Skip header and navigation

Refine By

17 records – page 1 of 2.

Change in Headache Suffering and Predictors of Headache after Mild Traumatic Brain Injury: A Population-Based, Controlled, Longitudinal Study with Twelve-Month Follow-Up.

https://arctichealth.org/en/permalink/ahliterature300860
Source
J Neurotrauma. 2019 Aug 02; :
Publication Type
Journal Article
Date
Aug-02-2019
Author
Lena H Nordhaug
Mattias Linde
Turid Follestad
Øystein Njølstad Skandsen
Vera Vik Bjarkø
Toril Skandsen
Anne Vik
Author Affiliation
1Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Source
J Neurotrauma. 2019 Aug 02; :
Date
Aug-02-2019
Language
English
Publication Type
Journal Article
Abstract
Headache attributed to traumatic injury to the head (HAIH) is claimed to be the most common sequela following mild traumatic brain injury (MTBI), but epidemiological evidence is scarce. We explored whether patients with MTBI had an increase in headache suffering following injury compared with controls. We also studied predictors of headache. The Trondheim MTBI follow-up study is a population-based, controlled, longitudinal study. We recruited patients exposed to MTBI and controls with minor orthopedic injuries from a trauma center and a municipal outpatient clinic, and community controls from the surrounding population. Information on headache was collected through questionnaires at baseline, and 3 and 12 months post-injury. We used a generalized linear mixed model to investigate the development of headache over time in the three groups, and logistic regression to identify predictors of headache. We included 378 patients exposed to MTBI, 82 trauma controls, and 83 community controls. The MTBI-group had a larger increase in odds of headache from baseline to the first 3 months post-injury than the controls, but not from baseline to 3-12 months post-injury. Predictors for acute HAIH were female sex and pathological imaging findings on computed tomography (CT) or magnetic resonance imaging (MRI). Predictors for persistent HAIH were prior MTBI, being injured under the influence of alcohol, and acute HAIH. Patients who experience HAIH during the first 3 months post-injury have a good chance to improve before 12 months post-injury. Female sex, imaging findings on CT or MRI, prior MTBI, and being injured under the influence of alcohol may predict exacerbation of headache.
PubMed ID
31195890 View in PubMed
Less detail

Cognitive Reserve Moderates Cognitive Outcome After Mild Traumatic Brain Injury.

https://arctichealth.org/en/permalink/ahliterature308825
Source
Arch Phys Med Rehabil. 2020 01; 101(1):72-80
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
01-2020
Author
Jonas Stenberg
Asta K Håberg
Turid Follestad
Alexander Olsen
Grant L Iverson
Douglas P Terry
Rune H Karlsen
Simen B Saksvik
Migle Karaliute
John A N Ek
Toril Skandsen
Anne Vik
Author Affiliation
Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Neurosurgery, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Source
Arch Phys Med Rehabil. 2020 01; 101(1):72-80
Date
01-2020
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adult
Brain Concussion - psychology
Case-Control Studies
Cognitive Dysfunction - psychology
Cognitive Reserve
Female
Humans
Linear Models
Longitudinal Studies
Male
Post-Concussion Syndrome - psychology
Risk factors
Abstract
To investigate whether cognitive reserve moderates differences in cognitive functioning between patients with mild traumatic brain injury (MTBI) and controls without MTBI and to examine whether patients with postconcussion syndrome have lower cognitive functioning than patients without postconcussion syndrome at 2 weeks and 3 months after injury.
Trondheim MTBI follow-up study is a longitudinal controlled cohort study with cognitive assessments 2 weeks and 3 months after injury.
Recruitment at a level 1 trauma center and at a general practitioner-run, outpatient clinic.
Patients with MTBI (n=160) according to the World Health Organization criteria, trauma controls (n=71), and community controls (n=79) (N=310).
A cognitive composite score was used as outcome measure. The Vocabulary subtest was used as a proxy of cognitive reserve. Postconcussion syndrome diagnosis was assessed at 3 months with the British Columbia Postconcussion Symptom Inventory.
Linear mixed models demonstrated that the effect of vocabulary scores on the cognitive composite scores was larger in patients with MTBI than in community controls at 2 weeks and at 3 months after injury (P=.001). Thus, group differences in the cognitive composite score varied as a function of vocabulary scores, with the biggest differences seen among participants with lower vocabulary scores. There were no significant differences in the cognitive composite score between patients with (n=29) and without (n=131) postconcussion syndrome at 2 weeks or 3 months after injury.
Cognitive reserve, but not postconcussion syndrome, was associated with cognitive outcome after MTBI. This supports the cognitive reserve hypothesis in the MTBI context and suggests that persons with low cognitive reserve are more vulnerable to reduced cognitive functioning if they sustain an MTBI.
PubMed ID
31562876 View in PubMed
Less detail

