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The association between anemia and falls in community-living women and men aged 65 years and older from the fifth Tromsø Study 2001-02: a replication study.

https://arctichealth.org/en/permalink/ahliterature293028
Source
BMC Geriatr. 2017 12 27; 17(1):292
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
12-27-2017
Author
Laila Arnesdatter Hopstock
Elisabeth Bøe Utne
Alexander Horsch
Tove Skjelbakken
Author Affiliation
Department of Health and Care Sciences, Faculty of Health Sciences, UiT The Arctic University of Norway, N-9037, Tromsø, Norway. laila.hopstock@uit.no.
Source
BMC Geriatr. 2017 12 27; 17(1):292
Date
12-27-2017
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Accidental Falls - prevention & control - statistics & numerical data
Aged
Aged, 80 and over
Anemia - complications - diagnosis - epidemiology - physiopathology
Cohort Studies
Female
Frailty - diagnosis - epidemiology - physiopathology
Geriatric Assessment - methods
Hemoglobins - analysis
Humans
Independent Living - statistics & numerical data
Male
Norway - epidemiology
Risk Assessment - methods
Risk factors
Self Report
Statistics as Topic
Abstract
Falls are common among elderly people, and the risk increase with age. Falls are associated with both health and social consequences for the patient, and major societal costs. Identification of risk factors should be investigated to prevent falls. Previous studies have shown anemia to be associated with increased risk of falling, but the results are inconsistent. The aim of this study was to investigate the association between anemia and self-reported falls among community-living elderly people. The study is a replication of the study by Thaler-Kall and colleagues from 2014, who studied the association between anemia and self-reported falls among 967 women and men 65 years and older in the KORA-Age study from 2009.
We included 2441 participants (54% women) 65 years and older from the population-based Tromsø 5 Study 2001-2002. Logistic regression models were used to investigate the association between anemia (hemoglobin
Notes
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PubMed ID
29282000 View in PubMed
Less detail

The association between anemia and falls in community-living women and men aged 65 years and older from the fifth Tromsø Study 2001-02: a replication study.

https://arctichealth.org/en/permalink/ahliterature287915
Source
BMC Geriatr. 2017 12 27;17(1):292
Publication Type
Article
Date
12-27-2017
Author
Laila Arnesdatter Hopstock
Elisabeth Bøe Utne
Alexander Horsch
Tove Skjelbakken
Source
BMC Geriatr. 2017 12 27;17(1):292
Date
12-27-2017
Language
English
Publication Type
Article
Abstract
Falls are common among elderly people, and the risk increase with age. Falls are associated with both health and social consequences for the patient, and major societal costs. Identification of risk factors should be investigated to prevent falls. Previous studies have shown anemia to be associated with increased risk of falling, but the results are inconsistent. The aim of this study was to investigate the association between anemia and self-reported falls among community-living elderly people. The study is a replication of the study by Thaler-Kall and colleagues from 2014, who studied the association between anemia and self-reported falls among 967 women and men 65 years and older in the KORA-Age study from 2009.
We included 2441 participants (54% women) 65 years and older from the population-based Tromsø 5 Study 2001-2002. Logistic regression models were used to investigate the association between anemia (hemoglobin
Notes
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Cites: J Bone Miner Res. 1998 Dec;13(12):1932-99844112
Cites: Aging Clin Exp Res. 2003 Feb;15(1):43-5012841418
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PubMed ID
29282000 View in PubMed
Less detail

The association between red cell distribution width and venous thromboembolism is not explained by myocardial infarction, stroke, or cancer.

