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13 records – page 1 of 2.

Source
Radiat Res. 2000 Sep;154(3):237-45
Publication Type
Article
Date
Sep-2000
Author
N A Koshurnikova
E S Gilbert
M. Sokolnikov
V F Khokhryakov
S. Miller
D L Preston
S A Romanov
N S Shilnikova
K G Suslova
V V Vostrotin
Author Affiliation
Branch No. 1 of the State Scientific Center "Biophysics Institute", Ozyorsk, Chelyabinsk Region, Russia.
Source
Radiat Res. 2000 Sep;154(3):237-45
Date
Sep-2000
Language
English
Publication Type
Article
Keywords
Adult
Body Burden
Bone Neoplasms - epidemiology - etiology
Cause of Death
Chondrosarcoma - epidemiology - etiology - mortality
Cohort Studies
England
Female
Humans
Lung Neoplasms - epidemiology - etiology
Male
Neoplasms, Radiation-Induced - epidemiology
Nuclear Energy
Occupational Diseases - epidemiology
Occupational Exposure
Osteosarcoma - epidemiology - etiology - mortality
Plutonium - adverse effects - urine
Pulmonary Fibrosis - etiology - mortality
Radiation monitoring
Risk
Russia - epidemiology
Sarcoma - epidemiology - etiology
Soft Tissue Neoplasms - epidemiology - etiology
United States
Abstract
Bone cancer mortality risks were evaluated in 11,000 workers who started working at the "Mayak" Production Association in 1948-1958 and who were exposed to both internally deposited plutonium and external gamma radiation. Comparisons with Russian and U.S. general population rates indicate excess mortality, especially among females, plutonium plant workers, and workers with external doses exceeding 1 Sv. Comparisons within the Mayak worker cohort, which evaluate the role of plutonium body burden with adjustment for cumulative external dose, indicate excess mortality among workers with burdens estimated to exceed 7.4 kBq (relative risk = 7.9; 95% CI = 1.6-32) and among workers in the plutonium plant who did not have routine plutonium monitoring data based on urine measurements (relative risk = 4.1; 95% CI = 1.2-14). In addition, analyses treating the estimated plutonium body burden as a continuous variable indicate increasing risk with increasing burden (P
PubMed ID
10956428 View in PubMed
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Influence of alpha and gamma radiations and non-radiation risk factors on the incidence of malignant liver tumors among Mayak PA workers.

https://arctichealth.org/en/permalink/ahliterature167552
Source
Health Phys. 2006 Oct;91(4):296-310
Publication Type
Article
Date
Oct-2006
Author
Z B Tokarskaya
G V Zhuntova
B R Scott
V F Khokhryakov
Z D Belyaeva
E K Vasilenko
V A Syrchikov
Author Affiliation
Southern Ural Biophysics Institute, P.O. Box 456780, Ozyorsk, Russia.
Source
Health Phys. 2006 Oct;91(4):296-310
Date
Oct-2006
Language
English
Publication Type
Article
Keywords
Alpha Particles
Case-Control Studies
Cohort Studies
Female
Gamma Rays
Humans
Incidence
Liver Neoplasms - epidemiology
Male
Middle Aged
Neoplasms, Radiation-Induced - epidemiology
Nuclear Reactors - statistics & numerical data
Occupational Diseases - epidemiology
Occupational Exposure - statistics & numerical data
Radiation Dosage
Risk Assessment - methods
Risk factors
Russia - epidemiology
Abstract
This Mayak worker-based study focuses on evaluating possible associations between malignant liver cancers and chronic alpha irradiation, chronic gamma irradiation, and non-radiation risk factors (alcohol consumption, smoking, viral hepatitis, chemical exposure, and chronic digestive diseases). This is the first multivariate study related to liver cancer among Mayak workers. The study was performed using the nested, case-control approach and includes 44 cases of malignant liver tumors diagnosed from 1972 to 1999, and 111 matched controls. Adjusted odds ratio (OR(ad)) was evaluated relative to a group of workers with alpha radiation doses to liver (D(alpha)) 2.0 Gy (corresponding (239)Pu body burden estimates >20.4 kBq) were significantly associated (p 2.0-5.0 Gy and was 62.5 (7.4, 500) for a group with D(alpha) > 5.0-16.9 Gy. The attributable risk (AR) was calculated as 82%. For HCC, O(Rad) was estimated as 8.4 (0.8, 85.3; p 2.0-9.3 Gy. For the indicated group, the AR was 14%. An association with high external gamma-ray doses (D(gamma)) to the total body was revealed for both HCC and for combined liver cancers when dose was treated as a continuous variable. However, we find no evidence that chronic low doses of gamma rays are associated with liver cancer occurrence. Cholangiocarcinoma (CHC) was not associated with either alpha- or gamma-ray exposure. As expected, an association between alcohol abuse and HCC was inferred [O(Rad) = 3.3 (1.2, 9); AR = 41%] but not for CHC or HAS.
