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8 records – page 1 of 1.

Absence of HTLV-1 related sequences in MS from high prevalence areas in western Norway.

https://arctichealth.org/en/permalink/ahliterature219178
Source
Acta Neurol Scand. 1994 Jan;89(1):65-8
Publication Type
Article
Date
Jan-1994
Author
K M Myhr
P. Frost
M. Grønning
R. Midgard
K H Kalland
D E Helland
H I Nyland
Author Affiliation
Department of Neurology, University of Bergen, Norway.
Source
Acta Neurol Scand. 1994 Jan;89(1):65-8
Date
Jan-1994
Language
English
Publication Type
Article
Keywords
Adult
Blotting, Southern
Cross-Sectional Studies
Female
HTLV-I Infections - epidemiology
Humans
Incidence
Male
Middle Aged
Multiple Sclerosis - epidemiology
Norway - epidemiology
Polymerase Chain Reaction
Risk factors
Abstract
In Western Norway, long-term follow up epidemiological studies have revealed significant increases in the incidence and prevalence rates of multiple sclerosis (MS) in stable populations, indicating the impact of exogenous factors. In this study 183 MS patients and 102 controls from high prevalence areas in Western Norway were investigated for human T-lymphotropic virus type I (HTLV-1) related sequences by polymerase chain reaction. Using primers targeting the gag, pol and env genes in the HTLV-1 provirus genome, no amplification products were detected in the 183 MS patients or 102 controls. The results strongly suggest that neither HTLV-1 nor a closely related retrovirus participate in the aetiology of MS.
Notes
Erratum In: Acta Neurol Scand 1994 Aug;90(2):143
PubMed ID
8178631 View in PubMed
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Disability and prognosis in multiple sclerosis: demographic and clinical variables important for the ability to walk and awarding of disability pension.

https://arctichealth.org/en/permalink/ahliterature194912
Source
Mult Scler. 2001 Feb;7(1):59-65
Publication Type
Article
Date
Feb-2001
Author
K M Myhr
T. Riise
C. Vedeler
M W Nortvedt
R. Grønning
R. Midgard
H I Nyland
Author Affiliation
Department of Neurology, Haukeland University Hospital, University of Bergen, Norway.
Source
Mult Scler. 2001 Feb;7(1):59-65
Date
Feb-2001
Language
English
Publication Type
Article
Keywords
Adult
Age of Onset
Autoimmune Diseases - economics - epidemiology
Canes - utilization
Cohort Studies
Cross-Sectional Studies
Disability Evaluation
Disease Progression
Female
Follow-Up Studies
Humans
Incidence
Insurance, Disability - economics - statistics & numerical data
Life tables
Male
Multiple Sclerosis - economics - epidemiology
Norway - epidemiology
Prognosis
Proportional Hazards Models
Severity of Illness Index
Survival Analysis
Treatment Outcome
Walking
Wheelchairs - utilization
Abstract
To evaluate disability and prognosis in an untreated population-based incidence cohort of multiple sclerosis (MS) patients.
The Expanded Disability Status Scale (EDSS) score was recorded in 220 MS patients. Disease progression was assessed by life table analysis with different endpoints and multivariate Cox regression analysis was performed for evaluation of prognostic factors.
The probability of being alive after 15 years was 94.8 +/- 1.8% (s.e.), of managing without a wheelchair (EDSS 3 years) predicted favorable outcome. There was also a trend towards favorable outcome in patients with optic neuritis, sensory symptoms and low age at onset but these factors were associated with the RR course. Motor symptoms and high age at onset indicated unfavorable outcome, but these factors were associated with the primary progressive course.
A RR course and long inter-episode intervals in the early phase of the disease were associated with a better outcome. Other onset characteristics indicating a favorable outcome were associated with the RR course while characteristics indicating an unfavorable outcome were associated with the PP course.
PubMed ID
11321195 View in PubMed
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[Do most of the persons with whiplash injury suffer of profit neurosis?].

https://arctichealth.org/en/permalink/ahliterature206808
Source
Tidsskr Nor Laegeforen. 1997 Nov 20;117(28):4120-2
Publication Type
Article
Date
Nov-20-1997
Author
I A Sulg
H I Nyland
Author Affiliation
Nevrologisk avdeling, Haukeland Sykehus, Bergen.
Source
Tidsskr Nor Laegeforen. 1997 Nov 20;117(28):4120-2
Date
Nov-20-1997
Language
Norwegian
Publication Type
Article
Keywords
Accidents, Traffic
Humans
Insurance Claim Review
Norway
Whiplash Injuries - diagnosis - economics - rehabilitation
Notes
Comment In: Tidsskr Nor Laegeforen. 1998 Jan 30;118(3):4349499736
PubMed ID
9441450 View in PubMed
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Etiology of and risk factors for cerebral infarction in young adults in western Norway: a population-based case-control study.