https://arctichealth.org/en/permalink/ahliterature293397
Source
Res Pract Thromb Haemost. 2018 Apr; 2(2):327-333
Publication Type
Journal Article
Date
Apr-2018
Author
Trygve S Ellingsen
Jostein Lappegård
Tove Skjelbakken
Ellisiv B Mathiesen
Inger Njølstad
Sigrid K Brækkan
John-Bjarne Hansen
Author Affiliation
K.G. Jebsen Thrombosis Research and Expertise Center (TREC) Department of Clinical Medicine UiT-The Arctic University of Norway Tromsø Norway.
Source
Res Pract Thromb Haemost. 2018 Apr; 2(2):327-333
Date
Apr-2018
Language
English
Publication Type
Journal Article
Abstract
Red cell distribution width (RDW) is a risk marker of venous thromboembolism (VTE), myocardial infarction (MI), stroke, and cancer. Due to interrelations between these diseases, the association between RDW and VTE may be explained by MI, stroke, or cancer.
To investigate whether the effect of RDW on VTE could be explained by intermediate development of MI, stroke, or cancer.
RDW was measured in 24 363 participants of the Tromsø Study in 1994-1995. Incident VTE, MI, stroke, and cancer were registered until December 31, 2010. Conventional and cause-specific Cox-regression models were used to estimate hazard ratios (HR) for VTE with 95% confidence intervals (CI) across categories of RDW.
There were 502 first VTEs during a median follow-up of 16 years. In conventional Cox regression analysis, RDW in the highest quartile was associated with a 71% (HR 1.71, 95% CI 1.09-2.67) and 27% (HR 1.27, 95% CI 0.88-1.85) higher risk of VTE in men and women, respectively, compared to subjects in the lowest quartiles. The risk of VTE among subjects with RDW in the highest quartile was similar for men and women of postmenopausal age. In cause-specific analysis, where each individual contributed with person-time until the first occurring event only, the risk estimates were similar to those of the conventional Cox-regression analysis.
Our findings suggest that the association between RDW and future risk of VTE is not explained by intermediate development of MI, stroke, or cancer.
Notes
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PubMed ID
30046735 View in PubMed
Less detail

Changes in body mass index and smoking habits have a different impact on hemoglobin concentration in men and women: a longitudinal follow-up of the Tromsø Study, 1994-2002.

https://arctichealth.org/en/permalink/ahliterature96309
Source
Gend Med. 2010 Jun;7(3):230-9
Publication Type
Article
Date
Jun-2010
Author
Tove Skjelbakken
Inger Marie S Dahl
Maja-Lisa Løchen
Author Affiliation
Institute of Community Medicine, University of Tromsø, Tromsø, Norway. tove.skjelbakken@unn.no
Source
Gend Med. 2010 Jun;7(3):230-9
Date
Jun-2010
Language
English
Publication Type
Article
Abstract
BACKGROUND: Body mass index (BMI) and smoking have been positively associated with hemoglobin concentration, and both are risk factors for cardiovascular disease. OBJECTIVE: The aim of this study was to assess whether there were sex differences in how changes in BMI and smoking habits influenced hemoglobin concentration. METHODS: In 1994-95 and 2001-02, a longitudinal, population-based study was conducted in the municipality of Tromsø, in northern Norway. Inhabitants aged > or =25 years were invited to participate. Participants replied to a questionnaire regarding health, physical activity, coffee and alcohol consumption, and smoking habits. Blood samples were drawn to analyze hemoglobin concentration. All analyses were performed separately for each sex. Differences between 1994-95 and 2001-02 were examined with t or chi(2) (McNemar) tests for paired data. Cross-sectional comparisons were made using 2-sample t tests. Different models of univariate and multiple linear regression analyses were used to investigate the impact of the various variables on hemoglobin change. RESULTS: Data from a total of 2105 men and 2945 women were examined. At baseline, mean age was 58.9 years for men (range, 25-78 years) and 57.8 years for women (range, 25-82 years); mean BMI was 26.1 kg/m(2) for men and 25.8 kg/m(2) for women. In men, hemoglobin decreased with age, on average from 147.5 to 145.1 g/L. In women, hemoglobin decreased from 135.6 to 134.7 g/L, but increased with increasing age up to 54 years, and thereafter decreased gradually. Mean BMI increased 0.8 kg/m(2) in men and 1.2 kg/m(2) in women. In total, 394 of 2057 men (19%) and 499 of 2889 women (17%) stopped smoking or smoked fewer cigarettes per day. In a univariate regression model, an increase of 1 kg/m(2) in BMI was associated with an increase in hemoglobin of 1.1 g/L (95% CI, 0.84 to 1.27) in men and 0.4 g/L (95% CI, 0.30 to 0.56) in women. In another univariate model, smoking cessation was associated with a decrease in hemoglobin of 1.9 g/L (95% CI, -3.32 to -0.56) in men and 1.7 g/L (95% CI, -2.93 to -0.56) in women. In men who smoked less and had a BMI increase of >2.5 kg/m(2), hemoglobin decreased 0.3 g/L. In contrast, hemoglobin decreased 3.4 g/L in men who smoked less and lost weight (P for trend,
PubMed ID
20638628 View in PubMed
Less detail

