Skip header and navigation

1 records – page 1 of 1.

Survival benefit in a randomized clinical trial of faecal occult blood screening for colorectal cancer.

https://arctichealth.org/en/permalink/ahliterature92956
Source
Br J Surg. 2008 Aug;95(8):1029-36
Publication Type
Article
Date
Aug-2008
Author
Lindholm E.
Brevinge H.
Haglind E.
Author Affiliation
Department of Surgery, Institute of Surgical Sciences, Göteborg University, Sahlgrenska University Hospital, Göteborg, Sweden.
Source
Br J Surg. 2008 Aug;95(8):1029-36
Date
Aug-2008
Language
English
Publication Type
Article
Keywords
Cohort Studies
Colorectal Neoplasms - diagnosis - mortality
Enema - methods - mortality
Follow-Up Studies
Humans
Incidence
Mass Screening - methods
Middle Aged
Occult Blood
Sigmoidoscopy - methods - mortality
Survival Analysis
Sweden - epidemiology
Abstract
BACKGROUND: Early detection of colorectal cancer could reduce cancer-specific mortality. The aim of this trial was to evaluate the effect of faecal occult blood test (FOBT) screening on colorectal cancer mortality in a Swedish population. METHODS: All 68,308 citizens in Göteborg born between 1918 and 1931 were randomized to a screening or a control group at the age of 60-64 years. All were screened two to three times with rehydrated Hemoccult-II. Compliance was 70.0 per cent (23,916 individuals). Those with a positive test result were offered sigmoidoscopy and a double-contrast enema. The primary endpoint was death from colorectal cancer. RESULTS: After a mean of 9 years from the last screening, there was a significant reduction in colorectal cancer mortality in the screening group compared with the control group. The overall risk ratio of death from colorectal cancer was 0.84 (95 per cent confidence interval 0.71 to 0.99). The groups did not differ in incidence of colorectal cancer or in overall mortality. CONCLUSION: FOBT screening significantly reduces colorectal cancer mortality.
Notes
Comment In: Br J Surg. 2008 Nov;95(11):1428-9; author reply 142918844282
PubMed ID
18563785 View in PubMed
Less detail