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Analysis of polybrominated diphenyl ethers in Swedish human milk. A time-related trend study, 1972-1997.

https://arctichealth.org/en/permalink/ahliterature49225
Source
J Toxicol Environ Health A. 1999 Nov 26;58(6):329-41
Publication Type
Article
Date
Nov-26-1999
Author
D. Meironyté
K. Norén
A. Bergman
Author Affiliation
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. Daiva.Meironyte@mbb.ki.se
Source
J Toxicol Environ Health A. 1999 Nov 26;58(6):329-41
Date
Nov-26-1999
Language
English
Publication Type
Article
Keywords
Adult
Environmental health - trends
Environmental Monitoring - methods
Female
Flame Retardants - analysis
Humans
Infant
Mass Fragmentography
Milk, human - chemistry
Phenyl Ethers - analysis
Polybrominated Biphenyls - analysis
Research Support, Non-U.S. Gov't
Sweden
Time Factors
Abstract
A previously described method for analysis of organochlorine compounds in human milk was adopted for analysis of brominated diphenyl ethers (BDEs) substituted with three to six bromine atoms. Analytes were extracted from human milk with the lipophilic gel Lipidex 5000. Further purifications were performed on partly deactivated aluminum oxide and silica gel columns, followed by gel permeation chromatography. The concentrations of BDEs were determined by gas chromatography/mass spectrometry (GC/MS). The average recoveries of 2,2',4-triBDE (BDE-17), 2,4,4'-triBDE (BDE-28), 2,2',4,4'-tetraBDE (BDE-47), 2,3',4,4'-tetraBDE (BDE-66), 2,2,3,4,4'-pentaBDE (BDE-85), 2,2',4,4',5-pentaBDE (BDE-99), 2,2',4,4',6-pentaBDE (BDE-100), 2,2',4,4',5,5'-hexaBDE (BDE-153), and 2,2',4,4',5,6'-hexaBDE (BDE-154) added to the samples before extraction ranged from 86% to 102%. Pooled samples of breast milk, collected at eight time periods between 1972 and 1997, were analyzed for PBDEs. BDE-47 was the most abundant PBDE congener in all samples. In total, eight PBDE congeners were identified in the milk. The sum of the concentrations of BDE congeners in human milk increased from 0.07 to 4.02 ng/g lipids during the 25-yr period studied.
PubMed ID
10580757 View in PubMed
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Craniofacial morphology and dental age in children with Silver-Russell syndrome.

https://arctichealth.org/en/permalink/ahliterature31072
Source
Orthod Craniofac Res. 2003 Feb;6(1):54-62
Publication Type
Article
Date
Feb-2003
Author
A. Bergman
H. Kjellberg
J. Dahlgren
Author Affiliation
Department of Orthodontics, Institute of Odontology, University of Göteborg, Göteborg, Sweden.
Source
Orthod Craniofac Res. 2003 Feb;6(1):54-62
Date
Feb-2003
Language
English
Publication Type
Article
Keywords
Abnormalities, Multiple - pathology
Adolescent
Age Determination by Teeth
Case-Control Studies
Child
Child, Preschool
Comparative Study
Dental Occlusion
Facial Asymmetry - pathology
Facial Bones - pathology
Female
Growth Disorders - pathology
Humans
Male
Malocclusion - pathology
Mandible - pathology
Maxilla - pathology
Palate - pathology
Radiography, Panoramic
Skull - pathology
Statistics, nonparametric
Syndrome
Tooth Eruption
Vertical Dimension
Abstract
OBJECTIVES: This investigation is a part of a multidisciplinary descriptive evaluation of the Silver-Russell syndrome (SRS). The aim of this study was to describe the craniofacial morphology, occlusion and dental age in children with the SRS. DESIGN: A descriptive literature-controlled study. SETTING AND SAMPLE POPULATION: Sixteen children diagnosed as having SRS, 10 boys and six girls, aged 4.4-14.5 years, were referred from different parts of Sweden to the Queen Silvia Children's Hospital, Göteborg University. EXPERIMENTAL VARIABLE: Facial morphology was measured on lateral and postero-anterior radiographs. Occlusion, tooth eruption and palatal height were measured on casts, and dental maturity was evaluated on orthopantomograms. OUTCOME MEASURE: Linear and angular measurements were obtained from lateral radiographs and the ratios of the linear measurements from the postero-anterior radiographs. The degree of tooth calcification shown on orthopantomograms was taken as a measure of dental maturity. Biometric measurements were taken and the degree of tooth eruption was recorded from the dental casts. The SRS children were compared with reference groups with t-test and z-scores. RESULTS: Overall, SRS children were found to have smaller linear facial dimensions and deviations in the facial proportions, such as a small retropositioned, and steeply inclined maxilla and mandible, and a proportionally larger anterior facial height in relation to the posterior facial height. In 40% of them a smaller facial height or length on one side (facial asymmetry) was correlated to the smaller side of the body. The frequency of malocclusions was higher, and the palatal height showed a tendency towards an increase. Dental maturity was within normal limits, while the time of tooth eruption was slightly delayed. CONCLUSIONS: The deviating facial morphology described above is a part of the syndrome, which is characterized by short stature, growth hormone deficiency and asymmetries of the body. The higher percentage of malocclusions in the SRS children might lead to a greater need of orthodontic treatment.
PubMed ID
12627796 View in PubMed
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Flame retardant exposure: polybrominated diphenyl ethers in blood from Swedish workers.

