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Effects of nitrate or nitro supplementation, with or without added chlorate, on Salmonella enterica serovar Typhimurium and Escherichia coli in swine feces.

https://arctichealth.org/en/permalink/ahliterature164812
Source
J Food Prot. 2007 Feb;70(2):308-15
Publication Type
Article
Date
Feb-2007
Author
Robin C Anderson
Yong S Jung
Christy E Oliver
Shane M Horrocks
Kenneth J Genovese
Roger B Harvey
Todd R Callaway
Thomas S Edrington
David J Nisbet
Author Affiliation
U.S. Department of Agriculture, Agricultural Research Service, Southern Plains Agricultural Research Center, Food and Feed Safety Research Unit, 2881 F&B Road, College Station, Texas, USA. anderson@ffsru.tamu.edu
Source
J Food Prot. 2007 Feb;70(2):308-15
Date
Feb-2007
Language
English
Publication Type
Article
Keywords
Animals
Chlorates - pharmacology
Colony Count, Microbial
Dose-Response Relationship, Drug
Drug Synergism
Escherichia coli - drug effects - growth & development
Feces - microbiology
Food contamination - analysis
Humans
Hydrogen-Ion Concentration
Nitrates - pharmacology
Nitro Compounds - pharmacology
Salmonella typhimurium - drug effects - growth & development
Swine
Abstract
The effects of coincubating the active agent of an experimental chlorate product with nitrate or select nitro compounds, possible inducers and competing substrates for the targeted respiratory nitrate reductase, on concentrations of experimentally inoculated Salmonella enterica serovar Typhimurium and indigenous Escherichia coli were determined. Studies were completed in swine fecal suspensions as a prelude to the administration of these inhibitors to pigs. Results confirmed the bactericidal effect of chlorate (5 to 10 mM) against these fecal enterobacteria, reducing (P 2 log CFU ml(-1) after 3 to 6 h of incubation. An effect (P
PubMed ID
17340863 View in PubMed
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