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7-year stability of blood pressure in the Canadian population.

https://arctichealth.org/en/permalink/ahliterature197147
Source
Prev Med. 2000 Oct;31(4):403-9
Publication Type
Article
Date
Oct-2000
Author
P T Katzmarzyk
T. Rankinen
L. Pérusse
R M Malina
C. Bouchard
Author Affiliation
Department of Kinesiology and Health Science, York University, North York, Ontario, Canada M3J IP3. katzmarz@yorku.ca
Source
Prev Med. 2000 Oct;31(4):403-9
Date
Oct-2000
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Distribution
Aged
Aging - physiology
Blood Pressure - physiology
Body mass index
Canada - epidemiology
Child
Female
Follow-Up Studies
Humans
Hypertension - epidemiology
Incidence
Male
Middle Aged
Prevalence
Retrospective Studies
Risk factors
Sex Distribution
Abstract
The purpose of the study was to examine the 7-year stability of systolic (SBP) and diastolic (DBP) blood pressures in the Canadian population.
The sample included 1,503 participants 7-69 years of age from the 1981 Canada Fitness Survey who were remeasured in Campbell's Survey of 1988. Both SBP and DBP were adjusted for the effects of body mass index (BMI) using regression procedures.
Interage correlations from baseline to follow-up ranged from -0.17 to 0.61 for SBP and from -0.22 to 0. 51 for DBP. With few exceptions, correlations were positive and significant, and were highest and most consistent in adulthood. Further, between 27 and 39% of participants in the upper or lower quintiles in 1981 remained there in 1988. There were few differences in adiposity between those who remained in the upper or lower quintiles and those who did not. One exception was that males who remained in the upper quintile of SBP had greater values for BMI, sum of skinfolds, and waist circumference at baseline. Among adults, the best predictor of future blood pressure was baseline blood pressure, which accounted for between 12 and 34% of the variance in follow-up blood pressure, followed by age, follow-up BMI, and, in females, baseline physical activity levels.
Blood pressure demonstrated low to moderate stability over 7 years in Canada, and baseline level of adiposity was related to the stability of SBP in males.
PubMed ID
11006066 View in PubMed
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AGT M235T and ACE ID polymorphisms and exercise blood pressure in the HERITAGE Family Study.

https://arctichealth.org/en/permalink/ahliterature197889
Source
Am J Physiol Heart Circ Physiol. 2000 Jul;279(1):H368-74
Publication Type
Article
Date
Jul-2000
Author
T. Rankinen
J. Gagnon
L. Pérusse
Y C Chagnon
T. Rice
A S Leon
J S Skinner
J H Wilmore
D C Rao
C. Bouchard
Author Affiliation
Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808, USA.
Source
Am J Physiol Heart Circ Physiol. 2000 Jul;279(1):H368-74
Date
Jul-2000
Language
English
Publication Type
Article
Keywords
Adult
Amino Acid Substitution
Angiotensinogen - genetics
Blood Pressure - genetics - physiology
Canada
Cohort Studies
DNA Transposable Elements
Diastole
European Continental Ancestry Group
Exercise - physiology
Female
Genotype
Humans
Male
Oxygen consumption
Peptidyl-Dipeptidase A - genetics
Physical Exertion - physiology
Polymorphism, Genetic
Sequence Deletion
Sex Characteristics
Systole
United States
Abstract
We investigated the association between angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) gene polymorphisms and exercise training responses of resting and exercise blood pressure (BP). BP at rest and during submaximal (50 watts) and maximal exercise tests was measured before and after 20 wk of endurance training in 476 sedentary normotensive Caucasian subjects from 99 families. AGT M235T and ACE insertion/deletion polymorphisms were typed with PCR-based methods. Men carrying the AGT MM and MT genotypes showed 3. 7 +/- 0.6 and 3.2 +/- 0.5 (SE) mmHg reductions, respectively, in diastolic BP at 50 watts (DBP(50)), whereas, in the TT homozygotes, the decrease was 0.4 +/- 1.0 mmHg (P = 0.016 for trend, adjusted for age, body mass index, and baseline DBP(50)). Men with the ACE DD genotype showed a slightly greater decrease in DBP(50) (4.4 +/- 0.6 mmHg) than the II and ID genotypes (2.8 +/- 0.7 and 2.4 +/- 0.5 mmHg, respectively, P = 0.050). Furthermore, a significant (P = 0.022) interaction effect between the AGT and ACE genes was noted for DBP(50); the AGT TT homozygotes carrying the ACE D allele showed no response to training. Men with the AGT TT genotype had greater (P = 0.007) diastolic BP (DBP) response to acute maximal exercise at baseline. However, the difference disappeared after the training period. No associations were found in women. These data suggest that, in men, the genetic variation in the AGT locus modifies the responsiveness of submaximal exercise DBP to endurance training, and interactions between the AGT and ACE loci can alter this response.