https://arctichealth.org/en/permalink/ahliterature201393
Source
Environ Health Perspect. 1999 Aug;107(8):643-8
Publication Type
Article
Date
Aug-1999
Author
A. Sjödin
L. Hagmar
E. Klasson-Wehler
K. Kronholm-Diab
E. Jakobsson
A. Bergman
Author Affiliation
Department of Environmental Chemistry, Stockholm University, Stockholm, Sweden. andreas.sjodin@mk.su.se
Source
Environ Health Perspect. 1999 Aug;107(8):643-8
Date
Aug-1999
Language
English
Publication Type
Article
Keywords
Adult
Biological Availability
Female
Flame Retardants - adverse effects - analysis - pharmacokinetics
Halogenated Diphenyl Ethers
Humans
Hydrocarbons, Brominated - adverse effects - blood - pharmacokinetics
Industry
Male
Occupational Exposure
Occupations
Phenyl Ethers - adverse effects - blood - pharmacokinetics
Polybrominated Biphenyls
Sweden
Abstract
Polybrominated diphenyl ethers (PBDEs) are used as additives in polymers and textiles to prohibit the development of fires. Because of the production and use of PBDEs, their lipophilic characteristics, and persistence, these compounds have become ubiquitous environmental contaminants. The aim of the present study was to determine potential exposures of PBDEs to clerks working full-time at computer screens and personnel at an electronics-dismantling plant, with hospital cleaners as a control group. Five PBDE congeners--2,2',4,4'-tetraBDE; 2,2',4,4',5,5'-hexaBDE; 2,2',4,4',5, 6'-hexaBDE; 2,2',3,4,4',5',6-heptaBDE; and decaBDE--were quantified in blood serum from all three categories of workers. Subjects working at the dismantling plant showed significantly higher levels of all PBDE congeners in their serum as compared to the control group. Decabromodiphenyl ether is present in concentrations of 5 pmol/g lipid weight (lw) in the personnel dismantling electronics; these concentrations are comparable to the concentrations of 2,2',4, 4'-tetraBDE. The latter compound was the dominating PBDE congener in the clerks and cleaners. The major compound in personnel at the dismantling plant was 2,2',3,4,4',5',6-heptaBDE. Concentrations of this PBDE congener are almost twice as high as for 2,2',4, 4'-tetraBDE in these workers and seventy times the level of this heptaBDE in cleaners. The total median PBDE concentrations in the serum from workers at the electronics-dismantling plant, clerks, and cleaners were 37, 7.3, and 5.4 pmol/g lw, respectively. The results show that decabromodiphenyl ether is bioavailable and that occupational exposure to PBDEs occurs at the electronics-dismantling plant.
Notes
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PubMed ID
10417362 View in PubMed
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A founder mutation of the BRCA1 gene in Western Sweden associated with a high incidence of breast and ovarian cancer.

