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[Antithrombotic treatment of atrial fibrillation in hospital]

https://arctichealth.org/en/permalink/ahliterature53835
Source
Tidsskr Nor Laegeforen. 2001 Oct 10;121(24):2800-4
Publication Type
Article
Date
Oct-10-2001
Author
G. Thomassen
M S Hansen
A. Nordøy
J B Hansen
Author Affiliation
Medisinsk avdeling Regionsykehuset i Tromsø 9038 Tromsø. johnbh@fagmed.uit.no
Source
Tidsskr Nor Laegeforen. 2001 Oct 10;121(24):2800-4
Date
Oct-10-2001
Language
Norwegian
Publication Type
Article
Keywords
Adult
Anticoagulants - administration & dosage
Atrial Fibrillation - drug therapy
English Abstract
Female
Fibrinolytic Agents - administration & dosage
Hospitalization
Humans
Male
Middle Aged
Norway
Practice Guidelines
Research Support, Non-U.S. Gov't
Retrospective Studies
Thrombolytic Therapy
Abstract
BACKGROUND: In clinical guidelines regarding atrial fibrillation, oral anticoagulation is recommended for patients over the age of 65 or with additional risk factors. The aim of the present study was to investigate how these recommendations are followed in clinical practice. MATERIAL AND METHODS: A retrospective study was conducted among patients hospitalized for atrial fibrillation at Tromsø University Hospital from 1995 to 1998. Data were obtained from hospital files. RESULTS: 362 patients with atrial fibrillation (57% men), mean age 68.4 years (range 24-96), were included. 23.5% had their first atrial fibrillation event. 224 (62%) patients experienced successful cardioversion during hospitalization(s), while 138 (38%) were discharged from hospital with chronic atrial fibrillation. 97 (70%) of these patients were given warfarin at discharge. Previous stroke and atrial fibrillation were significant predictors for warfarin prescription. Prescription did not increase with age. 28 (20%) of patients with chronic atrial fibrillation received acetylsalicylic acid, while 16 (12%) were not given antithrombotic treatment. INTERPRETATION: This study indicates a high degree of implementation of guidelines for antithrombotic treatment of patients with chronic atrial fibrillation in hospital practice.
PubMed ID
11706483 View in PubMed
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Coronary heart disease, serum lipids, platelets and dietary fish in two communities in northern Norway.

https://arctichealth.org/en/permalink/ahliterature55593
Source
Acta Med Scand. 1987;222(3):237-45
Publication Type
Article
Date
1987
Author
T. Simonsen
A. Vårtun
V. Lyngmo
A. Nordøy
Author Affiliation
Department of Internal Medicine, University Hospital, University of Tromsø, Norway.
Source
Acta Med Scand. 1987;222(3):237-45
Date
1987
Language
English
Publication Type
Article
Keywords
Adult
Animals
Blood Platelets - analysis
Collagen - pharmacology
Comparative Study
Coronary Disease - blood - mortality
Dietary Fats - administration & dosage
Fishes
Food Habits
Humans
Lipids - blood
Male
Middle Aged
Norway
Platelet Aggregation - drug effects
Risk factors
Abstract
Coronary heart disease (CHD) mortality was registered in an inland and a coastal community in Northern Norway. Subgroups of healthy males from the communities were investigated further. The daily consumption of fish in the coastal and inland areas was 132.4 g and 55.1 g respectively, and the intake of eicosapentaenoic acid was 0.9 g and 0.25 g. The content of n-3 polyunsaturated fatty acids in platelet phospholipids and primary bleeding time were similar in the two groups. Linoleic acid was lower and saturated fatty acids were higher in phospholipids in men from the coastal area. Collagen-induced platelet aggregation was increased and serum triglyceride concentration was higher in men from the coastal area. CHD mortality during a 10-year period was higher in the coastal area for both sexes. This may be associated with differences in serum triglyceride levels and platelet fatty acid composition. This study indicates that a high consumption of lean fish is not sufficient to induce changes in blood lipids and platelet function associated with low CHD mortality and it does not seem to prevent high CHD mortality.
PubMed ID
3425379 View in PubMed
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Effect of a moderate fish intake on blood pressure, bleeding time, hematology, and clinical chemistry in healthy males.

