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Environmental pollutants in blood donors: The multicentre Norwegian donor study.
Transfus Med. 2020 Jun; 30(3):201-209
Publication Type
Journal Article
Maria Averina
Tor Hervig
Sandra Huber
Mette Kjaer
Einar K Kristoffersen
Bjørn Bolann
Author Affiliation
Department of Laboratory Medicine, University Hospital of North Norway, Tromsø, Norway.
Transfus Med. 2020 Jun; 30(3):201-209
Publication Type
Journal Article
The aim of this study was to measure blood concentrations of environmental pollutants in Norwegian donors and evaluate the risk of pollutant exposure through blood transfusions.
Transfused blood may be a potential source of exposure to heavy metals and organic pollutants and presents a risk to vulnerable patient groups such as premature infants.
Donors were randomly recruited from three Norwegian blood banks: in Bergen, Tromsø and Kirkenes. Selected heavy metals were measured in whole blood using inductively coupled plasma mass spectrometry (ICP-MS), and perfluoroalkyl substances (PFAS) were measured in serum by ultrahigh-pressure liquid chromatography coupled with a triple-quadrupole mass spectrometer (UHPLC-MS/MS).
Almost 18% of blood donors had lead concentrations over the limit suggested for transfusions in premature infants (0.09?µmol/L). About 11% of all donors had mercury concentrations over the suggested limit of 23.7 nmol/L. Cadmium was higher than the limit, 16?nmol/L, in 4% of donors. Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations were over the suggested limit of 0.91?ng/mL in 68% and 100% of the donors, respectively. PFAS concentrations and heavy metal concentrations increased with donor's age.
A considerable percentage of donors had lead, PFOS and PFOA concentrations over the suggested limits. In addition, at each study site, there were donors with high mercury and cadmium concentrations. Selecting young donors for transfusions or measurements of pollutants in donor blood may be a feasible approach to avoid exposure through blood transfusions to vulnerable groups of patients such as premature infants.
PubMed ID
31926037 View in PubMed
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Predictors of mercury, lead, cadmium and antimony status in Norwegian never-pregnant women of fertile age.
PLoS One. 2017;12(12):e0189169
Publication Type
Christina Herland Fløtre
Kristin Varsi
Thea Helm
Bjørn Bolann
Anne-Lise Bjørke-Monsen
PLoS One. 2017;12(12):e0189169
Publication Type
Antimony - blood
Cadmium - blood
Lead - blood
Life Style
Mercury - blood
Young Adult
The toxic trace elements mercury (Hg), lead (Pb), cadmium (Cd) and antimony (Sb) are transferred over the placenta to the fetus and secreted into the breastmilk. All four elements bioaccumulate in the body and as maternal age at delivery is increasing in industrialized countries, the burden of toxic trace elements in never-pregnant women of fertile age is of concern.
Healthy, never-pregnant women aged 18 to 40 years (n = 158) were recruited between June 2012 and March 2015 in Bergen, Norway. Clinical data were collected and non-fasting venous blood samples were analyzed for whole blood Hg, Pb and Cd and serum Sb by ICP-MS and related to diet and life style factors.
In a multiple linear regression model, increasing age was associated with higher levels of Hg and Sb, but diet and life style factors were more important predictors. Median whole blood Hg was increased by a factor of 70 in women who had fish for dinner =1/week, compared to women who rarely or never ate fish (p
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PubMed ID
29206878 View in PubMed
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