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[Basic principles and results of brachytherapy in gynecological oncology].

https://arctichealth.org/en/permalink/ahliterature261530
Source
Vopr Onkol. 2014;60(4):422-8
Publication Type
Article
Date
2014
Author
S V Kanaev
V G Turkevich
S B Baranov
V V Savel'eva
Source
Vopr Onkol. 2014;60(4):422-8
Date
2014
Language
Russian
Publication Type
Article
Keywords
Brachytherapy
Cancer Care Facilities
Female
Genital Neoplasms, Female - radiotherapy
Humans
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Conformal
Russia
United States
Abstract
The fundamental basics of contact radiation therapy (brachytherapy) for gynecological cancer are presented. During brachytherapy the principles of conformal radiotherapy should be implemented, the aim of which is to sum the maximum possible dose of radiation to the tumor and decrease the dose load in adjacent organs and tissues, which allows reducing the frequency of radiation damage at treatment of primary tumors. It is really feasible only on modern technological level, thanks to precision topometry preparation, optimal computer dosimetrical and radiobiological planning of each session and radiotherapy in general. Successful local and long-term results of the contact radiation therapy for cancer of cervix and endometrium are due to optimal anatomical and topometrical ratio of the tumor localization, radioactive sources, and also physical and radiobiological laws of distribution and effects of ionizing radiation, the dose load accounting rules.
PubMed ID
25552060 View in PubMed
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[Clinical evaluation of the effectiveness of radiation treatment for cervical cancer].

https://arctichealth.org/en/permalink/ahliterature104100
Source
Vopr Onkol. 2014;60(3):366-70
Publication Type
Article
Date
2014
Author
V G Turkevich
Source
Vopr Onkol. 2014;60(3):366-70
Date
2014
Language
Russian
Publication Type
Article
Keywords
Adult
Aged
Brachytherapy
Dose Fractionation
Dose-Response Relationship, Radiation
Female
Humans
Middle Aged
Neoplasm Staging
Radiotherapy - methods
Radiotherapy Dosage
Retrospective Studies
Russia - epidemiology
Survival Analysis
Treatment Outcome
Uterine Cervical Neoplasms - mortality - pathology - radiotherapy
Abstract
The study is based on data on 1756 patients with cervical cancer treated as combined (remote + contact) and only the contact exposure with low, medium and high dose rate. For comparative radiobiological evaluation of reactions of irradiated tissues there were used the following radiobiological models: factor time-dose-fractionation, the cumulative radiation effect, linear- quadratic model in the variant of biologically effective dose. Survival of cervical cancer patients undergone combined radiation treatment was determined by the stage of disease. In particular, the survival of patients with Stage IB cervical cancer was significantly higher than in Stages IIB and IIIB, while in Stage IIB was significantly higher than in Stage IIIB. Long-term results of radiation treatment of patients with Stage IB1 (T1b1N0M0) and Stage IIB (T2bN0M0) cervical cancer did not depend on whether the contact radiation exposure was combined or single. The most preferred component of radiotherapy in women suffering from cervical cancer was brachytherapy with high dose rate.
PubMed ID
25033692 View in PubMed
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[Clinical evaluation of the effectiveness of radiation treatment for endometrial cancer].

https://arctichealth.org/en/permalink/ahliterature104099
Source
Vopr Onkol. 2014;60(3):371-4
Publication Type
Article
Date
2014
Author
V G Turkevich
Source
Vopr Onkol. 2014;60(3):371-4
Date
2014
Language
Russian
Publication Type
Article
Keywords
Adult
Aged
Brachytherapy
Dose Fractionation
Dose-Response Relationship, Radiation
Endometrial Neoplasms - mortality - pathology - radiotherapy
Female
Humans
Middle Aged
Neoplasm Staging
Radiotherapy - methods
Radiotherapy Dosage
Retrospective Studies
Russia - epidemiology
Survival Analysis
Treatment Outcome
Abstract
The study is based on data on 306 patients with endometrial cancer treated as combined (remote + contact) and only the contact exposure with low, medium and high dose rate. For comparative radiobiological evaluation of reactions of irradiated tissues there were used the following radiobiological models: factor time-dose-fractionation, the cumulative radiation effect, linear- quadratic model in the variant of biologically effective dose. Survival of endometrial cancer patients undergone combined or only the contact radiation treatment was determined by the stage of disease. In particular, the survival of patients with Stage IB endometrial cancer (combined radiation treatment) was significantly higher than in Stage IC, while in Stage IB (contact radiation treatment) was significantly higher than in Stages IC and IIB. Long-term results of radiation treatment of patients with all Stages of endometrial cancer were significantly better by 16% when only the contact radiation treatment was performed. The most preferred component of radiotherapy in women suffering from endometrial cancer with severe comorbidities was brachytherapy with high dose rate both in the combined and only contact irradiation.
PubMed ID
25033693 View in PubMed
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