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7 records – page 1 of 1.

Evaluation of the progeny of rats treated with topoisomerase II inhibitor vepesid.

https://arctichealth.org/en/permalink/ahliterature79366
Source
Bull Exp Biol Med. 2006 May;141(5):578-80
Publication Type
Article
Date
May-2006
Author
Borovskaya T G
Gol'dberg V E
Shchemerova Yu A
Perova A V
Timina E A
Pakhomova A V
Author Affiliation
Institute of Pharmacology, Tomsk Research Center, Siberian Division, Russian Academy of Medical Sciences. mmu@pharm.tsu.ru
Source
Bull Exp Biol Med. 2006 May;141(5):578-80
Date
May-2006
Language
English
Publication Type
Article
Keywords
Abnormalities, Drug-Induced
Animals
Animals, Newborn
Antineoplastic Agents, Phytogenic - toxicity
DNA Topoisomerases, Type II - antagonists & inhibitors
Etoposide - toxicity
Female
Fetal Death - chemically induced
Male
Pregnancy
Prenatal Exposure Delayed Effects
Rats
Rats, Wistar
Time Factors
Abstract
Progeny of Wistar rats treated with vepesid 1, 3, and 6 months before mating is characterized by common pathological changes. These changes were more pronounced and more diverse in animals descending from females receiving the cytostatic compared to the progeny of treated males. The severity of toxic effects depended on the period between mating and vepesid treatment. Cytostatic treatment 3 months before mating was associated with minimum toxicity for the progeny.
PubMed ID
17181057 View in PubMed
Less detail

Mechanisms of stimulation of granulocytopoiesis with neupogen in patients with breast cancer during chemotherapy.

https://arctichealth.org/en/permalink/ahliterature90624
Source
Bull Exp Biol Med. 2008 Apr;145(4):467-71
Publication Type
Article
Date
Apr-2008
Author
Khrichkova T Yu
Gol'dberg V E
Zhdanov V V
Matyash M G
Vysotckaya V V
Simolina E I
Shatalova V A
Popova N O
Miroshnichenko L A
Dygai A M
Author Affiliation
Institute of Pharmacology and Institute of Oncology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Russia.
Source
Bull Exp Biol Med. 2008 Apr;145(4):467-71
Date
Apr-2008
Language
English
Publication Type
Article
Keywords
Adult
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Breast Neoplasms - blood - drug therapy - pathology
Cell Differentiation - drug effects
Cell Proliferation - drug effects
Cells, Cultured
Doxorubicin - administration & dosage
Female
Filgrastim - administration & dosage - pharmacology
Granulocytes - drug effects - pathology - physiology
Hematopoiesis - drug effects
Humans
Middle Aged
Taxoids - administration & dosage
Treatment Outcome
Up-Regulation - drug effects
Abstract
The mechanisms of granulocytopoiesis stimulation with granulocytic CSF (neupogen), added to chemotherapy protocol (adriablastine+taxotere) in patients with stages III-IV breast cancer, were studied. The hemostimulatory effect of granulocytic CSF preparation is based on stimulation of proliferation and differentiation of granulomonocytopoisis precursor cell in the hemopoietic tissue, due to neupogen effects on hemopoietic elements and on the hemopoiesis-inducing microenvironment cells.
PubMed ID
19110596 View in PubMed
Less detail

Morphological and functional state of rat ovaries in the early and late periods after injection of vepesid.

https://arctichealth.org/en/permalink/ahliterature79364
Source
Bull Exp Biol Med. 2006 May;141(5):645-7
Publication Type
Article
Date
May-2006
Author
Borovskaya T G
Gol'dberg V E
Pakhomova A V
Perova A V
Timina E A
Author Affiliation
Institute of Pharmacology, Tomsk Research Center, Siberian Division, Russian Academy of Medical Sciences.
Source
Bull Exp Biol Med. 2006 May;141(5):645-7
Date
May-2006
Language
English
Publication Type
Article
Keywords
Animals
Antineoplastic Agents, Phytogenic - toxicity
Embryonic Development - drug effects
Etoposide - toxicity
Female
Maximum Tolerated Dose
Ovary - drug effects - pathology - physiology
Pregnancy
Rats
Rats, Wistar
Time Factors
Abstract
Morphological and functional state of the ovaries in female Wistar rats was assessed in the early and late periods after administration of antitumor drug vepesid in a single maximum tolerated dose. In the early period, the drug pronouncedly decreased the number of primordial follicles, bi- and multilayer follicles, and the total number of generative elements. The number of graafian vesicles and corpora lutea did not decrease. In the late period, exhaustion of the reserved potencies of gonads was more pronounced than in the control. Morphological alterations in the ovaries were accompanied by inhibition of the functional state of the female reproductive system in the period corresponding to the action on mature and primordial follicles. This inhibition manifested in increased postimplantation mortality.
PubMed ID
17181074 View in PubMed
Less detail

Pharmacological correction of etoposide ovariotoxicity.