PubMed ID
16966873 View in PubMed
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Interaction of radiation and smoking in lung cancer induction among workers at the Mayak nuclear enterprise.

https://arctichealth.org/en/permalink/ahliterature187487
Source
Health Phys. 2002 Dec;83(6):833-46
Publication Type
Article
Date
Dec-2002
Author
Z B Tokarskaya
B R Scott
G V Zhuntova
N D Okladnikova
Z D Belyaeva
V F Khokhryakov
H. Schöllnberger
E K Vasilenko
Author Affiliation
Southern Ural Biophysics Institute, Ozyorsk, Russia. tokarskaya@fib1ko.chel-65.chel.su
Source
Health Phys. 2002 Dec;83(6):833-46
Date
Dec-2002
Language
English
Publication Type
Article
Keywords
Aged
Case-Control Studies
Cohort Studies
Dose-Response Relationship, Radiation
Female
Humans
Lung Neoplasms - etiology
Male
Neoplasms, Radiation-Induced
Nuclear Reactors
Plutonium - adverse effects
Radiation
Russia
Smoking - adverse effects
Abstract
For radiation-related cancer risk evaluation, it is important to assess not only influences of individual risk factors but also their interactive effects (e.g., additive, multiplicative, etc.). Multivariate analysis methods adapted for interactive effects allow such assessments. We have used a multivariate analysis approach to investigate the pair-wise interactions of the previously identified three main etiological factors for lung cancer induction in Russian workers of the Mayak Production Association (PA) nuclear enterprise. These three factors are as follows: (1) body burden of inhaled plutonium-239 (239Pu), an influence on absorbed alpha-radiation dose; (2) cumulative, absorbed external gamma-radiation dose to the lung; and (3) level of cigarette smoking as indicated by a smoking index (SI). The SI represents the cigarettes smoked per day times years smoking. The Mayak PA workers were exposed by inhalation to both soluble and insoluble forms of 239Pu. Based on a cohort of 4,390 persons (77% male), we conducted a nested, case-control study of lung cancer induction using 486 matched cases and controls. Each case was matched to two controls. Matching was based on five factors: sex, year of birth, year work began, profession, and workplace. Three levels of smoking were considered: low (SI = 1 to 499), used as a reference level; middle (SI = 500 to 900); and high (SI = 901 to 2,000). For lung cancer induction, a supra-multiplicative effect was demonstrated for high external gamma-ray doses (> 2.0 Gy) plus high 239Pu intakes (body burden >2.3 kBq). This observation is consistent with the hypothesis of curvilinear dose-response relationships for lung cancer induction by high- and low-LET radiations. The interaction between radiation (external gamma rays or 239Pu body burden) and cigarette smoke was found to depend on the smoking level. For the middle level of smoking in combination with gamma radiation (> 2.0 Gy) or 239Pu body burden (> 2.3 kBq), results were consistent with additive effects. However, for the high level of smoking in combination with gamma radiation (> 2.0 Gy) or 239Pu body burden (> 2.3 kBq), results were consistent with the occurrence of multiplicative effects. These results indicate that low-dose risk estimates for radiation-induced lung cancer derived without adjusting for the influence of cigarette smoking could be greatly overestimated. Further, such systematic error may considerably distort the shape of the risk vs. dose curve and could possibly obscure the presence of a dose threshold for radiation-induced lung cancer.
