Skip header and navigation

Refine By

12 records – page 1 of 2.

An Sp1 binding site polymorphism in the COLIA1 gene predicts osteoporotic fractures in both men and women.

https://arctichealth.org/en/permalink/ahliterature204582
Source
J Bone Miner Res. 1998 Sep;13(9):1384-9
Publication Type
Article
Date
Sep-1998
Author
B L Langdahl
S H Ralston
S F Grant
E F Eriksen
Author Affiliation
Aarhus Bone and Mineral Research Group, University Department of Endocrinology, Aarhus University Hospital, Denmark.
Source
J Bone Miner Res. 1998 Sep;13(9):1384-9
Date
Sep-1998
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Biological Markers - analysis
Bone Density - genetics
Case-Control Studies
Collagen - genetics
Denmark - epidemiology
Female
Humans
Male
Middle Aged
Osteoporosis - complications - epidemiology - genetics
Polymerase Chain Reaction
Polymorphism, Genetic - genetics
Predictive value of tests
Regression Analysis
Sex Factors
Spinal Fractures - epidemiology - etiology - genetics
Abstract
Genetic factors play an important role in the pathogenesis of osteoporosis, and recent studies have shown that a polymorphic Sp1 binding site in collagen type I alpha1 (COLIA1) gene is associated with bone mass and vertebral fractures in women from the U.K. Information on the predictive value of the COLIA1 Sp1 polymorphism in other populations is limited, however, and no studies have yet been performed in osteoporotic males. In view of this, we analyzed COLIA1 genotypes in relation to bone density and biochemical markers of bone turnover and the presence of osteoporotic fractures in a case-control study of Danish men and women. COLIA1 genotype was determined by polymerase chain reaction analysis of genomic DNA extracted from peripheral blood samples and related to bone mass, biochemical markers of bone turnover, and the presence of fracture in a study of 375 osteoporotic vertebral fracture patients and normal controls. There was no significant effect of COLIA1 genotype on bone mass or biochemical markers when data from the control group (n = 195) and fracture group (n = 180) were analyzed separately. However, the genotype distribution was significantly different in the fracture cases compared with age-matched controls (chi2 = 16.48, n = 249,p = 0.0003) due mainly to over-representation of the ss genotype in the fracture patients (14.3% vs. 1.4%), equivalent to an odds ratio for vertebral fracture of 11.83 (95% confidence interval 2.64-52.97) in those with the ss genotype. Similar differences in genotype distribution between osteoporotic patients and controls were observed in both men (chi2 = 11.52, n = 95, p = 0.0032, OR = 2.04) and women (chi2 = 6.90, n = 154, p = 0.032, OR = 1.37). In keeping with the above, logistic regression analysis showed that the ss genotype was an independent predictor of osteoporotic fracture (p = 0.028). This study confirms that the COLIA1 Sp1 polymorphism is significantly associated with osteoporotic vertebral fractures. The association is seen in both men and women, and the effect on fracture risk appears to be partly independent of bone mineral density. Our results raise the possibility that genotyping at the Sp1 site could be of clinical value in identifying individuals at risk of osteoporotic fractures in both genders.
PubMed ID
9738510 View in PubMed
Less detail

[Attitude of general practitioners to the importance of gender and diet in disease prevention]

