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5HTR2A gene polymorphism and personality traits in patients with major psychoses.

https://arctichealth.org/en/permalink/ahliterature190821
Source
Eur Psychiatry. 2002 Mar;17(1):24-8
Publication Type
Article
Date
Mar-2002
Author
V E Golimbet
M V Alfimova
K K Manandyan
N G Mitushina
L I Abramova
V G Kaleda
I V Oleichik
YuB Yurov
V I Trubnikov
Author Affiliation
Laboratory of Preventive Genetics, Research Mental Health Center, Russian Academy of Medical Sciences, Zagorodnoe sh. 2/2, Moscow, Russia 113152. golimbet@mail.ru
Source
Eur Psychiatry. 2002 Mar;17(1):24-8
Date
Mar-2002
Language
English
Publication Type
Article
Keywords
Adult
Analysis of Variance
Female
Humans
Male
Moscow
Personality - genetics
Personality Inventory
Polymorphism, Genetic - genetics
Psychiatric Status Rating Scales
Psychotic Disorders - genetics
Receptors, Serotonin - genetics
Abstract
Serotonin receptor (5HTR2A) gene polymorphism has been reported to be associated with clinical phenotypes in schizophrenia. The current study attempted to investigate a relationship between 5HTR2A 102T/C polymorphism and personality traits as well as clinical symptoms in patients with ICD-10 diagnoses of schizophrenia and affective disorders. 5HTR2A genotyping, clinical and psychological assessment were administered to 375 patients, 104 first-degree healthy relatives of the patients and 157 controls. In the patients an association was observed between the 2/2 5HTR2A genotype and scores on the Hypochondriasis scale (MMPI) (ANOVA, F = 4.56; P = 0.011) and trait anxiety (F = 4.21; P = 0.002). A significant difference between 1/1 and 2/2 genotypes has been also found for Neuroticism scores (EPI) (t = 2.18; P = 0.0031). No significant differences by 5HTR2A genotype were observed in either the control or first-degree relatives group for all scales studied. Positive, negative and psychopathological symptoms emerged higher in the 2/2 genotype patients compared to other genotype carriers. Therefore, the 2/2 genotype may contribute to produce the phenotype, with specific clinical and pathological features in common, regardless of nosologic heterogeneity of psychoses.
PubMed ID
11918989 View in PubMed
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[Activity of polymorphic N-acetyltransferase in epilepsy].

https://arctichealth.org/en/permalink/ahliterature239409
Source
Zh Nevropatol Psikhiatr Im S S Korsakova. 1985;85(6):857-61
Publication Type
Article
Date
1985
Author
A S Barannikov
V I Trubnikov
Source
Zh Nevropatol Psikhiatr Im S S Korsakova. 1985;85(6):857-61
Date
1985
Language
Russian
Publication Type
Article
Keywords
Acetyltransferases - metabolism
Adolescent
Adult
Aged
Epilepsy - enzymology - genetics
Female
Humans
Isoenzymes - metabolism
Male
Middle Aged
Moscow
Polymorphism, Genetic
Prognosis
Abstract
Activity of polymorphic N-acetyl transferase characterized by bimodality (fast and slow acetylators) in normal subjects was studied in 150 epileptic patients. The epileptic versus normal subjects had a significant predominance of slow acetylators. The data obtained suggest that slow acetylation is one of the possible factors predisposing to epilepsy and responsible for a more severe course of the disease. The results of the study suggest that determination of the activity of polymorphic N-acetyl transferase may serve as a prognostic criterion of epilepsy.
PubMed ID
4024808 View in PubMed
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[Clinico-demographic characteristics and features of the social and occupational adaptation of schizophrenics in 3 population groups living in the northeastern region of the European portion of the USSR (clinico-epidemiologic study)].

https://arctichealth.org/en/permalink/ahliterature237902
Source
Zh Nevropatol Psikhiatr Im S S Korsakova. 1986;86(5):713-9
Publication Type
Article
Date
1986
Author
R G Gainullin
L M Shmaonova
V I Trubnikov
Source
Zh Nevropatol Psikhiatr Im S S Korsakova. 1986;86(5):713-9
Date
1986
Language
Russian
Publication Type
Article
Keywords
Adult
Employment
Ethnic Groups - psychology
Female
Humans
Male
Middle Aged
Rural Population
Russia
Schizophrenia - diagnosis - epidemiology
Social Adjustment
Syndrome
Transients and Migrants - psychology
Abstract
The authors conducted a clinico-epidemiological study of schizophrenics among the indigenous population, including that living in isolated areas and newcomers, taking into consideration forms of the disease course and employing a uniform syndromal assessment of the mental state. The authors have established general pathogenetic regularities of the course and their relationship with the age and sex. Patients from the indigenous population, particularly of geographically isolated areas, showed a higher incidence of schizophrenia, a more severe clinical picture of the disease and a lower level of social and occupational adaptation as compared to the migrated population.
PubMed ID
2943095 View in PubMed
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[Discriminant functions for the diagnosis of twin zygosity from questionnaire data].

