Skip header and navigation

Refine By

3 records – page 1 of 1.

Dietary acrylamide intake during pregnancy and fetal growth-results from the Norwegian mother and child cohort study (MoBa).

https://arctichealth.org/en/permalink/ahliterature118477
Source
Environ Health Perspect. 2013 Mar;121(3):374-9
Publication Type
Article
Date
Mar-2013
Author
Talita Duarte-Salles
Hans von Stedingk
Berit Granum
Kristine B Gützkow
Per Rydberg
Margareta Törnqvist
Michelle A Mendez
Gunnar Brunborg
Anne Lise Brantsæter
Helle Margrete Meltzer
Jan Alexander
Margaretha Haugen
Author Affiliation
Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway.
Source
Environ Health Perspect. 2013 Mar;121(3):374-9
Date
Mar-2013
Language
English
Publication Type
Article
Keywords
Acrylamide - administration & dosage - pharmacology
Cohort Studies
Diet
Environmental Exposure
Female
Fetal Development - drug effects
Hemoglobins - chemistry
Humans
Norway
Pregnancy
Questionnaires
Abstract
Acrylamide has shown developmental and reproductive toxicity in animals, as well as neurotoxic effects in humans with occupational exposures. Because it is widespread in food and can pass through the human placenta, concerns have been raised about potential developmental effects of dietary exposures in humans.
We assessed associations of prenatal exposure to dietary acrylamide with small for gestational age (SGA) and birth weight.
This study included 50,651 women in the Norwegian Mother and Child Cohort Study (MoBa). Acrylamide exposure assessment was based on intake estimates obtained from a food frequency questionnaire (FFQ), which were compared with hemoglobin (Hb) adduct measurements reflecting acrylamide exposure in a subset of samples (n = 79). Data on infant birth weight and gestational age were obtained from the Medical Birth Registry of Norway. Multivariable regression was used to estimate associations between prenatal acrylamide and birth outcomes.
Acrylamide intake during pregnancy was negatively associated with fetal growth. When women in the highest quartile of acrylamide intake were compared with women in the lowest quartile, the multivariable-adjusted odds ratio (OR) for SGA was 1.11 (95% CI: 1.02, 1.21) and the coefficient for birth weight was -25.7 g (95% CI: -35.9, -15.4). Results were similar after excluding mothers who smoked during pregnancy. Maternal acrylamide- and glycidamide-Hb adduct levels were correlated with estimated dietary acrylamide intakes (Spearman correlations = 0.24; 95% CI: 0.02, 0.44; and 0.48; 95% CI: 0.29, 0.63, respectively).
Lowering dietary acrylamide intake during pregnancy may improve fetal growth.
Notes
Cites: Scand J Work Environ Health. 2001 Aug;27(4):219-2611560335
Cites: Paediatr Perinat Epidemiol. 2009 Nov;23(6):597-60819840297
Cites: Trends Endocrinol Metab. 2002 Nov;13(9):364-812367816
Cites: Chemotherapy. 2002;48(6):267-7412673101
Cites: Toxicol Sci. 2003 Sep;75(1):7-1512805639
Cites: Int Arch Occup Environ Health. 2004 Apr;77(3):213-614740221
Cites: IARC Monogr Eval Carcinog Risks Hum. 1994;60:389-4337869577
Cites: Chem Res Toxicol. 1997 Jan;10(1):78-849074806
Cites: Mutat Res. 2005 Feb 7;580(1-2):3-2015668103
Cites: Food Chem Toxicol. 2005 Mar;43(3):365-41015680675
Cites: Birth Defects Res B Dev Reprod Toxicol. 2005 Feb;74(1):17-11315729727
Cites: Crit Rev Toxicol. 2006 Jul-Aug;36(6-7):481-60816973444
Cites: Int J Epidemiol. 2006 Oct;35(5):1146-5016926217
Cites: Toxicol Sci. 2007 Jul;98(1):110-717449897
Cites: Matern Child Nutr. 2008 Jan;4(1):14-2718171404
Cites: J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 1;878(27):2483-9020399714
Cites: Food Chem Toxicol. 2011 Aug;49(8):1843-821571030
Cites: Int J Epidemiol. 2011 Jun;40(3):647-6121324938
Cites: Chem Res Toxicol. 2011 Nov 21;24(11):1957-6521882862
Cites: Int J Hyg Environ Health. 2012 Feb;215(2):216-921937271
Cites: Food Chem Toxicol. 2012 Jul;50(7):2531-922525869
Cites: Environ Health Perspect. 2012 Dec;120(12):1739-4523092936
Cites: Food Chem Toxicol. 2010 Nov;48(11):3098-10820696196
Cites: Nutrition. 2011 Mar;27(3):343-5021329872
Cites: Am J Clin Nutr. 2000 May;71(5 Suppl):1344S-52S10799412
Cites: Acta Obstet Gynecol Scand. 2000 Jun;79(6):435-910857866
Cites: Acta Obstet Gynecol Scand. 2000 Jun;79(6):440-910857867
Cites: Chem Res Toxicol. 2000 Jun;13(6):517-2210858325
Cites: Semin Neonatol. 2000 Aug;5(3):231-4110956448
Cites: Matern Child Nutr. 2008 Jan;4(1):28-4318171405
Cites: Eur J Clin Nutr. 2008 Mar;62(3):314-2317356560
Cites: Cancer Causes Control. 2008 Apr;19(3):273-8117985202
Cites: Mutat Res. 2008 May 31;653(1-2):50-618485803
Cites: Food Chem Toxicol. 2008 Aug;46(8):2808-1418599176
Cites: Toxicol Lett. 2008 Nov 10;182(1-3):50-618790027
Cites: Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):5-1019124475
Cites: Toxicol Sci. 2009 Mar;108(1):90-919131562
Cites: Am J Clin Nutr. 2009 Mar;89(3):773-719158207
Cites: Cancer Causes Control. 2009 Apr;20(3):269-7818855107
Cites: Int J Cancer. 2009 May 15;124(10):2384-9019142870
Cites: J Agric Food Chem. 2002 Aug 14;50(17):4998-500612166997
PubMed ID
23204292 View in PubMed
Less detail

