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Peroxisome proliferator-activate receptors (PPARs) in polar bear (Ursus maritimus) as a target for environmental pollutants

https://arctichealth.org/en/permalink/ahliterature297157
Source
Universitetet i Bergen.
Publication Type
Dissertation
Date
2014
Author
Berg, Mari Katrine
Source
Universitetet i Bergen.
Date
2014
Language
English
Publication Type
Dissertation
Keywords
Arctic
Polar bear
Pollutants
Abstract
Environmental pollutants with metabolic disrupting abilities are present in the Arctic. Particularly high levels of pollutants have been found in the apex predator of the Arctic marine food web, the polar bear. This species is dependent on a highly regulated metabolic system as it undergoes a distinct feasting and fasting regime due to seasonal variation in availability of food. Key regulators in consumption and storage of energy are the peroxisome proliferator-activated receptors (PPARs, NR1C), members of the nuclear receptor superfamily.
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