The epidemiology of mild traumatic brain injury: the Trondheim MTBI follow-up study.

https://arctichealth.org/en/permalink/ahliterature291547
Source
Scand J Trauma Resusc Emerg Med. 2018 Apr 27; 26(1):34
Publication Type
Journal Article
Date
Apr-27-2018
Author
Toril Skandsen
Cathrine Elisabeth Einarsen
Ingunn Normann
Stine Bjøralt
Rune Hatlestad Karlsen
David McDonagh
Tom Lund Nilsen
Andreas Nylenna Akslen
Asta Kristine Håberg
Anne Vik
Author Affiliation
Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. toril.skandsen@ntnu.no.
Source
Scand J Trauma Resusc Emerg Med. 2018 Apr 27; 26(1):34
Date
Apr-27-2018
Language
English
Publication Type
Journal Article
Abstract
Mild traumatic brain injury (MTBI) is a frequent medical condition, and some patients report long-lasting problems after MTBI. In order to prevent MTBI, knowledge of the epidemiology is important and potential bias in studies should be explored. Aims of this study were to describe the epidemiological characteristics of MTBI in a Norwegian area and to evaluate the representativeness of patients successfully enrolled in the Trondheim MTBI follow-up study.
During 81 weeks in 2014 and 2015, all persons aged 16-60 years, presenting with possible MTBI to the emergency department (ED) at St. Olavs Hospital, Trondheim University Hospital or to Trondheim municipal outpatient ED, were evaluated for participation in the follow-up study. Patients were identified by CT referrals and patient lists. Patients who were excluded or missed for enrolment in the follow-up study were recorded.
We identified 732 patients with MTBI. Median age was 28 years, and fall was the most common cause of injury. Fifty-three percent of injuries occurred during the weekend. Only 29% of MTBI patients were hospitalised. Study specific exclusion criteria were present in 23%. We enrolled 379 in the Trondheim MTBI follow-up study. In this cohort, Glasgow Coma Scale score was 15 at presentation in 73%; 45% of patients were injured under the influence of alcohol. Patients missed for inclusion were significantly more often outpatients, females, injured during the weekend, and suffering violent injuries, but differences between enrolled and not enrolled patients were small.
Two thirds of all patients with MTBI in the 16-60 age group were treated without hospital admission, patients were often young, and half of the patients presented during the weekend. Fall was the most common cause of injury, and patients were commonly injured under the influence of alcohol, which needs to be addressed when considering strategies for prevention. The Trondheim MTBI follow-up study comprised patients who were highly representative for the underlying epidemiology of MTBI.
