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A clinical and neurophysiological investigation of a Danish kindred with heterozygous familial hypobetalipoproteinemia.

https://arctichealth.org/en/permalink/ahliterature41413
Source
Acta Paediatr Scand. 1979 Mar;68(2):155-9
Publication Type
Article
Date
Mar-1979
Author
G E Andersen
W. Trojaborg
H C Lou
Source
Acta Paediatr Scand. 1979 Mar;68(2):155-9
Date
Mar-1979
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Child
Child, Preschool
Denmark
Female
Heterozygote
Humans
Hypobetalipoproteinemia - diagnosis - genetics
Hypolipoproteinemia - genetics
Infant
Infant, Newborn
Lipids - blood
Lipoproteins - blood
Male
Middle Aged
Neurologic Examination
Pedigree
Abstract
A three-generation transmission of under five percentile values for serum low density lipoprotein and low density lipoprotein cholesterol typical of heterozygous familial hypobetalipoproteinemia was demonstrated in a Danish family. Slight clinical signs of CNS abnormality were found in 4 of the 8 subjects with heterozygous familial hypobetalipoproteinemia, but did not resemble the neurological findings in abetalipoproteinemia nor in the previously described patients with familial hypobetalipoproteinemia. There were no signs of myelin dysfunction in the central nervous system as judged from the normal latency of visual and somatosensory evoked potentials.
PubMed ID
419983 View in PubMed
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[Intrauterine growth retardation and premature delivery. The effect of smoking and psychosocial factors]

https://arctichealth.org/en/permalink/ahliterature11050
Source
Ugeskr Laeger. 1997 May 26;159(22):3393-400
Publication Type
Article
Date
May-26-1997
Author
M. Nordentoft
H C Lou
D. Hansen
J. Nim
O A Pryds
P J Rubin
R P Hemmingsen
Author Affiliation
Bispebjerg Hospital, psykiatrisk afdeling, John F. Kennedy Instituttet, Glostrup.
Source
Ugeskr Laeger. 1997 May 26;159(22):3393-400
Date
May-26-1997
Language
Danish
Publication Type
Article
Keywords
Adult
Alcohol Drinking - adverse effects
Denmark
English Abstract
Female
Fetal Growth Retardation - etiology - prevention & control - psychology
Humans
Infant, Newborn
Infant, Premature
Maternal Welfare
Obstetric Labor, Premature - etiology - prevention & control - psychology
Pregnancy
Questionnaires
Research Support, Non-U.S. Gov't
Smoking - adverse effects
Social Support
Socioeconomic Factors
Abstract
The purpose of the study is to investigate the influence of psychosocial stress, maternal schooling, social support, psychological well-being, alcohol and smoking on intrauterine growth retardation and premature delivery. At a Copenhagen university hospital 2432 consecutive Danish-speaking women in 20th week of pregnancy completed a questionnaire including the General Health Questionnaire and Severity of Psychosocial Stressor Scale and questions about social network, education, smoking and drinking habits. In 212 cases (8.7%) the women delivered before day 259 of gestation. In a multiple logistic regression model, pre-term delivery proved to be associated with psychosocial stress and poor school education. In 152 cases (6.3%) infants had a birth weight below the defined 10th percentile. In a multiple logistic regression model, IUGR was associated with smoking. In preventive programmes, such as anti-smoking campaigns, it should be kept in mind that women who smoke are also the least educated and have the poorest support from a social network.
PubMed ID
9199026 View in PubMed
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[Serious life events and congenital malformations. A national study with a complete follow-up]

https://arctichealth.org/en/permalink/ahliterature19959
Source
Ugeskr Laeger. 2001 Feb 19;163(8):1051-7
Publication Type
Article
Date
Feb-19-2001
Author
D. Hansen
H C Lou
J. Olsen
Author Affiliation
John F. Kennedy Instituttet, Glostrup. dhansen@dadlnet.dk
Source
Ugeskr Laeger. 2001 Feb 19;163(8):1051-7
Date
Feb-19-2001
Language
Danish
Publication Type
Article
Keywords
Abnormalities - epidemiology - etiology - psychology
Adult
Cohort Studies
Comorbidity
Death
Denmark
English Abstract
Female
Follow-Up Studies
Humans
Infant, Newborn
Life Change Events
Male
Neural Crest - abnormalities
Pregnancy
Pregnancy Complications - psychology
Registries
Research Support, Non-U.S. Gov't
Socioeconomic Factors
Stress, Psychological - complications
Abstract
INTRODUCTION: Emotional stress during organogenesis could, in theory, cause congenital malformations by increasing the level of cortisone, but documentation is lacking. We undertook a follow-up study to test the hypothesis that psychosocial stress increases the prevalence of malformations, in particular malformations of the cranial neural crest. MATERIAL AND METHODS: We defined serious life events as the death or first hospital admission for cancer or acute myocardial infarction of partners or children. All women exposed to severe life events during and up to 16 months before pregnancy in the period 1980 to 1992 were identified by means of five national registers. We studied 3560 exposed pregnancies and randomly selected 20,299 "not-exposed" pregnancies as the control cohort. RESULTS: Women exposed to severe life events gave birth to offspring with an increased prevalence of cranial neural crest malformations, at an adjusted odds ratio of 1.54; 95% CI (1.05-2.27). For other malformations the adjusted odds ratio was 1.14-95% CI (0.94-1.42). Women exposed in two consecutive pregnancies had a higher odds ratio for cranial neural crest malformations, with an adjusted odds ratio of 2.99; 95% CI (1.06-8.43). Death of an older child during the first trimester was associated with an adjusted odds ratio of cranial neural crest malformations in the offspring of 4.75; 95% CI (1.63-13.78). Unexpected death of a child during the first trimester was associated with an adjusted odds ratio of 8.36 in the offspring, 95% CI (2.41-28.99) for cranial neural crest malformations and 3.64, 95% CI (1.29-10.32) for other kinds of malformations. DISCUSSION AND CONCLUSION: These findings support the hypothesis that severe emotional stress during pregnancy, especially stress related to the death of a child, may cause congenital malformations, particularly those of the cranial neural crest.
PubMed ID
11242661 View in PubMed
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Serious life events and congenital malformations: a national study with complete follow-up.

