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[AIDS in Denmark. 1. Opportunistic infections and malignant diseases. Danish Study Group for HIV infection]

https://arctichealth.org/en/permalink/ahliterature7897
Source
Ugeskr Laeger. 1995 Mar 6;157(10):1347-51
Publication Type
Article
Date
Mar-6-1995
Author
J D Lundgren
K D Bentsen
C. Pedersen
J. Gerstoft
T. Seefeldt-Nielsen
T L Nielsen
G F Jensen
Author Affiliation
Infektionsmedicinsk afdeling, Hvidovre Hospital, København.
Source
Ugeskr Laeger. 1995 Mar 6;157(10):1347-51
Date
Mar-6-1995
Language
Danish
Publication Type
Article
Keywords
AIDS-Related Opportunistic Infections - diagnosis - epidemiology - microbiology
Acquired Immunodeficiency Syndrome - complications
Blood Transfusion - adverse effects
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes - immunology
Denmark - epidemiology
English Abstract
HIV Infections - complications
Humans
Male
Sarcoma, Kaposi - etiology
Sexual Behavior
Substance Abuse, Intravenous - complications
Abstract
To examine the distribution of AIDS-defining illnesses among Danish AIDS patients, data on 687 AIDS patients diagnosed in the period from 1980 to 1990 (93% of all reported cases in the period) were collected. The most frequent AIDS-defining illness was Pneumocystis carinii pneumonia followed by candida oesophagitis and Kaposis sarcoma. The proportion of homo/bisexual men presenting with Kaposis sarcoma as the initial AIDS-defining illness declined over time. Patients with extrapulmonary tuberculosis had higher CD4 cell counts than patients presenting with other illnesses. Cytomegalovirus chorioretinitis and atypical mycobacteriosis were seen more frequently after the time of the AIDS diagnosis, and a low CD4 cell count at time of the AIDS diagnosis was a significant predictor for the development of these opportunistic infections during follow-up. Danish AIDS patients present with a wide spectrum of HIV-related illnesses, reflecting their exposure to opportunistic microorganisms and the degree of immune deficiency. The pattern of HIV-related illnesses is changing over time, and therefore continuous surveillance is needed to optimize therapeutic and prophylactic regimens.
PubMed ID
7709482 View in PubMed
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[AIDS in Denmark. 2. Survival after the diagnosis of AIDS. Danish Study Group for HIV infection]

https://arctichealth.org/en/permalink/ahliterature7896
Source
Ugeskr Laeger. 1995 Mar 6;157(10):1352-6
Publication Type
Article
Date
Mar-6-1995
Author
J D Lundgren
C. Pedersen
K D Bentsen
J. Gerstoft
T. Seefeldt-Nielsen
T L Nielsen
G F Jensen
Author Affiliation
Infektionsmedicinsk afdeling, Hvidovre Hospital, København.
Source
Ugeskr Laeger. 1995 Mar 6;157(10):1352-6
Date
Mar-6-1995
Language
Danish
Publication Type
Article
Keywords
Acquired Immunodeficiency Syndrome - diagnosis - immunology - mortality
Adult
Age Factors
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes - immunology
Denmark - epidemiology
English Abstract
Female
HIV Infections - diagnosis - mortality
Humans
Male
Prognosis
Survival Rate
Time Factors
Abstract
The survival pattern was studied for 687 Danish AIDS patients (93% of notified cases in the study period) who were diagnosed with AIDS during the period from 1980 to 1990. The median survival was 17 months. Factors significantly associated with a shortened survival were transfusion-acquired HIV infection, age > 40 years, year of diagnosis before 1987, and the presence of either disseminated infection with Mycobacterium avium-complex, Cytomegalovirus chorioretinitis or malignant lymphoma at time of the AIDS diagnosis. There was also a significant association between survival and CD4 cell count at time of AIDS diagnosis. Patients who had CD4 cell counts above 200 x 10(6)/l had twice as long a survival as patients who had CD4 cell counts less than 50 x 10(6)/l. The prognosis of Danish AIDS patients remains poor. The most important determinant of survival time appears to be the degree of immune deficiency at time of diagnosis.