Notes
Cites: Neuroepidemiology. 2015;45(1):20-7 PMID 26201267
Cites: Brain Inj. 2017;31(8):1102-1108 PMID 28481634
Cites: J Neurotrauma. 2013 Nov 15;30(22):1831-44 PMID 23815563
Cites: Br J Sports Med. 2017 Jun;51(11):838-847 PMID 28446457
Cites: Drug Alcohol Rev. 2010 Mar;29(2):131-7 PMID 20447219
Cites: Lancet Neurol. 2017 Dec;16(12 ):987-1048 PMID 29122524
Cites: Arch Phys Med Rehabil. 2010 Nov;91(11):1637-40 PMID 21044706
Cites: J Head Trauma Rehabil. 2016 Nov/Dec;31(6):379-387 PMID 26360006
Cites: Lancet Neurol. 2013 Jan;12(1):53-64 PMID 23177532
Cites: J Neurotrauma. 2014 Jan 1;31(1):26-33 PMID 23952719
Cites: J Neurotrauma. 2013 Jan 1;30(1):11-6 PMID 22909262
Cites: Neuroepidemiology. 2008;30(2):120-8 PMID 18334828
Cites: Brain Inj. 1995 Jul;9(5):437-44 PMID 7550215
Cites: Scand J Trauma Resusc Emerg Med. 2009 Feb 20;17:6 PMID 19232086
Cites: J Neurol Neurosurg Psychiatry. 2003 Jan;74(1):39-43 PMID 12486264
Cites: J Neurotrauma. 2017 Jan 1;34(1):257-261 PMID 27029852
Cites: Am J Emerg Med. 2014 Aug;32(8):844-50 PMID 24857248
Cites: Acta Neurol Scand. 2004 Nov;110(5):281-90 PMID 15476456
Cites: Arch Phys Med Rehabil. 2014 Mar;95(3 Suppl):S132-51 PMID 24581902
Cites: Can J Neurol Sci. 2010 Nov;37(6):783-90 PMID 21059539
Cites: J Rehabil Med. 2004 Feb;(43 Suppl):22-7 PMID 15083869
Cites: Scand J Soc Med. 1984;12(1):7-14 PMID 6710102
Cites: J Neurotrauma. 2017 Apr 11;:null PMID 28398105
Cites: Addiction. 2006 Jul;101(7):993-1002 PMID 16771891
Cites: Neuroepidemiology. 1998;17(3):139-46 PMID 9648119
Cites: Bull World Health Organ. 2006 Jun;84(6):453-60 PMID 16799729
Cites: N C Med J. 2014 Jan-Feb;75(1):8-14 PMID 24487751
Cites: J Neurotrauma. 2007 Sep;24(9):1425-36 PMID 17892405
Cites: Neurology. 2013 Jun 11;80(24):2250-7 PMID 23508730
Cites: BMC Public Health. 2013 Nov 14;13:1076 PMID 24228707
Cites: J Head Trauma Rehabil. 2010 Mar-Apr;25(2):72-80 PMID 20234226
Cites: J Neurotrauma. 2016 Jan 15;33(2):232-41 PMID 26054639
Cites: J Neurol Neurosurg Psychiatry. 2008 May;79(5):567-73 PMID 17766433
Cites: Acta Neurol Scand. 2003 Apr;107(4):256-9 PMID 12675698
Cites: J Neurotrauma. 2016 Feb 15;33(4):339-45 PMID 26230219
Cites: Neurosurgery. 2015 Jan;76(1):67-80 PMID 25525693
Cites: J Rehabil Med. 2004 Feb;(43 Suppl):113-25 PMID 15083875
PubMed ID
29703222 View in PubMed
Less detail