PubMed ID
10899077 View in PubMed
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Apolipoprotein(a), fibrinopeptide A and carotid atherosclerosis in middle-aged men.

https://arctichealth.org/en/permalink/ahliterature217223
Source
Thromb Haemost. 1994 Oct;72(4):563-6
Publication Type
Article
Date
Oct-1994
Author
T. Rankinen
S. Väisänen
M. Mercuri
R. Rauramaa
Author Affiliation
Kuopio Research Institute of Exercise Medicine, Finland.
Source
Thromb Haemost. 1994 Oct;72(4):563-6
Date
Oct-1994
Language
English
Publication Type
Article
Keywords
Anthropometry
Apolipoproteins - analysis
Apoprotein(a)
Arteriosclerosis - blood - epidemiology
Blood pressure
Carotid Arteries - anatomy & histology
Carotid Artery Diseases - blood - epidemiology
Carotid Artery, Common - anatomy & histology
Carotid Stenosis - epidemiology
Cohort Studies
Diet
Fibrinopeptide A - analysis
Finland - epidemiology
Humans
Lipids - blood
Lipoprotein(a)
Male
Middle Aged
Muscle, Smooth, Vascular - ultrastructure
Risk factors
Smoking
Abstract
The association between apolipoprotein(a) [apo(a)], fibrinogen, fibrinopeptide A (FPA) and carotid intima-media thickness (IMT) was analyzed in Eastern Finnish men aged 50 to 60 years. Apo(a) correlated directly with carotid bifurcation (r = 0.26, p = 0.001), but not with common carotid IMT. Men in the lowest quartile of apo(a) had thinner (p = 0.013) IMT in bifurcation [1.59 mm (95% CI 1.49; 1.68)] compared to the men in the highest [1.91 mm (95% CI 1.73; 2.09)] apo(a) quartile. The difference remained (p = 0.038) after adjusting for confounders. Plasma fibrinogen was not related to carotid IMT, whereas FPA correlated with common carotid (r = 0.21, p = 0.016) and carotid bifurcation (r = 0.21, p = 0.018) IMT. These associations abolished after adjusting for the confounders. The data suggest that apo(a) associate with carotid atherosclerosis independent of other risk factors for ischemic cardiovascular diseases.
Notes
Comment In: Thromb Haemost. 1995 Aug;74(2):799-8008585028
PubMed ID
7878633 View in PubMed
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Association of risk factors and body iron status to carotid atherosclerosis in middle-aged eastern Finnish men.

https://arctichealth.org/en/permalink/ahliterature217619
Source
Eur Heart J. 1994 Aug;15(8):1020-7
Publication Type
Article
Date
Aug-1994
Author
R. Rauramaa
S. Väisänen
M. Mercuri
T. Rankinen
I. Penttila
M G Bond
Author Affiliation
Kuopio Research Institute of Exercise Medicine, Finland.