PubMed ID
12467291 View in PubMed
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Source
Radiat Res. 2000 Sep;154(3):246-52
Publication Type
Article
Date
Sep-2000
Author
E S Gilbert
N A Koshurnikova
M. Sokolnikov
V F Khokhryakov
S. Miller
D L Preston
S A Romanov
N S Shilnikova
K G Suslova
V V Vostrotin
Author Affiliation
Radiation Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20852, USA.
Source
Radiat Res. 2000 Sep;154(3):246-52
Date
Sep-2000
Language
English
Publication Type
Article
Keywords
Body Burden
Carcinoma, Hepatocellular - epidemiology - etiology - mortality
Cholangiocarcinoma - epidemiology - etiology - mortality
Cohort Studies
England - epidemiology
Female
Gamma Rays - adverse effects
Hemangiosarcoma - epidemiology - etiology - mortality
Humans
Liver - radiation effects
Liver Neoplasms - epidemiology - etiology - mortality
Male
Middle Aged
Neoplasms, Radiation-Induced - epidemiology - etiology - mortality
Nuclear Energy
Occupational Diseases - epidemiology - etiology - mortality
Occupational Exposure
Plutonium - adverse effects - urine
Radiometry
Risk
Russia - epidemiology
Sex Factors
United States - epidemiology
Abstract
Liver cancer mortality risks were evaluated in 11,000 workers who started working at the "Mayak" Production Association in 1948-1958 and who were exposed to both internally deposited plutonium and external gamma radiation. Comparisons with Russian liver cancer incidence rates indicate excess risk, especially among those with detectable plutonium body burdens and among female workers in the plutonium plant. Comparisons within the Mayak worker cohort which evaluate the role of plutonium body burden with adjustment for cumulative external dose indicate excess risk among workers with burdens estimated to exceed 7.4 kBq (relative risk = 17; 95% CI = 8. 0-36) and among workers in the plutonium plant who did not have routine plutonium monitoring data based on urine measurements (relative risk = 2.8; 95% CI = 1.3-6.2). In addition, analyses treating the estimated plutonium body burden as a continuous variable indicate increasing risk with increasing burden (P
PubMed ID
10956429 View in PubMed
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Lung cancer mortality among male nuclear workers of the Mayak facilities in the former Soviet Union.

https://arctichealth.org/en/permalink/ahliterature198202
Source
Radiat Res. 2000 Jul;154(1):3-11
Publication Type
Article
Date
Jul-2000
Author
M. Kreisheimer
N A Koshurnikova
E. Nekolla
V F Khokhryakov
S A Romanow
M E Sokolnikov
N S Shilnikova
P V Okatenko
A M Kellerer
Author Affiliation
Radiobiological Institute, University of Munich, Germany.
Source
Radiat Res. 2000 Jul;154(1):3-11
Date
Jul-2000
Language
English
Publication Type
Article
Keywords
Alpha Particles - adverse effects
Cohort Studies
Data Interpretation, Statistical
Humans
Lung Neoplasms - epidemiology - etiology - mortality
Male
Models, Statistical
Neoplasms, Radiation-Induced - chemically induced - mortality
Nuclear Reactors
Occupational Diseases - mortality
Occupational Exposure - adverse effects
Plutonium - toxicity
Russia - epidemiology
Abstract
An analysis of lung cancer mortality in a cohort of 1,669 Mayak workers who started their employment in the plutonium and reprocessing plants between 1948 and 1958 has been carried out in terms of a relative risk model. Particular emphasis has been given to a discrimination of the effects of external gamma-ray exposure and internal alpha-particle exposure due to incorporated plutonium. This study has also used the information from a cohort of 2,172 Mayak reactor workers who were exposed only to external gamma rays. The baseline lung cancer mortality rate has not been taken from national statistics but has been derived from the cohort itself. For both alpha particles and gamma rays, the results of the analysis are consistent with linear dose dependences. The estimated excess relative risk per unit organ dose equivalent in the lung due to the plutonium alpha particles at age 60 equals, according to the present study, 0.6/Sv, with a radiation weighting factor of 20 for alpha particles. The 95% confidence range is 0.39/Sv to 1.0/Sv. For the gamma-ray component, the present analysis suggests an excess relative risk for lung cancer mortality at age 60 of 0.20/Sv, with, however, a large 95% confidence range of-0.04/Sv to 0.69/Sv.