Evaluation of the Scandinavian guidelines for head injuries based on a consecutive series with computed tomography from a Norwegian university hospital.

https://arctichealth.org/en/permalink/ahliterature121019
Source
Scand J Trauma Resusc Emerg Med. 2012;20:62
Publication Type
Article
Date
2012
Author
Ingrid Haavde Strand
Ole Solheim
Kent Gøran Moen
Anne Vik
Author Affiliation
Department of Neurosurgery, St. Olavs University Hospital, Trondheim, Norway.
Source
Scand J Trauma Resusc Emerg Med. 2012;20:62
Date
2012
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Algorithms
Child
Child, Preschool
Comorbidity
Craniocerebral Trauma - epidemiology - radiography - therapy
Female
Guideline Adherence
Hospitals, University
Humans
Infant
Male
Middle Aged
Norway
Practice Guidelines as Topic
Prospective Studies
Scandinavia
Tomography, X-Ray Computed
Young Adult
Abstract
This study prospectively assesses clinical characteristics and management of consecutive minimal, mild and moderate head injury patients referred for CT scans. Compliance with the Scandinavian head injury guidelines and possible reasons for non-compliance is explored.
From January 16th 2006 to January 15th 2007, 1325 computed tomography (CT) examinations due to minimal, mild or moderate head injury according to the Head Injury Severity Scale (HISS) were carried out at our University Hospital. When ordering a CT scan due to head trauma, physicians were asked to fill out a questionnaire.
Guideline compliance was impossible to assess in 49.5% of all cases. This was due to non-assessable or missing key variables necessary in the decision making algorithm. One or more key variables for HISS classification were not assessable in 34.4% as it was unknown whether there had been loss of consciousness (LOC), duration of LOC was unknown or it was impossible to assess amnesia or focal neurologic deficits. Definite compliance with both CT and admittance recommendations in guidelines was seen in only 31.2%. In 54.2% of patients with minimal head injuries who underwent CT scans, imaging was not necessary according to guidelines. 59.1% of all patients were admitted to hospital, however only 23.7% of these were admitted because of the head-injury alone. Age?
Notes
Cites: Eur J Neurol. 2002 May;9(3):207-1911985628
Cites: Health Technol Assess. 2011 Aug;15(27):1-20221806873
Cites: Emerg Med J. 2011 Sep;28(9):778-8221030548
Cites: Injury. 2012 Sep;43(9):1423-3121835403
Cites: Injury. 2012 Sep;43(9):1415-822277106
Cites: Neurosurgery. 1988 Mar;22(3):449-533258961
Cites: J Trauma. 1991 Apr;31(4):483-7; discussion 487-92020033
Cites: J Trauma. 1991 Jun;31(6):801-4; discussion 804-52056543
Cites: Am Surg. 1991 Jan;57(1):14-71796791
Cites: J Trauma. 1992 Mar;32(3):359-61; discussion 361-31548725
Cites: J Trauma. 1992 Jul;33(1):11-31635094
Cites: J Trauma. 1992 Sep;33(3):385-941404507
Cites: Brain Inj. 1995 Jul;9(5):437-447550215
Cites: J Trauma. 2000 Apr;48(4):760-610780615
Cites: N Engl J Med. 2000 Jul 13;343(2):100-510891517
Cites: Lancet. 2001 May 5;357(9266):1391-611356436
Cites: J Neurotrauma. 2001 Jul;18(7):657-6411497092
Cites: Acta Neurol Scand. 1997 Jan;95(1):51-59048986
Cites: Ann Emerg Med. 1997 Jul;30(1):14-229209219
Cites: JAMA. 2005 Sep 28;294(12):1519-2516189365
Cites: BMJ. 2006 Sep 2;333(7566):46516895944
Cites: Ann Intern Med. 2007 Mar 20;146(6):397-40517371884
Cites: Emerg Med Australas. 2008 Oct;20(5):410-918973638
Cites: J Trauma. 2008 Dec;65(6):1309-1319077619
Cites: Ann Emerg Med. 2009 Feb;53(2):180-818339447
Cites: J Trauma. 2009 Jul;67(1):217-819590343
Cites: CMAJ. 2010 Oct 5;182(14):1527-3220732978
Cites: Scand J Trauma Resusc Emerg Med. 2011;19:2521496318
Cites: J Trauma. 2011 Jul;71(1):245-5121818031
PubMed ID
22947500 View in PubMed
Less detail

Frequency and prognostic factors of olfactory dysfunction after traumatic brain injury.