https://arctichealth.org/en/permalink/ahliterature10741
Source
Ugeskr Laeger. 1999 Jan 4;161(1):40-3
Publication Type
Article
Date
Jan-4-1999
Author
U. Hølund
G. Boysen
P. Charles
E F Eriksen
O K Overvad
B H Petersson
B. Sandström
A R Thomassen
M A Vittrup
Author Affiliation
Mejeriernes Ernaeringscenter, Arhus.
Source
Ugeskr Laeger. 1999 Jan 4;161(1):40-3
Date
Jan-4-1999
Language
Danish
Publication Type
Article
Keywords
Attitude of Health Personnel
Denmark
Dietary Services
English Abstract
Female
Food Habits
Health Behavior
Humans
Life Style
Male
Physicians, Family - psychology
Preventive Health Services - economics - organization & administration - standards
Primary Prevention
Questionnaires
Sex Factors
Abstract
Three hundred and seventy-four general practitioners (GPs) in Denmark filled in a questionnaire on attitudes to include information on gender and diet in the strategy for prevention of coronary heart disease, cancer, osteoporosis, and overweight/underweight. Risk factors for disease in general were ranked as follows: smoking, alcohol, stress, diet, physical exercise, heredity and hygiene. The patients' lack of motivation, insufficient time for each patient, and inadequate knowledge about nutrition were stated as barriers to dietary counselling. The GPs stated that the gender of the patient was important only to the counselling on osteoporosis. Lack of time and insufficient knowledge were perceived as barriers for including gender specific issues in prevention. It is concluded that GPs consider dietary counselling important but lack time and knowledge. The results point at a need for better pre- and postgraduate training in nutrition, and for a better reimbursement system for time spent on prevention.
PubMed ID
9922687 View in PubMed
Less detail

Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited.

https://arctichealth.org/en/permalink/ahliterature61816
Source
J Intern Med. 2000 Feb;247(2):260-8
Publication Type
Article
Date
Feb-2000
Author
H. Glerup
K. Mikkelsen
L. Poulsen
E. Hass
S. Overbeck
J. Thomsen
P. Charles
E F Eriksen
Author Affiliation
Department of Endocrinology, Aarhus Amtssygehus, University Hospital of Aarhus, Aarhus, Denmark. h.glerup@dadlnet.dk
Source
J Intern Med. 2000 Feb;247(2):260-8
Date
Feb-2000
Language
English
Publication Type
Article
Keywords
Adult
Alkaline Phosphatase - blood
Arabs
Calcium - blood - urine
Case-Control Studies
Clothing - adverse effects
Creatinine - blood
Cross-Sectional Studies
Denmark - ethnology
Female
Food Habits
Humans
Hydroxyproline - urine
Hyperparathyroidism, Secondary - blood - diagnosis
Magnesium - blood
Nutrition Policy
Parathyroid Hormone - blood
Phosphates - blood
Sunlight
Ultraviolet Rays
Vitamin D - administration & dosage - analogs & derivatives - blood
Vitamin D Deficiency - blood - etiology
Abstract
OBJECTIVES: Sunlight exposure of the skin is known to be the most important source of vitamin D. The aims of this study were: (i) to estimate vitamin D status amongst sunlight-deprived individuals (veiled Arab women, veiled ethnic Danish Moslem women and Danish controls); and (ii) through food intake analysis to estimate the oral intake of vitamin D necessary to keep a normal vitamin D status in sunlight-deprived individuals. DESIGN: Cross-sectional study amongst randomly selected Moslem women of Arab origin living in Denmark. Age-matched Danish women were included as controls. To control for racial differences, a group of veiled ethnic Danish Moslem women (all Caucasians) was included. SETTING: Primary Health Care Centre, City Vest and Department of Endocrinology and Metabolism C, University Hospital of Aarhus, Aarhus Amtssygehus, Aarhus, Denmark. SUBJECTS: Sixty-nine Arab women (60 veiled, nine non-veiled) and 44 age-matched Danish controls were randomly selected amongst patients contacting the primary health care centre for reasons other than vitamin D deficiency. Ten ethnic Danish Moslem women were included through a direct contact with their community. MAIN OUTCOME MEASURES: Serum levels of 25-hydroxyvitamin D were used as estimates of vitamin D status. Intact parathyroid hormone (PTH) was used to control for secondary hyperparathyroidism. Alkaline phosphatase and bone-specific alkaline phosphatase were used as markers for osteomalacic bone involvement. Oral intake of vitamin D and calcium were estimated through a historical food intake interview performed by a trained clinical dietician. RESULTS: Veiled Arab women displayed extremely low values of 25-hydroxyvitamin D: 7.1 +/- 1.1 nmol L-1, compared with 17.5 +/- 2. 3 (P
PubMed ID
10692090 View in PubMed
Less detail

Does body height reduction influence interpretation of lung function in COPD patients?

