Skip header and navigation

2 records – page 1 of 1.

Improved outcome of respiratory syncytial virus infection in a high-risk hospitalized population of Canadian children. Pediatric Investigators Collaborative Network on Infections in Canada.

https://arctichealth.org/en/permalink/ahliterature223131
Source
J Pediatr. 1992 Sep;121(3):348-54
Publication Type
Article
Date
Sep-1992
Author
L. Navas
E. Wang
V. de Carvalho
J. Robinson
Author Affiliation
Hospital for Sick Children, Toronto, Ontario, Canada.
Source
J Pediatr. 1992 Sep;121(3):348-54
Date
Sep-1992
Language
English
Publication Type
Article
Keywords
Adolescent
Age Factors
Anoxia - complications
Canada - epidemiology
Child
Child, Preschool
Heart Defects, Congenital - complications
Hospitalization
Humans
Immune Tolerance
Infant
Infant, Newborn
Infant, Premature
Lung Diseases - complications
Morbidity
Prognosis
Respiratory Syncytial Viruses
Respirovirus Infections - complications - epidemiology - mortality
Retrospective Studies
Risk factors
Abstract
To determine the outcomes in children at high risk for death or complications from respiratory disease who are hospitalized with respiratory syncytial virus (RSV) infection.
Retrospective chart review.
Twelve pediatric tertiary care centers.
All hospitalized children with an RSV infection diagnosed by a positive antigen detection test result or viral isolation during the study period from 1988 to 1991, encompassing three winter seasons. Charts from patients in the following high-risk groups were reviewed in detail: (1) congenital heart disease, (2) chronic lung disease, (3) immunodeficiency, (4) age less than 6 weeks, (5) gestational age less than 36 weeks, and (6) hypoxia (defined as oxygen saturation less than 90% or arterial oxygen pressure less than 60 mm Hg).
The age of all children, the date of RSV identification, and the use of oxygen supplementation, intensive care, and ventilatory support. In addition, the duration of these treatments and the duration of hospitalization were noted. Left-to-right shunting and pulmonary hypertension before RSV infection were determined in those children with congenital heart disease. The nature of the chronic lung disease was noted. Death within 2 weeks of RSV identification was recorded, and the use of ribavirin, bronchodilators, and corticosteroids was determined.
Significant year-to-year variation in the frequency of RSV infection was confirmed, with a peak during the 1989-1990 winter noted by the majority of centers (p = 0.0001). Of the 1584 patients in the study, 260 had underlying cardiac disease, 200 had chronic lung disease, 35 had compromised immune function, 378 had been premature, 373 were less than 6 weeks of age, and 338 had hypoxia. Seventeen patients died within 2 weeks (mortality rate 1%); significantly more patients with underlying cardiac disease (3.4%) or lung disease (3.5%) died. Immunocompromised patients had the longest hospital stay (median 39 days), followed by those patients with underlying cardiac or pulmonary disease (11 days); patients less than 6 weeks of age (5 days) and those with hypoxia (6 days) had the shortest hospital stays. Patients with underlying cardiac and pulmonary disease also required oxygen supplementation for a significantly longer period.
The year-to-year variation in frequency of RSV infection was confirmed in this study. Morbidity and mortality rates associated with RSV infection in a high-risk population in Canada were significantly lower than previously reported.
PubMed ID
1517907 View in PubMed
Less detail

Respiratory syncytial virus infections in hospitalized Canadian children: regional differences in patient populations and management practices. The Pediatric Investigators Collaborative Network on Infections in Canada.

https://arctichealth.org/en/permalink/ahliterature220543
Source
Pediatr Infect Dis J. 1993 Aug;12(8):659-63
Publication Type
Article
Date
Aug-1993
Author
B J Law
V. De Carvalho
Author Affiliation
Winnipeg Children's Hospital, Manitoba, Canada.
Source
Pediatr Infect Dis J. 1993 Aug;12(8):659-63
Date
Aug-1993
Language
English
Publication Type
Article
Keywords
Age Distribution
Canada - epidemiology
Child, Preschool
Female
Hospital Mortality
Humans
Infant
Male
Morbidity
Respiratory Syncytial Virus Infections - epidemiology - therapy
Respiratory Syncytial Virus, Human
Risk factors
Abstract
Respiratory syncytial virus (RSV) is the most frequent cause of hospitalization for respiratory tract infection during the first 2 years of life. The optimal approach to management remains controversial. During the 1991 to 1992 RSV season RSV-infected children admitted to eight Canadian tertiary care pediatric centers were followed to: (1) assess the morbidity and mortality attributable to RSV infection among hospitalized patients with and without known risk factors for severe disease; and (2) assess regional variation in the management of RSV infection. Of 529 RSV-infected patients 69% (363) had one or more of the risk factors for severe disease and the remaining 31% (166) had none. There were significant differences (P or = 7 days (39%, 6%). Among low risk patients, centers varied significantly (P
PubMed ID
8414779 View in PubMed
Less detail