The newly developed methodological and technical approaches to the further enhancement of the actual railway transport health care system which is poorly effective in the nowadays social and economic conditions are exposed. The development of the organizational and functional pattern of the primary prevention of non-communicable diseases to promote professional health among railway employees. The priority targets are such key profession of the the railway transport as locomotive crew workers. The overall approach is declared on the basis of the preventive, regular and permanent application of the suite of "health promoting technologies" considering the professional and working conditions, the structure of morbidity, the characteristics of the individual health and life-style of the employees. The outcomes of the carried out preventive activities in the framework of the new functional and structural organization of the ambulatory polyclinical unit of the sectorial health care system demonstrated the trustworthy positive amelioration of health and quality of life among the employees of the railway transport.