https://arctichealth.org/en/permalink/ahliterature242785
Source
Genetika. 1982 Nov;18(11):1894-8
Publication Type
Article
Date
Nov-1982
Author
I N Lunga
V I Trubnikov
A S Sergeev
Source
Genetika. 1982 Nov;18(11):1894-8
Date
Nov-1982
Language
Russian
Publication Type
Article
Keywords
Adolescent
Adult
Female
Humans
Male
Methods
Middle Aged
Moscow
Pregnancy
Questionnaires
Statistics as Topic
Twins
Twins, Dizygotic
Twins, Monozygotic
Urban Population
Abstract
Discriminant and successive analyses of formalized data obtained on the basis of questionnaire response were carried out in 232 twin samples of the same sex to estimate a degree of their similarity. The data were taken from the Twin Register of the Institute of Medical Genetics and treated concerning three characters: 1) subjective estimation of the similarity; 2) distinguishing twins by other people; 3) the use of special marks. The variants of discriminantal functions allowing to divide twin zygosity into monozygotic and dizygotic groups have been obtained, the classification error being 4 to 6%. The tables with diagnostic coefficients for twin zygosity diagnosis constructed on the basis of successive analysis are presented.
PubMed ID
6891354 View in PubMed
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[Genetic-epidemiologic study of adenoma and cancer of the large intestine].

https://arctichealth.org/en/permalink/ahliterature201377
Source
Genetika. 1999 Apr;35(4):516-23
Publication Type
Article
Date
Apr-1999
Author
N F Belev
E E Samotyia
P M Pikhut
E N Kudina
S D Khalipli
V I Trubnikov
T P Kazubskaia
R F Gar'kavtseva
Author Affiliation
Institute of Oncology, Ministry of Health of The Republic of Moldova, Chisinau, Russia.
Source
Genetika. 1999 Apr;35(4):516-23
Date
Apr-1999
Language
Russian
Publication Type
Article
Keywords
Adenoma - epidemiology - genetics
Breast Neoplasms - epidemiology
Female
Genital Neoplasms, Female - epidemiology
Humans
Intestinal Neoplasms - epidemiology - genetics
Intestine, Large
Male
Prevalence
Retrospective Studies
Russia - epidemiology
Abstract
A clinical/genealogical study of colorectal adenomas (CRA) and cancer (CRC), and multiple primary malignant tumors (MPMT) was performed. The CRA prevalence in the population was 4.7 +/- 1.4% (single CRA--6.3% and multiple CRA--3.0%). The frequencies of malignant adenomas, 0.7% CRC, and MPMT were 0.7, 0.17 +/- 0.07%, and 0.004 +/- 0.003%, respectively. The prevalence of cancer of the female reproductive organs was also estimated (cancer of uterine body, 0.2 +/- 0.1%; cancer of ovaries, 0.08 +/- 0.1%; cancer of uterine cervix, 0.55 +/- 0.1%; cancer of mammary gland 0.57 +/- 0.1%). The main parameters of the familial inheritance of adenomas, CRC, and MPMT were also studied in general and at various clinical variants of these pathologies. Among the first-degree relatives of patients with solitary and multiple adenomas, the adenoma frequencies were 5.9 +/- 0.6 and 3.7 +/- 0.5%, respectively. The CRC frequency among the first-degree relatives of patients with adenoma was 3.0 +/- 0.6% and the frequency of MPMT was 5.8 +/- 0.6%. On the basis of the data obtained on frequencies of malignant tumors in various groups of relatives, the following conclusions were made: (1) in families of each proband group, specific pathology was accumulated; (2) the familial frequency of malignant tumors increased with an increase in proliferative processes and the severity of a pathology in probands.
PubMed ID
10420276 View in PubMed
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[Heritability of neurodynamics and psychodynamics in human populations].