https://arctichealth.org/en/permalink/ahliterature19535
Source
Eur J Cancer. 2001 Oct;37(15):1904-9
Publication Type
Article
Date
Oct-2001
Author
Z. Einbeigi
A. Bergman
L G Kindblom
T. Martinsson
J M Meis-Kindblom
M. Nordling
M. Suurküla
J. Wahlström
A. Wallgren
P. Karlsson
Author Affiliation
Department of Oncology, Sahlgrenska University Hospital, S-413 45, Göteborg, Sweden. zakaria.einbeigi@oncology.gu.se
Source
Eur J Cancer. 2001 Oct;37(15):1904-9
Date
Oct-2001
Language
English
Publication Type
Article
Keywords
Adult
Aged
Breast Neoplasms - epidemiology - genetics
DNA Mutational Analysis - methods
Female
Founder Effect
Genes, BRCA1 - genetics
Humans
Incidence
Middle Aged
Multivariate Analysis
Mutation
Neoplastic Syndromes, Hereditary - epidemiology - genetics
Ovarian Neoplasms - epidemiology - genetics
Polymerase Chain Reaction - methods
Research Support, Non-U.S. Gov't
Risk assessment
Survival Rate
Sweden - epidemiology
Abstract
The aim of this study was to describe and characterise a founder mutation of the BRCA1 gene in western Sweden. Of 62 families screened for BRCA mutations, 24 had BRCA1 mutations and two had BRCA2 mutations. Tumours that occurred in family members were histologically reviewed and mutational status was analysed using archival paraffin-embedded tissues. The same BRCA1 mutation, 3171ins5, was found in 16 families who were clustered along the western coast of Sweden. Mutation analysis revealed a maternal linkage in 13 families and a paternal linkage in 3. There was complete agreement between mutation analysis results obtained from blood and archival tissues. The penetrance of breast or ovarian cancer by age 70 years was estimated to be between 59 and 93%. There were no differences in survivals between breast or ovarian cancer patients with the mutation and age-matched controls. Thus, a predominant BRCA1 gene founder mutation associated with a high risk of breast and ovarian cancer has been identified and found to occur in a restricted geographical area, thereby allowing timely and cost-effective mutation screening using blood samples or archival histological material.
PubMed ID
11576847 View in PubMed
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Health condition of the Baltic grey seal (Halichoerus grypus) during two decades. Gynaecological health improvement but increased prevalence of colonic ulcers.

https://arctichealth.org/en/permalink/ahliterature21070
Source
APMIS. 1999 Mar;107(3):270-82
Publication Type
Article
Date
Mar-1999
Author
A. Bergman
Author Affiliation
Contaminant Research Group, Swedish Museum of Natural History, Stockholm.
Source
APMIS. 1999 Mar;107(3):270-82
Date
Mar-1999
Language
English
Publication Type
Article
Keywords
Adrenal Cortex - pathology
Animals
Arteriosclerosis - veterinary
Colonic Diseases - veterinary
Female
Food Contamination
Genitalia, Female - pathology - physiopathology
Hoof and Claw - pathology
Leiomyoma - veterinary
Male
Pregnancy
Reproduction
Research Support, Non-U.S. Gov't
Seals, Earless - anatomy & histology - physiology
Skin - pathology
Skull - pathology
Sweden
Time Factors
Ulcer - veterinary
Uterine Neoplasms - veterinary
Abstract
Results obtained at postmortem examinations of 159 Baltic grey seals during the 20-year period 1977-1996 are presented. The investigation was initiated due to a serious reduction of the Baltic grey and ringed seal populations. Earlier, reduced reproductive ability with occlusions and stenoses of the uterus, as well as a disease complex in adult individuals of both sexes, was reported. The disease complex comprised lesions of claws, skull bone, intestine (colonic ulcers), kidneys (glomerulopathy, tubular cell proliferations), arteries (sclerosis) and adrenals (cortical hyperplasia, cortical adenomas). Besides occlusions and stenoses, tumours (leiomyomas) were common in the uterus. This report focuses on the results of a time-trend study covering the two decades 1977-1986 and 1987-1996. The prevalences (%) in the two decades of moderate to severe lesions of claws, intestine, arteries and adrenals are compared, as well as the prevalences of lesions of the female reproductive organs and rate of pregnancy. A similar comparison was made of animals born before 1980 and those born after 1979, in order to investigate a possible relation between the evident decrease in PCB and DDT pollution of the Baltic which occurred in the 1970s and seal health. A positive time trend respecting gynaecological health was confirmed, with a decreased prevalence of uterine obstructions, from 42 to 11%, and an increased prevalence of pregnancies, from 9 to 60%. The high incidence of uterine tumours (leiomyomas) seems to have decreased slowly (from 53 to 43%). Of special interest is the increased prevalence of colonic ulcers in young animals. The findings indicate that the food consumed by the Baltic seals may contain "new" or increased amounts of hitherto unidentified toxic factors which affect their immune system.
Notes
Erratum In: APMIS 1999 Sep;107(9):886
PubMed ID
10223299 View in PubMed
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High-risk indicators for family involvement in social work in health care: a review of the literature.

