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Adiposity and glycemic control in children exposed to perfluorinated compounds.

https://arctichealth.org/en/permalink/ahliterature104801
Source
J Clin Endocrinol Metab. 2014 Apr;99(4):E608-14
Publication Type
Article
Date
Apr-2014
Author
Clara Amalie G Timmermann
Laura I Rossing
Anders Grøntved
Mathias Ried-Larsen
Christine Dalgård
Lars B Andersen
Philippe Grandjean
Flemming Nielsen
Kira D Svendsen
Thomas Scheike
Tina K Jensen
Author Affiliation
Department of Environmental Medicine, Institute of Public Health (C.A.G.T., L.I.R., C.D., P.G., F.N., T.K.J.), and Institute of Sports Science and Clinical Biomechanics (A.G., M.R.-L., L.B.A.), University of Southern Denmark, 5000 Odense C, Denmark; and Department of Biostatistics (K.D.S., T.S.), University of Copenhagen, 1353 Copenhagen, Denmark.
Source
J Clin Endocrinol Metab. 2014 Apr;99(4):E608-14
Date
Apr-2014
Language
English
Publication Type
Article
Keywords
Adiposity - drug effects - physiology
Alkanesulfonic Acids - blood
Blood Glucose - drug effects - metabolism
Body mass index
Caprylates - blood
Child
Denmark - epidemiology
Environmental Exposure - analysis - statistics & numerical data
Environmental Pollutants - blood - toxicity
Female
Fluorocarbons - blood - toxicity
Humans
Insulin Resistance
Male
Obesity - blood - epidemiology
Skinfold thickness
Abstract
Our objective was to explore whether childhood exposure to perfluorinated and polyfluorinated compounds (PFCs), widely used stain- and grease-repellent chemicals, is associated with adiposity and markers of glycemic control.
Body mass index, skinfold thickness, waist circumference, leptin, adiponectin, insulin, glucose, and triglyceride concentrations were assessed in 8- to 10-year-old children in 1997 in a subset of the European Youth Heart Study, Danish component. Plasma PFC concentrations were available from 499 children. Linear regression models were performed to determine the association between PFC exposure and indicators of adiposity and markers of glycemic control.
There was no association between PFC exposures and adiposity or markers of glycemic control in normal-weight children. Among overweight children, an increase of 10 ng perfluorooctane sulfonic acid/mL plasma was associated with 16.2% (95% confidence interval [CI], 5.2%-28.3%) higher insulin concentration, 12.0% (95% CI, 2.4%-22.4%) higher ß-cell activity, 17.6% (95% CI, 5.8%-30.8%) higher insulin resistance, and 8.6% (95% CI, 1.2%-16.5%) higher triglyceride concentrations, and an increase of 10 ng perfluorooctanoic acid/mL plasma was associated with 71.6% (95% CI, 2.4%-187.5%) higher insulin concentration, 67.5% (95% CI, 5.5%-166.0%) higher ß-cell function, 73.9% (95% CI, 0.2%-202.0%) higher insulin resistance, and 76.2% (95% CI, 22.8%-153.0%) higher triglyceride concentrations.
Increased PFC exposure in overweight 8- to 10-year-old children was associated with higher insulin and triglyceride concentrations. Chance findings may explain some of our results, and due to the cross-sectional design, reverse causation cannot be excluded. The findings therefore need to be confirmed in longitudinal studies.
PubMed ID
24606078 View in PubMed
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Assessment of xenoestrogenic exposure by a biomarker approach: application of the E-Screen bioassay to determine estrogenic response of serum extracts.