Source
Eur Heart J. 1994 Aug;15(8):1020-7
Date
Aug-1994
Language
English
Publication Type
Article
Keywords
Carotid Stenosis - blood - epidemiology - ultrasonography
Cohort Studies
Coronary Artery Disease - blood - epidemiology - ultrasonography
Cross-Cultural Comparison
Cross-Sectional Studies
Exercise Test
Ferritins - blood
Finland - epidemiology
Humans
Intracranial Arteriosclerosis - blood - epidemiology - ultrasonography
Iron - blood
Life Style
Male
Middle Aged
Myocardial Infarction - blood - epidemiology - ultrasonography
Risk factors
Tunica Intima - ultrasonography
Tunica Media - ultrasonography
Abstract
High body iron stores have been proposed as a risk factor for advanced atherosclerosis. We investigated the prevalence of early atherosclerotic changes, and their relation to conventional CHD risk factors and body iron status. A cross-sectional study was carried out in 206 men aged 50 to 60 years (6% random population sample). Intima-media thickness (IMT) of the carotid artery was evaluated with high-resolution B-mode ultrasonography. Statistical analyses were performed separately for men with and without cardiovascular disease (CVD). Among all the study participants, 6.6% had IMT > 1.3 mm in the common carotid artery, whereas 53.8% had IMT > 1.5 mm in the carotid bifurcation. Respective values were 4.8% and 46.8% for those without CVD, and 8.5% and 62.2% for those with CVD. Mean IMT in the carotid bifurcation, the predilection site for atherosclerosis, was 1.85 mm (95% CI 1.72; 1.98) in the men with CVD, as compared to 1.65 mm (95% CI 1.56; 1.73) in the men free of CVD. Serum LDL cholesterol (beta = 0.26), saturated fat intake (beta = 0.20), blood haemoglobin (beta = -0.29), systolic blood pressure (beta = 0.21) and smoking (beta = 0.19), jointly explained 23% of the variance in the carotid bifurcation IMT in the men without CVD. Neither serum ferritin, transferrin nor dietary iron levels were associated with carotid bifurcation atherosclerosis. On the other hand, in the men with CVD, age (beta = 0.34) and physical activity (beta = -0.25) jointly explained 16.5% of the IMT variance in the carotid bifurcation.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
7988592 View in PubMed
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Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases.

https://arctichealth.org/en/permalink/ahliterature141350
Source
Int J Obes (Lond). 2011 May;35(5):676-83
Publication Type
Article
Date
May-2011
Author
M A Sarzynski
P. Jacobson
T. Rankinen
B. Carlsson
L. Sjöström
C. Bouchard
L M S Carlsson
Author Affiliation
Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Source
Int J Obes (Lond). 2011 May;35(5):676-83
Date
May-2011
Language
English
Publication Type
Article
Keywords
Adult
Bariatric Surgery - methods
Female
Genetic Association Studies
Genetic Markers - genetics
Genetic Variation
Humans
Male
Middle Aged
Obesity, Morbid - genetics - metabolism - surgery
Polymorphism, Single Nucleotide - genetics
Prospective Studies
Sweden
Weight Gain - genetics
Weight Loss - genetics
Abstract
To test whether DNA sequence variation in 11 obesity genes is associated with maximum weight loss and weight regain over 6 years of follow-up in bariatric surgery patients of the Swedish obese subjects (SOS) intervention study.
A total of 1443 subjects were available for analysis (vertical banded gastroplasty: n = 966, banding: n = 293 and gastric bypass: n = 184). Single-nucleotide polymorphisms (SNPs) from the following 11 genes were included: ADIPOQ, BDNF, FTO, GNB3, LEP, LEPR, MC4R, NR3C1, PPARG, PPARGC1A and TNF. General linear models were used to analyze associations between the SNPs and maximum weight loss and weight regain.