https://arctichealth.org/en/permalink/ahliterature145761
Source
Eur Respir J. 2010 Sep;36(3):540-8
Publication Type
Article
Date
Sep-2010
Author
A. Kjensli
M. Ryg
J A Falch
G. Armbrecht
L M Diep
E F Eriksen
I. Ellingsen
Author Affiliation
Glittreklinikken, Pb 104 Aaneby, N-1485 Hakadal, Norway. aina.kjensli@glittreklinikken.no
Source
Eur Respir J. 2010 Sep;36(3):540-8
Date
Sep-2010
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Body Height
Cross-Sectional Studies
Female
Humans
Lung - physiopathology
Male
Middle Aged
Norway
Osteoporosis - complications
Pulmonary Disease, Chronic Obstructive - complications - pathology - therapy
Reference Values
Respiratory Function Tests
Respiratory Physiological Phenomena
Abstract
Vertebral deformities are prevalent in chronic obstructive pulmonary disease (COPD) patients and may cause excessive loss of height. As height is used for calculating reference values for pulmonary function tests, larger than normal height reduction could cause overestimation of lung function. In this cross-sectional study of 465 COPD patients and 462 controls, we explored how often lung function is misinterpreted due to height reduction in COPD patients, and whether the number or severity of vertebral deformities correlate with height reduction. Measured height was compared to recalled tallest height (RTH) and height calculated from arm span (ASH) to assess height reduction. Vertebral deformities were assessed from radiographs and pulmonary function was assessed using standard formulae. Height reduction was frequent in both the study and control groups, and increased with the number and severity of vertebral deformities. When using current measured height, lung function was overestimated in a significant proportion of COPD patients at relatively modest height reductions. The effects were smallest for forced expiratory volume in 1 s and forced vital capacity, and most pronounced for total lung capacity and residual volume. Therefore, we propose that in COPD patients with excessive height reduction, one might use RTH or ASH in calculating predicted values. Furthermore, such patients should be evaluated for co-existing vertebral deformities and osteoporosis.
PubMed ID
20110396 View in PubMed
Less detail

Hypovitaminosis D myopathy without biochemical signs of osteomalacic bone involvement.

https://arctichealth.org/en/permalink/ahliterature198521
Source
Calcif Tissue Int. 2000 Jun;66(6):419-24
Publication Type
Article
Date
Jun-2000
Author
H. Glerup
K. Mikkelsen
L. Poulsen
E. Hass
S. Overbeck
H. Andersen
P. Charles
E F Eriksen
Author Affiliation
Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, University Hospital of Aarhus, Tage Hansensgade 2, DK-8000 Aarhus C, Denmark.
Source
Calcif Tissue Int. 2000 Jun;66(6):419-24
Date
Jun-2000
Language
English
Publication Type
Article
Keywords
Alkaline Phosphatase - blood
Arabs
Cross-Sectional Studies
Denmark
Female
Humans
Male
Middle Aged
Muscle Contraction - drug effects
Muscle, Skeletal - drug effects - physiology
Muscular Diseases - blood - etiology
Osteomalacia - blood - complications - drug therapy
Time Factors
Vitamin D - blood - therapeutic use
Vitamin D Deficiency - blood - complications
Abstract
The aims of this study were to investigate myopathy in relation to vitamin D status, and to study the muscular effects of vitamin D treatment on vitamin D-deficient individuals. Further, hypovitaminosis D myopathy was investigated in relation to alkaline phosphatase (ALP), the most commonly used marker for hypovitaminosis D osteopathy. Eight patients with osteomalacia had an isokinetic dynamometer test of all major muscle groups before and after 3 months of vitamin D treatment. The most pronounced improvements in muscle power were seen in the weight-bearing antigravity muscles of the lower limbs. A cross-sectional study was performed among 55 vitamin D-deficient veiled Arab women living in Denmark and 22 Danish controls. An isometric dynamometer model was used for determination of quadriceps muscle power. Both maximal voluntary contraction (MVC) and electrically stimulated values (single twitch, maximal production rate (MPR), and maximal relaxation rate (MRR)) were determined. The women underwent high-dose vitamin D treatment and were retested after 3 and 6 months. Prior to vitamin D treatment all parameters of muscle function in the group of vitamin D-deficient Arab women were significantly reduced compared with Danish controls. MVC: 259.4 +/- 11.0 N (Newton) versus 392.6 +/- 11. 4 N (P
PubMed ID
10821877 View in PubMed
Less detail

