The article presents results of study into the level of physical development, condition of the cardiovascular-, respiratory-, central nervous systems, immunobiologic resistance of the organism, prevalence of morphofunctional deviations from the norm, and morbidity rates among the students of the mining-trade secondary school (aged 15-18). It has been found out that adverse ecological situation in urban centres of the Donetsk Province together with specific character of training for occupation in coal industry have a marked negative effect on the functional status as well as health status of the adolescents. On the basis of the studies made a complex of measures has been designed to maintain and promote the health of students of the mining-trade secondary schools.
The antibody formation and expression of delayed type hypersensitivity (DTH) of several antigens under the conditions of their injection together with bacterial lipopolysaccharide (LPS) in mice have been studied. Water-phenol LPS extract from S. sonnei was used. The LPS was treated with the redox system (LPS-R) or not (LPS-PW). Besides, LPS was obtained by immunoaffinity method from avirulent (LPS-A) or virulent (LPS-V) S. sonnei. It had been found that the mice reacted by more intensive increase antibody formation to LPS or sheep erythrocytes if LPS-R or LPS-V were injected alone or together with erythrocytes. More intensive increase of lymph nodes was shown as well. When specified LPS were injected in mice together with E. coli they induced the immunosuppression of DTH. The LPS-PW and LPS-A caused the most feeble reaction of immune system in mice. It has been suggested that the differences of immune reaction are the reflection of conformation processes in LPS molecules.