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18 records – page 1 of 2.

[Analysis of intragenic polymorphic markers of the CFTR gene in cystic fibrosis patients and health donors from Bashkorostan].

https://arctichealth.org/en/permalink/ahliterature182092
Source
Genetika. 2003 Nov;39(11):1542-9
Publication Type
Article
Date
Nov-2003
Author
G F Korytina
T V Viktorova
T E Uvashchenko
V S Baranov
E K Khusnutdinova
Author Affiliation
Institute of Biochemistry and Genetics, Russian Academy of Sciences, Ufa, 450054 Bashkortostan, Russia.
Source
Genetika. 2003 Nov;39(11):1542-9
Date
Nov-2003
Language
Russian
Publication Type
Article
Keywords
Alleles
Case-Control Studies
Cystic Fibrosis - genetics
Cystic Fibrosis Transmembrane Conductance Regulator - genetics
Gene Frequency
Genetic markers
Genetics, Population
Haplotypes
Humans
Russia
Abstract
The differences in the polymorphic allele frequency distribution patterns of the biallelic (M470 and TUB20) and microsatellite (IVS6aGATT, IVS8CA, and IVS17CA) markers within the CFTR gene between normal and delF508 chromosomes have been established. For most of the marker loci similar distribution of the allele frequencies on normal and mutant chromosomes without delF508 was demonstrated. Certain polymorphic alleles displayed substantial linkage disequilibrium with the delF508 mutation. Analysis of the IVS6aGATT-IVS8CA-M470-IVS17CA-TUB20 haplotypes association on normal and mutant chromosomes provided identification of the delF508 ancestral haplotype. It was suggested that delF508 mutant chromosomes were introduced into the modern Bashkir gene pool as a result of Slavic migrations from the Eastern Europe. The IVS6aGATT-IVS8CA-M470-IVS17CA-TUB20 major haplotype (77272) revealed was statistically significantly most frequently found on the mutant chromosomes without the delF508 mutation. This finding suggests that the Bashkir cystic fibrosis patients, mostly belonging to the Turkic-speaking families, possessed specific CF gene defect associated with the given haplotype.
PubMed ID
14714468 View in PubMed
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[Association of cytochrome P450 genes polymorphisms (CYP1A1 and CYP1A2) with the development of chronic obstructive pulmonary disease in Bashkortostan].

https://arctichealth.org/en/permalink/ahliterature157882
Source
Mol Biol (Mosk). 2008 Jan-Feb;42(1):32-41
Publication Type
Article
Author
G F Korytina
L Z Akhmadishina
O V Kochetova
Sh Z Zagidullin
T V Viktorova
Source
Mol Biol (Mosk). 2008 Jan-Feb;42(1):32-41
Language
Russian
Publication Type
Article
Keywords
Adult
Aged
Bashkiria - ethnology
Cytochrome P-450 CYP1A1 - genetics
Cytochrome P-450 CYP1A2 - genetics
Ethnic Groups
Female
Genetic Markers - genetics
Genetic Predisposition to Disease - genetics
Haplotypes
Humans
Male
Middle Aged
Polymorphism, Genetic
Pulmonary Disease, Chronic Obstructive - enzymology - ethnology - genetics
Risk factors
Abstract
To assess the role that polymorphisms of cytochrome P450 genes play in genetic predisposition to chronic obstructive pulmonary disease (COPD), the allele and genotype distributions of CYPIA1 (2455 A/G, 3801T/C) and CYP1A2 (-2464T/delT, -163C/A) genes were studied in Tatar and Russian COPD patients and in cases of healthy individuals (Russian, Tatar and Bashkir), residents of Bashkortostan. It was shown that the CYP1A1 and CYP1A2 genes haplotypes frequency distribution patterns do not differed between Tatars and Russians ethnic groups (chi2 = 0.973, df = 3, p = 1.00 and chi2 = 1.546, df = 3, p = 0.92, respectively). Analysis of the the CYP1A1 and CYP1A2 genes haplotypes revealed statistically significant differences in the haplotypes frequency distributions between Bashkirs versus Russians and Tatars (chi2 = 12.328, df= 3,p = 0.008; chi2 = 9.218, df=3, p = 0.034, respectively for CYP1A1 gene and (chi2 = 18.779, df=3, p = 0.0001, chi = 14.326, df=3, p = 0.003, respectively for CYP1A2 gene). The (-2467)delT allele and CYP1A2*1D haplotype of CYPIA2 gene was associated with higher risk of COPD in Tatar ethnic group (OR = 1.83, 95% CI 1.24-2.71, chi2 = 9.48, p = 0.003 and chi2 = 9.733, p = 0.0027, Pcor = 0.008; OR = 3.908, 95% CI 1.56-10.19, respectively). On the other hand the CYP1A2*1A haplotype had protective effect (chi2 = 6.319, p = 0.0127, Pcor = 0.038; OR = 0.6012, 95% CI 0.402-0.898). But at the same time we did not find any differences in the genotypes and haplotypes frequency distributions of the CYP1A2 gene within the patients and healthy groups in Russian ethnic group. We also did not find any association of CYP1A1 gene with COPD in ethnic groups of Bashkortostan.
PubMed ID
18389617 View in PubMed
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[Association of polymorphic variants of FTO and MC4R genes with obesity in a Tatar population].