https://arctichealth.org/en/permalink/ahliterature61592
Source
Environ Health. 2003 Oct 15;2(1):12
Publication Type
Article
Date
Oct-15-2003
Author
Thomas Høj Rasmussen
Flemming Nielsen
Helle Raun Andersen
Jesper Bo Nielsen
Pal Weihe
Philippe Grandjean
Author Affiliation
Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark. thoj@health.sdu.dk
Source
Environ Health. 2003 Oct 15;2(1):12
Date
Oct-15-2003
Language
English
Publication Type
Article
Keywords
Biological Assay - methods
Biological Markers - blood
Chromatography, Gas
Cohort Studies
Denmark
Diet
Environmental Monitoring - methods
Environmental Pollutants - analysis - blood
Estrogens, Non-Steroidal - analysis - blood
Female
Humans
In Vitro
Maternal Exposure
Polychlorinated Biphenyls - analysis - blood
Pregnancy
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Women's health
Xenobiotics - analysis - blood
Abstract
BACKGROUND: Epidemiological documentation of endocrine disruption is complicated by imprecise exposure assessment, especially when exposures are mixed. Even if the estrogenic activity of all compounds were known, the combined effect of possible additive and/or inhibiting interaction of xenoestrogens in a biological sample may be difficult to predict from chemical analysis of single compounds alone. Thus, analysis of mixtures allows evaluation of combined effects of chemicals each present at low concentrations. METHODS: We have developed an optimized in vitro E-Screen test to assess the combined functional estrogenic response of human serum. The xenoestrogens in serum were separated from endogenous steroids and pharmaceuticals by solid-phase extraction followed by fractionation by high-performance liquid chromatography. After dissolution of the isolated fraction in ethanol-DMSO, the reconstituted extract was added with estrogen-depleted fetal calf serum to MCF-7 cells, the growth of which is stimulated by estrogen. After a 6-day incubation on a microwell plate, cell proliferation was assessed and compared with the effect of a 17-beta-estradiol standard. RESULTS AND CONCLUSIONS: To determine the applicability of this approach, we assessed the estrogenicity of serum samples from 30 pregnant and 60 non-pregnant Danish women thought to be exposed only to low levels of endocrine disruptors. We also studied 211 serum samples from pregnant Faroese women, whose marine diet included whale blubber that contain a high concentration of persistent halogenated pollutants. The estrogenicity of the serum from Danish controls exceeded the background in 22.7 % of the cases, while the same was true for 68.1 % of the Faroese samples. The increased estrogenicity response did not correlate with the lipid-based concentrations of individual suspected endocrine disruptors in the Faroese samples. When added along with the estradiol standard, an indication of an enhanced estrogenic response was found in most cases. Thus, the in vitro estrogenicity response offers a promising and feasible approach for an aggregated exposure assessment for xenoestrogens in serum.
PubMed ID
14613489 View in PubMed
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Association between perfluorinated compound exposure and miscarriage in Danish pregnant women.

https://arctichealth.org/en/permalink/ahliterature269093
Source
PLoS One. 2015;10(4):e0123496
Publication Type
Article
Date
2015
Author
Tina Kold Jensen
Louise Bjørkholt Andersen
Henriette Boye Kyhl
Flemming Nielsen
Henrik Thybo Christesen
Philippe Grandjean
Source
PLoS One. 2015;10(4):e0123496
Date
2015
Language
English
Publication Type
Article
Keywords
Abortion, Spontaneous - chemically induced
Adult
Case-Control Studies
Denmark
Environmental Exposure
Female
Fluorocarbons - toxicity
Humans
Pregnancy
Prospective Studies
Abstract
Perfluorinated alkylated substances (PFAS) have been extensively used in consumer products and humans are widely exposed to these persistent compounds. A recent study found no association between exposure to perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) and miscarriage, but no studies have examined adverse effect of the more recently introduced PFASs. We therefore conducted a case-control study within a population-based, prospective cohort during 2010-2012. Newly pregnant women residing in the Municipality of Odense, Denmark were invited to enroll in the Odense Child Cohort at their first antenatal visit before pregnancy week 12. Among a total of 2,874 participating women, 88 suffered a miscarriage and 59 had stored serum samples, of which 56 occurred before gestational week 12. They were compared to a random sample (N=336) of delivering women, who had also donated serum samples before week 12. Using a case-control design, 51 of the women suffering a miscarriage were matched on parity and gestational day of serum sampling with 204 delivering women. In a multiple logistic regression with adjustment for age, BMI, parity and gestational age at serum sampling, women with the highest tertile of exposure to perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA) in pregnancy had odds ratios for miscarriage of 16.5 (95% CI 7.4-36.6-36.5) and 2.67 (1.31-5.44), respectively, as compared to the lowest tertile. In the matched data set, the OR were 37.9 (9.9-145.2) and 3.71 (1.60-8.60), respectively. The association with perfluorohexane sulfonic acid (PFHxS) was in the same direction, but not statistically significant, while no association was found with PFOA and PFOS. Our findings require confirmation due to the possible public health importance, given that all pregnant women are exposed to these widely used compounds.
Notes
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PubMed ID
25848775 View in PubMed
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Association between perfluorinated compounds and time to pregnancy in a prospective cohort of Danish couples attempting to conceive.