Importance of diet and sex in prevention of coronary artery disease, cancer, osteoporosis, and overweight or underweight: a study of attitudes and practices of Danish primary care physicians.

https://arctichealth.org/en/permalink/ahliterature11048
Source
Am J Clin Nutr. 1997 Jun;65(6 Suppl):2004S-2006S
Publication Type
Article
Date
Jun-1997
Author
U. Hølund
A. Thomassen
G. Boysen
P. Charles
E F Eriksen
K. Overvad
B. Petersson
B. Sandström
M. Vittrup
Author Affiliation
Nutrition Department, Danish Dairy Board, Aarhus, Denmark.
Source
Am J Clin Nutr. 1997 Jun;65(6 Suppl):2004S-2006S
Date
Jun-1997
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Attitude of Health Personnel
Child
Child, Preschool
Comparative Study
Coronary Disease - prevention & control
Denmark
Diet
Family Practice
Female
Humans
Infant
Male
Middle Aged
Neoplasms - prevention & control
Obesity - prevention & control
Osteoporosis - prevention & control
Physician's Practice Patterns
Primary Health Care
Questionnaires
Risk factors
Sex Factors
Abstract
General practitioners (GPs) in Denmark (n = 374) answered a questionnaire on attitudes toward including information on diet and sex in the prevention of coronary artery disease, cancers, osteoporosis, and weight problems. Risk factors for disease were ranked as follows: smoking, alcohol, stress, diet, physical exercise, heredity, and hygiene. Patients' lack of motivation, insufficient time for each patient, and inadequate knowledge about nutrition were listed by GPs as barriers to dietary counseling. GPs stated that the sex of the patient was important only for counseling on osteoporosis. Lack of time and insufficient knowledge were perceived as barriers to including sex-specific issues in prevention. One-half of the GPs were questioned about the issue of prevention on the basis of female case stories and the other half on the basis of male case stories with identical wording. Responses to the case stories indicated that GPs would give dietary guidance and recommend loss of weight to slightly overweight male patients to a much greater degree than to overweight female patients for prevention of coronary artery disease, give dietary counseling and recommend loss of weight and exercise to female patients more than to male patients for prevention of cancers, recommend a supplement of calcium and vitamin D for prevention of osteoporosis to female patients, and recommend weight gain and discuss psychosocial issues more with underweight female patients than with underweight male patients. Female GPs included measures of prevention such as dietary counseling, exercise prescription, dietary supplement prescription, and discussion of psychosocial issues to a greater extent than did male GPs.
PubMed ID
9174510 View in PubMed
Less detail

Measurement of cortical porosity of the proximal femur improves identification of women with nonvertebral fragility fractures.

https://arctichealth.org/en/permalink/ahliterature261713
Source
Osteoporos Int. 2015 Apr 16;
Publication Type
Article
Date
Apr-16-2015
Author
L A Ahmed
R. Shigdel
R M Joakimsen
O P Eldevik
E F Eriksen
A. Ghasem-Zadeh
Y. Bala
R. Zebaze
E. Seeman
Å. Bjørnerem
Source
Osteoporos Int. 2015 Apr 16;
Date
Apr-16-2015
Language
English
Publication Type
Article
Abstract
We tested whether cortical porosity of the proximal femur measured using StrAx1.0 software provides additional information to areal bone mineral density (aBMD) or Fracture Risk Assessment Tool (FRAX) in differentiating women with and without fracture. Porosity was associated with fracture independent of aBMD and FRAX and identified additional women with fractures than by osteoporosis or FRAX thresholds.
Neither aBMD nor the FRAX captures cortical porosity, a major determinant of bone strength. We therefore tested whether combining porosity with aBMD or FRAX improves identification of women with fractures.
We quantified femoral neck (FN) aBMD using dual-energy X-ray absorptiometry, FRAX score, and femoral subtrochanteric cortical porosity using StrAx1.0 software in 211 postmenopausal women aged 54-94 years with nonvertebral fractures and 232 controls in Tromsø, Norway. Odds ratios (ORs) were calculated using logistic regression analysis.
Women with fractures had lower FN aBMD, higher FRAX score, and higher cortical porosity than controls (all p?20 %, whereas porosity >80th percentile identified 61 women (29 %). Porosity identified 26 % additional women with fractures than identified by the osteoporosis threshold and 21 % additional women with fractures than by this FRAX threshold.
Cortical porosity is a risk factor for fracture independent of aBMD and FRAX and improves identification of women with fracture.
PubMed ID
25876879 View in PubMed
Less detail

