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Body mass index in male and female children with infantile autism.

https://arctichealth.org/en/permalink/ahliterature31495
Source
Autism. 2002 Jun;6(2):197-205
Publication Type
Article
Date
Jun-2002
Author
Svend Erik Mouridsen
Bente Rich
Torben Isager
Author Affiliation
Department of Child and Adolescent Psychiatry, Bispebjerg Hospital, Copenhagen, Denmark.
Source
Autism. 2002 Jun;6(2):197-205
Date
Jun-2002
Language
English
Publication Type
Article
Keywords
Autistic Disorder - diagnosis
Body mass index
Child
Child, Preschool
Denmark
Female
Humans
Intelligence
Male
Reference Values
Research Support, Non-U.S. Gov't
Sex Factors
Abstract
Morphometry, the measurement of forms, is an ancient practice. Recently, evidence has grown to support the notion that aberrant neurodevelopment may play a role in the pathophysiology of autism. Is the body, like the brain, affected by abnormal development in these patients? The aim of this study was to evaluate body mass index (BMI) of children with infantile autism, by comparing the BMI of 117 children with infantile autism with the corresponding BMI percentiles in an age- and sex-matched reference population. The BMI distribution of the male, but not female, children with infantile autism was significantly lower than that of the age-matched reference population. There was no evidence that BMI was associated with intelligence or socioeconomic status among children with infantile autism.
PubMed ID
12083285 View in PubMed
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Diseases of the circulatory system among adult people diagnosed with infantile autism as children: A longitudinal case control study.

https://arctichealth.org/en/permalink/ahliterature281166
Source
Res Dev Disabil. 2016 Oct;57:193-200
Publication Type
Article
Date
Oct-2016
Author
Svend Erik Mouridsen
Bente Rich
Torben Isager
Source
Res Dev Disabil. 2016 Oct;57:193-200
Date
Oct-2016
Language
English
Publication Type
Article
Keywords
Adult
Aged
Autistic Disorder - epidemiology
Cardiovascular Diseases - epidemiology
Case-Control Studies
Denmark - epidemiology
Female
Humans
Longitudinal Studies
Male
Middle Aged
Myocardial Ischemia - epidemiology
Prevalence
Registries
Abstract
Research dealing with adult people with autism spectrum disorders (ASD) noticeably lags behind studies of children and young individuals with ASD.
The objective of this study was to compare the prevalence and types of diseases of the circulatory system in a clinical sample of 118 adult people diagnosed with infantile autism (IA) as children with 336 sex and age matched controls from the general population.
All participants were screened through the nationwide Danish National Hospital Register. The average observation time of both groups was 37.2 years, and mean age at follow-up was 49.6 years.
Of the 118 people with IA, 11 (9.3%) were registered with at least one disease of the circulatory system against 54 (16.1%) in the comparison group (p=0.09; OR=0.54; 95% CI 0.3-1.2). Ischemic heart diseases occurred significantly more frequently among people in the comparison group (p=0.02).
It is argued that diseases of the circulatory system may be underdiagnosed in people with IA because of the difficulties they face with respect to identifying and communicating symptoms of ill health. Bearing in mind that cardiovascular disease is the primary cause of death in most developed countries, it is suggested that to prevent disease and manage health conditions, health monitoring is essential in adult people with IA.
PubMed ID
27448332 View in PubMed
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Diseases of the gastrointestinal tract in individuals diagnosed as children with atypical autism: a Danish register study based on hospital diagnoses.