https://arctichealth.org/en/permalink/ahliterature301779
Source
Brain Inj. 2018; 32(8):1021-1027
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
2018
Author
Mette Bratt
Toril Skandsen
Thomas Hummel
Kent G Moen
Anne Vik
Ståle Nordgård
Anne-S Helvik
Author Affiliation
a Department of Otorhinolaryngology , St. Olavs University Hospital , Trondheim , Norway.
Source
Brain Inj. 2018; 32(8):1021-1027
Date
2018
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adolescent
Adult
Aged
Brain Injuries, Traumatic - complications - psychology
Cross-Sectional Studies
Female
Follow-Up Studies
Head - diagnostic imaging
Humans
Logistic Models
Male
Middle Aged
Olfaction Disorders - diagnosis - epidemiology - etiology
Prognosis
Quality of Life
Retrospective Studies
Statistics, nonparametric
Tomography Scanners, X-Ray Computed
Young Adult
Abstract
To assess the frequency and factors associated with posttraumatic olfactory dysfunction, including anosmia, in a follow-up of patients with moderate and severe traumatic brain injury (TBI).
The setting was a cross-sectional study of patients that were consecutively included in the Trondheim TBI database, comprising injury-related variables. Eligible participants 18-65 years were contacted 9-104 months post trauma and asked olfactory-related questions. Those reporting possible posttraumatic change of olfaction were invited to further examination using the Sniffin' Sticks panel.
Of 211 eligible participants, 182 (86.3%) took part in telephone interviews and 25(13.7%) were diagnosed with olfactory dysfunction. 60% of these, or 8.2% of all participants, had anosmia. In age-adjusted logistic regression analyses, fall (OR 2.5, 95% CI 1.0-6.2), skull base fracture (OR 2.9, 95% CI 1.2-7.1) and cortical contusion(s) (OR 6.0, 95% CI 2.1-17.3) were associated with olfactory dysfunction. In an analysis of anosmia, fall (OR 3.4, 95% CI 1.1-10.6) and cortical contusion(s) (OR 19.7, 95% CI 2.5-156.0) were associated with the outcome.
Of the study participants 13.7% had olfactory dysfunction and 8.2% had anosmia. Higher age, trauma caused by fall and CT displaying skull base fracture and cortical contusion(s) were related to olfactory dysfunction.
PubMed ID
29741969 View in PubMed
Less detail

Headaches in patients with previous head injuries: A population-based historical cohort study (HUNT).

https://arctichealth.org/en/permalink/ahliterature288351
Source
Cephalalgia. 2016 Oct;36(11):1009-1019
Publication Type
Article
Date
Oct-2016
Author
Lena Hoem Nordhaug
Anne Vik
Knut Hagen
Lars Jacob Stovner
Torunn Pedersen
Gøril Bruvik Gravdahl
Mattias Linde
Source
Cephalalgia. 2016 Oct;36(11):1009-1019
Date
Oct-2016
Language
English
Publication Type
Article
Keywords
Adult
Age Distribution
Brain Injuries, Traumatic - diagnosis - epidemiology
Causality
Cohort Studies
Comorbidity
Female
Headache - diagnosis - epidemiology
Headache Disorders, Secondary - diagnosis - epidemiology
Humans
Male
Middle Aged
Migraine Disorders - diagnosis - epidemiology
Norway - epidemiology
Prevalence
Risk factors
Severity of Illness Index
Sex Distribution
Abstract
Background Headache attributed to head injury is claimed to be among the most common secondary headache disorders, yet available epidemiological evidence is scarce. We evaluated the prevalence of headache among individuals previously exposed to head injury by a comparison to an uninjured control group. Methods This population-based historical cohort study used data from hospital records on previous exposure to head injury linked to a large epidemiological survey with data on headache occurrence. Participants without head injury, according to hospital records, were used as controls. The head injuries were classified according to the Head Injury Severity Scale (HISS) and the International Classification of Headache Disorders (ICHD-3 beta). Binary logistic regression was performed to investigate the association between headache and head injury, controlling for potential confounders. Results The exposed group consisted of 940 individuals and the control group of 38,751 individuals. In the multivariate analyses, adjusting for age, sex, anxiety, depression and socioeconomic status, there were significant associations between mild head injury and any headache, migraine, chronic daily headache and medication overuse headache. Conclusion Headache was more likely among individuals previously referred to a hospital for a mild head injury compared to uninjured controls.
PubMed ID
26634833 View in PubMed
Less detail

Incidence and mortality of moderate and severe traumatic brain injury in children: A ten year population-based cohort study in Norway.