https://arctichealth.org/en/permalink/ahliterature127981
Source
Hum Reprod. 2012 Mar;27(3):873-80
Publication Type
Article
Date
Mar-2012
Author
Sonja Vestergaard
Flemming Nielsen
Anne-Maria Andersson
Niels Henrik Hjøllund
Philippe Grandjean
Helle Raun Andersen
Tina Kold Jensen
Author Affiliation
Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, J.B. Winsloews Vej 17A, DK-5000 Odense C, Denmark. svestergaard@health.sdu.dk
Source
Hum Reprod. 2012 Mar;27(3):873-80
Date
Mar-2012
Language
English
Publication Type
Article
Keywords
Adult
Alkanesulfonic Acids - blood - pharmacology
Cohort Studies
Denmark
Female
Fertility - drug effects
Fluorocarbons - blood - pharmacology
Food Contamination
Humans
Male
Maternal Exposure
Odds Ratio
Pregnancy
Time Factors
Abstract
Perfluorinated chemicals (PFCs) have been widely used and have emerged as important food contaminants. A recent study on pregnant women suggested that PFC exposure was associated with a longer time to pregnancy (TTP). We examined the association between serum concentrations of PFCs in females and TTP in 222 Danish first-time pregnancy planners during the years 1992-1995.
The couples were enrolled in the study when discontinuing birth control and followed for six menstrual cycles or until a clinically recognized pregnancy occurred. Fecundability ratio (FR) was calculated using discrete-time survival models. In addition, odds ratio (OR) for TTP >6 cycles was calculated.
OR for TTP >6 cycles for those with PFC concentrations above the median were 0.96 [95% confidence interval (CI): 0.54-1.64] for perfluorooctane sulfonic acid (PFOS), the major PFC, compared with those below the median. FRs for those with PFOS concentrations above the median were 1.05 (95% CI: 0.74-1.48) compared with those below the median. Other PFCs showed the same lack of association with TTP. The results were not affected by adjustment for covariates. PFOS and perfluorooctanoic acid concentrations were similar to those observed in a previous Danish study.
These findings suggest that exposure to PFCs affects TTP only to a small extent, if at all.
PubMed ID
22246448 View in PubMed
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Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination.

https://arctichealth.org/en/permalink/ahliterature279289
Source
J Immunotoxicol. 2017 Jan 16;:1-11
Publication Type
Article
Date
Jan-16-2017
Author
Clara Amalie Gade Timmermann
Esben Budtz-Jørgensen
Tina Kold Jensen
Christa Elyse Osuna
Maria Skaalum Petersen
Ulrike Steuerwald
Flemming Nielsen
Lars K Poulsen
Pál Weihe
Philippe Grandjean
Source
J Immunotoxicol. 2017 Jan 16;:1-11
Date
Jan-16-2017
Language
English
Publication Type
Article
Abstract
Perfluoroalkyl substances (PFASs) are highly persistent chemicals that might be associated with asthma and allergy, but the associations remain unclear. Therefore, this study examined whether pre- and postnatal PFAS exposure was associated with childhood asthma and allergy. Measles, mumps, and rubella (MMR) vaccination in early life may have a protective effect against asthma and allergy, and MMR vaccination is therefore taken into account when evaluating these associations. In a cohort of Faroese children whose mothers were recruited during pregnancy, serum concentrations of five PFASs - Perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) - were measured at three timepoints (maternal serum in pregnancy week 34-36 and child serum at ages 5 and 13 years) and their association with immunoglobulin E (IgE) (cord blood and at age 7 years) and asthma/allergic diseases (questionnaires at ages 5 and 13 years and skin prick test at age 13 years) was determined. A total of 559 children were included in the analyses. Interactions with MMR vaccination were evaluated. Among 22 MMR-unvaccinated children, higher levels of the five PFASs at age 5 years were associated with increased odds of asthma at ages 5 and 13. The associations were reversed among MMR-vaccinated children. Prenatal PFAS exposure was not associated with childhood asthma or allergic diseases regardless of MMR vaccination status. In conclusion, PFAS exposure at age 5 was associated with increased risk of asthma among a small subgroup of MMR-unvaccinated children but not among MMR-vaccinated children. While PFAS exposure may impact immune system functions, this study suggests that MMR vaccination might be a potential effect-modifier.
PubMed ID
28091126 View in PubMed
Less detail

