Skip header and navigation

4 records – page 1 of 1.

Prognostic impact of genomic instability in colorectal cancer.

https://arctichealth.org/en/permalink/ahliterature104693
Source
Br J Cancer. 2014 Apr 15;110(8):2159-64
Publication Type
Article
Date
Apr-15-2014
Author
T S Hveem
M A Merok
M E Pretorius
M. Novelli
M S Bævre
O H Sjo
N. Clinch
K. Liestøl
A. Svindland
R A Lothe
A. Nesbakken
H E Danielsen
Author Affiliation
1] Institute for Cancer Genetics and Informatics, Oslo University Hospital, PO Box 4950 Nydalen, 0424 Oslo, Norway [2] Centre for Cancer Biomedicine, University of Oslo, PO Box 4950 Nydalen, 0424 Oslo, Norway [3] Department of Informatics, University of Oslo, PO Box 1080 Blindern, 0316 Oslo, Norway.
Source
Br J Cancer. 2014 Apr 15;110(8):2159-64
Date
Apr-15-2014
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Aneuploidy
Colorectal Neoplasms - diagnosis - genetics - pathology
DNA, Neoplasm - genetics
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Male
Microsatellite Instability
Middle Aged
Neoplasm Recurrence, Local - genetics
Neoplasm Staging
Norway
Prognosis
Abstract
The prognostic impact of an indication of chromosomal instability (CIN) is evaluated in a consecutive series of 952 colorectal cancer patients treated at Aker University Hospital, Norway, during 1993-2003. Microsatellite instability (MSI) in this case series has recently been reported and made it possible to find the co-occurrence and compare the prognostic significance of CIN and MSI.
Data sets for overall survival (OS; n=855) and time to recurrence (TTR; n=579) were studied. To reveal CIN we used automated image cytometry (ICM). Non-diploid histograms were taken as indicative of the presence of CIN. PCR-based measures of MSI in this material have already been described.
As with MSI, CIN was found to be an independent predictor of early relapse and death among stage II patients (TTR: n=278: HR 2.19 (95% CI: 1.35-3.55), P=0.002). Of the MSI tumours (16%), 71% were found to be DNA diploid, 21% were DNA tetraploid and 8% were DNA aneuploid. Among microsatellite stable tumours, 24% were DNA diploid, 15% were DNA tetraploid and 61% were DNA aneuploid.
For patients presenting with stage II disease, genomic instability as detected by DNA image cytometry has the potential to provide a useful biomarker for relapse and cancer-related death following surgery with curative intent.
Notes
Cites: Br J Cancer. 2001 Jan;84(2):232-611161382
Cites: Eur J Surg Oncol. 2002 Mar;28(2):126-3411884047
Cites: World J Surg. 2002 Jan;26(1):59-6611898035
Cites: Ann Oncol. 2003 Oct;14(10):1494-50014504048
Cites: CA Cancer J Clin. 2004 Jan-Feb;54(1):8-2914974761
Cites: Nature. 1998 Dec 17;396(6712):643-99872311
Cites: Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8681-610411935
Cites: Gastroenterology. 2006 Sep;131(3):729-3716952542
Cites: Oncogene. 2007 Apr 19;26(18):2642-817043639
Cites: J Natl Cancer Inst. 2007 Jul 4;99(13):998-100317596575
Cites: Dis Colon Rectum. 2007 Nov;50(11):1800-1017874166
Cites: Colorectal Dis. 2008 Jan;10(1):33-4017672872
Cites: Gut. 2008 Jul;57(7):941-5018364437
Cites: Nat Rev Clin Oncol. 2010 Jun;7(6):318-2520440283
Cites: Eur J Cancer. 2010 Oct;46(15):2788-9820627535
Cites: Br J Cancer. 2011 Oct 11;105(8):1218-2321934680
Cites: Gut. 2012 Nov;61(11):1560-722213796
Cites: J Pathol. 2013 Feb;229(3):441-823165447
Cites: Ann Oncol. 2013 May;24(5):1274-8223235802
Cites: Am J Gastroenterol. 2013 Nov;108(11):1785-9324042191
PubMed ID
24642618 View in PubMed
Less detail
Source
Tidsskr Nor Laegeforen. 1997 Apr 30;117(11):1582-3
Publication Type
Article
Date
Apr-30-1997
Author
H E Danielsen
Author Affiliation
Avdeling for patologi det Norske Radiumhospital, Oslo.
Source
Tidsskr Nor Laegeforen. 1997 Apr 30;117(11):1582-3
Date
Apr-30-1997
Language
Norwegian
Publication Type
Article
Keywords
Cost-Benefit Analysis
Norway
Telemedicine - economics
PubMed ID
9198937 View in PubMed
Less detail

[Telepathology at the Norwegian Radium Hospital]

https://arctichealth.org/en/permalink/ahliterature68917
Source
Tidsskr Nor Laegeforen. 2000 Aug 10;120(18):2170-3
Publication Type
Article
Date
Aug-10-2000
Author
P. Knudsen
A J Ryther
J A Nesheim
V M Abeler
J M Nesland
H E Danielsen
Author Affiliation
Avdeling for Patologi Det Norske Radiumhospital, Oslo.
Source
Tidsskr Nor Laegeforen. 2000 Aug 10;120(18):2170-3
Date
Aug-10-2000
Language
Norwegian
Publication Type
Article
Keywords
Diagnosis, Computer-Assisted
English Abstract
Frozen Sections
Hospitals, Special - organization & administration
Humans
Image Processing, Computer-Assisted
Internet
Norway
Pathology Department, Hospital - organization & administration
Radiology
Referral and Consultation
Remote Consultation
Telepathology - methods - organization & administration - trends
Abstract
BACKGROUND: The article gives an overview of the telepathology activity at the Norwegian Radium Hospital from the service was launched in 1994 and up until today. We show the development during these years and discuss telepathology in general terms. We also discuss those aspects that determine how well a telepathology service functions. MATERIAL AND METHODS: 74 frozen section slides were diagnosed by two different telepathology systems. One of these systems was used for examining its appropriateness as a tool for second opinion in pathology. A new Internet-based system was developed that provided additional functionality. RESULTS: A telepathology system with a digital camera outperforms one with an analog camera with respect to diagnostic accuracy. INTERPRETATION: Image quality determines the precision of a telepathology service. Telepathology is a feasible tool for second opinion in pathology.
Notes
Comment In: Tidsskr Nor Laegeforen. 2000 Sep 10;120(21):257911071002
PubMed ID
11006741 View in PubMed
Less detail
Source
Tidsskr Nor Laegeforen. 1999 Apr 10;119(9):1335
Publication Type
Article
Date
Apr-10-1999
Author
V M Abeler
H E Danielsen
Source
Tidsskr Nor Laegeforen. 1999 Apr 10;119(9):1335
Date
Apr-10-1999
Language
Norwegian
Publication Type
Article
Keywords
Norway
Telepathology
Notes
Comment On: Tidsskr Nor Laegeforen. 1999 Jan 30;119(3):355-810074829
PubMed ID
10327860 View in PubMed
Less detail