Skip header and navigation

Refine By

3 records – page 1 of 1.

Brainstem size and function at term age in relation to later neurosensory disability in high-risk, preterm infants.

https://arctichealth.org/en/permalink/ahliterature58609
Source
Acta Paediatr. 2001 Aug;90(8):909-15
Publication Type
Article
Date
Aug-2001
Author
A M Valkama
E U Tolonen
L I Kerttul
E L Pääkkö
L K Vainionpää
M E Koivist
Author Affiliation
Department of Paediatric, University of Oulu, Finland. marita.valkama@oulu.fi
Source
Acta Paediatr. 2001 Aug;90(8):909-15
Date
Aug-2001
Language
English
Publication Type
Article
Keywords
Brain Stem - pathology - physiopathology
Cerebral Palsy - diagnosis - etiology
Cohort Studies
Deafness - diagnosis - etiology
Evoked Potentials, Auditory, Brain Stem
Female
Follow-Up Studies
Humans
Infant, Newborn
Infant, Premature - physiology
Magnetic Resonance Imaging - methods
Male
Research Support, Non-U.S. Gov't
Sensitivity and specificity
Abstract
The aim of this study was to measure brainstem size on magnetic resonance imaging (MRI) scans of high-risk. preterm infants, to assess brainstem function by brainstem auditory-evoked potentials (BAEP) and to determine the predictive value of these measures for the neurosensory outcome. A total of 51 preterm infants (gestational age
PubMed ID
11529541 View in PubMed
Less detail

Nerve lesions after therapy for childhood acute lymphoblastic leukemia.

https://arctichealth.org/en/permalink/ahliterature21845
Source
Cancer. 1998 Jan 1;82(1):200-7
Publication Type
Article
Date
Jan-1-1998
Author
A H Harila-Saari
L K Vainionpää
T T Kovala
E U Tolonen
B M Lanning
Author Affiliation
Department of Pediatrics, University of Oulu, Finland.
Source
Cancer. 1998 Jan 1;82(1):200-7
Date
Jan-1-1998
Language
English
Publication Type
Article
Keywords
Adolescent
Antimetabolites, Antineoplastic - administration & dosage - adverse effects
Antineoplastic Agents, Phytogenic - administration & dosage - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Axons - drug effects - physiology - radiation effects
Brachial Plexus - drug effects - physiopathology - radiation effects
Case-Control Studies
Child
Child, Preschool
Combined Modality Therapy
Comparative Study
Cranial Irradiation
Demyelinating Diseases - diagnosis - etiology
Evoked Potentials, Somatosensory - physiology
Female
Humans
Leukemia, Lymphocytic, Acute - drug therapy - radiotherapy
Male
Median Nerve - drug effects - physiopathology - radiation effects
Methotrexate - administration & dosage - adverse effects
Motor Skills - drug effects - physiology - radiation effects
Peripheral Nervous System Diseases - diagnosis - etiology
Psychomotor Disorders - etiology - physiopathology
Reflex, Stretch - drug effects - physiology - radiation effects
Research Support, Non-U.S. Gov't
Risk factors
Spinal Cord - drug effects - physiopathology - radiation effects
Spinal Cord Diseases - diagnosis - etiology
Tibial Nerve - drug effects - physiopathology - radiation effects
Vincristine - administration & dosage - adverse effects
Abstract
BACKGROUND: The objective of the current study was to use somatosensory evoked potentials (SEP) to detect signs of nerve lesions in the peripheral nerve and in the central nervous system (CNS) after 3 years of treatment for childhood acute lymphoblastic leukemia (ALL). METHODS: The somatosensory potentials evoked by stimulation of the median nerve and posterior tibial nerve were recorded in 31 children with ALL after 3 years of therapy. All patients were examined clinically. The 14 standard risk patients had been treated with chemotherapy according to the Nordic regimen, and the 17 intermediate risk or high risk patients had been treated with chemotherapy and cranial irradiation according to the ALL BFM-83 protocol. RESULTS: A decrease in amplitudes was observed at the brachial plexus and spinal cord (C7) in the median SEP, and at the knee, spinal cord (Th12), and cortex in the tibial SEP, indicating axonal injury within the entire CNS in the patients with ALL compared with healthy age-, gender-, and height-matched controls. Prolongation of the SEP latencies was found within the spinal cord, indicating demyelination. These SEP changes had persisted for 2 years since the last injection/infusion of vincristine or methotrexate, which are the principal neurotoxic drugs used in chemotherapy for ALL. Clinical signs of nerve injury such as depressed deep tendon reflexes and gross or fine motor difficulties were found in approximately 33% of the patients and dysdiadochokinesia in 50%. CONCLUSIONS: Treatment of ALL in children principally with vincristine and methotrexate causes long-standing axonal injury throughout the nervous system and demyelination within the spinal cord. These changes are associated with clinical neurologic findings.
PubMed ID
9428498 View in PubMed
Less detail

Prediction of permanent hearing loss in high-risk preterm infants at term age.

https://arctichealth.org/en/permalink/ahliterature58744
Source
Eur J Pediatr. 2000 Jun;159(6):459-64
Publication Type
Article
Date
Jun-2000
Author
A M Valkama
K T Laitakari
E U Tolonen
M R Väyrynen
L K Vainionpää
M E Koivisto
Author Affiliation
Department of Paediatrics, University of Oulu, Finland. marita.valkama@oulu.fi
Source
Eur J Pediatr. 2000 Jun;159(6):459-64
Date
Jun-2000
Language
English
Publication Type
Article
Keywords
Deafness - diagnosis
Evoked Potentials, Auditory, Brain Stem
Female
Follow-Up Studies
Humans
Infant, Newborn
Infant, Premature
Male
Neonatal Screening
Predictive value of tests
Research Support, Non-U.S. Gov't
Risk factors
Sensitivity and specificity
Abstract
The aim of this series was to assess hearing screenings; auditory brainstem responses (ABR), transient evoked otoacoustic emissions (TEOAE) and free field auditory responses (FF) for the prediction of permanent bilateral hearing loss in high-risk preterm infants at term post-conceptional age. A total of 51 preterm infants (gestational age
PubMed ID
10867855 View in PubMed
Less detail