https://arctichealth.org/en/permalink/ahliterature53427
Source
Eur J Neurol. 2004 Jan;11(1):25-30
Publication Type
Article
Date
Jan-2004
Author
H. Naess
H I Nyland
L. Thomassen
J. Aarseth
K-M Myhr
Author Affiliation
Department of Neurology, Haukeland University Hospital, University of Bergen, Bergen, Norway. halvor.naess@haukeland.no
Source
Eur J Neurol. 2004 Jan;11(1):25-30
Date
Jan-2004
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Arteriosclerosis - complications
Case-Control Studies
Cerebral Infarction - etiology
Female
Humans
Hypertension - complications
Male
Middle Aged
Multivariate Analysis
Myocardial Infarction - complications
Norway - epidemiology
Questionnaires
Research Support, Non-U.S. Gov't
Risk factors
Sex Factors
Smoking - adverse effects
Abstract
We sought to study the etiology of and risk factors for cerebral infarction in young adults in Hordaland County, Norway. All patients aged 15-49 years living in Hordaland County with a first-ever cerebral infarction during 1988-97 were included. Etiology was analyzed in subgroups defined by sex, age (/=40 years), circulation territory (anterior versus posterior circulation) and short-term functional outcome [modified Rankin score (mRS) 2]. A questionnaire was used to evaluate possible risk factors amongst the patients compared with an age- and sex-matched control group. The distribution of etiology was significantly different in all subgroups. Atherosclerosis was frequent amongst men (22.8% vs. 4.2%) and patients >/= 40 years (20.8% vs. 2.7%). All patients with microangiopathy had favorable short-term outcome. Significant risk factors were smoking more than 15 cigarettes per day (P
PubMed ID
14692884 View in PubMed
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Long-term outcome of cerebral infarction in young adults.

https://arctichealth.org/en/permalink/ahliterature47207
Source
Acta Neurol Scand. 2004 Aug;110(2):107-12
Publication Type
Article
Date
Aug-2004
Author
H. Naess
H I Nyland
L. Thomassen
J. Aarseth
K-M Myhr
Author Affiliation
Department of Neurology, Haukeland University Hospital, University of Bergen, Bergen, Norway. halvor.naess@haukeland.no
Source
Acta Neurol Scand. 2004 Aug;110(2):107-12
Date
Aug-2004
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Cerebral Infarction - complications - diagnosis - mortality
Employment
Female
Follow-Up Studies
Humans
Male
Marital status
Middle Aged
Myocardial Infarction - complications
Norway - epidemiology
Prognosis
Recovery of Function
Recurrence
Research Support, Non-U.S. Gov't
Seizures - complications
Time Factors
Abstract
OBJECTIVES: We analysed the long-term outcome of 232 young adults aged 15-49 years with first-ever cerebral infarction in 1988-1997 in western Norway. MATERIAL AND METHODS: Mortality, recurrence, epilepsy, functional state as evaluated by modified Rankin scale (mRS), and employment were analysed at follow-up (mean time 5.7 years). RESULTS: Twenty-three (9.9%) patients had died. Recurrence occurred in 9.9%, and post-stroke seizures developed in 10.5%. Recurrence was associated with diabetes mellitus (P = 0.005). Favourable functional outcome (mRS = 2) was found in 77.9%. The functional outcome was better in posterior than anterior circulation infarctions (P = 0.011). Unfavourable functional outcome (mRS > 2) was associated with diabetes mellitus (P = 0.001) and severity of neurological deficits on admission for the index stroke (P
PubMed ID
15242418 View in PubMed
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Performance of the SF-36, SF-12, and RAND-36 summary scales in a multiple sclerosis population.

https://arctichealth.org/en/permalink/ahliterature72088
Source
Med Care. 2000 Oct;38(10):1022-8
Publication Type
Article
Date
Oct-2000
Author
M W Nortvedt
T. Riise
K M Myhr
H I Nyland
Author Affiliation
Department of Public Health and Primary Health Care, University of Bergen, Norway. monica.nortvedt@hib.no
Source
Med Care. 2000 Oct;38(10):1022-8
Date
Oct-2000
Language
English
Publication Type
Article
Keywords
Activities of Daily Living
Cross-Sectional Studies
Disability Evaluation
Female
Health Status Indicators
Humans
Male
Mental health
Middle Aged
Multiple Sclerosis - rehabilitation
Norway
Outcome Assessment (Health Care) - methods
Quality of Life
Reproducibility of Results
Research Support, Non-U.S. Gov't
Abstract
BACKGROUND: Multiple sclerosis (MS) patients accumulate both physical and mental health problems along with disease progression. Valid and sensitive outcome measures are important to measure disease effects and the effect of treatment. OBJECTIVE: The objective of this study was to test the performance of the physical and mental summary scales of SF-36, SF-12, and RAND-36. METHODS: The scales were evaluated by comparing the scores of a cohort of 194 MS patients with general population data and using the Expanded Disability Status Scale (EDSS) and the Incapacity Status Scale-mental as criterion variables for physical functioning and mental health. RESULTS: All 3 physical summary scales were markedly reduced and correlated highly with the EDSS. The SF-36 mental summary score was only slightly reduced among MS patients (0.2 SD) compared with the general population, despite significantly reduced scores on all 4 health scales being most related to mental health and despite a high prevalence of mental health problems. This results from the poor physical functioning (mean scale score, 2.3 SD below the general population) and the orthogonal factor rotation used to derive independent measures of physical and mental health. Similar results were found for the SF-12. The nonorthogonal RAND-36 physical and mental summary scores were both markedly reduced. This is more compatible with the disease progression in MS and the results of the other measures of physical and mental health used in the study. CONCLUSIONS: The SF-36 and SF-12 mental health summary scales appear to overestimate mental health in people with MS.
PubMed ID
11021675 View in PubMed
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Quality of life in multiple sclerosis: measuring the disease effects more broadly.

