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The -629C>A polymorphism in the CETP gene does not explain the association of TaqIB polymorphism with risk and age of myocardial infarction in Icelandic men.

https://arctichealth.org/en/permalink/ahliterature53840
Source
Atherosclerosis. 2001 Nov;159(1):187-92
Publication Type
Article
Date
Nov-2001
Author
G. Eiriksdottir
M K Bolla
B. Thorsson
G. Sigurdsson
S E Humphries
V. Gudnason
Author Affiliation
Molecular Genetics Laboratory, Hjartavernd, Icelandic Heart Association, Lagmuli 9, 108, Reykjavik, Iceland. gudny@hjarta.is
Source
Atherosclerosis. 2001 Nov;159(1):187-92
Date
Nov-2001
Language
English
Publication Type
Article
Keywords
Aged
Carrier Proteins - genetics
Gene Frequency
Genotype
Glycoproteins
Homozygote
Humans
Iceland
Linkage Disequilibrium
Lipids - blood
Lipoproteins, HDL Cholesterol - blood
Male
Myocardial Infarction - blood - genetics
Polymerase Chain Reaction
Polymorphism, Genetic
Promoter Regions (Genetics) - genetics
Prospective Studies
Research Support, Non-U.S. Gov't
Risk factors
Abstract
The aim of this study was to examine whether the well-established effect of the common TaqIB polymorphism in intron 1 of the gene for cholesterol ester transfer protein (CETP) on high density lipoprotein cholesterol (HDL-C) concentration and increased risk of myocardial infarction (MI), could be explained by the recently identified -629C>A functional polymorphism in the promoter. Non-fatal MI cases (388 male) and a control group of 794 healthy men were recruited from the 30 year long prospective Reykjavik Study. In the healthy men the frequency of the TaqIB B2 allele was 0.47 (95% CI: 0.44-0.50) and there was a strong allelic association with the -629A allele (D=-0.21, P
PubMed ID
11689220 View in PubMed
Less detail

Advanced cardiac life support in the prehospital setting: the Reykjavik experience.

https://arctichealth.org/en/permalink/ahliterature55432
Source
J Intern Med. 1989 Feb;225(2):129-35
Publication Type
Article
Date
Feb-1989
Author
O. Einarsson
F. Jakobsson
G. Sigurdsson
Author Affiliation
Department of Medicine, Reykjavik City Hospital, Iceland.
Source
J Intern Med. 1989 Feb;225(2):129-35
Date
Feb-1989
Language
English
Publication Type
Article
Keywords
Adult
Aged
Ambulances
Evaluation Studies
Female
Heart Arrest - mortality - therapy
Humans
Iceland
Life Support Care
Male
Middle Aged
Physicians
Urban Population
Abstract
Since 1982 a mobile emergency care unit (emergency ambulance) manned by a physician has been operated in Reykjavik. During 1982-1986 there were 138 attempted resuscitations in sudden cardiorespiratory arrest from cardiac causes. Twenty-four patients (17%) were discharged home, all but one without mental impairment. Seventy-three patients presented with ventricular fibrillation, 21 (29%) of which were discharged. The mean ambulance response time was 5 min. Bystanders initiated cardiopulmonary resuscitation (CPR) in 40 cases (29%) which significantly improved the outcome. In witnessed arrests, 19 of 36 patients (53%) with bystander-initiated CPR were discharged compared to 5 of 62 patients (8%) where CPR awaited the arrival of the ambulance team. These results are comparable to those obtained in larger metropolitan areas. In small urban areas the size of Reykjavik (population of 110,000), an advanced and efficient prehospital care can be organized as an extension of the emergency departments role.
PubMed ID
2921594 View in PubMed
Less detail

Age-related loss of proximal femoral strength in elderly men and women: the Age Gene/Environment Susceptibility Study--Reykjavik.