[Prevention in general practice. Are female and male patients treated the same way? A questionnaire study]

https://arctichealth.org/en/permalink/ahliterature21278
Source
Ugeskr Laeger. 1999 Jan 4;161(1):44-8
Publication Type
Article
Date
Jan-4-1999
Author
U. Hølund
G. Boysen
P. Charles
E F Eriksen
O K Overvad
B H Petersson
B. Sandström
A R Thomassen
M A Vittrup
Author Affiliation
Mejeriernes Ernaeringscenter, Arhus.
Source
Ugeskr Laeger. 1999 Jan 4;161(1):44-8
Date
Jan-4-1999
Language
Danish
Publication Type
Article
Keywords
Adult
Denmark
Dietary Services
English Abstract
Family Practice
Female
Health Behavior
Humans
Life Style
Male
Middle Aged
Physician's Practice Patterns
Preventive Health Services
Primary Prevention
Questionnaires
Sex Factors
Abstract
Three hundred and seventy-four general practitioners (GPs) in Denmark filled in a questionnaire on practices regarding prevention of coronary heart disease (CHD), cancer, osteoporosis, and overweight/underweight. Half of the GPs were questioned about the issue of prevention based upon female case stories and the other half on male case stories with identical wording. The GPs more often in relation to: Prevention of CHD gave dietary counselling and recommended weight loss to slightly overweight male than female patients. Prevention of cancers gave dietary counselling and recommended weight loss and increase of exercise to female than to male patients. Prevention of osteoporosis recommended a supplement of calcium and vitamin D to female than to male patients. Treatment of underweight recommended weight gain and discussion of psycho-social issues to underweight female than male patients. In conclusion, GPs distinguish between men and women in relation to prevention strategies in general practice. There is a need for well-described prevention and action strategies with relevant gender differentiation for use in general practice.
PubMed ID
9922688 View in PubMed
Less detail

Procollagen type 1 amino-terminal propeptide (P1NP) and risk of hip fractures in elderly Norwegian men and women. A NOREPOS study.

https://arctichealth.org/en/permalink/ahliterature260681
Source
Bone. 2014 Jul;64:1-7
Publication Type
Article
Date
Jul-2014
Author
T E Finnes
C M Lofthus
H E Meyer
E F Eriksen
E M Apalset
G S Tell
P. Torjesen
S O Samuelsen
K. Holvik
Source
Bone. 2014 Jul;64:1-7
Date
Jul-2014
Language
English
Publication Type
Article
Keywords
Aged
Cohort Studies
Female
Hip Fractures - blood - epidemiology
Humans
Male
Norway - epidemiology
Peptide Fragments - blood
Procollagen - blood
Proportional Hazards Models
Risk factors
Abstract
The current study aimed to assess a possible association between the bone turnover marker procollagen type 1 amino-terminal propeptide (P1NP) and future hip fractures in elderly Norwegian men and women and to elucidate the relation between P1NP, bone mineral density and 25-hydroxyvitamin D (25(OH)D). Men and women aged 71 to 77 from two population based health studies in Norway (1999-2001) were followed for a median period of 7.3 years with respect to hip fractures. The study was designed as a case-cohort study. P1NP and 25(OH)D were analysed in frozen serum samples obtained at baseline in hip fracture patients (n=340) and in randomly selected sex stratified sub-cohorts. Bone mineral density was measured by dual-energy X-ray absorptiometry (DXA) in a subset of participants. Cox proportional hazards regression with inverse probability weighting and robust variance was performed. No significant correlation between 25(OH)D and P1NP was found. A negative correlation between P1NP and BMD was observed in women (Rho=-0.36, p=0.001). A similar trend was observed in men. No association between quartiles of P1NP and rate of subsequent hip fractures was found. Spline analyses suggested a higher rate of hip fracture at P1NP levels above 60 µg/L in both men and women. A higher hip fracture rate, which was independent of BMD, was also indicated in women with very low levels of P1NP.
PubMed ID
24667179 View in PubMed
Less detail