https://arctichealth.org/en/permalink/ahliterature120612
Source
Autism. 2013 Jan;17(1):55-63
Publication Type
Article
Date
Jan-2013
Author
Svend Erik Mouridsen
Torben Isager
Bente Rich
Author Affiliation
Bispebjerg University Hospital, Denmark. Svend.Erik.Mouridsen@regionh.dk
Source
Autism. 2013 Jan;17(1):55-63
Date
Jan-2013
Language
English
Publication Type
Article
Keywords
Child
Child Development Disorders, Pervasive - complications - epidemiology
Comorbidity
Denmark - epidemiology
Female
Gastrointestinal Diseases - classification - epidemiology - etiology
Humans
Male
Prevalence
Registries
Retrospective Studies
Abstract
The purpose of this study is to compare the prevalence and types of diseases (International classification of mental and behavioural disorders, 10th edition codes K20-K93) relating to the gastrointestinal tract in a clinical sample of 89 individuals diagnosed as children with atypical autism/pervasive developmental disorder not otherwise specified with 258 controls from the general population. All participants were screened through the nationwide Danish National Hospital Register. The average observation time was 32.9 years, and mean age at the end of the observation period was 48.5 years. Among the 89 cases with atypical autism, a total of 22 (24.7%) were registered with at least one diagnosis of any disease of the gastrointestinal tract, against 47 of 258 (18.2%) in the comparison group (p = 0.22; odds ratio = 1.5; 95% confidence interval = 0.8-2.6). Without reaching statistical significance, the rate of diseases of the gastrointestinal tract was particularly high (odds ratio = 1.2) in those with intelligence quotient
PubMed ID
22987890 View in PubMed
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Epilepsy and other neurological diseases in the parents of children with infantile autism. A case control study.

https://arctichealth.org/en/permalink/ahliterature163048
Source
Child Psychiatry Hum Dev. 2008 Mar;39(1):1-8
Publication Type
Article
Date
Mar-2008
Author
Svend Erik Mouridsen
Bente Rich
Torben Isager
Author Affiliation
Department of Child and Adolescent Psychiatry, Bispebjerg University Hospital, Copenhagen 2400, Denmark. sem01@bbh.hosp.dk
Source
Child Psychiatry Hum Dev. 2008 Mar;39(1):1-8
Date
Mar-2008
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Autistic Disorder - epidemiology
Case-Control Studies
Central Nervous System Diseases - epidemiology
Child
Child of Impaired Parents - statistics & numerical data
Child, Preschool
Denmark - epidemiology
Epilepsy - epidemiology
Female
Humans
Male
Parents
Phenotype
Registries
Abstract
In order to study the broader phenotype of infantile autism (IA) we compared the rates and types of epilepsy and other neurological diseases in the parents of 111 consecutively admitted patients with IA with a matched control group of parents of 330 children from the general population. All participants were screened through the nationwide Danish National Hospital Register (DNHR). We inquired about epilepsy and other neurological diseases during an observation period of 27 years. A similar proportion of case- and control mothers had a diagnosis of any neurological disease, 9.9% vs 10.6%. For case fathers the proportion was 5.7% vs 9.7%. No single neurological disease was significantly more frequent among parents of persons with IA. Our study lent support to the notion that epilepsy and other neurological diseases are not part of the broader IA phenotype.
PubMed ID
17564832 View in PubMed
Less detail

Epilepsy in individuals with a history of Asperger's syndrome: a Danish nationwide register-based cohort study.

https://arctichealth.org/en/permalink/ahliterature119967
Source
J Autism Dev Disord. 2013 Jun;43(6):1308-13
Publication Type
Article
Date
Jun-2013
Author
Svend Erik Mouridsen
Bente Rich
Torben Isager
Author Affiliation
Centre for Child and Adolescent Psychiatry, Bispebjerg University Hospital, 2400, Copenhagen, Denmark. Svend.Erik.Mouridsen@regionh.dk
Source
J Autism Dev Disord. 2013 Jun;43(6):1308-13
Date
Jun-2013
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Asperger Syndrome - epidemiology
Child
Child, Preschool
Cohort Studies
Denmark - epidemiology
Epilepsy - epidemiology
Female
Humans
Male
Registries
Young Adult
Abstract
We performed a nationwide, register-based retrospective follow-up study of epilepsy in all people who were born between January 1, 1980 and June 29, 2006 and registered in the Danish Psychiatric Central Register with Asperger's syndrome on February 7, 2011. All 4,180 identified cases with AS (3,431 males and 749 females) were screened through the nationwide Danish National Hospital Register (DNHR) with respect to epilepsy. Mean age at follow-up was 18.1 years (range 4-31 years). Of the 4,180 individuals with AS, 164 (3.9%) were registered with at least one epilepsy diagnosis in the DNHR, which is significantly increased (p
PubMed ID
23054204 View in PubMed
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Fractures in individuals with and without a history of infantile autism. A Danish register study based on hospital discharge diagnoses.