PubMed ID
7709483 View in PubMed
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Cardiovascular risk factors during estrogen-norethindrone and cholecalciferol treatment.

https://arctichealth.org/en/permalink/ahliterature222836
Source
Arch Intern Med. 1992 Nov;152(11):2265-8
Publication Type
Article
Date
Nov-1992
Author
B. Myrup
G F Jensen
P. McNair
Author Affiliation
Department of Clinical Chemistry, Frederiksberg Hospital, Copenhagen, Denmark.
Source
Arch Intern Med. 1992 Nov;152(11):2265-8
Date
Nov-1992
Language
English
Publication Type
Article
Keywords
Aged
Blood Pressure - drug effects
Body mass index
Cardiovascular Diseases - epidemiology
Cholecalciferol - therapeutic use
Cholesterol - blood
Cholesterol, HDL - blood - drug effects
Denmark - epidemiology
Double-Blind Method
Drug Combinations
Estradiol - therapeutic use
Estriol - therapeutic use
Estrogen Replacement Therapy
Female
Humans
Norethindrone - analogs & derivatives - therapeutic use
Risk factors
Time Factors
Abstract
The effect of cholecalciferol and estrogen-norethindrone treatment on total cholesterol level, high-density lipoprotein cholesterol level, blood pressure, and body mass index was investigated in 74 postmenopausal women in a double-blind, randomized trial. Blood pressure and body mass index did not change throughout the study. We demonstrated a decrease (11%) in serum cholesterol level after 1 year of treatment with estrogen-norethindrone. When this treatment was combined with cholecalciferol, a similar decrease (13%) was observed. The hypocholesterolemic effect was correlated to body mass index in a way that indicated the most pronounced decrease in lean women. The high-density lipoprotein cholesterol/total cholesterol fraction increased by 45% after 1 year of estrogen-norethindrone treatment, while an increase of 25% after 1 year was seen when cholecalciferol was added to the treatment. The latter increase was not different from a similar increase in the placebo group. The possible dyslipidemic effect of cholecalciferol, along with the risk of hypercalcemia, emphasizes the caution necessary in cholecalciferol treatment.
PubMed ID
1332634 View in PubMed
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Comparison of remifentanil and low-dose fentanyl for fast-track cardiac anesthesia: a prospective randomized study.

https://arctichealth.org/en/permalink/ahliterature260284
Source
Heart Surg Forum. 2013 Dec;16(6):E324-8
Publication Type
Article
Date
Dec-2013
Author
Boris Khanykin
Rizwan Siddiqi
Per F Jensen
Dennis R Bigler
Gennady V Atroshchenko
Source
Heart Surg Forum. 2013 Dec;16(6):E324-8
Date
Dec-2013
Language
English
Publication Type
Article
Keywords
Aged
Analgesics, Opioid - administration & dosage
Anesthesia Recovery Period
Anesthesia, General - methods - mortality
Cardiac Surgical Procedures - methods - mortality
Denmark - epidemiology
Dose-Response Relationship, Drug
Female
Fentanyl - administration & dosage
Hospital Mortality
Humans
Intubation, Intratracheal - mortality
Length of Stay
Male
Middle Aged
Operative Time
Pain, Postoperative - prevention & control
Piperidines - administration & dosage
Prevalence
Risk factors
Survival
Treatment Outcome
Abstract
Different anesthetic techniques have been used for fast tracking in cardiac anesthesia. Remifentanil, with its unique pharmacokinetic profile, could be an ideal drug for fast tracking. Possible limitations of remifentanil are rapid onset of postoperative pain after discontinuation of the drug infusion, which may increase the risk of an ischemic event. We conducted this randomized study to compare the efficacy of remifentanil versus low doses of fentanyl in fast-track cardiac anesthesia. It has been hypothesized that remifentanil would provide a safe anesthesia with no impact on myocardial function and with positive effects on extubation time and mobilization.