The average maximum weight loss was 33.7 kg (s.d. 13.3; min -95.5 kg, max +2.0 kg), which was reached 2.2 (s.d. 1.6) years after the surgery. Subjects regained approximately 12 kg (range 0.0-51.4 kg) by year 6. After correcting for multiple testing, the FTO SNP rs16945088 remained significantly associated with maximum weight loss (P = 0.0002), as minor allele carriers lost approximately 3 kg less compared with common allele homozygotes. This association was particularly evident in the banding surgery patients (P
Notes
Erratum In: Int J Obes (Lond). 2012 Jul;36(7):1016
PubMed ID
20733583 View in PubMed
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Does aging mean a better life for women?

https://arctichealth.org/en/permalink/ahliterature208595
Source
J Am Geriatr Soc. 1997 May;45(5):594-7
Publication Type
Article
Date
May-1997
Author
M K Eronen
T. Rankinen
R. Rauramaa
R. Sulkava
A. Nissinen
Author Affiliation
Department of Community Health and General Practice, University of Kuopio, Finland.
Source
J Am Geriatr Soc. 1997 May;45(5):594-7
Date
May-1997
Language
English
Publication Type
Article
Keywords
Activities of Daily Living
Aging - physiology - psychology
Cohort Studies
Female
Finland
Follow-Up Studies
Health status
Humans
Middle Aged
Personal Satisfaction
Physical Fitness
Quality of Life
Self Disclosure
Women's health
Abstract
To study 10-year changes in selected quality of life dimensions in a cohort of aging Eastern Finnish women.
Ten-year follow-up of a representative population sample.
The county of Kuopio in Eastern Finland.
In 1982, a representative sample (n = 296) of 50 to 60-year-old women was examined in the FIN-MONICA study. Ten years later, 241 of the participants were re-examined.
Self-administered questionnaires were used to collect the data. Self-rated health, self-rated physical fitness, frequency of leisure time physical activity, functional capacity, reported symptoms, occurrence of diseases, and satisfaction with family life and economic situation were measured. In 1992, total life satisfaction at that moment and 5 years earlier were also assessed.
The self-rated health assessment remained unchanged. During the 10 years from 1982 to 1992, the proportion of women who reported diagnosed cardiopulmonary diseases increased; angina pectoris, in particular, increased from 6% to 20%. However, even though their running ability had decreased, the number of women rating their physical fitness as good or fairly good increased from 23% to 32%. The participants reported significantly less headache and feelings of exhaustion than they had 10 years earlier. Average satisfaction with their economic situation increased, and satisfaction with family life remained the same. Thirty-seven percent of the women rated their current life situation as better than 5 years previously, 29% felt that it had remained the same, and 34% indicated that it had become worse during the past 5 years.
These data suggest that some quality of life dimensions may improve during aging in postmenopausal women.
PubMed ID
9158581 View in PubMed
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Factor VII coagulant activity in relation to serum lipoproteins and dietary fat in middle-aged men.

https://arctichealth.org/en/permalink/ahliterature215748
Source
Thromb Haemost. 1995 Mar;73(3):435-8
Publication Type
Article
Date
Mar-1995
Author
S. Väisänen
T. Rankinen
I. Penttilä
R. Rauramaa
Author Affiliation
Kuopio Research Institute of Exercise Medicine, Finland.
