Hormonal status was examined in 30 intact male Wistar rats (body mass 200-220 g) and 10 healthy male volunteers aged 25-35 years. Hormonal status and influence of exercise were assessed in human males after 2, 10 and 19 days of stay in the sanatorium situated 2000 m above the sea level. The animals were decapitated on day 24 of their stay in the mountains. Blood from the rats' cervical vessels was examined for glucose, beta-lipoproteins, triiodothyronine, thyroxine, TTH, hydrocortisone. The findings indicate that stay in conditions of medium-height mountains climate aroused adaptation reactions in the hormonal systems, i.e. activation of thyroid hormones. An additional course of mineral water contributed to further rise of the blood hormones. Hormonal trends in the volunteers were similar. There was also a rise in the levels of beta-lipoproteins which was arrested by physical exercise.
Wistar rat experiments provided evidence for marked inhibition of early insulin secretion after a single dose of radon water (radon concentration 200 nCi/1). Hepatocytes and activity of transaminase remained unchanged. Miners in long contact with radon in mines (radon concentration in the air of mines 1.5 nCi/1) develop long-term adaptation of the hormonal systems associated with hyperadaptosis in the system of hormonal regulation of glycohomeostasis.