https://arctichealth.org/en/permalink/ahliterature128686
Source
Bone. 2012 Mar;50(3):743-8
Publication Type
Article
Date
Mar-2012
Author
T F Lang
S. Sigurdsson
G. Karlsdottir
D. Oskarsdottir
A. Sigmarsdottir
J. Chengshi
J. Kornak
T B Harris
G. Sigurdsson
B Y Jonsson
K. Siggeirsdottir
G. Eiriksdottir
V. Gudnason
J H Keyak
Author Affiliation
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143-0946, USA. thomas.lang@ucsf.edu
Source
Bone. 2012 Mar;50(3):743-8
Date
Mar-2012
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Aging - physiology
Bone Density - physiology
Disease Susceptibility
Female
Femur - physiology - radiography
Hip Fractures - etiology - physiopathology - radiography
Humans
Male
Sex Factors
Abstract
The risk of hip fracture rises rapidly with age, and is particularly high in women. This increase in fracture risk reflects both the age-related change in the risk of falling and decrements in the strength of the proximal femur. To better understand the extent to which proximal femoral density, structure and strength change with age as a function of gender, we have carried out a longitudinal analysis of proximal femoral volumetric quantitative computed tomographic (vQCT) images in men and women, analyzing changes in trabecular and cortical bone properties, and using subject-specific finite element modeling (FEM) to estimate changes in bone strength. In the AGES-Reykjavik Study vQCT scans of the hip were performed at a baseline visit in 2002-2006 and at a second visit 5.05±0.25 years later. From these, 223 subjects (111 men, 112 women, aged 68-87 years) were randomly selected. The subjects were evaluated for longitudinal changes in three bone variables assessed in a region similar to the total femur region quantified by DXA: areal bone mineral density (aBMD), trabecular volumetric bone mineral density (tBMD) and the ratio of cortical to total tissue volume (cvol/ivol). They were also evaluated for changes in bone strength using FEM models of the left proximal femur. Models were analyzed under single-limb stance loading (F(Stance)), which approximates normal physiologic loading of the hip, as well as a load approximating a fall onto the posterolateral aspect of the greater trochanter (F(Fall)). We computed five-year absolute and percentage changes in aBMD, tBMD, cvol/ivol, F(Fall) and F(Stance). The Mann-Whitney Test was employed to compare changes in bone variables between genders and the Wilcoxon Signed Rank Test was used to compare changes in bone strength between loading conditions. Multiple (linear) regression was employed to determine the association of changes in F(Fall) and F(Stance) with baseline age and five-year weight loss. Both men and women showed declines in indices of proximal femoral density and structure (aBMD: men -3.9±6.0%, women -6.1±6.2%; tBMD: men -14.8±20.3%, women -23.9±26.8%; cvol/ivol: men -2.6±4.6%, women -4.7±4.8%, gender difference: p
Notes
Cites: J Clin Densitom. 2009 Jul-Sep;12(3):330-619577939
Cites: Ann N Y Acad Sci. 2010 Mar;1192:57-6520392218
Cites: J Bone Miner Res. 2010 Mar;25(3):482-9119594320
Cites: J Bone Miner Res. 2010 May;25(5):994-100119874201
Cites: Bone. 2011 Jun 1;48(6):1239-4521419886
Cites: J Bone Miner Res. 2000 Apr;15(4):710-2010780863
Cites: J Biomech. 2000 Feb;33(2):209-1410653034
Cites: Bone. 2006 Jul;39(1):152-816459156
Cites: Osteoporos Int. 2000;11(7):592-911069193
Cites: Med Eng Phys. 2001 Apr;23(3):165-7311410381
Cites: Med Eng Phys. 2001 Nov;23(9):657-6411755810
Cites: J Am Geriatr Soc. 2003 Dec;51(12):1740-714687352
Cites: J Bone Miner Res. 2004 Jun;19(6):1006-1215125798
Cites: Arch Intern Med. 1998 May 11;158(9):990-69588432
Cites: J Biomech. 1998 Feb;31(2):125-339593205
Cites: J Bone Miner Res. 2004 Dec;19(12):1945-5415537436
Cites: Lancet. 2005 Jul 9-15;366(9480):129-3516005335
Cites: Clin Orthop Relat Res. 2005 Aug;(437):219-2816056052
Cites: Osteoporos Int. 2006;17(9):1329-3616767524
Cites: J Bone Miner Res. 2006 Aug;21(8):1197-20616869717
Cites: Bone. 2006 Sep;39(3):644-5116790372
Cites: Bone. 2007 Jan;40(1):169-7416876496
Cites: Bone. 2007 Mar;40(3):662-7317175209
Cites: Am J Epidemiol. 2007 May 1;165(9):1076-8717351290
Cites: J Bone Miner Res. 2008 Aug;23(8):1326-3318348697
Cites: J Bone Miner Res. 2009 Mar;24(3):475-8319049327
PubMed ID
22178403 View in PubMed
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Are bone turnover markers associated with volumetric bone density, size, and strength in older men and women? The AGES-Reykjavik study.