Source
Thromb Haemost. 1995 Mar;73(3):435-8
Date
Mar-1995
Language
English
Publication Type
Article
Keywords
Antigens - analysis
Apolipoprotein A-II - blood
Apolipoproteins B - blood
Body mass index
Cardiovascular Diseases - blood - epidemiology
Cholesterol - blood
Cohort Studies
Dietary Fats
Factor VII - analysis
Finland - epidemiology
Food Habits
Humans
Lipoproteins - blood
Male
Middle Aged
Multivariate Analysis
Risk factors
Smoking - blood
Triglycerides - blood
Abstract
The associations of serum lipoproteins and habitual diet to factor VII coagulant activity (FVIIc) were analysed in 119 middle-aged men. FVIIc was measured by one-stage clotting assay, cholesterol and triglycerides enzymatically, serum apolipoproteins (apo) immunoturbidimetrically and habitual diet using four-day food records. ApoB, cholesterol, triglycerides, apoA-II, LDL cholesterol and dietary fat correlated directly to FVIIc (p 38 E%), in the middle tertile FVIIc increased gradually from low to high fat intake, whereas in the highest apoB tertile FVIIc was not related to dietary fat (p = 0.038 for age-adjusted interaction). The present data demonstrate a direct relation between apoB and FVIIc in middle-aged men. Low fat diet seem to associate to decreased FVIIc especially in subjects in the lower end of the apoB distribution.
PubMed ID
7667825 View in PubMed
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Familial risk of high blood pressure in the Canadian population.

https://arctichealth.org/en/permalink/ahliterature193697
Source
Am J Hum Biol. 2001 Sep-Oct;13(5):620-5
Publication Type
Article
Author
P T Katzmarzyk
T. Rankinen
L. Pérusse
D C Rao
C. Bouchard
Author Affiliation
School of Kinesiology and Health Science, York University, North York, Ontario, Canada. katzmarz@yorku.ca
Source
Am J Hum Biol. 2001 Sep-Oct;13(5):620-5
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Body mass index
Canada - epidemiology
Child
Female
Humans
Hypertension - epidemiology - genetics
Male
Middle Aged
Prevalence
Regression Analysis
Risk factors
Abstract
Familial risk ratios for high blood pressure were estimated in a representative sample of the Canadian population. The sample consisted of 14,069 participants 7-69 years of age from 5,753 families participating in the 1981 Canada Fitness Survey. Resting systolic (SBP) and diastolic (DBP) blood pressures were adjusted for the effects of body mass index using regression procedures. Varying degrees of high blood pressure were defined as the 75(th), 85(th), and 95(th) percentiles of age- and sex-specific values. Age- and sex-standardized risk ratios (SRRs) were calculated comparing the prevalences in the general population to those in spouses and first-degree relatives of probands with high blood pressure. SRRs for the 95(th) percentile were, for SBP and DBP, respectively, 1.37 and 1.45 in spouses and 1.33 and 2.36 in first-degree relatives of probands. SRRs decrease with decreasing percentile cut-offs used to define high blood pressure (95(th) > 85(th) > 75(th)), and SRRs are generally higher in first-degree relatives than in spouses, particularly for DBP. The results indicate significant familial risk for high blood pressure in the Canadian population, and the pattern of SRRs suggests that genetic factors may be responsible for a portion of the risk.
PubMed ID
11505470 View in PubMed
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Genome-wide linkage analysis of systolic and diastolic blood pressure: the Qu├ębec Family Study.

https://arctichealth.org/en/permalink/ahliterature196922
Source
Circulation. 2000 Oct 17;102(16):1956-63
Publication Type
Article
Date
Oct-17-2000
Author
T. Rice
T. Rankinen
M A Province
Y C Chagnon
L. Pérusse
I B Borecki
C. Bouchard
D C Rao
Author Affiliation
Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA. treva@wubios.wustl.edu
Source
Circulation. 2000 Oct 17;102(16):1956-63
Date
Oct-17-2000
Language
English
Publication Type
Article
Keywords
Age Distribution
Aged
Blood Pressure - genetics
Body mass index
Chromosome Mapping
Diastole - genetics
Female
Genetic Linkage
Genetic Variation
Genome, Human
Humans
Hypertension - epidemiology - genetics
Lod Score
Male
Microsatellite Repeats
Middle Aged
Obesity - epidemiology - genetics
Physical Chromosome Mapping
Polymorphism, Restriction Fragment Length
Quantitative Trait, Heritable
Quebec - epidemiology
Regression Analysis
Sex Distribution
Systole - genetics
Abstract
Blood pressure (BP), an important risk factor for coronary heart disease, is a complex trait with multiple genetic etiologies. While some loci affecting BP variation are known (eg, angiotensinogen), there are likely to be novel signals that can be detected with a genome scan approach.