Dietary benzo(a)pyrene intake during pregnancy and birth weight: associations modified by vitamin C intakes in the Norwegian Mother and Child Cohort Study (MoBa).

https://arctichealth.org/en/permalink/ahliterature107027
Source
Environ Int. 2013 Oct;60:217-23
Publication Type
Article
Date
Oct-2013
Author
Talita Duarte-Salles
Michelle A Mendez
Helle Margrete Meltzer
Jan Alexander
Margaretha Haugen
Author Affiliation
Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway. Electronic address: duartesallest@fellows.iarc.fr.
Source
Environ Int. 2013 Oct;60:217-23
Date
Oct-2013
Language
English
Publication Type
Article
Keywords
Adult
Ascorbic Acid - pharmacology
Benzo(a)pyrene - administration & dosage - analysis - toxicity
Birth Weight - drug effects
Child
Cohort Studies
Diet - statistics & numerical data
Female
Fetal Development - drug effects
Food - classification
Food Contamination - analysis - statistics & numerical data
Heredodegenerative Disorders, Nervous System - chemically induced
Humans
Infant
Maternal Exposure - statistics & numerical data
Microphthalmos - chemically induced
Multivariate Analysis
Mutagenicity Tests
Norway - epidemiology
Parity
Polycyclic Hydrocarbons, Aromatic - toxicity
Pregnancy
Pregnancy Outcome - epidemiology
Prenatal Exposure Delayed Effects - epidemiology
Abstract
Maternal exposure to polycyclic aromatic hydrocarbons (PAH) during pregnancy has been associated with reduced fetal growth. However, the role of diet, the main source of PAH exposure among non-smokers, remains uncertain.
To assess associations between maternal exposure to dietary intake of the genotoxic PAH benzo(a)pyrene [B(a)P] during pregnancy and birth weight, exploring potential effect modification by dietary intakes of vitamins C, E and A, hypothesized to influence PAH metabolism.
This study included 50,651 women in the Norwegian Mother and Child Cohort Study (MoBa). Dietary B(a)P and nutrient intakes were estimated based on total consumption obtained from a food frequency questionnaire (FFQ) and estimated based on food composition data. Data on infant birth weight were obtained from the Medical Birth Registry of Norway (MBRN). Multivariate regression was used to assess associations between dietary B(a)P and birth weight, evaluating potential interactions with candidate nutrients.
The multivariate-adjusted coefficient (95%CI) for birth weight associated with maternal energy-adjusted B(a)P intake was -20.5g (-31.1, -10.0) in women in the third compared with the first tertile of B(a)P intake. Results were similar after excluding smokers. Significant interactions were found between elevated intakes of vitamin C (>85mg/day) and dietary B(a)P during pregnancy for birth weight (P
PubMed ID
24071023 View in PubMed
Less detail

