is very common among HIV-infected persons in Italy and Spain. Despite these recent changes in the incidence of tuberculosis, there is currently no evidence of its increased transmission among the youngest age groups of the indigenous populations. Properly designed disease surveillance systems are critical for monitoring the tuberculosis trends so that each country can identify its own high-risk groups and target interventions to prevent, diagnose, and treat the disease. Tuberculosis remains a global disease and because of increasing human migrations, its elimination in Western Europe cannot be envisaged without concomitant improvements in its control in high-incidence, resource-poor countries.
PubMed ID
8324847 View in PubMed
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Tuberculosis trends in eastern Europe and the former USSR.

https://arctichealth.org/en/permalink/ahliterature7936
Source
Tuber Lung Dis. 1994 Dec;75(6):400-16
Publication Type
Article
Date
Dec-1994
Author
M C Raviglione
H L Rieder
K. Styblo
A G Khomenko
K. Esteves
A. Kochi
Author Affiliation
Tuberculosis Programme, World Health Organization, Geneva, Switzerland.
Source
Tuber Lung Dis. 1994 Dec;75(6):400-16
Date
Dec-1994
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Antitubercular Agents - therapeutic use
Child
Disease Notification
Europe, Eastern - epidemiology
Female
HIV Infections - complications
Humans
Infant, Newborn
Male
Middle Aged
Morbidity
Tuberculosis - complications - epidemiology - mortality
USSR - epidemiology
Abstract
The aim of this paper is to assess trends in tuberculosis morbidity and mortality in the countries of Eastern Europe and the former USSR. Data on morbidity and mortality were obtained from reports of the Ministries of Health, a 1992 WHO questionnaire, national tuberculosis associations, and other sources. The quality of surveillance of tuberculosis cases differs widely between countries. Ranging from 19 to 80 per 100,000 population in 1990-1992, tuberculosis notification rates of most Eastern European and former USSR countries are higher than those of Western European countries. The lowest tuberculosis notification rate is reported in the Czech Republic, while the highest are reported in Romania and Kazakhstan. While in Albania, Croatia and Slovenia notification rates have continued to decline, in the remaining countries of Eastern Europe the declining trend has recently stopped. Nevertheless, countries such as the Czech Republic, Hungary, Poland and the Slovak Republic have experienced a distinct rate decrease when the 3-year average rate around 1985 is compared to that around 1990, despite the very recent levelling-off or increase. In Romania, the previous decline in notification rate ended in 1985 and in the period 1986-1992 an average 5.4% annual increase was observed. In this country, two-thirds of all cases still occur among young adults. Among the Baltic countries of the former USSR, the declining trend continues in Estonia, whereas in Latvia and Lithuania notification rates decreased less markedly from 1985 to 1990 than in the first half of the 1980s. Among the other European countries of the former USSR, Russia and Ukraine had a slow decline in the first half of the 1980s and a more pronounced one from 1985 to 1990. During the latter period of time, in Belarus and Moldova the decrease has been steeper. In the Caucasian countries of the former USSR, where underreporting and low case-finding are recognized, case rates have stabilized in Armenia, while in Azerbaijan and Georgia there was a decrease from 1985 to 1990. Among the Asian countries of the former USSR, Kazakhastan and Tajikistan reported a lower decline in case rates from 1985 to 1990 than from 1980 to 1985. Kyrgyzstan, Turkmenistan, and Uzbekistan reported increases in notification rates from 1985 to 1990: in Turkmenistan an average 5.5% annual increase in rate was observed between 1987 and 1991. Tuberculosis mortality is steadily increasing in Romania, Armenia, Kyrgyzstan, Latvia, Lithuania, Moldova, and Turkmenistan, while no decline is seen in most of the other countries of Eastern Europe and the former USSR.(ABSTRACT TRUNCATED AT 400 WORDS)
PubMed ID
7718828 View in PubMed
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