A genome-wide scan was performed in 125 random and 81 obese families participating in the Québec Family Study. A multipoint variance-components linkage analysis of 420 markers (353 microsatellites and 67 restriction fragment length polymorphisms) revealed several signals (P:
Notes
Comment In: Circulation. 2000 Oct 17;102(16):1877-811034931
PubMed ID
11034945 View in PubMed
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Is adiposity at normal body weight relevant for cardiovascular disease risk?

https://arctichealth.org/en/permalink/ahliterature191474
Source
Int J Obes Relat Metab Disord. 2002 Feb;26(2):176-83
Publication Type
Article
Date
Feb-2002
Author
S. Tanaka
K. Togashi
T. Rankinen
L. Pérusse
A S Leon
D C Rao
J S Skinner
J H Wilmore
C. Bouchard
Author Affiliation
Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808-4124, USA.
Source
Int J Obes Relat Metab Disord. 2002 Feb;26(2):176-83
Date
Feb-2002
Language
English
Publication Type
Article
Keywords
Adipose Tissue
Adolescent
Adult
Blood glucose
Blood pressure
Body Composition
Body mass index
Body Weight
Cardiovascular Diseases - epidemiology - etiology
Case-Control Studies
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cross-Sectional Studies
Female
Humans
Logistic Models
Male
Middle Aged
Obesity - complications
Odds Ratio
Prevalence
Quebec - epidemiology
Risk factors
Triglycerides
Abstract
To examine the relation between adiposity and risk factors for cardiovascular disease (CVD) in normal weight (NW) individuals.
Cross-sectional study using the sample of white people, aged from 17 to 60 y from the Québec Family Study and the Heritage Family Study. NW subjects with a body mass index (BMI) between 18.5 and 25 kg/m(2) (181 males and 265 females) and overweight (OW) subjects with a BMI between 25 and 30 kg/m(2) (133 males and 114 females) were retained for this study. NW subjects were divided into quintiles of each adiposity variable, then the quintiles and the OW group were evaluated for the presence of CVD risk factors. Using logistic regression analysis, the odds ratio (OR) for the prevalence of risk factors for each quintile of each adiposity variable and the OW group was estimated relative to the first quintile in NW subjects. Mean values of adiposity variables were compared between the subjects with and without risk factors. In these analyses, age and study cohort effects were taken into account.
Percentage body fat (%fat) and fat mass (FM) measured by underwater weighing were available as adiposity variables. Risk factors included systolic and diastolic blood pressure, LDL and HDL cholesterol, triglycerides and fasting glucose.
Wide ranges of values were observed for adiposity variables. HDL cholesterol, triglycerides and fasting glucose in NW males and HDL cholesterol in NW females were significantly correlated with all adiposity variables. For males, higher quintiles of adiposity variables in the NW group and the OW group tended to have higher ORs compared to the first quintiles for the risk factor variables. The fifth quintiles of all adiposity variables had the highest ORs (3.15 for %fat and 3.77 for FM) and they were significantly different from the first quintiles. OW males had ORs similar to those of the fifth quintiles for the risk factor variables. On the other hand, for females, the relatively linear associations were less clear in the NW group. In NW males, the subjects with at least one risk factor had significantly higher %fat and FM than the subjects without risk factors. In NW females, no significant difference was observed for these adiposity variables between the subjects with and without risk factors.
NW males with elevated adiposity had higher prevalence of risk factors than NW males with less adiposity and the prevalence in the former was rather similar to that seen in OW males. On the other hand, measures of adiposity added little additional information to the BMI classification of NW on CVD risk factors in females.
PubMed ID
11850748 View in PubMed
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21 records – page 1 of 3.