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Association of CD44 isoform immunohistochemical expression with myometrial and vascular invasion in endometrioid endometrial carcinoma.
Gynecol Oncol. 2002 Jan;84(1):58-61
Publication Type
Gary N Stokes
Jack B Shelton
Christopher M Zahn
Brian S Kendall
Author Affiliation
Department of Pathology, Third Medical Group, Elmendorf AFB, Alaska 99506, USA.
Gynecol Oncol. 2002 Jan;84(1):58-61
Publication Type
Antigens, CD44 - biosynthesis
Carcinoma, Endometrioid - blood supply - metabolism - pathology
Endometrial Neoplasms - blood supply - metabolism - pathology
Glycoproteins - biosynthesis
Myometrium - pathology
Neoplasm Invasiveness
Neovascularization, Pathologic - metabolism
Protein Isoforms
OBJECTIVE: Appropriate clinical management of cases of FIGO Grade I and II endometrial carcinoma relies heavily on the determination of myometrial invasion (MI). There are no reports addressing expression of the cell adhesion molecule CD44 in the subset of Grade I and II endometrioid carcinoma (EC) as it relates to prognosis, including MI. METHODS: Immunohistochemical staining for CD44s and CD44v6 was evaluated in 40 hysterectomy specimens with Grade I and II EC, including 11 noninvasive ECs, 14 with MI 50%). Staining characteristics according to the presence of MI and vascular space invasion (VSI) were evaluated. Strong membranous staining of >10% of tumor cells was interpreted as positive. RESULTS: CD44v6 staining was positive in 20% (8/40) of cases, including 45% (5/11) of EC without MI but only 10% (3/29) with MI (P = 0.025). CD44v6 staining was not present in deeply invasive tumors (0/15), while it was present in 8/25 superficially or noninvasive tumors (P = 0.016). Sensitivity and specificity were 25 and 100%, respectively, using CD44v6 in evaluating deep myometrial invasion. CD44s showed a trend toward positive staining when comparing noninvasive versus invasive tumors and noninvasive/superficially invasive versus deeply invasive tumors (P = 0.08 and 0.12, respectively). CD44s or CD44v6 staining was highly specific for absence of VSI, although statistical comparison did not reach significance. CONCLUSION: Deeply invasive EC was associated with a consistent lack of CD44v6 expression. This may have potential clinical utility if this finding is demonstrated in further study of prehysterectomy sampling specimens containing EC.
PubMed ID
11748977 View in PubMed
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