We compared the postoperative course of patients, the remifentanil group (RG) and the low-dose fentanyl group (LDFG), in whom remifentanil and low-dose fentanyl, respectively, were used for fast-track cardiac anesthesia. The study was designed as a prospective randomized study. The primary outcomes were changes in the cardiac index and creatine kinase MB fraction (CKMB), extubation times, mobilization times, and lengths of stay in the intensive care unit (ICU) and the hospital. Frequency of myocardial infarction (MI), reoperations due to excessive bleeding, renal impairment, and cerebral complications were registered as well.
Seventy-one patients were enrolled in the study, and 7 were excluded due to difficult airway, bleeding, and technical difficulties. The RG comprised 33 patients and the LDFG comprised of 31 patients. There were no differences between the groups in terms of age, Euroscore, types of surgery, extracorporeal circulation, and aortic cross-clamp time. We did not find significant difference in cardiac index, CKMB, extubation times, mobilization times, length of stay in the ICU and in the hospital between the groups. Postoperative complications such as MI, rates of reoperations, renal and cerebral complications and incidence of atrial fibrillation did not show any significant differences.
Remifentanil fast-track anesthesia for cardiac patients has no negative impact on myocardial function. Both remifentanil and low-dose fentanyl are equally effective and safe for fast-track cardiac anesthesia. The study did not highlight any statistical superiority of remifentanil anesthesia over low-dose fentanyl anesthesia.
PubMed ID
24370801 View in PubMed
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A comparison of the progression rate to acquired immunodeficiency syndrome between intravenous drug users and homosexual men.

https://arctichealth.org/en/permalink/ahliterature7937
Source
Scand J Soc Med. 1994 Dec;22(4):309-14
Publication Type
Article
Date
Dec-1994
Author
A. Eskild
P. Magnus
C. Sohlberg
F. Jensen
P. Kittelsen
Author Affiliation
Department of Epidemiology, National Institute of Public Health, Oslo, Norway.
Source
Scand J Soc Med. 1994 Dec;22(4):309-14
Date
Dec-1994
Language
English
Publication Type
Article
Keywords
Acquired Immunodeficiency Syndrome - diagnosis - epidemiology - transmission
Adult
Female
Follow-Up Studies
HIV Seropositivity - diagnosis - epidemiology - transmission
HIV Seroprevalence - trends
HIV-1
Homosexuality, Male - statistics & numerical data
Humans
Male
Norway - epidemiology
Research Support, Non-U.S. Gov't
Substance Abuse, Intravenous - epidemiology
Urban Population - statistics & numerical data
Abstract
In order to study differences in progression to Acquired Immunodeficiency Syndrome (AIDS) between risk groups, 205 homosexual men and 185 intravenous drug users (IVDUs) were followed from diagnosed seropositivity for Human Immunodeficiency Virus Type-1 (HIV) for a mean period of 46 months (range 1-88 months). Seven (4%) IVDUs and 55 homosexual men (27%) were diagnosed with AIDS during the follow-up period. The probability of being AIDS-free four years after diagnosed HIV positivity was 0.96 for IVDUs (SE 0.02) and 0.73 (SE 0.04) for homosexual men (p
PubMed ID
7716443 View in PubMed
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Cord blood 25(OH)-vitamin D deficiency and childhood asthma, allergy and eczema: the COPSAC2000 birth cohort study.