https://arctichealth.org/en/permalink/ahliterature268064
Source
Osteoporos Int. 2015 Dec 2;
Publication Type
Article
Date
Dec-2-2015
Author
E A Marques
V. Gudnason
G. Sigurdsson
T. Lang
F. Johannesdottir
K. Siggeirsdottir
L. Launer
G. Eiriksdottir
T B Harris
Source
Osteoporos Int. 2015 Dec 2;
Date
Dec-2-2015
Language
English
Publication Type
Article
Abstract
Association between serum bone formation and resorption markers and bone mineral, structural, and strength variables derived from quantitative computed tomography (QCT) in a population-based cohort of 1745 older adults was assessed. The association was weak for lumbar spine and femoral neck areal and volumetric bone mineral density.
The aim of this study was to examine the relationship between levels of bone turnover markers (BTMs; osteocalcin (OC), C-terminal cross-linking telopeptide of type I collagen (CTX), and procollagen type 1N propeptide (P1NP)) and quantitative computed tomography (QCT)-derived bone density, geometry, and strength indices in the lumbar spine and femoral neck (FN).
A total of 1745 older individuals (773 men and 972 women, aged 66-92 years) from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik cohort were studied. QCT was performed in the lumbar spine and hip to estimate volumetric trabecular, cortical, and integral bone mineral density (BMD), areal BMD, bone geometry, and bone strength indices. Association between BTMs and QCT variables were explored using multivariable linear regression.
Major findings showed that all BMD measures, FN cortical index, and compressive strength had a low negative correlation with the BTM levels in both men and women. Correlations between BTMs and bone size parameters were minimal or not significant. No associations were found between BTMs and vertebral cross-sectional area in women. BTMs alone accounted for only a relatively small percentage of the bone parameter variance (1-10 %).
Serum CTX, OC, and P1NP were weakly correlated with lumbar spine and FN areal and volumetric BMD and strength measures. Most of the bone size indices were not associated with BTMs; thus, the selected bone remodeling markers do not reflect periosteal bone formation. These results confirmed the limited ability of the most sensitive established BTMs to predict bone structural integrity in older adults.
PubMed ID
26630978 View in PubMed
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The association between parathyroid hormone, vitamin D and bone mineral density in 70-year-old Icelandic women.

https://arctichealth.org/en/permalink/ahliterature195328
Source
Osteoporos Int. 2000;11(12):1031-5
Publication Type
Article
Date
2000
Author
G. Sigurdsson
L. Franzson
L. Steingrimsdottir
H. Sigvaldason
Author Affiliation
Department of Internal Medicine, University Hospital, Fossvogur, Reykjavik, Iceland. maria@shr.is
Source
Osteoporos Int. 2000;11(12):1031-5
Date
2000
Language
English
Publication Type
Article
Keywords
Absorptiometry, Photon - methods
Aged
Analysis of Variance
Bone Density - physiology
Bone Remodeling - physiology
Calcium - administration & dosage
Cod Liver Oil - administration & dosage
Collagen - urine
Cross-Sectional Studies
Female
Humans
Iceland
Osteocalcin - blood
Parathyroid Hormone - blood
Vitamin D - blood
Abstract
Parathyroid hormone (PTH) may be an important determinant of cortical bone remodeling in the elderly. Vitamin D status is one of the determining factors in this relationship. The aim of this study was to quantify the relationship between serum PTH, vitamin D and bone mineral density (BMD) in elderly women in Reykjavik (64 degrees N), where daily intake of cod liver oil is common and mean calcium intake is high. In PTH correlated inversely with 25(OH)D (r = -0.26, p
PubMed ID
11256894 View in PubMed
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Association of bone turnover markers with volumetric bone loss, periosteal apposition, and fracture risk in older men and women: the AGES-Reykjavik longitudinal study.