https://arctichealth.org/en/permalink/ahliterature20178
Source
Lancet. 2000 Sep 9;356(9233):875-80
Publication Type
Article
Date
Sep-9-2000
Author
D. Hansen
H C Lou
J. Olsen
Author Affiliation
Neuropediatric Department, John F Kennedy Institute, Glostrup, Denmark. dhansen@dadlnet.dk
Source
Lancet. 2000 Sep 9;356(9233):875-80
Date
Sep-9-2000
Language
English
Publication Type
Article
Keywords
Abnormalities - epidemiology
Adolescent
Adult
Aged
Child
Cohort Studies
Confidence Intervals
Death
Denmark - epidemiology
Embryonic and Fetal Development
Family Health
Female
Follow-Up Studies
Humans
Logistic Models
Male
Middle Aged
Myocardial Infarction - epidemiology - psychology
Neoplasms - epidemiology - psychology
Neural Tube Defects - epidemiology
Odds Ratio
Pregnancy
Pregnancy Trimester, First
Prevalence
Registries
Research Support, Non-U.S. Gov't
Stress, Psychological - epidemiology
Abstract
BACKGROUND: Emotional stress during organogenesis could, in theory, cause congenital malformations. We undertook a follow-up study to test the hypothesis that psychosocial stress increases the prevalence of malformations, particularly of the cranial neural crest. METHODS: We defined severe life events as death or first hospital admission for cancer or acute myocardial infarction in partners or children. From 1980 to 1992 all women exposed to severe life events during pregnancy and up to 16 months previously were identified by means of five national registers. We included 3560 exposed pregnancies and 20,299 pregnancies without such exposures randomly selected as a control cohort. FINDINGS: The frequency of cranial-neural-crest malformations was higher in pregnancies with exposure to severe life events than in those without such exposure (42 [1.18%] vs 131 [0.65%]; adjusted odds ratio 1.54 [95% CI 1.05-2.27]). For other malformations, the frequencies were 3.04% and 3.26% (1.14 [0.94-1.42]). Women exposed in two consecutive pregnancies had a higher risk of cranial-neural-crest malformations (2.99 [1.06-8.43]). Death of an older child during the first trimester was associated with an adjusted odds ratio of cranial-neural-crest malformations of 4.75 (1.63-13.8). Unexpected death of a child during the first trimester was associated with adjusted odds ratios of 8.36 (2.41-29.0) for cranial-neural-crest malformations and 3.64 (1.29-10.3) for other malformations. INTERPRETATION: These findings support the hypothesis that severe emotional stress during pregnancy, especially that related to death of a child, may cause congenital malformations, particularly those of the cranial neural crest.
Notes
Erratum In: Lancet 2001 Jun 30;357(9274):2142
PubMed ID
11036891 View in PubMed
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[The significance of psychosocial stress for pregnancy course and fetal development]

https://arctichealth.org/en/permalink/ahliterature59209
Source
Ugeskr Laeger. 1996 Apr 22;158(17):2369-72
Publication Type
Article
Date
Apr-22-1996
Author
D. Hansen
H C Lou
M. Nordentoft
O A Pryds
F R Jensen
J. Nim
R P Hemmingsen
Author Affiliation
Neonatalklinikken, og obstetrisk klinik, Staten Seruminstitut, Rigshospitalet,København.
Source
Ugeskr Laeger. 1996 Apr 22;158(17):2369-72
Date
Apr-22-1996
Language
Danish
Publication Type
Article
Keywords
Birth weight
Cephalometry
Denmark
Embryonic and Fetal Development
English Abstract
Female
Humans
Infant, Newborn
Life Change Events
Neurologic Examination
Pregnancy
Pregnancy outcome
Prospective Studies
Questionnaires
Research Support, Non-U.S. Gov't
Socioeconomic Factors
Stress, Psychological - complications
Abstract
In a population-based study, 3021 women in a central Copenhagen district received a questionnaire on environmental and psychological factors during mid-gestation. Of these, 70 women were selected consecutively on the basis of moderate to severe stressful life-events (DSM-III-R categories 3 to 5), in combination with an inadequate social network. They were compared with 50 non-stressed women with an intact social network. Stress and smoking significantly affected birthweight and head circumference. When birthweight was corrected, stress remained a significant determinant of small head circumference, indicating a specific effect on brain development. Stress also led to a suboptimal Prechtl neonatal neurological score. These findings suggest the existence of a fetal stress syndrome with adverse effects on fetal development, including deficient brain development.
PubMed ID
8685988 View in PubMed
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7 records – page 1 of 1.