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Cardiovascular and electrocardiographic effects of iopentol in left ventricular angiography. Comparison of the low-osmolar, non-ionic iopentol (Imagopaque 350) and the hyper-osmolar, ionic metrizoate meglumine-Na-Ca (Isopaque Coronar 370) in patients with coronary heart disease.

https://arctichealth.org/en/permalink/ahliterature54580
Source
Eur Radiol. 1997;7 Suppl 4:S156-61
Publication Type
Article
Date
1997
Author
H. Vik-Mo
R. Danielsen
K. Skinningsrud
T. Haider
A. Bjørkhaug
Author Affiliation
Division of Cardiology, University Hospital Trondheim, Norway.
Source
Eur Radiol. 1997;7 Suppl 4:S156-61
Date
1997
Language
English
Publication Type
Article
Keywords
Angiocardiography
Contrast Media - adverse effects
Coronary Disease - radiography
Double-Blind Method
Electrocardiography - drug effects
Female
Hemodynamic Processes - drug effects
Humans
Male
Metrizoate - adverse effects - analogs & derivatives - diagnostic use
Middle Aged
Safety
Triiodobenzoic Acids - adverse effects - diagnostic use
Ventricular Dysfunction, Left - radiography
Abstract
The aim of the study was to evaluate and compare the hemodynamic and electrocardiographic effects following injection of the non-ionic, low-osmolar contrast medium iopentol (Imagopaque 350, Nycomed Imaging AS, Oslo, Norway) and the ionic, hyper-osmolar contrast medium metrizoate meglumine-Na-Ca (Isopaque Coronar 370, Nycomed Imaging AS, Oslo, Norway) when used for left ventricular angiography. The study was performed in a double-blind, randomized manner in 82 patients with severe coronary heart disease. The patients who received iopentol experienced less adverse events and subjective discomfort of lesser intensity than those who received metrizoate (p = 0.0001). Both contrast media induced a biphasic change in left ventricular (LV) systolic pressure, with an initial fall followed by a prolonged rise, but the alterations were statistically significantly more pronounced with metrizoate than with iopentol. The changes in LV end-diastolic pressure (p = 0.023), and LV negative dP/dt (p = 0.002) were significantly more pronounced with metrizoate than with iopentol. Cardiac output and heart rate increased more with metrizoate, while stroke volume was equally increased by both agents. A prolonged increase in the QT-interval, throughout the 10-min observation period, was seen only after injection of metrizoate (p = 0.0006 for comparison between contrast media). CONCLUSION: Iopentol was well tolerated and induced markedly less severe hemodynamic and electrocardiographic alterations than did metrizoate in patients with severe coronary heart disease.
PubMed ID
9204361 View in PubMed
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Copper and zinc in human serum in Norway. Relationship to geography, sex and age.

https://arctichealth.org/en/permalink/ahliterature243476
Source
Scand J Clin Lab Invest. 1982 Feb;42(1):35-9
Publication Type
Article
Date
Feb-1982
Author
K. Helgeland
T. Haider
J. Jonsen
Source
Scand J Clin Lab Invest. 1982 Feb;42(1):35-9
Date
Feb-1982
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Copper - blood
Female
Humans
Male
Middle Aged
Norway
Sex Factors
Spectrophotometry, Atomic
Statistics as Topic
Zinc - blood
Abstract
Serum samples were collected from the adult population, age groups from 20 to 54 years, in 11 different Norwegian municipalities and analysed for zinc and copper by atomic absorption spectroscopy. Significant differences were found between several of the municipalities when the mean concentration of zinc in serum in 200 randomized samples were compared, with only two municipalities being different for copper. The values for zinc ranged from 13.8 to 18.3 mumol/l and copper varied between 16.3 and 19.2 mumol/l. An age related increase in the copper concentration was evident in the male population, and age-adjusted means showed a slight, but significantly higher serum copper concentration in females (18.4 mumol/l) than in males (16.5 mumol/l). For zinc the opposite sex-relationship was indicated with the highest values in males, 15.8 compared to 15.1 mumol/l in serum from females. No significant correlations were found between the concentrations of zinc and copper in serum. In all age groups of women, however, a small negative correlation was found giving a significant tendency.
PubMed ID
7134789 View in PubMed
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Intervention on cardiovascular disease risk factors in Finnmark county: changes after a period of three years. The Cardiovascular Disease Study in Finnmark County, Norway.

https://arctichealth.org/en/permalink/ahliterature53003
Source
Scand J Soc Med. 1985;13(1):1-13
Publication Type
Article
Date
1985
Author
S. Tretli
K. Bjartveit
O P Foss
T. Haider
P G Lund-Larsen
Source
Scand J Soc Med. 1985;13(1):1-13
Date
1985
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Blood pressure
Cardiovascular Diseases - etiology - prevention & control
Cholesterol - blood
Diet
Female
Health education
Humans
Male
Middle Aged
Risk
Smoking
Abstract
In Finnmark county in Norway, 12 329 males and females aged 20-49 years participated in two screening examinations with an interval of 3 years. The primary health service attempted, without receiving any extra resources, to reduce the risk of cardiovascular disease by means of a personal intervention programme among high-risk individuals and a health education programme directed at all residents in the county. During these 3 years the serum total-cholesterol (cross-sectionally) level decreased on average by about 0.3 mmol/l due to: firstly, a decrease among persons recommended a follow-up examination and secondly a decrease among household members of persons followed-up. The effect of a recommendation to attend a follow-up examination because of high blood pressure was doubtful. Cigarette consumption (cross-sectionally) decreased 12% for males and 4% for females. The joint decrease (improvement) in risk factors indicates a possible health benefit of about 20%, calculated in terms of myocardial infarction over 10 years.
PubMed ID
3992210 View in PubMed
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