https://arctichealth.org/en/permalink/ahliterature273828
Source
Osteoporos Int. 2016 Jun 24;
Publication Type
Article
Date
Jun-24-2016
Author
E A Marques
V. Gudnason
T. Lang
G. Sigurdsson
S. Sigurdsson
T. Aspelund
K. Siggeirsdottir
L. Launer
G. Eiriksdottir
T B Harris
Source
Osteoporos Int. 2016 Jun 24;
Date
Jun-24-2016
Language
English
Publication Type
Article
Abstract
Association between serum bone formation and resorption markers and cortical and trabecular bone loss and the concurrent periosteal apposition in a population-based cohort of 1069 older adults was assessed. BTM levels moderately reflect the cellular events at the endosteal and periosteal surfaces but are not associated with fracture risk.
We assessed whether circulating bone formation and resorption markers (BTM) were individual predictors for trabecular and cortical bone loss, periosteal expansion, and fracture risk in older adults aged 66 to 93 years from the AGES-Reykjavik study.
The sample for the quantitative computed tomography (QCT)-derived cortical and trabecular BMD and periosteal expansion analysis consisted of 1069 participants (474 men and 595 women) who had complete baseline (2002 to 2006) and follow-up (2007 to 2011) hip QCT scans and serum baseline BTM. During the median follow-up of 11.7 years (range 5.4-12.5), 54 (11.4 %) men and 182 (30.6 %) women sustained at least one fracture of any type.
Increase in BTM levels was associated with faster cortical and trabecular bone loss at the femoral neck and proximal femur in men and women. Higher BTM levels were positively related with periosteal expansion rate at the femoral neck in men. Markers were not associated with fracture risk.
This data corroborates the notion from few previous studies that both envelopes are metabolically active and that BTM levels may moderately reflect the cellular events at the endosteal and periosteal surfaces. However, our results do not support the routine use of BTM to assess fracture risk in older men and women. In light of these findings, further studies are justified to examine whether systemic markers of bone turnover might prove useful in monitoring skeletal remodeling events and the effects of current osteoporosis drugs at the periosteum.
PubMed ID
27341810 View in PubMed
Less detail

Association of bone turnover markers with volumetric bone loss, periosteal apposition, and fracture risk in older men and women: the AGES-Reykjavik longitudinal study.