Haemoglobin and anaemia in a gender perspective: the Tromsø Study.

https://arctichealth.org/en/permalink/ahliterature51878
Source
Eur J Haematol. 2005 May;74(5):381-8
Publication Type
Article
Date
May-2005
Author
Tove Skjelbakken
Bodil Langbakk
Inger Marie S Dahl
Maja-Lisa Løchen
Author Affiliation
Institute of Community Medicine, University of Tromsø, Tromsø, Norway. tove.skjelbakken@ism.uit.no
Source
Eur J Haematol. 2005 May;74(5):381-8
Date
May-2005
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Aged
Aged, 80 and over
Anemia - blood - epidemiology
Female
Hemoglobins - analysis
Humans
Male
Middle Aged
Norway - epidemiology
Prevalence
Sex Characteristics
Abstract
OBJECTIVES: To examine the gender-specific distribution of haemoglobin (Hb) and the World Health Organization (WHO) criteria for anaemia compared with the 2.5 percentile for Hb. METHODS: A population-based study from Tromsø, Northern Norway. All inhabitants above 24 yr were invited. In total, 26 530 (75%) had their Hb analysed. RESULTS: The 2.5-97.5 percentile of Hb was 129-166 and 114-152 g/L for all men and women, respectively. In men, mean Hb decreased from 148 to 137 g/L between 55-64 and 85+ yr. In women, mean Hb increased from 132 to 137 g/L between 35-44 and 65-74 yr and then decreased to 131 g/L among the oldest. Using the WHO criteria for anaemia (Hb:
PubMed ID
15813911 View in PubMed
Less detail

Impact of red cell distribution width on future risk of cancer and all-cause mortality among cancer patients - the Tromsø Study.

https://arctichealth.org/en/permalink/ahliterature264205
Source
Haematologica. 2015 Jun 25;
Publication Type
Article
Date
Jun-25-2015
Author
Trygve S Ellingsen
Jostein Lappegård
Tove Skjelbakken
Sigrid K Brækkan
John-Bjarne Hansen
Source
Haematologica. 2015 Jun 25;
Date
Jun-25-2015
Language
English
Publication Type
Article
PubMed ID
26113420 View in PubMed
Less detail

Inflammatory biomarkers as risk factors for future atrial fibrillation. An eleven-year follow-up of 6315 men and women: the Tromsø study.