https://arctichealth.org/en/permalink/ahliterature221084
Source
Soc Work. 1993 May;38(3):281-8
Publication Type
Article
Date
May-1993
Author
A. Bergman
L. Wells
M. Bogo
S. Abbey
V. Chandler
L. Embleton
S. Guirgis
A. Huot
T. McNeill
L. Prentice
Author Affiliation
University of Toronto, Ontario, Canada.
Source
Soc Work. 1993 May;38(3):281-8
Date
May-1993
Language
English
Publication Type
Article
Keywords
Canada
Family Health
Health Services Needs and Demand - trends
Holistic Health
Home Nursing - psychology
Humans
Referral and Consultation
Risk factors
Social Support
Social Work - trends
Stress, Psychological
United States
Abstract
Shifts in health concerns, fiscal restraints, technological advances, and demands for accountability have created severe tensions within health care settings. New demands point to the need for a redefinition of services. High-risk screening appears to be a clear method of delineating service need. A review of the empirical literature highlights individual, family, and illness variables that alone and together may improve identification of patients and families in need of social work services. The development of screening mechanisms may be a useful vehicle for improved psychosocial care and for the planning of social work services.
PubMed ID
8511657 View in PubMed
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Influence of the consumption of fatty Baltic Sea fish on plasma levels of halogenated environmental contaminants in Latvian and Swedish men.

https://arctichealth.org/en/permalink/ahliterature49216
Source
Environ Health Perspect. 2000 Nov;108(11):1035-41
Publication Type
Article
Date
Nov-2000
Author
A. Sjödin
L. Hagmar
E. Klasson-Wehler
J. Björk
A. Bergman
Author Affiliation
Department of Environmental Chemistry, Stockholm University, Stockholm, Sweden.
Source
Environ Health Perspect. 2000 Nov;108(11):1035-41
Date
Nov-2000
Language
English
Publication Type
Article
Keywords
Adult
Aged
Animals
Diet
Environmental health
Fishes
Food contamination - analysis
Humans
Latvia
Male
Middle Aged
Polychlorinated Biphenyls - blood - chemistry
Research Support, Non-U.S. Gov't
Seawater
Sweden
Water Pollutants, Chemical - blood
Abstract
We examined the influence of widely varied consumption of fatty fish from the Baltic Sea and of age on plasma concentrations of polychlorinated biphenyls (PCBs), polychlorobiphenylols (OH-PCBs), 2, 2-bis(4-chlorophenyl)-1,1,1-trichloroethane (4,4'-DDT), 2, 2-bis(4-chlorophenyl)-1,1-dichloroethane (4,4'-DDE), 2,2',4, 4'-tetrabromodiphenyl ether (BDE-47), hexachlorobenzene (HCB), and pentachlorophenol (PCP) in Latvian and Swedish men. Both age and fish consumption were significantly correlated with the concentrations of [sigman]PCB, [sigman]OH-PCB, 4,4'-DDE, 4,4'-DDT, and HCB. In the case of BDE-47, no significant relationship with age was observed, and fish consumption had the largest relative effect on plasma concentrations of this contaminant. This relationship may be a result of exposure to BDE-47 having been more recent than that of PCBs and DDE, or because the half-life of BDE-47 may be shorter than that of PCB and DDE. Latvian men demonstrated higher plasma levels of DDE and DDT but lower levels of [sigman]PCB and PCP than did Swedish men. The corresponding levels of HCB and BDE-47 were similar in both countries. The Spearman's rank correlation coefficient obtained by comparing the level of the metabolite 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107) to the combined levels of its parent compounds, 2,3,3',4, 4'-pentachlorobiphenyl (CB-105) and 2,3',4,4',5-pentachlorobiphenyl (CB-118), was higher than the median correlation coefficient obtained upon comparing the level of this metabolite to all other possible combinations of two PCB levels. No other increased correlation between metabolite and parent PCB concentration was observed.
PubMed ID
11102293 View in PubMed
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Methylsulfonyl metabolites of PCBs and DDE in human milk in Sweden, 1972-1992.