https://arctichealth.org/en/permalink/ahliterature263708
Source
Genetika. 2015 Feb;51(2):248-55
Publication Type
Article
Date
Feb-2015
Author
O V Kochetova
G F Korytina
L Z Akhmadishina
E E Semenov
T V Viktorova
Source
Genetika. 2015 Feb;51(2):248-55
Date
Feb-2015
Language
Russian
Publication Type
Article
Keywords
Adult
Alleles
Body mass index
Body Weight
Ethnic Groups - genetics
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Middle Aged
Obesity - genetics - pathology
Polymorphism, Single Nucleotide - genetics
Proteins - genetics
Receptor, Melanocortin, Type 4 - genetics
Russia
Abstract
Obesity is a chronic relapsing disease that leads to numerous ailments and requires lifelong treatment. Genetic predisposition is one of the mostly discussed aspects of obesity development, and genome-wide association studies have provided evidence that several variants of the FTO and MC4R genes are significantly associated with obesity. In this study the association of FTO (rs9939609, rs7202116, and rs9930506) and MC4R (rs12970134 and rs17782313) genes' SNPs with obesity in Tatar women has been analyzed. In the investigation 340 women with obesity (Body Mass Index (BMI) = 30 kg/m2) and 330 women from a control group (BMI up to 24.9 kg/m2) took part. The FTO rs9939609 (p = 0.0002) and rs9930506 (p = 0.0005) SNPs were shown to be associated with obesity risk following an additive model, while the MC4R rs12970134 (p = 0.0076) and rs1778231 (p = 0.021) SNPs were associated by a recessive model. We also showed an association of quantitative parameters (age, weight, and BMI) with two the FTO rs9939609 and rs9930506 SNPs and the association of age and the MC4R rs12970134 SNP. Our study demonstrates the role of genetic variability in FTO and MC4R genes in obesity development in Tatar women from Russia.
PubMed ID
25966591 View in PubMed
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[Association of polymorph variants of CYP1A2 and CYP1A1 genes with reproductive and thyroid diseases in female workers of petrochemical industry].

