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Heart rate is associated with markers of fatty acid desaturation: the GOCADAN study.

https://arctichealth.org/en/permalink/ahliterature125766
Source
Int J Circumpolar Health. 2012;71:17343
Publication Type
Article
Date
2012
Author
Sven O E Ebbesson
Juan C Lopez-Alvarenga
Peter M Okin
Richard B Devereux
Maria Elizabeth Tejero
William S Harris
Lars O E Ebbesson
Jean W MacCluer
Charlotte Wenger
Sandra Laston
Richard R Fabsitz
John Kennish
William J Howard
Barbara V Howard
Jason Umans
Anthony G Comuzzie
Author Affiliation
GOCADAN Department, Norton Sound Health Corporation, Nome, AK 99762, USA. soebbesson@alaska.edu
Source
Int J Circumpolar Health. 2012;71:17343
Date
2012
Language
English
Publication Type
Article
Keywords
Adult
Alaska
Biological Markers - blood
Cardiovascular Diseases - enzymology - mortality
Cohort Studies
Cross-Sectional Studies
Fatty Acid Desaturases - blood
Female
Heart Rate - physiology
Humans
Inuits
Male
Abstract
To determine if heart rate (HR) is associated with desaturation indexes as HR is associated with arrhythmia and sudden death.
A community based cross-sectional study of 1214 Alaskan Inuit.
Data of FA concentrations from plasma and red blood cell membranes from those =35 years of age (n =?819) were compared to basal HR at the time of examination. Multiple linear regression with backward stepwise selection was employed to analyze the effect of the desaturase indexes on HR, after adjustment for relevant covariates.
The ?(5) desaturase index (?(5)-DI) measured in serum has recently been associated with a protective role for cardiovascular disease. This index measured here in plasma and red blood cells showed a negative correlation with HR. The plasma stearoyl-CoA-desaturase (SCD) index, previously determined to be related to cardiovascular disease (CVD) mortality, on the other hand, was positively associated with HR, while the ?(6) desaturase index (?(6)-DI) had no significant effect on HR.
Endogenous FA desaturation is associated with HR and thereby, in the case of SCD, possibly with arrhythmia and sudden death, which would at least partially explain the previously observed association between cardiovascular mortality and desaturase activity.
Notes
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PubMed ID
22456045 View in PubMed
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Individual saturated fatty acids are associated with different components of insulin resistance and glucose metabolism: the GOCADAN study.

https://arctichealth.org/en/permalink/ahliterature99207
Source
Int J Circumpolar Health. 2010 Aug 18;
Publication Type
Article
Date
Aug-18-2010
Author
Sven O E Ebbesson
M Elizabeth Tejero
Juan Carlos López-Alvarenga
William S Harris
Lars O E Ebbesson
Richard B Devereux
Jean W Maccluer
Charlotte Wenger
Sandra Laston
Richard R Fabsitz
Barbara V Howard
Anthony G Comuzzie
Author Affiliation
GOCADAN Department, Norton Sound Health Corporation, Nome, Alaska 99762, USA. soebbesson@alaska.edu.
Source
Int J Circumpolar Health. 2010 Aug 18;
Date
Aug-18-2010
Language
English
Publication Type
Article
Abstract
Objectives. Type 2 diabetes and the consumption of saturated fatty acids (FAs) are on the rise among Alaska Inuits. This analysis, based on a cross-sectional study, explores the possible associations of saturated FA content in red blood cells (RBCs) and parameters of glucose metabolism in a sample of Alaska Natives. Study design and methods. The sample included 343 women and 282 men aged 35-74. Statistical analyses explored the associations of selected RBC (myristic, palmitic and stearic acids) FAs with fasting glucose (plasma), fasting insulin (plasma), 2h glucose (2-hour glucose tolerance test), 2h insulin and homeostasis model assessment (HOMA) index. The models included sex and glucose metabolism status as fixed factors and age, body mass index (BMI), waist circumference, physical activity (METS) and FA content in RBCs as covariates. Measures of insulin, glucose and HOMA index were used as dependent variables. Results. Myristic acid was positively associated with fasting insulin (beta=0.47, p
PubMed ID
20719107 View in PubMed
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