https://arctichealth.org/en/permalink/ahliterature62305
Source
Am J Clin Nutr. 1987 Sep;46(3):424-36
Publication Type
Article
Date
Sep-1987
Author
R. von Houwelingen
A. Nordøy
E. van der Beek
U. Houtsmuller
M. de Metz
G. Hornstra
Source
Am J Clin Nutr. 1987 Sep;46(3):424-36
Date
Sep-1987
Language
English
Publication Type
Article
Keywords
Adult
Animals
Bleeding time
Blood pressure
Diet
Dietary Fats - pharmacology
Enzymes - blood
Fishes
Humans
Kidney Function Tests
Liver Function Tests
Male
Patient compliance
Platelet Function Tests
Research Support, Non-U.S. Gov't
Abstract
This paper describes the outline and first results of an international study to investigate the effect of a reasonable amount of dietary fish on some aspects of cardiovascular risk. In Maastricht and Zeist, The Netherlands, and Tromsø, Norway, healthy male volunteers were given a dietary supplement consisting of 100 g/d of mackerel or meat for a 6-wk period. Compliance was monitored on the basis of the urinary excretion of lithium, which was added to the supplements. Average compliance was approximately 80% and this decreased slightly in time. Systolic blood pressure decreased in both groups to a comparable degree; consequently no specific effect of the fish supplement was observed. The fish supplement significantly prolonged bleeding times. Hematology was hardly affected but platelet counts decreased significantly. No indications were obtained for adverse effects of the fish supplement.
PubMed ID
3630961 View in PubMed
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Habitual fish consumption, plasma phospholipid fatty acids, and serum lipids: the Tromsø study.

https://arctichealth.org/en/permalink/ahliterature223741
Source
Am J Clin Nutr. 1992 Jun;55(6):1126-34
Publication Type
Article
Date
Jun-1992
Author
K H Bønaa
K S Bjerve
A. Nordøy
Author Affiliation
Institute of Community Medicine, University of Tromsø, Norway.
Source
Am J Clin Nutr. 1992 Jun;55(6):1126-34
Date
Jun-1992
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Animals
Cholesterol - blood
Cod Liver Oil - administration & dosage
Cross-Sectional Studies
Diet Records
Dietary Fats - administration & dosage
Fatty Acids - blood
Fatty Acids, Omega-3 - administration & dosage
Female
Fishes
Humans
Lipids - blood
Lipoproteins - blood
Male
Middle Aged
Norway
Phospholipids - blood
Statistics as Topic
Triglycerides - blood
gamma-Glutamyltransferase - blood
Abstract
We examined the cross-sectional relationships between the frequency of habitual fish consumption, plasma phospholipid fatty acids, and serum lipids and lipoproteins in 152 men and women. There was a significant association between fish consumption starting from 1 dish/wk and plasma n-3, n-6, and n-9 fatty acids. Plasma eicosapentaenoic acid (EPA; 20: 5n-3) reflected fish consumption to a greater extent than did docosahexaenoic acid (DHA;22:6n-3). Triglycerides decreased (P less than 0.05) with fish consumption. In multivariate analysis in which anthropometric and lifestyle factors were controlled for, EPA correlated inversely with triglycerides (P less than 0.05) and positively with high-density-lipoprotein (HDL) cholesterol and apolipoprotein A-I (both P less than 0.001). In contrast, DHA did not correlate with triglycerides and showed negative associations to HDL cholesterol and apolipoprotein A-I (both P less than 0.001). Platelet phospholipid EPA, but not DHA, was associated with lower triglyceride and higher HDL-cholesterol concentrations (both P less than 0.05). This study suggests that long-term intake of small amounts of fish has biological effects, and that EPA and DHA have divergent relations with lipoprotein metabolism.
PubMed ID
1350705 View in PubMed
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Improvement in clinical work through feedback: intervention study.

https://arctichealth.org/en/permalink/ahliterature201731
Source
BMJ. 1999 Jun 26;318(7200):1738-9
Publication Type
Article
Date
Jun-26-1999
Author
R. Jorde
A. Nordoy
Author Affiliation
Department of Internal Medicine, University Hospital of Tromso, 9038 Tromso, Norway.
Source
BMJ. 1999 Jun 26;318(7200):1738-9
Date
Jun-26-1999
Language
English
Publication Type
Article
Keywords
Documentation - standards
Feedback
Hospitals, University
Humans
Medical Records - standards
Medical Staff, Hospital - standards
Norway
Nursing Staff, Hospital - standards
Patient Discharge
Patient satisfaction
Quality of Health Care
Questionnaires
Notes
Cites: BMJ. 1991 Aug 17;303(6799):398-4021912809
Cites: Qual Health Care. 1996 Mar;5(1):51-410157273
Cites: Qual Health Care. 1992 Mar;1(1):56-6010136833
Cites: N Engl J Med. 1993 Oct 21;329(17):1271-38413397
PubMed ID
10381710 View in PubMed
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Increased lipid peroxidation during long-term intervention with high doses of n-3 fatty acids (PUFAs) following an acute myocardial infarction.