https://arctichealth.org/en/permalink/ahliterature120029
Source
Gend Med. 2012 Dec;9(6):536-547.e2
Publication Type
Article
Date
Dec-2012
Author
Audhild Nyrnes
Inger Njølstad
Ellisiv B Mathiesen
Tom Wilsgaard
John-Bjarne Hansen
Tove Skjelbakken
Lone Jørgensen
Maja-Lisa Løchen
Author Affiliation
Department of Community Medicine, University of Tromsø, Tromsø, Norway. audhild.nyrnes@uit.no
Source
Gend Med. 2012 Dec;9(6):536-547.e2
Date
Dec-2012
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Atrial Fibrillation - epidemiology
Biological Markers - blood
C-Reactive Protein
Coronary Disease - epidemiology
Electrocardiography
Female
Fibrinogen - metabolism
Humans
Inflammation - blood
Leukocyte Count
Male
Middle Aged
Multivariate Analysis
Norway - epidemiology
Osteoprotegerin - blood
Proportional Hazards Models
Prospective Studies
Risk factors
Sex Factors
Abstract
Inflammatory biomarkers are reported as risk factors for atrial fibrillation (AF), but their impact is uncertain.
We investigated the associations between inflammatory biomarkers and future AF in a large general cohort.
Available markers were white blood cells (WBCs) with subgroups, fibrinogen, high-sensitivity C-reactive protein (hs-CRP), and osteoprotegerin (OPG). A total of 6315 men and women from a population survey in Tromsø, Norway in 1994 to 1995 were followed for a mean of 10.9 years. Mean age at baseline was 60 years. Measurements of height, weight, blood pressure, heart rate, total cholesterol, high-density lipoprotein (HDL) cholesterol, WBC count, and information on diabetes, angina, myocardial infarction, and antihypertensive treatment, were obtained at baseline. Fibrinogen, hs-CRP, and OPG were obtained at a follow-up visit. The outcome measure was first-ever AF, documented on an electrocardiogram. The Cox proportional hazards regression model was used to estimate hazard ratios of AF.
In the multivariable analysis, adjusted for traditional cardiovascular risk factors and other inflammatory biomarkers, hs-CRP was associated with AF in men only (hazard ratio = 1.14 for a 1 SD increase; 95% CI, 1.02-1.28). There was a significant increase in AF across quartiles of WBCs in men (P = 0.007) and in the total study population (P = 0.004). OPG was associated with AF in patients free of coronary heart disease at baseline. Fibrinogen and subgroups of WBCs showed no significant association with AF.
This population-based cohort study showed that hs-CRP was independently associated with AF in men, but apparently not in women, and that patients with WBCs in the upper quartile had increased risk of AF.
PubMed ID
23046763 View in PubMed
Less detail

Red cell distribution width is associated with future risk of incident stroke. The Tromsø Study.

https://arctichealth.org/en/permalink/ahliterature276659
Source
Thromb Haemost. 2016 Jan;115(1):126-34
Publication Type
Article
Date
Jan-2016
Author
Jostein Lappegård
Trygve S Ellingsen
Tove Skjelbakken
Ellisiv B Mathiesen
Inger Njølstad
Tom Wilsgaard
Jan Brox
Sigrid K Brækkan
John-Bjarne Hansen
Source
Thromb Haemost. 2016 Jan;115(1):126-34
Date
Jan-2016
Language
English
Publication Type
Article
Keywords
Adult
Aged
Cell Size
Chi-Square Distribution
Erythrocyte Indices
Erythrocytes - pathology
Female
Humans
Incidence
Male
Middle Aged
Multivariate Analysis
Norway - epidemiology
Predictive value of tests
Proportional Hazards Models
Prospective Studies
Risk assessment
Risk factors
Stroke - blood - diagnosis - epidemiology - mortality
Time Factors
Abstract
Red cell distribution width (RDW), a measure of the variability in size of the circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with incident stroke and case fatality in subjects recruited from the general population. Baseline characteristics were obtained from 25,992 subjects participating in the fourth survey of the Tromsø Study, conducted in 1994/95. Incident stroke was registered from inclusion until December 31, 2010. Cox regression models were used to calculate hazard ratios (HR) with 95% confidence intervals (95% CI) for stroke, adjusted for age, sex, body mass index, smoking, haemoglobin level, white blood cell count, thrombocyte count, hypertension, total cholesterol, triglycerides, self-reported diabetes, and red blood cell count. During a median follow-up of 15.8 years, 1152 participants experienced a first-ever stroke. A 1% increment in RDW yielded a 13% higher risk of stroke (multivariable HR: 1.13, 95% CI: 1.07-1.20). Subjects with RDW in the highest quintile compared to the lowest had a 37% higher risk of stroke in multivariable analysis (HR: 1.37, 95% CI: 1.11-1.69). Subjects with RDW above the 95-percentile had 55% higher risk of stroke compared to those in the lowest quintile (HR: 1.55, 95% CI: 1.16-2.06). All risk estimates remained unchanged after exclusion of subjects with anaemia (n=1102). RDW was not associated with increased risk of death within one year or during the entire follow-up after an incident stroke. RDW is associated with incident stroke in a general population, independent of anaemia and traditional atherosclerotic risk factors.
PubMed ID
26290352 View in PubMed
Less detail

Red cell distribution width is associated with incident myocardial infarction in a general population: the Tromsø Study.

