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Maternal-serum-alphafetoprotein screening for fetal malformations in 28 062 pregnancies. A four-year experience from a low-risk area.

https://arctichealth.org/en/permalink/ahliterature65623
Source
Acta Obstet Gynecol Scand. 1985;64(6):511-4
Publication Type
Article
Date
1985
Author
B. Nørgaard-Pedersen
P. Bagger
J. Bang
W. Fischer-Rasmussen
C. Gad
E. Hasch
P E Helkjaer
J C Jacobsen
J. Kjeldsen
E. Kjaersgaard
Source
Acta Obstet Gynecol Scand. 1985;64(6):511-4
Date
1985
Language
English
Publication Type
Article
Keywords
Abdominal Muscles - abnormalities
Abnormalities - epidemiology - metabolism
Adult
Amniotic Fluid - metabolism
Concanavalin A - diagnostic use
Denmark
Female
Humans
Mass Screening
Neural Tube Defects - epidemiology
Pregnancy
Prenatal Diagnosis
Risk
alpha-Fetoproteins - metabolism
Abstract
From 1st March, 1980 and up to 29th February 1984 a multicenter serum alpha-fetoprotein (S-AFP) screening project was carried out for the detection of severe fetal malformations. S-AFP was determined by a radio-immunoassay in 28 062 pregnant women between the 16th and 20th week of gestation. Patients with elevated S-AFP values, e.g. above 95 percentile, were examined further with a second S-AFP and by ultrasound scan. 244 amniocenteses (0.9%) were carried out to detect 62 malformations (21 anencephalies, 14 spina bifidas, 2 encephaloceles, 7 omphaloceles, 5 gastroschises, 4 chromosome abnormalities and 9 other malformations). Fifteen of the 16 cases of spina bifida could not be verified by ultrasound scan, whereas all other malformations except chromosome abnormalities were confirmed by ultrasonography. Two cases of spina bifida and one case of skin-covered encephalocele had normal S-AFP concentrations and were therefore not detected. There were no definitive false-positives, e.g. therapeutic abortion of a normal fetus. Our conclusion is that a nationwide S-AFP screening should be recommended.
PubMed ID
2414967 View in PubMed
Less detail

Three years' experience with prenatal diagnosis in a Danish county.

https://arctichealth.org/en/permalink/ahliterature65744
Source
Lancet. 1982 Nov 6;2(8306):1044-5
Publication Type
Article
Date
Nov-6-1982