https://arctichealth.org/en/permalink/ahliterature211566
Source
Environ Health Perspect. 1996 Jul;104(7):766-72
Publication Type
Article
Date
Jul-1996
Author
K. Norén
A. Lundén
E. Pettersson
A. Bergman
Author Affiliation
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Source
Environ Health Perspect. 1996 Jul;104(7):766-72
Date
Jul-1996
Language
English
Publication Type
Article
Keywords
Female
Humans
Methylation
Milk, human - chemistry
Molecular Structure
Pesticide Residues - metabolism
Polychlorinated Biphenyls - metabolism
Retrospective Studies
Sweden
Abstract
A multicomponent method used for analysis of organochlorine pesticides, polychlorinated biphenyls (PCBs), naphthalenes, dibenzo-p-dioxins, and dibenzofurans was adapted for the analysis of methylsulfonyl metabolites of chlorinated biphenyls (MeSO2-CBs) and of p,p'-DDE (MeSO2-DDE) in human milk. The extraction and initial purification was made by liquid-gel partitioning. Additional purification and separation steps were achieved by adsorption and gel permeation chromatography. The mean recoveries of 23 MeSO2-CBs and MeSO2-DDE standards, added to the milk before extraction, were 80-97%. Human milk sampled in Stockholm during 1972, 1976, 1980, 1984/85, 1990, 1991, and 1992 was analyzed by GC-MS. During the time course studied, the concentrations of MeSO2-CBs decreased from approximately 9 to 2 ng/g lipids and of MeSO2-DDE from 5 to 0.4 ng/g lipids. The concentrations of MeSO2-CBs and MeSO2-DDE correlated to the levels of total PCB and p,p'-DDE, respectively. 3-MeSO2-DDE was the major isomer of the aryl methyl sulfones studied in the milk. PCB methyl sulfones with five and six chlorine atoms in the molecule were predominant among the PCB methyl sulfones Generally, the concentrations of 4-MeSO2-CBs were higher than the corresponding 3-MeSO2-CB compound. The major MeSO2-CBs in the milk were 4-MeSO2-2,5,2',3',4'-pentaCB (4-87) and 4-MeSO2-2,3,6,2',4',5'-hexaCB (4-149).
Notes
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PubMed ID
8841763 View in PubMed
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Plasma levels of persistent organohalogens and hormone levels in adult male humans.

https://arctichealth.org/en/permalink/ahliterature61753
Source
Arch Environ Health. 2001 Mar-Apr;56(2):138-43
Publication Type
Article
Author
L. Hagmar
J. Björk
A. Sjödin
A. Bergman
E M Erfurth
Author Affiliation
Department of Occupational and Environmental Medicine, University Hospital, Lund, Sweden.
Source
Arch Environ Health. 2001 Mar-Apr;56(2):138-43
Language
English
Publication Type
Article
Keywords
Adult
Aged
Animals
Chromatography, Gas
Diet
Fishes
Follicle Stimulating Hormone - blood
Food Contamination
Humans
Hydrocarbons, Halogenated - blood
L-Lactate Dehydrogenase - blood
Latvia
Male
Middle Aged
Questionnaires
Research Support, Non-U.S. Gov't
Sweden
Testosterone - blood
Thyroid Hormones - blood
Abstract
In this study the authors assessed the possible relationship between high dietary exposure to persistent organohalogens (OHS) through fatty fish from the Baltic Sea and hormone levels in adult men. Blood samples were drawn from 110 men who consumed varying amounts of fish (i.e., 0-32 meals per month) for analysis of plasma levels of 18 polychlorinated biphenyl (PCB) congeners, 5 hydroxy-PCBs, 1,1,1-trichloro-2,2-bis(4-chlorophenyl)-ethane (p,p'-DDT), 1,1-dichloro-2,2-bis(4-chlorophenyl)-ethene (p,p'-DDE), hexachlorobenzene, and 2,2',4,4'-tetrabromodiphenyl ether. In addition, plasma levels of follicle-stimulating hormone, luteinizing hormone, prolactin, plasma thyrotropin, free and total T3, free and total T4, and free testosterone were analyzed. The authors adjusted for age, and the only significant associations that remained were negative correlations between 2,2',4,4'-tetrabromodiphenyl ether and plasma thyrotropin (p
PubMed ID
11339677 View in PubMed
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15 records – page 1 of 2.