Serum parathyroid hormone is associated with increased cortical porosity of the inner transitional zone at the proximal femur in postmenopausal women: the Tromsø Study.

https://arctichealth.org/en/permalink/ahliterature298132
Source
Osteoporos Int. 2018 02; 29(2):421-431
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
02-2018
Author
M Osima
T T Borgen
M Lukic
G Grimnes
R M Joakimsen
E F Eriksen
Å Bjørnerem
Author Affiliation
Department of Community Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, N-9037, Tromsø, Norway. mos015@uit.no.
Source
Osteoporos Int. 2018 02; 29(2):421-431
Date
02-2018
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Absorptiometry, Photon - methods
Aged
Aged, 80 and over
Biomarkers - blood
Bone Density - physiology
Bone Remodeling - physiology
Case-Control Studies
Female
Femur - pathology - physiopathology
Femur Neck - physiopathology
Humans
Middle Aged
Osteoporosis, Postmenopausal - blood - etiology - physiopathology
Osteoporotic Fractures - blood - etiology - physiopathology
Parathyroid Hormone - blood - physiology
Porosity
Postmenopause - blood
Vitamin D - analogs & derivatives - blood
Vitamin D Deficiency - blood - complications - physiopathology
Abstract
Serum parathyroid hormone (PTH) was associated with increased bone turnover markers and cortical porosity of the inner transitional zone at the proximal femur. These results suggest that PTH through increased intracortical bone turnover leads to trabecularisation of inner cortical bone in postmenopausal women.
Vitamin D deficiency leads to secondary hyperparathyroidism and increased risk for fractures, whereas its association with cortical porosity is less clear. We tested (i) whether serum 25-hydroxyvitamin D (25(OH)D) and PTH were associated with cortical porosity and (ii) whether the associations of 25(OH)D) and PTH with fracture risk are dependent on cortical porosity.
This case-control study included 211 postmenopausal women, 54-94 years old, with prevalent fractures and 232 controls from the Tromsø Study. Serum 25(OH)D, PTH, and bone turnover markers (procollagen type I N-terminal propeptide [PINP] and C-terminal cross-linking telopeptide of type I collagen [CTX]) were measured. Femoral subtrochanteric cortical and trabecular parameters were quantified using computed tomography, and femoral neck areal bone mineral density (FN aBMD) was quantified using dual-energy X-ray absorptiometry.
Compared with controls, fracture cases exhibited reduced serum 25(OH)D and increased PTH, PINP, and CTX, increased femoral subtrochanteric cortical porosity, and reduced cortical thickness and FN aBMD (all, p??0.10). PTH was associated with increased PINP, CTX, and cortical porosity of the inner transitional zone and reduced trabecular bone volume/tissue volume and FN aBMD (p ranging from 0.003 to 0.054). Decreasing 25(OH)D and increasing PTH were associated with increased odds for fractures, independent of age, height, weight, calcium supplementation, serum calcium, cortical porosity, and thickness.
These data suggest that serum PTH, not 25(OH)D, is associated with increased intracortical bone turnover resulting in trabecularisation of the inner cortical bone; nevertheless, decreasing 25(OH)D) and increasing PTH are associated with fracture risk, independent of cortical porosity and thickness.
PubMed ID
29134242 View in PubMed
Less detail

12 records – page 1 of 2.