Associations between Exposure to Persistent Organic Pollutants in Childhood and Overweight up to 12 Years Later in a Low Exposed Danish Population.

https://arctichealth.org/en/permalink/ahliterature273916
Source
Obes Facts. 2015;8(4):282-92
Publication Type
Article
Date
2015
Author
Jeanett L Tang-Péronard
Tina K Jensen
Helle R Andersen
Mathias Ried-Larsen
Anders Grøntved
Lars B Andersen
Clara A G Timmermann
Flemming Nielsen
Berit L Heitmann
Source
Obes Facts. 2015;8(4):282-92
Date
2015
Language
English
Publication Type
Article
Keywords
Adolescent
Child
Denmark
Dichlorodiphenyl Dichloroethylene - adverse effects
Environmental Pollutants - adverse effects
Female
Hexachlorobenzene - adverse effects - toxicity
Humans
Hydrocarbons, Chlorinated - adverse effects
Longitudinal Studies
Male
Obesity - chemically induced
Organic Chemicals - adverse effects
Overweight - chemically induced
Polychlorinated Biphenyls - adverse effects
Young Adult
Abstract
Persistent organic pollutants (POPs) have metabolic disrupting abilities and are suggested to contribute to the obesity epidemic. We investigated whether serum concentrations of POPs at 8-10 years of age were associated with subsequent development of overweight at age 14-16 and 20-22 years.
The study was based on data from the European Youth Heart Study, Danish component (1997). Concentrations of several polychlorinated biphenyls (PCBs) and the organochlorine pesticides p,p-dichlorodiphenyldichloroethylene (DDE) and hexachlorobenzene (HCB) were measured in serum from children aged 8-10 years (n = 509). Information on BMI z-scores, waist circumference and % body fat were collected at clinical examinations at ages 8-10, 14-16 and 20-22 years. Multiple linear regression analyses were performed taking potential confounders into account.
Overall, POP serum concentrations were low: median SPCB 0.18 µg/g lipid, DDE 0.04 µg/g lipid and HCB 0.03 µg/g lipid. POPs were generally not associated with weight gain at 14-16 and 20-22 years of age, except for an inverse association among the highest exposed girls at 20-22 years of age, which might possibly be explained by multiple testing or residual confounding.
This study suggests that, in a low exposed population, childhood serum concentrations of PCB, DDE, and HCB are not associated with subsequent weight gain.
PubMed ID
26228100 View in PubMed
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Associations between plasma concentrations of PCB 28 and possible indoor exposure sources in Danish school children and mothers.

https://arctichealth.org/en/permalink/ahliterature275191
Source
Environ Int. 2016 Feb;87:13-9
Publication Type
Article
Date
Feb-2016
Author
Emilie Lund Egsmose
Elvira Vaclavik Bräuner
Marie Frederiksen
Thit Aarøe Mørck
Volkert Dirk Siersma
Pernille Winton Hansen
Flemming Nielsen
Philippe Grandjean
Lisbeth E Knudsen
Source
Environ Int. 2016 Feb;87:13-9
Date
Feb-2016
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Air Pollutants - blood
Air Pollution, Indoor - analysis
Child
Construction Materials - analysis
Denmark
Environmental Monitoring - methods
Female
Humans
Linear Models
Male
Mothers
Polychlorinated biphenyls - blood
Schools - standards
Students
Abstract
Polychlorinated biphenyls (PCBs) are ubiquitously present in the environment and are suspected of carcinogenic, neurotoxic and immunotoxic effects. Significantly higher plasma concentrations of the congener PCB 28 occur in children compared to adults. Exposure in schools may contribute to this difference.
To determine whether increased blood plasma concentrations of PCB 28 in Danish school children and mothers are associated with living in homes or attending schools constructed in the PCB period (1959-1977).
PCB 28 was analyzed in plasma samples from 116 children aged 6-11years and 143 mothers living in an urban and a rural area in Denmark and participating in the European pilot project DEMOCOPHES (Demonstration of a study to COordinate and Perform Human Biomonitoring on a European Scale). In Denmark, PCBs were used in construction in the period 1950-1977, and year of construction or renovation of the homes and schools was used as a proxy for indoor PCB exposure. Linear regression models were used to assess the association between potential PCB exposure from building materials and lipid adjusted concentrations of PCB 28 in plasma, with and without adjustment for potential confounders.
Among the 116 children and 143 mothers, we were able to specify home construction period in all but 4 children and 5 mothers leaving 111 children and 138 mothers for our analyses. The median lipid adjusted plasma PCB 28 concentration was 3 (range: 1-28) ng/g lipid in the children and 2 (range: 1-8) ng/g lipid in the mothers. Children living in homes built in the PCB period had significantly higher lipid adjusted plasma PCB 28 concentrations compared to children living in homes built before or after the PCB period. Following adjustment for covariates, PCB 28 concentrations in children were 40 (95% CI: 13; 68) percent higher than concentrations of children living in homes constructed at other times. Furthermore, children attending schools built or substantially refurbished in the PCB period also had significantly higher (46%, 95% CI: 22; 70) PCB 28 concentrations compared to children attending schools constructed before or after the PCB period, while their mothers had similar concentrations. Adjustment for the most prevalent congener, PCB 153, did not change this effect of home or school construction. When both home and school construction year were included in the models, the increase in lipid adjusted plasma PCB 28 for children living in or attending schools from the PCB period was no longer statistically significant. The individual effect of home and school construction periods could not be evaluated further with the available data.
Our results suggest that PCB exposure in the indoor environment in schools and homes constructed during the PCB period may contribute significantly to children's plasma PCB 28 concentration. Efforts to minimize PCB exposure in indoor environments should be considered.
PubMed ID
26638015 View in PubMed
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Associations of Exposure to Perfluoroalkyl Substances With Thyroid Hormone Concentrations and Birth Size.