https://arctichealth.org/en/permalink/ahliterature53534
Source
Eur J Clin Nutr. 2003 Jun;57(6):793-800
Publication Type
Article
Date
Jun-2003
Author
H. Grundt
D W T Nilsen
M A Mansoor
A. Nordøy
Author Affiliation
Department of Clinical Chemistry, Central Hospital in Rogaland, POB 8100, 4068 Stavanger, Norway. heidi@madlalia.no
Source
Eur J Clin Nutr. 2003 Jun;57(6):793-800
Date
Jun-2003
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Chromatography, High Pressure Liquid
Corn Oil - administration & dosage - pharmacology
Double-Blind Method
Fatty Acids, Omega-3 - administration & dosage - pharmacology
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Lipid Peroxidation - drug effects
Male
Malondialdehyde - metabolism
Middle Aged
Myocardial Infarction - drug therapy - metabolism
Phospholipids - blood
Thiobarbituric Acid Reactive Substances - metabolism
Abstract
OBJECTIVE: To assess the oxidative burden of a highly concentrated compound of n-3 PUFAs as compared to corn oil by measuring thiobarbituric acid-malondialdehyde complex (TBA-MDA) by HPLC. We also studied the influence on TBA-MDA of statins combined with n-3 PUFAs or corn oil. DESIGN: A prospective, randomised, double-blind, controlled study. SETTING: One hospital centre in Stavanger, Norway. SUBJECTS: A total of 300 subjects with an acute myocardial infarction (MI). INTERVENTIONS: Gelatine capsules, containing 850-882 mg EPA and DHA as concentrated ethylesters, or 1 g of corn oil, were ingested in a dose of two capsules twice a day for at least 1 y. Alpha-tocopherol (4 mg) was added to all capsules to protect the PUFAs against oxidation. RESULTS: After 1 y TBA-MDA increased modestly in the n-3 PUFA group (n=125), as compared to the corn oil group (n=130), P=0.027. Multiple linear regression analyses of fatty acids in serum total phospholipids (n=56) on TBA-MDA measured after 12 months intervention, showed no dependency. Performing best subsets regression, serum phospholipid concentration of arachidonic acid (20:4 n-6 PUFA) was identified as a predictor of TBA-MDA at 12 months follow-up, P=0.004.We found no impact of statins on TBA-MDA. CONCLUSION: TBA-MDA increased modestly after long-term intervention with n-3 PUFAs compared to corn oil post-MI, suggesting biological changes induced by n-3 PUFAs, rather than simply reflecting their concentration differences. The peroxidative potential of n-3 PUFAs was not modified by statin treatment. SPONSORSHIP:: Pharmacia A/S and Pronova A/S, Norway.
PubMed ID
12792664 View in PubMed
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Ischaemic heart disease, serum lipids and platelets in Norwegian populations with traditionally low or high fish consumption.

https://arctichealth.org/en/permalink/ahliterature55460
Source
J Intern Med Suppl. 1989;731:83-9
Publication Type
Article
Date
1989
Author
T. Simonsen
A. Nordøy
Author Affiliation
Department of Internal Medicine, University Hospital, University of Tromsø, Norway.
Source
J Intern Med Suppl. 1989;731:83-9
Date
1989
Language
English
Publication Type
Article
Keywords
Animals
Bleeding time
Blood Platelets - analysis
Coronary Disease - blood - mortality - prevention & control
Diet
Eicosapentaenoic Acid - administration & dosage
Epidemiologic Methods
Fishes
Humans
Linoleic Acids - blood
Linolenic Acids - blood
Lipids - blood
Male
Norway
Retrospective Studies
Abstract
In an inland and a coastal community, mortality from coronary heart disease (CHD) was registered over a 10-year period. Healthy males representing these two communities were investigated. A dietary registration showed a high saturated fat intake and a daily consumption of fish of 132.4 and 55.1 g and 0.9 and 0.2 g of eicosapentaenoic acid (EPA), in the two groups respectively. The contents of n-3 fatty acids in platelet phospholipids and primary bleeding times were similar, but collagen-induced platelet aggregation was higher in the coastal area. Higher serum triglyceride levels, higher content of saturated fatty acids and lower content of linoleic acid in platelet phospholipids were observed in males from the coastal area. CHD mortality was higher in the coastal area for both sexes. Daily dietary supplement of cod liver oil prolonged the bleeding time, reduced n-6 and increased n-3 fatty acids of platelet phospholipids. This studies indicate that a high content of lean fish and diet rich in saturated fat is not sufficient to prevent CHD.
PubMed ID
2539837 View in PubMed
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[Old age neglected in physicians' education].

