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Characterization of malignant colon tumors with 31P nuclear magnetic resonance phospholipid and phosphatic metabolite profiles.

https://arctichealth.org/en/permalink/ahliterature4070
Source
Cancer. 1995 Nov 15;76(10):1715-23
Publication Type
Article
Date
Nov-15-1995
Author
T E Merchant
P M Diamantis
G. Lauwers
T. Haida
J N Kasimos
J. Guillem
T. Glonek
B D Minsky
Author Affiliation
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Source
Cancer. 1995 Nov 15;76(10):1715-23
Date
Nov-15-1995
Language
English
Publication Type
Article
Keywords
Cell Differentiation
Colonic Neoplasms - metabolism - pathology
Humans
Lymphatic Metastasis
Magnetic Resonance Spectroscopy
Neoplasm Invasiveness
Phosphates - metabolism
Phospholipids - metabolism
Prognosis
Research Support, Non-U.S. Gov't
Abstract
BACKGROUND. To further characterize selected pathologic features on a biochemical level, the authors analyzed the nuclear magnetic resonance metabolite and phospholipid spectra of 30 malignant colon tumors using 31P magnetic resonance spectroscopy. METHODS. Eleven individual generic phospholipids were identified in the spectra of 17 phospholipid extracts, and 31 individual phosphatic metabolites were identified in the spectra of 13 perchloric acid extracts. The metabolites and lipids were quantified for statistical intergroup comparisons based on tumor stage, lymph node status, differentiation, mucin production, blood vessel invasion (BVI), and lymphatic vessel invasion (LVI). RESULTS. Significant elevations in the relative concentration of alpha-glycerol phosphate were noted when comparing AJCC tumor classification (T3 vs. T2, 0.92 +/- 0.14 vs. 0.46 +/- 0.11, P
PubMed ID
8625039 View in PubMed
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