https://arctichealth.org/en/permalink/ahliterature308429
Source
J Clin Endocrinol Metab. 2020 03 01; 105(3):
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Date
03-01-2020
Author
Christina Xiao
Philippe Grandjean
Damaskini Valvi
Flemming Nielsen
Tina Kold Jensen
Pal Weihe
Youssef Oulhote
Author Affiliation
Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Source
J Clin Endocrinol Metab. 2020 03 01; 105(3):
Date
03-01-2020
Language
English
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Keywords
Adult
Alkanesulfonic Acids - toxicity
Animals
Birth Weight - drug effects
Body Size - drug effects
Caprylates - toxicity
Denmark
Female
Fetal Development - drug effects
Fluorocarbons - toxicity
Humans
Infant, Newborn
Male
Maternal Age
Maternal Exposure - adverse effects
Pregnancy
Prospective Studies
Seafood - toxicity
Thyroid Gland - drug effects - metabolism
Thyroid Hormones - blood - metabolism
Water Pollutants, Chemical - toxicity
Whales, Pilot
Young Adult
Abstract
Adequate thyroid function during pregnancy is essential for optimal fetal growth. Gestational exposure to perfluoroalkyl substances (PFAS) can negatively affect birth size and disrupt maternal and neonatal thyroid function, although the interrelationship is unclear.
We aimed to quantify the associations between maternal serum-PFAS concentrations and birth weight, birth length, and cranial circumference. We also aimed to estimate associations between PFAS and thyroid hormone (TH) concentrations, thereby elucidating whether THs potentially mediate the associations between PFAS concentrations and birth size.
We studied a population-based prospective cohort of 172 mother-singleton pairs from the Faroe Islands. Twelve PFAS were measured in maternal serum obtained at 34 weeks of gestation. THs were measured in maternal and cord serum. Associations between PFAS concentrations and birth size and TH concentrations were estimated using multivariable linear regressions. Sex-stratified analyses along with a mediation analysis were performed to estimate potential mediating effects of THs in the association between PFAS and birth outcomes.
Several PFASs were negatively associated with birth weight, length, and head circumference, and a general positive association between maternal serum-PFASs and cord serum-thyroid-stimulating hormone (TSH; also known as thyrotropin) was found. For instance, a doubling in perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) was associated with a 53% (95% CI, 18%-99%) and 40% (95% CI, 8%-81%) increases in TSH concentrations, respectively. There was little evidence of sexually dimorphic associations. Overall, THs were not found to mediate associations between PFASs and birth size.
In this study, several PFASs were negatively associated with birth size and increased THs; however, this did not explain lower birth weight among children exposed to PFAS.
PubMed ID
31665456 View in PubMed
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Blood Harmane (1-Methyl-9H-Pyrido[3,4-b]indole) and Mercury in Essential Tremor: A Population-Based, Environmental Epidemiology Study in the Faroe Islands.