https://arctichealth.org/en/permalink/ahliterature268551
Source
PLoS One. 2014;9(6):e99856
Publication Type
Article
Date
2014
Author
Bo L Chawes
Klaus Bønnelykke
Pia F Jensen
Ann-Marie M Schoos
Lene Heickendorff
Hans Bisgaard
Source
PLoS One. 2014;9(6):e99856
Date
2014
Language
English
Publication Type
Article
Keywords
Adult
Age of Onset
Asthma - blood - epidemiology
Child
Child, Preschool
Cohort Studies
Denmark - epidemiology
Eczema - blood - epidemiology
Female
Fetal Blood - chemistry
Humans
Hypersensitivity - blood - epidemiology
Infant
Infant, Newborn
Male
Pregnancy
Pregnancy Complications - blood - epidemiology
Vitamin D - analogs & derivatives - analysis - blood
Vitamin D Deficiency - blood - epidemiology
Young Adult
Abstract
Epidemiological studies have suggested an association between maternal vitamin D dietary intake during pregnancy and risk of asthma and allergy in the offspring. However, prospective clinical studies on vitamin D measured in cord blood and development of clinical end-points are sparse.
To investigate the interdependence of cord blood 25-hydroxyvitamin D (25(OH)-Vitamin D) level and investigator-diagnosed asthma- and allergy-related conditions during preschool-age.
Cord blood 25(OH)-Vitamin D level was measured in 257 children from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2000) at-risk mother-child cohort. Troublesome lung symptoms (TROLS), asthma, respiratory infections, allergic rhinitis, and eczema, at age 0-7 yrs were diagnosed exclusively by the COPSAC pediatricians strictly adhering to predefined algorithms. Objective assessments of lung function and sensitization were performed repeatedly from birth.
After adjusting for season of birth, deficient cord blood 25(OH)-Vitamin D level (
Notes
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PubMed ID
24925304 View in PubMed
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Cumulative risk assessment of the intake of organophosphorus and carbamate pesticides in the Danish diet.

https://arctichealth.org/en/permalink/ahliterature30728
Source
Food Addit Contam. 2003 Aug;20(8):776-85
Publication Type
Article
Date
Aug-2003
Author
A F Jensen
A. Petersen
K. Granby
Author Affiliation
Institute of Food Safety and Nutrition, Danish Veterinary and Food Administration, Søborg, Denmark.
Source
Food Addit Contam. 2003 Aug;20(8):776-85
Date
Aug-2003
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Carbamates
Cereals - chemistry
Denmark
Diet
Diet Surveys
Environmental Exposure
Food contamination - analysis
Fruit - chemistry
Humans
Insecticides - administration & dosage
Middle Aged
Organophosphorus Compounds
Pesticide Residues - analysis
Risk Assessment - methods
Vegetables - chemistry
Abstract
The aim of the study is to evaluate the potential cumulative effects of organophosphorus and carbamate pesticides that act through a common mechanism of toxicity, and to assess the long- and short-term risks for the Danish population. The intake estimates are based on dietary intake data collected in the Danish nation-wide food consumption survey in 1995. The pesticide data are based on the Danish pesticide residue-monitoring programme from 1996-2001. The amount of 35 organophosphorus pesticides and carbamates were included in the cumulative risk assessment. Processing factors, such as reduction of pesticide levels by rinsing and peeling, were applied in the exposure assessment. The "Toxicity Equivalence Factor" (TEF) approach was used to normalise the toxicity of the different organophosphorus and carbamate pesticides. Cumulative chronic exposure of organophosphorus and carbamates pesticides via fruit, vegetables and cereals is for adults 0.8-2% of the Acceptable Daily Intake (ADI) in chlorpyrifos equivalents, and 0.03-11% of the ADI in methamidophos equivalents; and for children 2-5% of the ADI in the chlorpyrifos equivalents, and 0.07-27% of the ADI in methamidophos equivalents. Neither Acute Reference Dose (ARfD) nor ADI was exceeded for any of the compounds studied. The results indicate that the Danish population is neither exposed to any cumulative chronic risk, nor at risk of acute exposure, from consumption of organophosphorus and carbamate pesticides from fruit, vegetables and cereals.