https://arctichealth.org/en/permalink/ahliterature267085
Source
J Am Heart Assoc. 2014 Aug;3(4)
Publication Type
Article
Date
Aug-2014
Author
Tove Skjelbakken
Jostein Lappegård
Trygve S Ellingsen
Elizabeth Barrett-Connor
Jan Brox
Maja-Lisa Løchen
Inger Njølstad
Tom Wilsgaard
Ellisiv B Mathiesen
Sigrid K Brækkan
John-Bjarne Hansen
Source
J Am Heart Assoc. 2014 Aug;3(4)
Date
Aug-2014
Language
English
Publication Type
Article
Keywords
Adult
Aged
Erythrocyte Indices
Female
Humans
Longitudinal Studies
Male
Middle Aged
Myocardial Infarction - blood - epidemiology
Norway - epidemiology
Proportional Hazards Models
Prospective Studies
Abstract
Red cell distribution width (RDW), a measure of the variability in size of circulating erythrocytes, is associated with mortality and adverse outcome in selected populations with cardiovascular disease. It is scarcely known whether RDW is associated with incident myocardial infarction (MI). We aimed to investigate whether RDW was associated with risk of first-ever MI in a large cohort study with participants recruited from a general population.
Baseline characteristics, including RDW, were collected for 25 612 participants in the Tromsø Study in 1994-1995. Incident MI during follow-up was registered from inclusion through December 31, 2010. Cox regression models were used to calculate hazard ratios with 95% confidence intervals for MI, adjusted for age, sex, body mass index, smoking, hemoglobin, white blood cells, platelets, and other traditional cardiovascular risk factors. A total of 1779 participants experienced a first-ever MI during a median follow-up time of 15.8 years. There was a linear association between RDW and risk of MI, for which a 1% increment in RDW was associated with a 13% increased risk (hazard ratio 1.13; 95% CI, 1.07 to 1.19). Participants with RDW above the 95th percentile had 71% higher risk of MI compared with those with RDW in the lowest quintile (hazard ratio 1.71; 95% CI, 1.34 to 2.20). All effect estimates were essentially similar after exclusion of participants with anemia (n=1297) from the analyses.
RDW is associated with incident MI in a general population independent of anemia and cardiovascular risk factors.
Notes
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PubMed ID
25134681 View in PubMed
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Red cell distribution width is associated with incident venous thromboembolism (VTE) and case-fatality after VTE in a general population.

https://arctichealth.org/en/permalink/ahliterature267421
Source
Thromb Haemost. 2015 Jan;113(1):193-200
Publication Type
Article
Date
Jan-2015
Author
Trygve S Ellingsen
Jostein Lappegård
Tove Skjelbakken
Sigrid K Brækkan
John-Bjarne Hansen
Source
Thromb Haemost. 2015 Jan;113(1):193-200
Date
Jan-2015
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Cause of Death
Erythrocyte Indices
Female
Humans
Incidence
Male
Middle Aged
Multivariate Analysis
Norway - epidemiology
Predictive value of tests
Prognosis
Proportional Hazards Models
Recurrence
Risk assessment
Risk factors
Time Factors
Venous Thromboembolism - blood - diagnosis - mortality
Abstract
Recent studies suggest an association between red cell distribution width (RDW) and incident venous thromboembolism (VTE). We aimed to investigate the impact of RDW on risk of incident and recurrent VTE, and case-fatality, in a general population. RDW was measured in 26,223 participants enrolled in the Tromsø Study in 1994-1995. Incident and recurrent VTE events and deaths during follow-up were registered until January 1, 2012. Multivariate Cox proportional hazards regression models were used to calculate hazard ratios (HR) with 95% confidence intervals (CI). There were 647 incident VTE events during a median of 16.8 years of follow-up. Individuals with RDW in the highest quartile (RDW=13.3%) had 50% higher risk of an incident VTE than those in the lowest quartile (RDW=12.3%). The association was strongest for unprovoked deep-vein thrombosis (HR highest vs lowest quartile of RDW: 1.8, 95% CI 1.1-3.1). VTE patients with baseline RDW=13.3% had 30% higher risk of all-cause mortality after the initial VTE event than VTE patients with RDW
PubMed ID
25274492 View in PubMed
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