https://arctichealth.org/en/permalink/ahliterature291359
Source
Osteoporos Int. 2016 12; 27(12):3485-3494
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Intramural
Date
12-2016
Author
E A Marques
V Gudnason
T Lang
G Sigurdsson
S Sigurdsson
T Aspelund
K Siggeirsdottir
L Launer
G Eiriksdottir
T B Harris
Author Affiliation
Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. elisa.marques@nih.gov.
Source
Osteoporos Int. 2016 12; 27(12):3485-3494
Date
12-2016
Language
English
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Intramural
Keywords
Aged
Aged, 80 and over
Biomarkers - blood
Bone Density
Bone remodeling
Female
Femur Neck - pathology
Fractures, Bone - epidemiology
Humans
Iceland
Longitudinal Studies
Male
Abstract
Association between serum bone formation and resorption markers and cortical and trabecular bone loss and the concurrent periosteal apposition in a population-based cohort of 1069 older adults was assessed. BTM levels moderately reflect the cellular events at the endosteal and periosteal surfaces but are not associated with fracture risk.
We assessed whether circulating bone formation and resorption markers (BTM) were individual predictors for trabecular and cortical bone loss, periosteal expansion, and fracture risk in older adults aged 66 to 93 years from the AGES-Reykjavik study.
The sample for the quantitative computed tomography (QCT)-derived cortical and trabecular BMD and periosteal expansion analysis consisted of 1069 participants (474 men and 595 women) who had complete baseline (2002 to 2006) and follow-up (2007 to 2011) hip QCT scans and serum baseline BTM. During the median follow-up of 11.7 years (range 5.4-12.5), 54 (11.4 %) men and 182 (30.6 %) women sustained at least one fracture of any type.
Increase in BTM levels was associated with faster cortical and trabecular bone loss at the femoral neck and proximal femur in men and women. Higher BTM levels were positively related with periosteal expansion rate at the femoral neck in men. Markers were not associated with fracture risk.
This data corroborates the notion from few previous studies that both envelopes are metabolically active and that BTM levels may moderately reflect the cellular events at the endosteal and periosteal surfaces. However, our results do not support the routine use of BTM to assess fracture risk in older men and women. In light of these findings, further studies are justified to examine whether systemic markers of bone turnover might prove useful in monitoring skeletal remodeling events and the effects of current osteoporosis drugs at the periosteum.
Notes
Cites: Crit Rev Eukaryot Gene Expr. 2009;19(3):219-33 PMID 19883366
Cites: Bone. 2005 Feb;36(2):311-6 PMID 15780957
Cites: Am J Epidemiol. 2007 May 1;165(9):1076-87 PMID 17351290
Cites: Bone. 2002 Aug;31(2):313-8 PMID 12151084
Cites: J Bone Miner Res. 2003 Feb;18(2):312-8 PMID 12568408
Cites: J Bone Miner Res. 2003 Jun;18(6):949-54 PMID 12817746
Cites: Bone. 2015 Dec;81:1-6 PMID 26112819
Cites: Bone. 2005 Jan;36(1):13-21 PMID 15663998
Cites: J Bone Miner Res. 1998 Feb;13(2):297-302 PMID 9495524
Cites: Bone. 2011 Dec;49(6):1232-41 PMID 21920485
Cites: Ann Rheum Dis. 2008 Sep;67(9):1249-55 PMID 18065499
Cites: Nat Rev Rheumatol. 2012 Jun 05;8(7):379-89 PMID 22664836
Cites: J Bone Miner Res. 2014 Apr;29(4):1015-24 PMID 24014423
Cites: J Clin Endocrinol Metab. 2008 Jul;93(7):2622-32 PMID 18460567
Cites: J Bone Miner Res. 2004 Mar;19(3):386-93 PMID 15040826
Cites: Calcif Tissue Int. 2014 May;94(5):560-7 PMID 24590144
Cites: Bone. 2012 Mar;50(3):628-37 PMID 22154841
Cites: J Bone Miner Res. 2010 Feb;25(2):393-403 PMID 19961336
Cites: Bone. 2002 Jun;30(6):807-9 PMID 12052445
Cites: Osteoporos Int. 2016 May;27(5):1765-76 PMID 26630978
Cites: Osteoporos Int. 2015 Feb;26(2):617-27 PMID 25224294
Cites: J Bone Miner Res. 1999 Sep;14(9):1614-21 PMID 10469291
Cites: Bone. 2011 Dec;49(6):1125-30 PMID 21872686
Cites: Joint Bone Spine. 2012 Jan;79(1):26-31 PMID 21723772
Cites: J Bone Miner Res. 2005 Apr;20(4):579-87 PMID 15765176
Cites: Lancet. 2010 May 15;375(9727):1729-36 PMID 20472174
Cites: J Bone Miner Res. 1992 Dec;7(12):1475-82 PMID 1481733
Cites: Osteoporos Int. 2003;14 Suppl 3:S2-8 PMID 12730770
Cites: J Bone Miner Res. 2009 Dec;24(12):2032-8 PMID 19453262
Cites: Osteoporos Int. 2003 Apr;14(2):141-5 PMID 12730775
Cites: Osteoporos Int. 2011 Feb;22(2):391-420 PMID 21184054
Cites: Eur J Epidemiol. 2007;22(9):631-9 PMID 17653601
Cites: Bone. 2006 Sep;39(3):644-51 PMID 16790372
Cites: Clin Chim Acta. 2005 Jun;356(1-2):67-75 PMID 15936304
Cites: Nutr J. 2012 Mar 13;11:12 PMID 22413931
Cites: J Bone Miner Res. 2000 Dec;15(12):2473-8 PMID 11127212
Cites: Crit Rev Biomed Eng. 2006;34(3):215-71 PMID 16930125
Cites: J Bone Miner Res. 2013 Oct;28(10 ):2165-76 PMID 23609070
PubMed ID
27341810 View in PubMed
Less detail