PubMed ID
13129794 View in PubMed
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The Danish contribution to the European DEMOCOPHES project: A description of cadmium, cotinine and mercury levels in Danish mother-child pairs and the perspectives of supplementary sampling and measurements.

https://arctichealth.org/en/permalink/ahliterature267585
Source
Environ Res. 2015 Aug;141:96-105
Publication Type
Article
Date
Aug-2015
Author
Thit A Mørck
Flemming Nielsen
Jeanette K S Nielsen
Janne F Jensen
Pernille W Hansen
Anne K Hansen
Lea N Christoffersen
Volkert D Siersma
Ida H Larsen
Linette K Hohlmann
Mette T Skaanild
Hanne Frederiksen
Pierre Biot
Ludwine Casteleyn
Marike Kolossa-Gehring
Gerda Schwedler
Argelia Castaño
Jürgen Angerer
Holger M Koch
Marta Esteban
Greet Schoeters
Elly Den Hond
Karen Exley
Ovnair Sepai
Louis Bloemen
Reinhard Joas
Anke Joas
Ulrike Fiddicke
Ana Lopez
Ana Cañas
Dominique Aerts
Lisbeth E Knudsen
Source
Environ Res. 2015 Aug;141:96-105
Date
Aug-2015
Language
English
Publication Type
Article
Keywords
Adult
Biological Markers - analysis - blood - urine
Cadmium - analysis - blood - urine
Child
Cotinine - urine
Denmark
Environmental Monitoring - methods - statistics & numerical data
Environmental Pollutants - analysis - blood - urine
Europe
Female
Hair - chemistry
Humans
Male
Mercury - analysis - blood - urine
Middle Aged
Mothers
Questionnaires
Sampling Studies
Seafood - statistics & numerical data
Smoking - urine
Abstract
Human biomonitoring (HBM) is an important tool, increasingly used for measuring true levels of the body burdens of environmental chemicals in the general population. In Europe, a harmonized HBM program was needed to open the possibility to compare levels across borders. To explore the prospect of a harmonized European HBM project, DEMOCOPHES (DEMOnstration of a study to COordinate and Perform Human biomonitoring on a European Scale) was completed in 17 European countries. The basic measurements performed in all implemented countries of DEMOCOPHES included cadmium, cotinine and phthalate metabolites in urine and mercury in hair. In the Danish participants, significant correlations between mothers and children for mercury in hair and cotinine in urine were found. Mercury in hair was further significantly associated with intake of fish and area of residence. Cadmium was positively associated with BMI in mothers and an association between cadmium and cotinine was also found. As expected high cotinine levels were found in smoking mothers. For both mercury and cadmium significantly higher concentrations were found in the mothers compared to their children. In Denmark, the DEMOCOPHES project was co-financed by the Danish ministries of health, environment and food safety. The co-financing ministries agreed to finance a number of supplementary measurements of substances of current toxicological, public and regulatory interest. This also included blood sampling from the participants. The collected urine and blood samples were analyzed for a range of other persistent and non-persistent environmental chemicals as well as two biomarkers of effect. The variety of supplementary measurements gives the researchers further information on the exposure status of the participants and creates a basis for valuable knowledge on the pattern of exposure to various chemicals.
PubMed ID
25440293 View in PubMed
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Danish integrated antimicrobial resistance monitoring and research program.