PubMed ID
10856959 View in PubMed
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Lung cancer mortality among nuclear workers of the Mayak facilities in the former Soviet Union. An updated analysis considering smoking as the main confounding factor.

https://arctichealth.org/en/permalink/ahliterature184564
Source
Radiat Environ Biophys. 2003 Jul;42(2):129-35
Publication Type
Article
Date
Jul-2003
Author
M. Kreisheimer
M E Sokolnikov
N A Koshurnikova
V F Khokhryakov
S A Romanow
N S Shilnikova
P V Okatenko
E A Nekolla
A M Kellerer
Author Affiliation
Radiobiological Institute, University of Munich, Schillerstrasse 42, 80336 Munich, Germany. michael.kreisheimer@lrz.uni-muenchen.de
Source
Radiat Environ Biophys. 2003 Jul;42(2):129-35
Date
Jul-2003
Language
English
Publication Type
Article
Keywords
Cohort Studies
Confounding Factors (Epidemiology)
Dose-Response Relationship, Radiation
Humans
Lung Neoplasms - epidemiology - etiology - mortality
Male
Models, Statistical
Neoplasms, Radiation-Induced - mortality
Nuclear Reactors
Occupational Diseases - epidemiology - mortality
Occupational Exposure - adverse effects
Plutonium - adverse effects
Risk assessment
Russia
Smoking
Abstract
A new analysis of lung cancer mortality in a cohort of male Mayak workers who started their employment in the plutonium and reprocessing plants between 1948 and 1958 has been carried out in terms of a relative risk model. The follow-up has been extended until 1999, moreover a new dosimetry system (DOSES2000) has been established. Particular emphasis has been given to a discrimination of the effects of external gamma-exposure and internal alpha-exposure due to incorporated plutonium. This study has also utilized and incorporated the information from a cohort of Mayak reactor workers, who were exposed only externally to gamma-rays. The influence of smoking as the main confounding factor for lung cancer has been studied. The baseline lung cancer mortality rate was not taken from national statistics but was derived from the cohort itself. The estimated excess relative risk for the plutonium alpha-rays was 0.23/Sv (95%CI: 0.16-0.31). The resulting risk coefficient for external gamma-ray exposure was very low with a statistically insignificant estimate of 0.058/Sv (95%CI: -0.072-0.20). The inferred relative risk for smokers was 16.5 (95%CI: 12.6-20.5).
PubMed ID
12851829 View in PubMed
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Mayak worker dosimetry study: an overview.

https://arctichealth.org/en/permalink/ahliterature161924
Source
Health Phys. 2007 Sep;93(3):190-206
Publication Type
Article
Date
Sep-2007
Author
E K Vasilenko
V F Khokhryakov
S C Miller
J J Fix
K. Eckerman
D O Choe
M. Gorelov
V V Khokhryakov
V. Knyasev
M P Krahenbuhl
R I Scherpelz
M. Smetanin
K. Suslova
V. Vostrotin
Author Affiliation
Mayak Production Association, Ozyorsk, Russia.