https://arctichealth.org/en/permalink/ahliterature134451
Source
J Autism Dev Disord. 2012 Apr;42(4):619-24
Publication Type
Article
Date
Apr-2012
Author
Svend Erik Mouridsen
Bente Rich
Torben Isager
Author Affiliation
Centre for Child and Adolescent Psychiatry, Bispebjerg University Hospital, 2400 Copenhagen, Denmark. Svend.Erik.Mouridsen@regionh.dk
Source
J Autism Dev Disord. 2012 Apr;42(4):619-24
Date
Apr-2012
Language
English
Publication Type
Article
Keywords
Adult
Autistic Disorder - diagnosis - epidemiology
Comorbidity
Denmark
Female
Follow-Up Studies
Fractures, Bone - diagnosis - epidemiology
Humans
Male
Middle Aged
Prevalence
Registries
Abstract
We compared the prevalence and types of fractures in a clinical sample of 118 individuals diagnosed as children with infantile autism (IA) with 336 matched controls from the general population. All participants were screened through the nationwide Danish National Hospital Register. The average observation time was 30.3 years (range 27.3-30.4 years), and mean age at follow-up was 42.7 years (range 27.3-57.3 years). Of the 118 individuals with IA, 14 (11.9%) were registered with at least one fracture diagnosis against 83 (24.7%) in the comparison group (p = 0.004; OR = 0.41; 95%CI 0.22-0.76), but the nature of their fractures seems somewhat different. Epilepsy was a risk factor, but only in the comparison group. Our results lend no support to the notion that fracture is a common comorbid condition in a population of people diagnosed with IA as children.
PubMed ID
21584848 View in PubMed
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A longitudinal study of epilepsy and other central nervous system diseases in individuals with and without a history of infantile autism.

https://arctichealth.org/en/permalink/ahliterature141955
Source
Brain Dev. 2011 May;33(5):361-6
Publication Type
Article
Date
May-2011
Author
Svend Erik Mouridsen
Bente Rich
Torben Isager
Author Affiliation
Centre for Child and Adolescent Psychiatry, Bispebjerg University Hospital, Copenhagen, Denmark. Svend.Erik.Mouridsen@regionh.dk
Source
Brain Dev. 2011 May;33(5):361-6
Date
May-2011
Language
English
Publication Type
Article
Keywords
Adult
Autistic Disorder - epidemiology - physiopathology
Case-Control Studies
Central Nervous System Diseases - epidemiology
Child
Comorbidity
Denmark
Epilepsy - epidemiology
Female
Humans
Intelligence
Longitudinal Studies
Male
Middle Aged
Registries
Retrospective Studies
Risk factors
Abstract
To compare the prevalence and types of epilepsy and other central nervous system (CNS) diseases in a clinical sample of 118 individuals diagnosed as children with infantile autism (IA) with 336 matched controls from the general population.
All participants were screened through the nationwide Danish National Hospital Register (DNHR). The average observation time was 30.3years (range 27-30years), and mean age at follow-up was 42.7years (range 27-57years).
Of the 118 individuals with IA, 29 (24.6%) were registered with at least one epilepsy diagnosis against 5 (1.5%) in the comparison group (p
PubMed ID
20655678 View in PubMed
Less detail

The Sex Ratio of Full and Half Siblings of People Diagnosed With ADHD in Childhood and Adolescence: A Danish Nationwide Register-Based Cohort Study.

https://arctichealth.org/en/permalink/ahliterature287528
Source
J Atten Disord. 2016 Dec;20(12):1017-1022
Publication Type
Article
Date
Dec-2016
Author
Svend Erik Mouridsen
Bente Rich
Torben Isager
Source
J Atten Disord. 2016 Dec;20(12):1017-1022
Date
Dec-2016
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Attention Deficit Disorder with Hyperactivity - diagnosis - ethnology
Autism Spectrum Disorder - diagnosis - ethnology
Child
Child, Preschool
Cohort Studies
Denmark
European Continental Ancestry Group
Female
Humans
Male
Registries
Risk factors
Sex Factors
Sex ratio
Siblings
Abstract
It has been suggested that high levels of prenatal testosterone exposure are implied in the etiology of male preponderance disorders such as autism spectrum disorder and ADHD. Within this scope, we studied the sex ratio (proportion of males) in siblings of individuals diagnosed with ADHD in childhood and adolescence.
We did a nationwide, register-based cohort study of the sex ratio in siblings of the 16,381 patients in Denmark diagnosed with ADHD at age 17 years and younger and registered in the nationwide Danish Psychiatric Central Register between January 1, 1994 and May 28, 2013.
Among the 33,151 siblings, 17,041 were males and 16,110 females. This yields a sex ratio of 0.514, which is not statistically significant different from the Danish live birth sex ratio of 0.513 during the relevant years (p = .70).
These findings provide no support for the hypothesis that the sex ratio is elevated among the siblings of people with ADHD.
PubMed ID
24752665 View in PubMed
Less detail