Maternal dietary intake of dioxins and polychlorinated biphenyls and birth size in the Norwegian Mother and Child Cohort Study (MoBa).

https://arctichealth.org/en/permalink/ahliterature107028
Source
Environ Int. 2013 Oct;60:209-16
Publication Type
Article
Date
Oct-2013
Author
Eleni Papadopoulou
Ida H Caspersen
Helen E Kvalem
Helle K Knutsen
Talita Duarte-Salles
Jan Alexander
Helle Margrete Meltzer
Manolis Kogevinas
Anne Lise Brantsæter
Margaretha Haugen
Author Affiliation
Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway; Pompeu Fabra University, Barcelona, Spain. Electronic address: eleni.papadopoulou@fhi.no.
Source
Environ Int. 2013 Oct;60:209-16
Date
Oct-2013
Language
English
Publication Type
Article
Keywords
Adult
Animals
Birth weight
Cohort Studies
Dioxins - analysis
Eating
Female
Fetal Development
Food contamination - analysis
Humans
Infant, Newborn
Male
Maternal Exposure - statistics & numerical data
Norway - epidemiology
Polychlorinated biphenyls - analysis
Pregnancy
Pregnancy Outcome - epidemiology
Prenatal Exposure Delayed Effects - epidemiology
Regression Analysis
Seafood - analysis
Tetrachlorodibenzodioxin - analysis
Young Adult
Abstract
Maternal diet not only provides essential nutrients to the developing fetus but is also a source of prenatal exposure to environmental contaminants. We investigated the association between dietary intake of dioxins and PCBs during pregnancy and birth size. The study included 50,651 women from the Norwegian Mother and Child Cohort Study (MoBa). Dietary information was collected by FFQs and intake estimates were calculated by combining food consumption and food concentration of dioxins, dioxin-like PCBs and non-dioxin-like PCBs. We used multivariable regression models to estimate the association between dietary intake of dioxins and PCBs and fetal growth. The contribution of fish and seafood intake during pregnancy was 41% for dietary dioxins and dioxin-like PCBs and 49% for dietary non-dioxin-like PCBs. Further stratified analysis by quartiles of seafood intake during pregnancy was conducted. We found an inverse dose-response association between dietary intake of dioxins and PCBs and fetal growth after adjustment for confounders. Newborns of mothers in the upper quartile of dioxin and dioxin-like PCBs intake had 62g lower birth weight (95% CI: -73, -50), 0.26cm shorter birth length (95% CI: -0.31, -0.20) and 0.10cm shorter head circumference (95% CI: -0.14, -0.06) than newborns of mothers in the lowest quartile of intake. Similar negative associations for intake of dioxins and dioxin-like PCBs were found after excluding women with intakes above the tolerable weekly intake (TWI=14pg TEQ/kg bw/week). The negative association of dietary dioxins and PCBs with fetal growth was weaker as seafood intake was increasing. No association was found between dietary dioxin and PCB intake and the risk for small-for-gestational age neonate. In conclusion, dietary intakes of dioxins and PCBs during pregnancy were negatively associated with fetal growth, even at intakes below the TWI.
PubMed ID
24071022 View in PubMed
Less detail