https://arctichealth.org/en/permalink/ahliterature122008
Source
Med Tr Prom Ekol. 2012;(5):41-8
Publication Type
Article
Date
2012
Author
A R Irmiakova
O V Kochetova
M K Gainullina
O V Sivochalova
T V Viktorova
Source
Med Tr Prom Ekol. 2012;(5):41-8
Date
2012
Language
Russian
Publication Type
Article
Keywords
Adult
Case-Control Studies
Chemical Industry
Cytochrome P-450 CYP1A1 - genetics
Cytochrome P-450 CYP1A2 - genetics
Female
Fibrocystic Breast Disease - enzymology - epidemiology - etiology - genetics
Gene Frequency
Genetic Predisposition to Disease
Homozygote
Humans
Leiomyoma - enzymology - epidemiology - etiology - genetics
Middle Aged
Occupational Exposure - adverse effects - analysis
Occupational Health
Petroleum Pollution - adverse effects - analysis
Polymorphism, Genetic
Regression Analysis
Russia
Thyroid Diseases - enzymology - epidemiology - etiology - genetics
Abstract
The article presents results obtained in study of relationship between polymorph variants of CYP1A1 and CYP1A2 genes with reproductive and thyroid diseases risk in female workers of petrochemical industry, when compared with reference group females. Variants TD and DD of CYP1A2 gene appeared to be associated with nodes formation in uterus and breast in female workers and reference group females. Following liability markers are obtained: homozygous in rare allele genotype CC of CYP1A1 gene for reproductive and thyroid diseaes (fibrous cystic mastopathy and nodular goitre), heterozygous genotype AG of CYP1A1 gene in uterine myoma and fibrous cystic mastopathy, homozygous in deleted T genotype of CYP1A2 gene in autoimmune thyroiditis. Occupational hazards and long length of service at hazardous industries increase effects of rare alleles of the genes studied.
PubMed ID
22855999 View in PubMed
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[Comparative analysis of cytogenetic instability in buccal epithelial cells in the urban and rural dwellers of the Republic of Bashkortostan].

https://arctichealth.org/en/permalink/ahliterature128611
Source
Gig Sanit. 2011 Sep-Oct;(5):40-2
Publication Type
Article
Author
A T Volkova
T V Viktorova
Source
Gig Sanit. 2011 Sep-Oct;(5):40-2
Language
Russian
Publication Type
Article
Keywords
Adolescent
Bashkiria - epidemiology
Chromosome Aberrations - chemically induced - statistics & numerical data
Cytogenetic Analysis
Environmental Pollution - adverse effects
Female
Genetic Testing
Humans
Male
Mouth Mucosa - drug effects - ultrastructure
Rural Population - statistics & numerical data
Sex Factors
Urban Population - statistics & numerical data
Abstract
The frequency of cytogenetic instability in buccal epithelial cells was studied in the urban and rural dwellers of the Republic of Bashkortostan. A total of 26256 cells from 24 students who had been born in Ufa and 26951 cells from 25 students who had lived in a rural area before entering the Institute were analyzed. The students' age was 17 to 19 years. The study has indicated that cytogenetic instability and other types of karyological anomalies in the buccal epithelial cells of rural and urban dwellers depend on gender and environmental factors.
PubMed ID
22185000 View in PubMed
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[Contribution of polymorphic variants of the genes of xenobiotic transformation enzymes, antioxidative defense, and DNA repair to the development of individual predisposition to hepatobiliary and reproductive system diseases in petrochemical workers].

https://arctichealth.org/en/permalink/ahliterature127923
Source
Gig Sanit. 2011 Nov-Dec;(6):54-7
Publication Type
Article
Author
T V Viktorova
O V Kochetova
K F Safina
M K Gainullina
L Z Akhmadishina
G F Korytina
Source
Gig Sanit. 2011 Nov-Dec;(6):54-7
Language
Russian
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Antioxidants - metabolism
Biliary Tract Diseases - epidemiology - etiology - genetics
Biotransformation - genetics
Case-Control Studies
Chemical Industry
DNA Repair - genetics
Drug-Induced Liver Injury - epidemiology - etiology - genetics
Female
Gene Frequency
Genetic Predisposition to Disease
Genital Diseases, Female - epidemiology - etiology - genetics
Humans
Middle Aged
Occupational Diseases - enzymology - epidemiology - etiology - genetics
Petroleum
Polymorphism, Genetic
Russia
Xenobiotics - pharmacokinetics - toxicity
Young Adult
Abstract
The paper gives the basic results of studying the polymorphic loci of the genes of xenobiotic transformation enzymes, antioxidative defense, and DNA repair in petrochemical workers. Polymerase chain reaction-restriction fragment length polymorphism assay was used to identify markers of the predisposition to the development of toxic hepatitis in men and impaired reproduction in women.
PubMed ID
22250394 View in PubMed
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[Gene polymorphism of xenobiotics in workers of petroleum and chemical industry].

