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Peptide-containing nerves in the human pregnant uterine cervix: an immunohistochemical study exploring the effect of RU 486 (mifepristone).

https://arctichealth.org/en/permalink/ahliterature65160
Source
Hum Reprod. 1990 Oct;5(7):870-6
Publication Type
Article
Date
Oct-1990
Author
G. Fried
B. Meister
A. Rådestad
Author Affiliation
Department of Obstetrics and Gynaecology, Karolinska Institutet, Stockholm, Sweden.
Source
Hum Reprod. 1990 Oct;5(7):870-6
Date
Oct-1990
Language
English
Publication Type
Article
Keywords
Calcitonin - metabolism
Calcitonin Gene-Related Peptide - metabolism
Cervix Uteri - drug effects - innervation
Female
Fluorescent Antibody Technique
Galanin
Humans
Mifepristone - pharmacology
Neuropeptide Y - metabolism
Neuropeptides - metabolism
Peptides - metabolism
Pregnancy
Research Support, Non-U.S. Gov't
Somatostatin - metabolism
Substance P - metabolism
Tissue Distribution
Tyrosine 3-Monooxygenase - metabolism
Vasoactive Intestinal Peptide - metabolism
Abstract
The presence of several neuropeptides (neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP), substance P (SP), galanin (GAL), enkephalin (ENK), somatostatin (SOM) was established in the early pregnant human cervix using indirect immunofluorescence immunohistochemistry. Several peptides (VIP, NPY, CGRP, GAL) were present both in free nerves among smooth muscle cells and around blood vessels. Others (SP, SOM) were only seen as single varicosities among smooth muscle cells. Randomized treatment of patients with RU 486 (mifepristone) prior to surgical sampling revealed no clearcut differences in peptide immunoreactivities. After RU 486 treatment, however, there was a tendency towards a decrease of NPY- and VIP-immunoreactivity, and an increase of CGRP-immunoreactivity.
PubMed ID
1702449 View in PubMed
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Somatic complications and contraceptive techniques following legal abortion.

https://arctichealth.org/en/permalink/ahliterature65362
Source
Acta Obstet Gynecol Scand. 1989;68(6):515-21
Publication Type
Article
Date
1989
Author
G. Fried
E. Ostlund
C. Ullberg
M. Bygdeman
Author Affiliation
Department of Obstetrics and Gynaecology, Karolinska Sjukhuset, Stockholm, Sweden.
Source
Acta Obstet Gynecol Scand. 1989;68(6):515-21
Date
1989
Language
English
Publication Type
Article
Keywords
Abortion, Legal - adverse effects
Adult
Age Factors
Chlamydia Infections - epidemiology
Chlamydia trachomatis - isolation & purification
Contraception Behavior
Female
Humans
Parity
Postoperative Complications - epidemiology
Pregnancy
Reoperation
Research Support, Non-U.S. Gov't
Sweden - epidemiology
Abstract
The purpose of this study was to establish the frequency of complications following legal abortion at our hospital, and also to examine the use of contraceptives among these patients. All women who requested abortion in the first or second trimester up to week 15 during an 8-month period (n = 1000) were included in the study. The patients were characterized with regard to age, parity, previous abortion, contraceptive technique before and after the abortion, presence of endocervical/urethral Chlamydia trachomatis and frequency and type of somatic complications following the abortion. The overall frequency of complications (infection, bleeding, recurettage) was 5.4%, and 2.7% were readmitted to the hospital. No certain relation between complication rate and gestational length, age or parity was seen, possibly related to selective prostaglandin pretreatment of the cervix and doxycycline treatment of patients with positive cultures for Chlamydia trachomatis. In contrast to previous Scandinavian studies, we found a smaller proportion of young patients, a low percentage of Chlamydial infections, and an unchanged high rate of failure to use contraceptives.
PubMed ID
2520806 View in PubMed
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