Source
Health Phys. 2007 Sep;93(3):190-206
Date
Sep-2007
Language
English
Publication Type
Article
Keywords
Body Burden
Bone Marrow - radiation effects
Bone and Bones - radiation effects
Cohort Studies
Databases, Factual
Female
Humans
Liver - radiation effects
Lung - radiation effects
Male
Nuclear Warfare
Occupational Exposure
Plutonium
Radiometry
Russia
Abstract
The Mayak Production Association (MPA) was the first plutonium production plant in the former Soviet Union. Workers at the MPA were exposed to relatively large internal radiation intakes and external radiation exposures, particularly in the early years of plant operations. This paper describes the updated dosimetry database, "Doses-2005." Doses-2005 represents a significant improvement in the determination of absorbed organ dose from external radiation and plutonium intake for the original cohort of 18,831 Mayak workers. The methods of dose reconstruction of absorbed organ doses from external radiation uses: 1) archive records of measured dose and worker exposure history, 2) measured energy and directional response characteristics of historical Mayak film dosimeters, and 3) calculated dose conversion factors for Mayak Study-defined exposure scenarios using Monte Carlo techniques. The methods of dose reconstruction for plutonium intake uses two revised models developed from empirical data derived from bioassay and autopsy cases and/or updates from prevailing or emerging International Commission on Radiological Protection models. Other sources of potential significant exposure to workers such as medical diagnostic x-rays, ambient onsite external radiation, neutron radiation, intake of airborne effluent, and intake of nuclides other than plutonium were evaluated to determine their impact on the dose estimates.
PubMed ID
17693770 View in PubMed
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Metabolism and dosimetry of actinide elements in occupationally-exposed personnel of Russia and the United States: a summary progress report.

https://arctichealth.org/en/permalink/ahliterature198212
Source
Health Phys. 2000 Jul;79(1):63-71
Publication Type
Article
Date
Jul-2000
Author
V F Khokhryakov
K G Suslova
R E Filipy
J R Alldredge
E E Aladova
S E Glover
V V Vostrotin
Author Affiliation
Branch No. 1, Federal Research Center Institute of Biophysics, Ozersk, Chelyabinsk Region, Russia.
Source
Health Phys. 2000 Jul;79(1):63-71
Date
Jul-2000
Language
English
Publication Type
Article
Keywords
Aerosols
Americium - pharmacokinetics
Humans
Longitudinal Studies
Occupational Exposure
Plutonium - pharmacokinetics
Radiometry
Registries
Respiratory System - metabolism
Russia
United States
Abstract
The United States Transuranium and Uranium Registries (USTUR) and the Dosimetry Registry of the Mayak Industrial Association (DRMIA) have been independently collecting tissues at autopsy of plutonium workers in their respective countries for nearly 30 y. The tissues are analyzed radiochemically and the analytical data are used to develop, modify, or refine biokinetic models that describe the depositions and translocations of plutonium and transplutonium elements in the human body. The purpose of this collaborative research project is to combine the unique information on humans, gathered by the two Registries, into a joint database and perform analyses of the data. A series of project tasks are directly concerned with dosimetry in Mayak workers and involve biokinetic modeling for actinide elements. Transportability coefficients derived from in-vitro solubility measurements of actinide-containing aerosols (as measured by the DRMIA) were related to specific workplaces within Mayak facilities. The transportability coefficients of inhaled aerosols significantly affected the translocation rates of plutonium from the respiratory tract to the systemic circulation. Parameters for a simplified lung model, used by Branch No. 1, Federal Research Center Institute of Biophysics (FIB-1) and the Mayak Production Association for dose assessment at long times after inhalation of plutonium-containing aerosols, were developed on the basis of joint USTUR and DRMIA data. This model has separate sets of deposition and transfer parameters for three aerosol transportability groups, allowing work histories of the workers to be considered in the dose-assessment process. FIB-1 biokinetic models were extended to include the distributions of actinide elements in systemic organs of workers, and a relationship between the health of individual workers and plutonium distribution in tissues was determined. Workers who suffered from liver diseases generally had a smaller fraction of systemic plutonium in the liver at death and a larger fraction in the skeleton than did relatively healthy workers. Also, the fraction of total systemic plutonium excreted per day was significantly greater for workers with liver diseases than for relatively healthy workers. These observations could have a considerable effect on organ dosimetry in health-impaired workers whose dose assessments were based solely on urinary excretion rates. A comparison of this model to other biokinetic models, such as those published by the International Commission for Radiological Protection, is currently underway as is the documentation of uncertainty estimates associated with the model.