https://arctichealth.org/en/permalink/ahliterature244451
Source
Nord Med. 1981 Jun;96(6-7):182-3
Publication Type
Article
Date
Jun-1981
Author
A. Nordøy
Source
Nord Med. 1981 Jun;96(6-7):182-3
Date
Jun-1981
Language
Danish
Publication Type
Article
Keywords
Aged
Education, Medical, Graduate
Geriatrics - education
Humans
Scandinavia
PubMed ID
7243568 View in PubMed
Less detail

[Use of statins following myocardial infarction before and after the 4S study]

https://arctichealth.org/en/permalink/ahliterature54187
Source
Tidsskr Nor Laegeforen. 1999 Aug 30;119(20):2986-9
Publication Type
Article
Date
Aug-30-1999
Author
E. Krefting
J B Hansen
A. Nordøy
Author Affiliation
Medisinsk avdeling Regionsykehuset i Tromsø.
Source
Tidsskr Nor Laegeforen. 1999 Aug 30;119(20):2986-9
Date
Aug-30-1999
Language
Norwegian
Publication Type
Article
Keywords
Anticholesteremic Agents - administration & dosage
Cholesterol - blood
Cohort Studies
Controlled Clinical Trials
Coronary Disease - prevention & control
English Abstract
Female
Guidelines
Humans
Male
Middle Aged
Myocardial Infarction - complications - drug therapy - prevention & control
Norway
Prescriptions, Drug
Retrospective Studies
Risk factors
Abstract
The 4S study was followed by guidelines for statin treatment of patients with manifest coronary heart disease recommending statins for patients with serum cholesterol above 5.5 mmol/l, age below 70 years, and more than three years life expectancy. The purpose of the present study was to investigate how these guidelines were implemented in clinical practice. A retrospective registration was conducted on two cohorts of patients; patients with myocardial infarction in 1994 (before 4S) (n = 101) and 1996 (n = 100). Risk factors for coronary diseases and the use of statins were registered from the patients records. No significant differences in risk factors between the two cohorts were observed. The proportion of patients given statins increased from 4% in 1994 to 40% in 1996, whereas 50% of patients with serum cholesterol above 5.5 mmol/l were given statins in 1996. Statin treatment was usually instituted during hospitalization. Awareness of actual prescription and handling of statin treatment, and adaption of knowledge from clinical studies to clinical practice is probably needed for further improvement of statin treatment.
PubMed ID
10504844 View in PubMed
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[Use of statins in hospitals after myocardial infarction]

https://arctichealth.org/en/permalink/ahliterature53782
Source
Tidsskr Nor Laegeforen. 2001 Sep 10;121(21):2467-71
Publication Type
Article
Date
Sep-10-2001
Author
A T Notø
L. Steffensen
A. Nordøy
J B Hansen
Author Affiliation
Medisinsk avdeling Regionsykehuset i Tromsø 9038 Tromsø.
Source
Tidsskr Nor Laegeforen. 2001 Sep 10;121(21):2467-71
Date
Sep-10-2001
Language
Norwegian
Publication Type
Article
Keywords
Adult
Aged
Anticholesteremic Agents - administration & dosage
Cholesterol - blood
Drug Utilization
English Abstract
Female
Follow-Up Studies
Hospitals, County - statistics & numerical data
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
Male
Middle Aged
Myocardial Infarction - drug therapy - mortality
Norway
Patient Admission
Practice Guidelines
Prescriptions, Drug - statistics & numerical data
Research Support, Non-U.S. Gov't
Retrospective Studies
Treatment Outcome
Abstract
BACKGROUND: The objective of this study was to register the frequency of statin prescription during the initial hospitalization for acute myocardial infarction and therapeutic intensity at follow-up. MATERIAL AND METHODS: A retrospective study among patients aged below 70 of both sexes with acute myocardial infarction, who survived the initial hospitalization at the University Hospital of Tromsø during 1995-1998. RESULTS: 473 patients with acute myocardial infarction, 76% men, mean age 57.4 (range 33-70 yrs) were included. Statin treatment was started in 55% of the patients within discharge from the hospital. Total cholesterol (odds ratio 0.51, 0.41-0.64; 95% CI) and decreasing age (1.60, 1.21-2.10) were significant predictors for statin prescription. Statin treatment started during hospitalization increased gradually from 42% in 1995 to 91% in 1998 (p
PubMed ID
11875920 View in PubMed
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10 records – page 1 of 1.