Community screening for glucose intolerance in middle-aged Icelandic men. Deterioration to diabetes over a period of 71/2 years.

https://arctichealth.org/en/permalink/ahliterature48950
Source
Acta Med Scand. 1981;210(1-2):21-6
Publication Type
Article
Date
1981
Author
G. Sigurdsson
G. Gottskálksson
T. Thorsteinsson
D. Davidsson
O. Olafsson
S. Samuelsson
N. Sigfusson
Source
Acta Med Scand. 1981;210(1-2):21-6
Date
1981
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Blood Glucose - analysis
Body Weight
Diabetes Mellitus - epidemiology
Follow-Up Studies
Glucose Tolerance Test
Humans
Iceland
Male
Mass Screening
Middle Aged
Risk
Abstract
A number of 2203 middle-aged Icelandic men (aged 34-61 years) participated in a health survey in Reykjavik in 1967-68. Blood glucose in the fasting state and during an oral glucose tolerance test (OGTT) showed a unimodal distribution with a slight skewness towards higher values. A positive age gradient was established, which showed an increment of about 7 mg/dl per decade in capillary blood sugar values at 11/2 hours after a 50 g oral glucose load. The age gradient was mostly independent of age-related changes in body weight. A 71/2 year followup of the eligible participants (response rate 80%) showed an overall 1% incidence of metabolic deterioration to "overt diabetes" during this period. Those with positive screening tests (50 g OFTT) at baseline were at greater risk of developing diabetes, but the incidence of deterioration in this group was low, about 1% per year. The progression to diabetes was significantly related to body weight at baseline, suggesting that weight reduction might be beneficial in individuals showing impaired glucose tolerance at medical examination. This study, however, lends support to recent reports showing that mildly impaired glucose tolerance cannot be equated with early diabetes.
PubMed ID
7293824 View in PubMed
Less detail

Coronary heart disease mortality amongst non-insulin-dependent diabetic subjects in Iceland: the independent effect of diabetes. The Reykjavik Study 17-year follow up.