https://arctichealth.org/en/permalink/ahliterature301924
Source
Eur J Paediatr Neurol. 2019 May; 23(3):500-506
Publication Type
Journal Article
Date
May-2019
Author
Mari Olsen
Anne Vik
Tom Ivar Lund Nilsen
Oddvar Uleberg
Kent Gøran Moen
Oddrun Fredriksli
Espen Lien
Torun Gangaune Finnanger
Toril Skandsen
Author Affiliation
Clinic of Physical Medicine and Rehabilitation, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, NTNU, Trondheim, Norway. Electronic address: mari.olsen@ntnu.no.
Source
Eur J Paediatr Neurol. 2019 May; 23(3):500-506
Date
May-2019
Language
English
Publication Type
Journal Article
Keywords
Adolescent
Brain Injuries, Traumatic - epidemiology
Child
Child, Preschool
Cohort Studies
Female
Humans
Incidence
Infant
Infant, Newborn
Male
Norway - epidemiology
Retrospective Studies
Abstract
In this study we wanted to estimate population-based rates of incidence and mortality of moderate and severe traumatic brain injury (TBI) in children in one specific region in Norway.
In the region there are seven acute care hospitals (ACHs) in addition to a Level 1 trauma centre. Of 702 869 inhabitants (2014), 145 395 were children aged 0-16 years. Data were collected during ten years (2004-2014). All children aged 0-16 years with moderate (Glasgow Coma Scale [GCS] score 9-13) or severe (GCS score = 8) TBI admitted to the Level 1 trauma centre were prospectively included. Children treated outside the Level 1 trauma centre were retrospectively included from the ACHs. Children who died from TBI prehospitally were included from the National Cause of Death Registry. Poisson regression was used to estimate incidence rate ratios (with a 95% confidence interval) comparing age, sex, and time periods.
A total of 71 children with moderate or severe TBI were identified. Crude incidence rates were 2·4 (95% CI 1·7-3·3) for moderate and 2·5 (95% CI 1·8-3·4) for severe TBI per 100 000 person-years (py). Mortality rate from TBI was 1·2 (95% CI 0·7-1·9) per 100 000 py, and 88% were prehospital deaths.
The incidence rates and mortality of moderate and severe TBI were low compared to international reports. Most likely explained by successful national prevention of TBI.
PubMed ID
30879962 View in PubMed
Less detail

Incidence of Mild Traumatic Brain Injury: A Prospective Hospital, Emergency Room and General Practitioner-Based Study.

https://arctichealth.org/en/permalink/ahliterature301538
Source
Front Neurol. 2019; 10:638
Publication Type
Journal Article
Date
2019
Author
Toril Skandsen
Tom Lund Nilsen
Cathrine Einarsen
Ingunn Normann
David McDonagh
Asta Kristine Haberg
Anne Vik
Author Affiliation
Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Source
Front Neurol. 2019; 10:638
Date
2019
Language
English
Publication Type
Journal Article
Abstract
Background: There are no recent estimates of incidence rates of mild traumatic brain injury (MTBI) from Norway. Moreover, reported incidence rates rarely comprise cases of MTBI evaluated in the primary care setting. In this study, we utilized existing data collected as part of the recruitment to a large, follow-up study of patients with MTBI. We estimated the incidence rate of MTBI, including patients who visited outpatient clinics, in the age group 16-59 years in a Norwegian region. Methods: During 81 weeks in 2014 and 2015, all persons aged 16-59 years, presenting with possible MTBI to the emergency department (ED) at St. Olavs Hospital, Trondheim University Hospital or to the general practitioner (GP)-run Trondheim municipal outpatient ED, were evaluated for a diagnosis of MTBI. Patients were identified by computerized tomography (CT) referrals and patient lists. Patients referred to acute CT from their primary GP with suspicion of MTBI were also recorded. This approach identified 732 patients with MTBI. Age- and sex-specific incidence rates of MTBI were calculated using population figures from the regional catchment area. Results: Overall incidence of MTBI in people between 16 and 59 years was 302 per 100,000 person-years (95% confidence interval 281-324). The incidence rate was highest in the age group 16-20 years, where rates were 835 per 100,000 person-years in males and 726 in females. Conclusion: The overall incidence rate of MTBI was lower than expected from existing estimates. Like other reports, the incidence was highest in the late teens.
PubMed ID
31275229 View in PubMed
Less detail

The Influence of Traumatic Axonal Injury in Thalamus and Brainstem on Level of Consciousness at Scene or Admission: A Clinical Magnetic Resonance Imaging Study.