https://arctichealth.org/en/permalink/ahliterature159169
Source
Emerg Infect Dis. 2007 Nov;13(11):1632-9
Publication Type
Article
Date
Nov-2007
Author
Anette M Hammerum
Ole E Heuer
Hanne-Dorthe Emborg
Line Bagger-Skjøt
Vibeke F Jensen
Anne-Marie Rogues
Robert L Skov
Yvonne Agersø
Christian T Brandt
Anne Mette Seyfarth
Arno Muller
Karin Hovgaard
Justin Ajufo
Flemming Bager
Frank M Aarestrup
Niels Frimodt-Møller
Henrik C Wegener
Dominique L Monnet
Author Affiliation
National Center for Antimicrobials and Infection Control, Statens Serum Institut, Copenhagen, Denmark. ama@ssi.dk
Source
Emerg Infect Dis. 2007 Nov;13(11):1632-9
Date
Nov-2007
Language
English
Publication Type
Article
Keywords
Animal Husbandry - methods
Animals
Anti-Infective Agents - administration & dosage
Bacterial Infections - drug therapy - microbiology
Denmark
Drug Resistance, Multiple, Bacterial
European Union
Food Microbiology
Humans - microbiology
Meat - microbiology
Microbial Sensitivity Tests
Veterinary Drugs
Abstract
Resistance to antimicrobial agents is an emerging problem worldwide. Awareness of the undesirable consequences of its widespread occurrence has led to the initiation of antimicrobial agent resistance monitoring programs in several countries. In 1995, Denmark was the first country to establish a systematic and continuous monitoring program of antimicrobial drug consumption and antimicrobial agent resistance in animals, food, and humans, the Danish Integrated Antimicrobial Resistance Monitoring and Research Program (DANMAP). Monitoring of antimicrobial drug resistance and a range of research activities related to DANMAP have contributed to restrictions or bans of use of several antimicrobial agents in food animals in Denmark and other European Union countries.
Notes
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PubMed ID
18217544 View in PubMed
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Diagnosis of Clostridium difficile: real-time PCR detection of toxin genes in faecal samples is more sensitive compared to toxigenic culture.

https://arctichealth.org/en/permalink/ahliterature268443
Source
Eur J Clin Microbiol Infect Dis. 2015 Apr;34(4):727-36
Publication Type
Article
Date
Apr-2015
Author
M B F Jensen
K E P Olsen
X C Nielsen
A M Hoegh
R B Dessau
T. Atlung
J. Engberg
Source
Eur J Clin Microbiol Infect Dis. 2015 Apr;34(4):727-36
Date
Apr-2015
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Bacterial Toxins - analysis - genetics
Cell Culture Techniques - methods
Child
Child, Preschool
Clostridium Infections - diagnosis
Clostridium difficile - isolation & purification
Denmark
Feces - microbiology
Female
Humans
Infant
Male
Middle Aged
Molecular Diagnostic Techniques - methods
Real-Time Polymerase Chain Reaction - methods
Sensitivity and specificity
Young Adult
Abstract
The diagnosis of Clostridium difficile infection (CDI) requires the detection of toxigenic C. difficile or its toxins and a clinical assessment. We evaluated the performance of four nucleic acid amplification tests (NAATs) detecting toxigenic C. difficile directly from faeces compared to routine toxigenic culture. In total, 300 faecal samples from Danish hospitalised patients with diarrhoea were included consecutively. Culture was performed in duplicate (routine and 'expanded toxigenic culture': prolonged and/or re-culture) and genotypic toxin profiling by polymerase chain reaction (PCR), PCR ribotyping and toxinotyping (TT) were performed on culture-positive samples. In parallel, the samples were analysed by four NAATs; two targeting tcdA or tcdB (illumigene C. difficile and PCRFast C. difficile A/B) and two multi-target real-time (RT) PCR assays also targeting cdt and tcdC alleles characteristic of epidemic and potentially more virulent PCR ribotypes 027, 066 and 078 (GeneXpert C. difficile/Epi and an 'in-house RT PCR' two-step algorithm). The multi-target assays were significantly more sensitive compared to routine toxigenic culture (p?95%), and in-house PCR displayed 100% correct identification of PCR ribotypes 066 and 078. Furthermore, the presence of the PCR enhancer bovine serum albumin (BSA) was found to be related to high sensitivity and low inhibition rate. Rapid laboratory diagnosis of toxigenic C. difficile by RT PCR was accurate.
PubMed ID
25421216 View in PubMed
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39 records – page 1 of 4.