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Characterization of malignant colon tumors with 31P nuclear magnetic resonance phospholipid and phosphatic metabolite profiles.

https://arctichealth.org/en/permalink/ahliterature4070
Source
Cancer. 1995 Nov 15;76(10):1715-23
Publication Type
Article
Date
Nov-15-1995
Author
T E Merchant
P M Diamantis
G. Lauwers
T. Haida
J N Kasimos
J. Guillem
T. Glonek
B D Minsky
Author Affiliation
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Source
Cancer. 1995 Nov 15;76(10):1715-23
Date
Nov-15-1995
Language
English
Publication Type
Article
Keywords
Cell Differentiation
Colonic Neoplasms - metabolism - pathology
Humans
Lymphatic Metastasis
Magnetic Resonance Spectroscopy
Neoplasm Invasiveness
Phosphates - metabolism
Phospholipids - metabolism
Prognosis
Research Support, Non-U.S. Gov't
Abstract
BACKGROUND. To further characterize selected pathologic features on a biochemical level, the authors analyzed the nuclear magnetic resonance metabolite and phospholipid spectra of 30 malignant colon tumors using 31P magnetic resonance spectroscopy. METHODS. Eleven individual generic phospholipids were identified in the spectra of 17 phospholipid extracts, and 31 individual phosphatic metabolites were identified in the spectra of 13 perchloric acid extracts. The metabolites and lipids were quantified for statistical intergroup comparisons based on tumor stage, lymph node status, differentiation, mucin production, blood vessel invasion (BVI), and lymphatic vessel invasion (LVI). RESULTS. Significant elevations in the relative concentration of alpha-glycerol phosphate were noted when comparing AJCC tumor classification (T3 vs. T2, 0.92 +/- 0.14 vs. 0.46 +/- 0.11, P
PubMed ID
8625039 View in PubMed
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Esophageal cancer phospholipids correlated with histopathologic findings: a 31P NMR study.

https://arctichealth.org/en/permalink/ahliterature3994
Source
NMR Biomed. 1999 Jun;12(4):184-8
Publication Type
Article
Date
Jun-1999
Author
T E Merchant
B D Minsky
G Y Lauwers
P M Diamantis
T. Haida
T. Glonek
Author Affiliation
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, USA. thomas.merchant@stjude.org
Source
NMR Biomed. 1999 Jun;12(4):184-8
Date
Jun-1999
Language
English
Publication Type
Article
Keywords
Esophageal Neoplasms - metabolism - pathology
Humans
Magnetic Resonance Spectroscopy
Phospholipids - metabolism
Abstract
We analyzed 36 esophageal tumor specimens for phospholipid content using phosphorus nuclear magnetic resonance spectroscopy (31P NMR) and correlated the individual phospholipid profiles with specific clinical and histopathologic features. Among the 18 phospholipids identified in the esophageal tumor specimens, the mean mole percentage concentration of dimethylphosphatidylethanolamine, lysoalkylacylphosphatidylcholine, lysophosphatidic acid, lysophosphatidylcholine (deacylated at the glycerol-1 carbon), and lysoethanolamine plasmalogen correlated with pathologic T stage, nuclear grade, or the presence of lymphatic invasion. 31P NMR produces well-dispersed phospholipid spectra and a precise determination of phospholipid relative mole percentages. These data provide a statistical correlation between histopathologic features and molecules known to play an important role in cellular activities and processes unique to malignant tissues.
PubMed ID
10421909 View in PubMed
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