https://arctichealth.org/en/permalink/ahliterature48052
Source
J Intern Med. 1998 Oct;244(4):309-16
Publication Type
Article
Date
Oct-1998
Author
S. Vilbergsson
G. Sigurdsson
H. Sigvaldason
N. Sigfusson
Author Affiliation
The Icelandic Heart Association, University of Iceland, Department of Medicine, Reykjavik.
Source
J Intern Med. 1998 Oct;244(4):309-16
Date
Oct-1998
Language
English
Publication Type
Article
Keywords
Adult
Age Distribution
Aged
Coronary Disease - blood - complications - mortality
Diabetes Mellitus, Type 2 - blood - complications - mortality
Female
Follow-Up Studies
Glucose Tolerance Test
Humans
Iceland - epidemiology
Life expectancy
Male
Middle Aged
Proportional Hazards Models
Risk
Risk factors
Survival Rate
Abstract
OBJECTIVES: The main aim of this study was to estimate the independent risk for coronary heart disease (CHD) death associated with non-insulin dependent (Type 2) diabetes (NIDDM) and effect on life expectancy. DESIGN AND SETTING: The Reykjavik Study is a prospective cardiovascular population study which started in 1967. A randomized selection procedure identified individuals for invitation to participate, based on their year and date of birth. Participants were examined in the years 1967-91 in one research clinic in Reykjavik. SUBJECTS AND METHODS: The population in this survey were Icelandic Caucasian males and females, born 1907-35 and therefore 34-79 years old when their examination was performed. Altogether 9139 males and 9773 females attended, and of those 267 males and 210 female were NIDDM as defined by a questionnaire or an oral glucose tolerance test. Other factors measured in the study included systolic and diastolic blood pressure, fasting total cholesterol, triglycerides, uric acid, smoking habits, height, and weight. The causes of death were determined by a review of all death certificates. Results. The relative risk of death from CHD (95% confidence limits), independently associated with NIDDM, was 2.0 (1.5-2.6) for males and 2.4 (1.6-3.6) for females. The relative risk of death from all causes was 1.9 (1.6-2.3) and 1.7 (1.3-2.1), respectively, for male and female diabetic patients. CONCLUSIONS: Non-insulin dependent diabetes mellitus carried twice the risk of CHD death in both sexes, independently of other risk factors. The diagnosis of NIDDM at the age 55 years reduced an individual's life expectancy by about five years, mostly because of increased CHD death rate.
PubMed ID
9797494 View in PubMed
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Decline in ischaemic heart disease in Iceland and change in risk factor levels.

https://arctichealth.org/en/permalink/ahliterature55245
Source
BMJ. 1991 Jun 8;302(6789):1371-5
Publication Type
Article
Date
Jun-8-1991
Author
N. Sigfusson
H. Sigvaldason
L. Steingrimsdottir
I I Gudmundsdottir
I. Stefansdottir
T. Thorsteinsson
G. Sigurdsson
Author Affiliation
Icelandic Heart Association, Reykjavik.
Source
BMJ. 1991 Jun 8;302(6789):1371-5
Date
Jun-8-1991
Language
English
Publication Type
Article
Keywords
Blood Pressure - physiology
Cholesterol - blood
Coronary Disease - epidemiology - etiology - mortality
Diet - trends
Dietary Fats - administration & dosage
Female
Humans
Iceland - epidemiology
Male
Middle Aged
Myocardial Infarction - epidemiology
Risk factors
Smoking - adverse effects
Abstract
OBJECTIVE--To monitor trends in mortality and morbidity due to ischaemic heart disease and compare these with observed levels of risk factors from population surveys. DESIGN--Analysis of trends in death rates from ischaemic heart disease in Iceland compared with expected rates computed from population surveys. Risk factor levels together with beta factors obtained from Cox's regression analysis were used to compute expected death rates. Trends in morbidity due to acute myocardial infarction were assessed and secular trends in dietary consumption compared with trends in cholesterol concentrations. SETTING--Reykjavik, Iceland (total population 250,000; over half the population live in Reykjavik). SUBJECTS--12,814 randomly selected residents in the Reykjavik area aged 45-64 (6623 men, 6191 women; 72% and 80% of those invited). MAIN OUTCOME MEASURES--Age adjusted rates of myocardial infarction and deaths from ischaemic heart disease. Expected risk from risk factor levels (smoking, total serum cholesterol concentration, systolic blood pressure) at each unique survey visit. RESULTS--Mortality from ischaemic heart disease has decreased by 17-18% since 1970. During 1981-6 the myocardial infarction attack rate in men under 75 decreased by 23%. A decrease occurred in the level of all three major risk factors after 1968. The fall in the serum cholesterol concentration coincided with a reduction in consumption of dairy fat and margarine. The calculated reduction in risk for the age group 45-64 was about 35%, which was closely similar to the observed decrease in mortality due to ischaemic heart disease in that age group. CONCLUSION--The reduction in mortality from ischaemic heart disease was substantially due to a decreased incidence of myocardial infarction and could be attributed largely to the reduction in risk factors.
PubMed ID
2059715 View in PubMed
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38 records – page 1 of 4.