https://arctichealth.org/en/permalink/ahliterature311822
Source
Neuroepidemiology. 2020; 54(3):272-280
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Date
2020
Author
Elan D Louis
Eina H Eliasen
Monica Ferrer
Daniella Iglesias Hernandez
Shahin Gaini
Wendy Jiang
Wei Zheng
Flemming Nielsen
Maria Skaalum Petersen
Author Affiliation
Department of Neurology, Yale School of Medicine, Yale University, New Haven, Connecticut, USA, elan.louis@yale.edu.
Source
Neuroepidemiology. 2020; 54(3):272-280
Date
2020
Language
English
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Keywords
Aged
Aged, 80 and over
Case-Control Studies
Denmark
Essential Tremor - blood - chemically induced
Female
Harmine - analogs & derivatives - blood - toxicity
Humans
Male
Mercury - blood - toxicity
Middle Aged
Neurotoxins - blood - toxicity
Abstract
Essential tremor (ET) is among the most prevalent neurological diseases. Its environmental determinants are poorly understood. Harmane (1-methyl-9H-pyrido[3, 4-b]indole), a dietary tremor-producing neurotoxin, has been linked to ET in a few studies in New York and Madrid. Mercury, also a tremor-producing neurotoxin, has not been studied in ET. The Faroe Islands have been the focus of epidemiological investigations of numerous neurological disorders.
In this population-based, case-control study, we directly measured blood harmane concentrations (HA) and blood mercury concentrations (Hg) in ET cases and controls.
In total, 1,328 Faroese adults were screened; 26 ET cases were identified whose (HA) and (Hg) were compared to 197 controls.
Although there were no statistically significant differences between diagnostic groups, median (HA) was 2.7× higher in definite ET (4.13 g-10/mL) and 1.5× higher in probable ET (2.28 g-10/mL) than controls (1.53 g-10/mL). Small sample size was a limitation. For definite ET versus controls, p = 0.126. (Hg) were similar between groups.
We demonstrated marginally elevated (HA) in definite and probable ET. These data are similar to those previously published and possibly extend etiological links between this neurotoxin and ET to a third locale. The study did not support a link between mercury and ET.
PubMed ID
32007995 View in PubMed
Less detail

Blood Harmane (1-Methyl-9H-Pyrido[3,4-b]indole) and Mercury in Essential Tremor: A Population-Based, Environmental Epidemiology Study in the Faroe Islands.

https://arctichealth.org/en/permalink/ahliterature307085
Source
Neuroepidemiology. 2020; 54(3):272-280
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Date
2020
Author
Elan D Louis
Eina H Eliasen
Monica Ferrer
Daniella Iglesias Hernandez
Shahin Gaini
Wendy Jiang
Wei Zheng
Flemming Nielsen
Maria Skaalum Petersen
Author Affiliation
Department of Neurology, Yale School of Medicine, Yale University, New Haven, Connecticut, USA, elan.louis@yale.edu.
Source
Neuroepidemiology. 2020; 54(3):272-280
Date
2020
Language
English
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Abstract
Essential tremor (ET) is among the most prevalent neurological diseases. Its environmental determinants are poorly understood. Harmane (1-methyl-9H-pyrido[3, 4-b]indole), a dietary tremor-producing neurotoxin, has been linked to ET in a few studies in New York and Madrid. Mercury, also a tremor-producing neurotoxin, has not been studied in ET. The Faroe Islands have been the focus of epidemiological investigations of numerous neurological disorders.
In this population-based, case-control study, we directly measured blood harmane concentrations (HA) and blood mercury concentrations (Hg) in ET cases and controls.
In total, 1,328 Faroese adults were screened; 26 ET cases were identified whose (HA) and (Hg) were compared to 197 controls.
Although there were no statistically significant differences between diagnostic groups, median (HA) was 2.7× higher in definite ET (4.13 g-10/mL) and 1.5× higher in probable ET (2.28 g-10/mL) than controls (1.53 g-10/mL). Small sample size was a limitation. For definite ET versus controls, p = 0.126. (Hg) were similar between groups.
We demonstrated marginally elevated (HA) in definite and probable ET. These data are similar to those previously published and possibly extend etiological links between this neurotoxin and ET to a third locale. The study did not support a link between mercury and ET.
PubMed ID
32007995 View in PubMed
Less detail

46 records – page 1 of 5.