https://arctichealth.org/en/permalink/ahliterature72299
Source
Neurology. 1999 Sep 22;53(5):1098-103
Publication Type
Article
Date
Sep-22-1999
Author
M W Nortvedt
T. Riise
K M Myhr
H I Nyland
Author Affiliation
Department of Public Health and Primary Health Care, University of Bergen, Norway.
Source
Neurology. 1999 Sep 22;53(5):1098-103
Date
Sep-22-1999
Language
English
Publication Type
Article
Keywords
Adult
Aged
Female
Humans
Male
Middle Aged
Multiple Sclerosis - physiopathology
Quality of Life
Abstract
OBJECTIVE: To compare the Expanded Disability Status Scale (EDSS) and self-rated quality of life scores (SF-36 Health Survey) as measures of disease impact in a representative sample of MS patients. BACKGROUND: The EDSS is the most common outcome measure of impairment/disability for MS patients but is heavily weighted toward mobility. Sensitive outcome measures are needed that also capture other aspects of the effects of MS. METHODS: The authors performed a cross-sectional study of the cohort of all individuals with onset of MS between 1976 and 1986 who were diagnosed before 1995 in Hordaland County, Norway. A total of 194 patients (94%) participated. RESULTS: The patients had lower mean scores for all eight SF-36 health dimensions compared with sex- and age-adjusted scores in a general population. EDSS scores correlated highly with physical functioning (r = -0.86, R2 = 0.73), and explained some of the variation in social functioning (r = -0.48, R2 = 0.23) and general health (r = -0.46, R2 = 0.21) but little for the other dimensions. CONCLUSIONS: The SF-36 captures the broad effects of MS, and the results showed that patients also are bothered frequently with health problems such as bodily pain and low vitality. These problems, which are not reflected in the Expanded Disability Status Scale, should be given more attention in the treatment of MS and when evaluating interventions.
Notes
Comment In: Neurology. 2001 May 8;56(9):125011342708
PubMed ID
10496273 View in PubMed
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Reduced quality of life among multiple sclerosis patients with sexual disturbance and bladder dysfunction.

https://arctichealth.org/en/permalink/ahliterature71866
Source
Mult Scler. 2001 Aug;7(4):231-5
Publication Type
Article
Date
Aug-2001
Author
M W Nortvedt
T. Riise
K M Myhr
A M Landtblom
A. Bakke
H I Nyland
Author Affiliation
Department of Public Health and Primary Health Care, University of Bergen, Norway.
Source
Mult Scler. 2001 Aug;7(4):231-5
Date
Aug-2001
Language
English
Publication Type
Article
Keywords
Adult
Age of Onset
Aged
Bladder Diseases - etiology
Cohort Studies
Cross-Sectional Studies
Disease Progression
Female
Humans
Male
Middle Aged
Multiple Sclerosis - physiopathology - psychology
Norway
Quality of Life
Recurrence
Research Support, Non-U.S. Gov't
Sexual Dysfunction, Physiological - etiology
Abstract
OBJECTIVE: Physical disability explains only part of the reduced quality of life found among multiple sclerosis (MS) patients. Bladder dysfunction and sexual disturbance are frequent and distressing problems for MS patients. We therefore estimated the relationship between the presence and degree of sexual disturbance/bladder dysfunction and the patients' quality of life as measured by the SF-36 Health Survey. METHODS: We performed a cross-sectional study of all individuals with the onset of MS between 1976 and 1986 in Hordaland County, Norway. The disease duration at examination was 9-19 years; 194 patients (94%) participated. RESULTS: Fifty-three per cent of the patients with low physical disability (Expanded Disability Status Scale (EDSS) 4.0) were 86 and 81% respectively. The patients with sexual disturbance had markedly and significantly reduced scores on all eight SF-36 scales, this was after adjustment for disease development measured by the EDSS. The patients without sexual disturbance scored 0.5 s.d. lower than a normal population on the social functioning scale, whereas those with marked sexual disturbance scored 1.5 s.d. lower. Similar results were found for the patients with bladder dysfunction. CONCLUSION: Bladder and sexual problems are associated with a marked reduction in the quality of life, also among patients with otherwise low disability. This underlines the need for identifying and treating these problems.
PubMed ID
11548982 View in PubMed
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8 records – page 1 of 1.