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Hypertension and identification of toxin in human urine and serum following a cluster of mussel-associated paralytic shellfish poisoning outbreaks.

https://arctichealth.org/en/permalink/ahliterature5603
Source
Toxicon. 1997 May;35(5):711-22
Publication Type
Article
Date
May-1997
Author
B D Gessner
P. Bell
G J Doucette
E. Moczydlowski
M A Poli
F. Van Dolah
S. Hall
Author Affiliation
Alaska Division of Public Health, Anchorage 99501, USA.
Source
Toxicon. 1997 May;35(5):711-22
Date
May-1997
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Alaska - epidemiology
Animals
Bivalvia
Chromatography, High Pressure Liquid
Disease Outbreaks
Female
Humans
Hypertension - chemically induced
Male
Middle Aged
Paralysis - chemically induced
Poisoning - epidemiology - etiology
Research Support, U.S. Gov't, Non-P.H.S.
Saxitoxin - analysis - metabolism - poisoning
Sodium Channel Blockers
Sodium Channels - drug effects
Abstract
Following four outbreaks of paralytic shellfish poisoning on Kodiak Island, Alaska, during 1994, medical records of ill persons were reviewed and interviews were conducted. Urine and serum specimens were analyzed at three independent laboratories using four different saxitoxin binding assays. High-performance liquid chromatography was used to determine the presence of specific toxin congeners. Among 11 ill persons, three required mechanical ventilation and one died. Mean peak systolic and diastolic blood pressure measurements were 172 (range 128-247) and 102 (range 78-165) mmHg, respectively, and blood pressure measurements corresponded with ingested toxin dose. All four different laboratory methodologies detected toxin in serum at 2.8-47 nM during acute illness and toxin in urine at 65-372 nM after acute symptom resolution. The composition of specific paralytic shellfish poisons differed between mussels and human biological specimens, suggesting that human metabolism of toxins had occurred. The results of this study indicate that saxitoxin analogues may cause severe hypertension. In addition, we demonstrate that saxitoxins can be detected in human biological specimens, that nanomolar serum toxin levels may cause serious illness and that human metabolism of toxin may occur. Clearance of paralytic shellfish poisons from serum was evident within 24 hr and urine was identified as a major route of toxin excretion in humans.
PubMed ID
9203296 View in PubMed
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Paralytic shellfish poisoning in Kodiak, Alaska.

https://arctichealth.org/en/permalink/ahliterature75584
Source
West J Med. 1997 Nov;167(5):351-3
Publication Type
Article
Date
Nov-1997
Author
B D Gessner
J P Middaugh
G J Doucette
Author Affiliation
Alaska Division of Public Health, Anchorage 99501, USA.
Source
West J Med. 1997 Nov;167(5):351-3
Date
Nov-1997
Language
English
Publication Type
Article
Keywords
Adult
Alaska
Animals
Bivalvia
Diagnosis, Differential
Food Poisoning - diagnosis - etiology - therapy
Humans
Male
Shellfish
PubMed ID
9392992 View in PubMed
Less detail