PubMed ID
10855779 View in PubMed
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Mortality among personnel who worked at the Mayak complex in the first years of its operation.

https://arctichealth.org/en/permalink/ahliterature211649
Source
Health Phys. 1996 Jul;71(1):90-3
Publication Type
Article
Date
Jul-1996
Author
N A Koshurnikova
G D Bysogolov
M G Bolotnikova
V F Khokhryakov
V V Kreslov
P V Okatenko
S A Romanov
N S Shilnikova
Author Affiliation
Public Health Ministry of the Russian Federation, Biophysics Institute Branch NI, Chelyabinsk-65, Russian Federation.
Source
Health Phys. 1996 Jul;71(1):90-3
Date
Jul-1996
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Female
Humans
Lung Neoplasms - mortality
Male
Middle Aged
Neoplasms, Radiation-Induced - mortality
Occupational Diseases - mortality
Radiation Dosage
Russia
Abstract
Epidemiological studies revealed increased cancer mortality among persons who began working at the Mayak complex during the period 1948-1958. Estimation of cancer risk was carried out for the sites of cancer that showed increased mortality and dependence on dose of external gamma- or internal alpha-irradiation.
PubMed ID
8655338 View in PubMed
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Relative role of plutonium excretion with urine and feces from human body.

https://arctichealth.org/en/permalink/ahliterature180577
Source
Health Phys. 2004 May;86(5):523-7
Publication Type
Article
Date
May-2004
Author
V F Khokhryakov
K G Suslova
T I Kudryavtseva
A E Schadilov
V V Vostrotin
N Yu Lagounova
A Yu Barabanshchikova
Author Affiliation
Southern Ural Biophysics Institute, Federal Research Center of Biophysics, Ozyorskoe Shosse 19, Ozyorsk, Chelyabinsk Region, Russia, 456780. khohryakov@lab3.fib.ozersk.ru
Source
Health Phys. 2004 May;86(5):523-7
Date
May-2004
Language
English
Publication Type
Article
Keywords
Administration, Inhalation
Aged
Aged, 80 and over
Air Pollutants, Radioactive - analysis - pharmacokinetics - urine
Body Burden
Feces - chemistry
Female
Humans
Male
Metabolic Clearance Rate - physiology
Middle Aged
Models, Biological
Nuclear Reactors
Occupational Exposure - analysis
Plutonium - administration & dosage - analysis - pharmacokinetics - urine
Radiation Dosage
Radiation Protection - methods
Radiometry - methods
Relative Biological Effectiveness
Risk Assessment - methods
Russia
Abstract
The ratio of plutonium content in 35 pairs of daily fecal and urine samples from 19 former MAYAK workers several decades after the end of occupational exposure was measured in clinical conditions. No dependence of the ratio Pu(feces)/Pu(urine) on plutonium aerosol transportability, sex, and age of workers was revealed in the late times after the end of occupational exposure. It was found that at the late times after the end of occupational exposure, the ratio of feces/urine is characterized by the lognormal distribution with the median value, 0.57, and error for this index characterized geometric deviation, sigmag = 1.12 Urinary and fecal excretions were analyzed after chronic exposure to inhaled plutonium compounds of different transportability for another group of 345 workers. During 500-16,000 d after the started chronic inhalation, plutonium biokinetic model ("Doses-2000") used in Southern Ural Biophysics Institute (SUBI) and based on the ICRP Publication 66 overestimated the feces/urine ratio by an order of magnitude as compared with the observed values. It indicates a necessity for further improvement of the biokinetic model used in SUBI.
PubMed ID
15083148 View in PubMed
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13 records – page 1 of 2.