https://arctichealth.org/en/permalink/ahliterature236922
Source
Genetika. 1986 Jun;22(6):1047-55
Publication Type
Article
Date
Jun-1986
Author
K B Bulaeva
V I Trubnikov
S A Isaichev
T A Pavlova
N P Dubinin
Source
Genetika. 1986 Jun;22(6):1047-55
Date
Jun-1986
Language
Russian
Publication Type
Article
Keywords
Analysis of Variance
Consanguinity
Dagestan
Genetic Variation
Genetics, Behavioral
Genetics, Population
Humans
Models, Genetic
Moscow
Phenotype
Abstract
A component analysis of human neurodynamic and psychodynamic characters in the norm was carried out in 8 human populations characterized by different degrees of isolation and ethnic origin. An increase in phenotypic variability and a decrease in heritability with increasing complexity of organization of the characters under study were demonstrated for all these populations. The additive effect plays the major role in genetic determination of neurodynamic and psychodynamic characters studied. For a number of neurodynamic parameters the effect of intralocus dominance indicative of the oligogenic determination system was observed. Data in favour of real contribution of the factors linked to X-chromosome were obtained for simple sensomotor reactions.
PubMed ID
3732804 View in PubMed
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[Multivariate genetic analysis of the neurodynamic and psychodynamic parameters in human populations].

https://arctichealth.org/en/permalink/ahliterature241677
Source
Genetika. 1983 Aug;19(8):1364-71
Publication Type
Article
Date
Aug-1983
Author
K B Bulaeva
V I Trubnikov
Source
Genetika. 1983 Aug;19(8):1364-71
Date
Aug-1983
Language
Russian
Publication Type
Article
Keywords
Analysis of Variance
Dagestan
Ethnic Groups
Genetic Variation
Genetics, Behavioral
Genetics, Population
Genotype
Humans
Mental Processes - physiology
Nervous System Physiological Phenomena
Phenotype
Abstract
The first attempt at using multivariate genetic analysis to study the neurodynamic and psychodynamic levels of individual organization in Daghestan isolates is described. The absence of close similarity between dendrograms of templates of phenotypical and genotypical correlations is explained by lower heritability of the parameters under study. Interpopulation differences revealed by the multivariate genetic analysis are the result of differences in the genetic and social structures of the populations.
PubMed ID
6685089 View in PubMed
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[Status and prospects of genetic studies of ischemic heart disease]

https://arctichealth.org/en/permalink/ahliterature55654
Source
Vestn Akad Med Nauk SSSR. 1986;(9):25-33
Publication Type
Article
Date
1986

[The genetics of breast cancer. A genetic dispersion analysis and the genetic heterogeneity of breast cancer].

https://arctichealth.org/en/permalink/ahliterature232706
Source
Genetika. 1988 Aug;24(8):1456-61
Publication Type
Article
Date
Aug-1988
Author
M D Nefedov
R F Gar'kavtseva
V I Trubnikov
Source
Genetika. 1988 Aug;24(8):1456-61
Date
Aug-1988
Language
Russian
Publication Type
Article
Keywords
Breast Neoplasms - epidemiology - genetics
Female
Genotype
Humans
Menopause - genetics
Moscow
Phenotype
Risk factors
Abstract
The multifactorial nature of breast cancer was established based on population and family study, the contribution of genetic factors being 52% (premenopausal--62 and postmenopausal--39%). Genetic heterogeneity of different coefficients of inheritance of breast cancer with the portion of common genes was shown to be 53%. The analysis of breast cancer interaction with other malignant neoplasms revealed that the development of other malignant neoplasms was the result of the influence of partially common genes. On the basis of data obtained in this study, the tables of repeated risk for the relatives have been worked out which may be used for medico-genetic consultations.
PubMed ID
3203886 View in PubMed
Less detail

[The genetics of breast cancer, population and familial research and segregation analysis].

https://arctichealth.org/en/permalink/ahliterature233018
Source
Genetika. 1988 Jun;24(6):1105-12
Publication Type
Article
Date
Jun-1988
Author
M D Nefedov
R F Gar'kavtseva
V I Trubnikov
Source
Genetika. 1988 Jun;24(6):1105-12
Date
Jun-1988
Language
Russian
Publication Type
Article
Keywords
Adult
Alleles
Breast Neoplasms - epidemiology - genetics
Female
Gene Frequency
Genetic Techniques
Genetics, Population
Heterozygote
Homozygote
Humans
Male
Moscow
Mutation
Phenotype
Urban Population
Abstract
The data on clinico-genealogy studies of 1046 probands with breast cancer and their relatives are presented. The nature of inheritance corresponded to the Mendelian model. As to other families, there is no strong evidence for the monogene model both with complete and incomplete penetrance of mutant homo- and heterozygotes. Penetrance of homozygotes was 7.9-30.5%, this being 2.0-7.3% for heterozygotes. The conclusion is drawn that it is necessary to consider the regularities of inheritance of breast cancer in the light of the multifactorial model.
PubMed ID
3049234 View in PubMed
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10 records – page 1 of 1.