https://arctichealth.org/en/permalink/ahliterature87438
Source
Bull Exp Biol Med. 2007 May;143(5):614-6
Publication Type
Article
Date
May-2007
Author
Borovskaya T G
Timina E A
Perova A V
Pakhomova A V
Shchemerova Yu A
Gol'dberg V E
Author Affiliation
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Russia.
Source
Bull Exp Biol Med. 2007 May;143(5):614-6
Date
May-2007
Language
English
Publication Type
Article
Keywords
Animals
Antineoplastic Agents, Phytogenic - toxicity
Buserelin - pharmacology
Etoposide - toxicity
Female
Fertility Agents, Female - pharmacology
Ovary - drug effects
Rats
Rats, Wistar
Abstract
The possibility of reducing the ovariotoxicity of antitumor drug etoposide with buserelin, a hypothalamic regulator of pituitary function, was studied in female Wistar rats. Quantitative analysis of ovarian structural and functional elements on serial sections through the entire organ showed that 3 months after combined treatment with etoposide and buserelin, the morphological picture of the ovarian glands did not differ from that in intact animals of the same age, while etoposide monotherapy led to earlier development of atrophic processes. Six months after treatment, the number of bi- and multilayer follicles was significantly higher in rats receiving combined therapy compared to animals treated with etoposide alone.
PubMed ID
18239783 View in PubMed
Less detail

The stage of offspring of female rats after treatment with cytostatics of various groups.

https://arctichealth.org/en/permalink/ahliterature88842
Source
Bull Exp Biol Med. 2008 Oct;146(4):429-32
Publication Type
Article
Date
Oct-2008
Author
Borovskaya T G
Perova A V
Pachomova A V
Poluektova M E
Gol'dberg V E
Author Affiliation
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru
Source
Bull Exp Biol Med. 2008 Oct;146(4):429-32
Date
Oct-2008
Language
English
Publication Type
Article
Keywords
Animals
Carboplatin - toxicity
Cisplatin - toxicity
Cytostatic Agents - toxicity
Drug Administration Schedule
Epirubicin - toxicity
Etoposide - toxicity
Female
Male
Paclitaxel - toxicity
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced
Rats
Rats, Wistar
Time Factors
Abstract
We examined the offspring of female rats that were mated with intact males in the delayed period after administration of cytostatic drugs Farmorubicin, platidiam, carboplatin, etoposide, and paclitaxel (1, 3, and 6 months post-treatment). Toxicity of these drugs in the offspring decreased in the following order: paclitaxel > etoposide > carboplatin > platidiam > Farmorubicin. The toxic effect depended not only on the type of cytostatic treatment, but also on the period of conception.
PubMed ID
19489312 View in PubMed
Less detail

State of central and peripheral pools of hemopoietic precursor cells in patients with malignant neoplasms during chemotherapy.

https://arctichealth.org/en/permalink/ahliterature81939
Source
Bull Exp Biol Med. 2005 Nov;140(5):635-9
Publication Type
Article
Date
Nov-2005
Author
Khrichkova T Yu
Gol'dberg V E
Matyash M G
Vysotskaya V V
Author Affiliation
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Source
Bull Exp Biol Med. 2005 Nov;140(5):635-9
Date
Nov-2005
Language
English
Publication Type
Article
Keywords
Antineoplastic Agents - pharmacology
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Bone Marrow Cells - cytology - drug effects
Breast Neoplasms - drug therapy
Cyclophosphamide - therapeutic use
Doxorubicin - therapeutic use
Erythrocytes - cytology
Fluorouracil - therapeutic use
Granulocytes - cytology
Hematopoietic Stem Cells - cytology
Hemoglobins - metabolism
Humans
Lung Neoplasms - drug therapy
Abstract
We studied toxic effects of various schemes of cytostatic treatment on central and peripheral pools of hemopoietic precursor cells in patients with III-IV stages of lung cancer and breast cancer. It was found that erythro- and granulomonocytopoietic precursors are characterized by high resistance to cytostatic treatment compared to morphologically discernible bone marrow elements, which is probably a evolutionary developed property of this cell type aimed at rapid recovery of the hemopoietic tissue.
PubMed ID
16758643 View in PubMed
Less detail

Toxic effect of an antitumor drug paclitaxel on morphofunctional characteristics of the liver in rats.

https://arctichealth.org/en/permalink/ahliterature91159
Source
Bull Exp Biol Med. 2008 Feb;145(2):263-5
Publication Type
Article
Date
Feb-2008
Author
Ermolaeva L A
Dubskaya T Yu
Fomina T I
Vetoshkina T V
Gol'dberg V E
Author Affiliation
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Source
Bull Exp Biol Med. 2008 Feb;145(2):263-5
Date
Feb-2008
Language
English
Publication Type
Article
Keywords
Animals
Antineoplastic Agents, Phytogenic - toxicity
Biological Markers - blood
Female
Hepatocytes - cytology - drug effects
Liver - drug effects - enzymology - pathology
Paclitaxel - toxicity
Rats
Abstract
Single intravenous injection of paclitaxel to rats in a maximum tolerated dose of 4.6 mg/kg was accompanied by permanent structural and functional changes in the liver. The observed changes were typical of nonspecific reactive hepatitis: infiltration with lymphocytes and macrophages, pyknosis, and focal fatty degeneration of hepatocytes. Liver enzyme activity increased in blood plasma.
PubMed ID
19023985 View in PubMed
Less detail

7 records – page 1 of 1.