The sex ratio of full and half siblings of people diagnosed with an autism spectrum disorder: a Danish Nationwide Register Study.

https://arctichealth.org/en/permalink/ahliterature266557
Source
Child Psychiatry Hum Dev. 2014 Oct;45(5):493-9
Publication Type
Article
Date
Oct-2014
Author
Svend Erik Mouridsen
Bente Rich
Torben Isager
Source
Child Psychiatry Hum Dev. 2014 Oct;45(5):493-9
Date
Oct-2014
Language
English
Publication Type
Article
Keywords
Adolescent
Child
Child Development Disorders, Pervasive - diagnosis - etiology
Child, Preschool
Cohort Studies
Denmark
Female
Humans
Infant
Male
Registries
Risk factors
Sex Factors
Sex ratio
Siblings
Abstract
In the extreme male brain theory of autism sex steroid hormones are hypothesized to influence brain development and to mediate sex differences in developmental psychopathology. Within this scope we examined the sex ratio (proportion of males) in siblings of individuals diagnosed with autism spectrum disorders (ASD). We did a nationwide, register based cohort study of the sex ratio in 17,380 siblings of the 10,297 patients diagnosed with ASD at age 17 years and younger and registered in the nationwide Danish Psychiatric Central Register between 1994 and 2012. Among the 17,380 siblings 8,828 were males and 8,552 females. This yields a sex ratio of 0.508, which is not different from the Danish live birth sex ratio of 0.513 during the relevant years (P = 0.18). Overall, our findings provide no support for the hypothesis that there are relatively more males among the siblings of people with ASD. Accordingly, our results do not give support to the extreme male brain theory of autism.
PubMed ID
24213328 View in PubMed
Less detail

Sibling sex ratio of individuals diagnosed with autism spectrum disorder as children.

https://arctichealth.org/en/permalink/ahliterature150117
Source
Dev Med Child Neurol. 2010 Mar;52(3):289-92
Publication Type
Article
Date
Mar-2010
Author
Svend Erik Mouridsen
Bente Rich
Torben Isager
Author Affiliation
Department of Child and Adolescent Psychiatry, Bispebjerg University Hospital, Copenhagen, Denmark. sem01@bbh.hosp.dk
Source
Dev Med Child Neurol. 2010 Mar;52(3):289-92
Date
Mar-2010
Language
English
Publication Type
Article
Keywords
Amniotic Fluid - chemistry
Asperger Syndrome - epidemiology - genetics - metabolism
Autistic Disorder - epidemiology - genetics - metabolism
Catchment Area (Health)
Child
Child, Preschool
Chromosomes, Human, X - genetics
Denmark - epidemiology
Female
Fetal Development
Humans
International Classification of Diseases
Male
Pregnancy
Prenatal Diagnosis - statistics & numerical data
Sex Distribution
Siblings
Testosterone - analysis - metabolism
Abstract
To study the sex ratio (proportion of males) in siblings of individuals diagnosed with autism spectrum disorders (ASDs) as children.
In the current study, we extended previous studies dealing with the androgen theory of autism and examined sex ratios in the siblings of 326 individuals with ASD (245 males, 81 females) who had been consecutively assessed at two Danish university clinics of child psychiatry during the 25-year period from 1960 to 1985.
Among the 513 siblings, 300 were males and 213 females. This yields a sex ratio of 0.585, which is significantly higher than the Danish live-birth sex ratio over the same period (0.514, p=0.001). The sibling sex ratio was not associated with the IQ in the autistic probands.
Our findings suggest a potential indirect confirmation of the androgen theory of autism.
Notes
Comment In: Dev Med Child Neurol. 2010 Mar;52(3):22819549192
PubMed ID
19549197 View in PubMed
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11 records – page 1 of 2.