https://arctichealth.org/en/permalink/ahliterature288239
Source
J Neurotrauma. 2018 Feb 09;
Publication Type
Article
Date
Feb-09-2018
Author
Hans Kristian Moe
Kent Gøran Moen
Toril Skandsen
Kjell Arne Kvistad
Steven Laureys
Asta Håberg
Anne Vik
Source
J Neurotrauma. 2018 Feb 09;
Date
Feb-09-2018
Language
English
Publication Type
Article
Abstract
The aim of this study was to investigate how traumatic axonal injury (TAI) lesions in the thalamus, basal ganglia, and brainstem on clinical brain magnetic resonance imaging (MRI) are associated with level of consciousness in the acute phase in patients with moderate to severe traumatic brain injury (TBI). There were 158 patients with moderate to severe TBI (7-70 years) with early 1.5T MRI (median 7 days, range 0-35) without mass lesion included prospectively. Glasgow Coma Scale (GCS) scores were registered before intubation or at admission. The TAI lesions were identified in T2*gradient echo, fluid attenuated inversion recovery, and diffusion weighted imaging scans. In addition to registering TAI lesions in hemispheric white matter and the corpus callosum, TAI lesions in the thalamus, basal ganglia, and brainstem were classified as uni- or bilateral. Twenty percent of patients had TAI lesions in the thalamus (7% bilateral), 18% in basal ganglia (2% bilateral), and 29% in the brainstem (9% bilateral). One of 26 bilateral lesions in the thalamus or brainstem was found on computed tomography. The GCS scores were lower in patients with bilateral lesions in the thalamus (median four) and brainstem (median five) than in those with corresponding unilateral lesions (median six and eight, p?=?0.002 and 0.022). The TAI locations most associated with low GCS scores in univariable ordinal regression analyses were bilateral TAI lesions in the thalamus (odds ratio [OR] 35.8; confidence interval [CI: 10.5-121.8], p?
PubMed ID
29334825 View in PubMed
Less detail

Joint effect of modifiable risk factors on the risk of aneurysmal subarachnoid hemorrhage: a cohort study.

https://arctichealth.org/en/permalink/ahliterature125084
Source
Stroke. 2012 Jul;43(7):1885-9
Publication Type
Article
Date
Jul-2012
Author
Haakon Lindekleiv
Marie S Sandvei
Pål R Romundstad
Tom Wilsgaard
Inger Njølstad
Tor Ingebrigtsen
Anne Vik
Ellisiv B Mathiesen
Author Affiliation
Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, University Hospital of North Norway, N-9037 Tromsø, Norway. haakon.lindekleiv@gmail.com
Source
Stroke. 2012 Jul;43(7):1885-9
Date
Jul-2012
Language
English
Publication Type
Article
Keywords
Adult
Alcohol drinking - epidemiology
Cohort Studies
Female
Follow-Up Studies
Humans
Hypertension - complications - epidemiology
Male
Middle Aged
Norway - epidemiology
Prospective Studies
Risk factors
Smoking - adverse effects - epidemiology
Subarachnoid Hemorrhage - epidemiology - etiology - prevention & control
Abstract
The joint effect of risk factors on the risk of aneurysmal SAH (aSAH) has been studied sparsely.
We examined the potential synergism between cigarette smoking, hypertension, and regular alcohol consumption and the risk of aSAH in a prospective, population-based cohort of participants from the Nord-Trøndelag Health Study and the Tromsø Study in Norway. Interaction was assessed on additive and multiplicative scales.
We identified 122 cases of aSAH over 977 895 person-years of follow-up. Interaction was observed between current smoking and hypertension on the additive scale, (relative excess risk because of interaction, 6.40; 95% CI, 0.88-11.92, adjusted for sex and age). We found no significant interaction between hypertension and regular alcohol consumption or current cigarette smoking and regular alcohol consumption on the additive scale. No significant interaction was detected on the multiplicative scale.
The joint effect of current smoking and hypertension on the risk of aSAH was stronger than was the sum of the independent effects of each factor. Persons at risk of aSAH should be advised of a markedly stronger risk for aSAH with the combination of current smoking and hypertension. In addition, the finding suggests that combining smoking cessation and blood pressure lowering may have an extra risk reduction effect on preventing aSAH.
PubMed ID
22517600 View in PubMed
Less detail

17 records – page 1 of 2.