https://arctichealth.org/en/permalink/ahliterature180041
Source
Med Tr Prom Ekol. 2004;(4):19-22
Publication Type
Article
Date
2004
Author
O V Makarova
L K Karimova
G G Gimranova
S Kh Churmantaeva
T V Viktorova
Source
Med Tr Prom Ekol. 2004;(4):19-22
Date
2004
Language
Russian
Publication Type
Article
Keywords
Adult
Aged
Air Pollutants, Occupational - pharmacokinetics
Alleles
Cytochrome P-450 CYP1A1 - genetics
DNA - analysis
Extraction and Processing Industry
Female
Gene Deletion
Gene Frequency - genetics
Glutathione Transferase - genetics
Humans
Male
Metabolic Detoxication, Drug - genetics
Middle Aged
Petroleum
Polymerase Chain Reaction
Polymorphism, Genetic
Russia
Workplace - standards
Xenobiotics - pharmacokinetics
Abstract
Increasing use of aromatic hydrocarbons and their derivatives, known mutagens and carcinogens, in petrochemistry leads to higher number of workers having occupational contact with those chemicals. Most alien chemicals (xenobiotics) incorporated into human body do not demonstrate direct biological effects but undergo various biologic transformations. Humans proved to have genetic control over metabolism of xenobiotics entering the body, so various individuals depending on genetic features could be resistant or otherwise be extremely sensitive to chemical agents.
PubMed ID
15152552 View in PubMed
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[Genetic Association of ADRA2A and ADRB3 Genes with Metabolic Syndrome among the Tatars].

https://arctichealth.org/en/permalink/ahliterature268178
Source
Genetika. 2015 Jul;51(7):830-4
Publication Type
Article
Date
Jul-2015
Author
O V Kochetova
T V Viktorova
O E Mustafina
A A Karpov
E K Khusnutdinova
Source
Genetika. 2015 Jul;51(7):830-4
Date
Jul-2015
Language
Russian
Publication Type
Article
Keywords
Blood glucose - genetics
Case-Control Studies
Diabetes Mellitus, Type 2 - genetics
Female
Genetic Predisposition to Disease
Heterozygote
Humans
Insulin - blood - genetics
Metabolic Syndrome X - genetics
Polymorphism, Single Nucleotide
Receptors, Adrenergic, alpha-2 - genetics
Receptors, Adrenergic, beta-3 - genetics
Russia - ethnology
Abstract
An association study was performed for genetic polymorphisms in ADRB3 (rs4994) and ADRA2A (rs1800544, rs553668) genes to estimate their effect on quantitative parameters, including glucose, insulin, and HOMA-IR index in women from the Tatar population of Russia. It has been shown that CT and CC are associated with metabolic syndrome and increased insulin. It was shown that ADRA2A (rs1800544) gene polymorphism was associated with high levels of insulin and an increased HOMA-IR index in GG- and GC-genotype carriers.
PubMed ID
26410938 View in PubMed
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[Genomic typing of the Echinococcus granulosus isolates from the areas of Southern Urals].

https://arctichealth.org/en/permalink/ahliterature166268
Source
Parazitologiia. 2006 Sep-Oct;40(5):479-84
Publication Type
Article
Author
G I Lukmanova
A A Gumeov
M M Tuigunov
T V Viktorova
Source
Parazitologiia. 2006 Sep-Oct;40(5):479-84
Language
Russian
Publication Type
Article
Keywords
Adolescent
Animals
Cattle
Child
DNA, Helminth - genetics
Echinococcosis - epidemiology - genetics
Echinococcus granulosus - genetics
Female
Genotype
Humans
Male
Russia
Abstract
Nine larvocysts of Echinococcus granulosus isolated from nine patients and one cyst derived from a naturally infested cattle have been examined. Genomic typing was carried out in order to identify strains of E. granulosus. All DNA samples were shown to have the same genotype, E. granulosus G1.
PubMed ID
17144408 View in PubMed
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[Genotypes of vitamin-D-binding protein (DBP) in patients with chronic obstructive pulmonary disease and healthy population of Republic Bashkortostan].

https://arctichealth.org/en/permalink/ahliterature169602
Source
Mol Biol (Mosk). 2006 Mar-Apr;40(2):231-8
Publication Type
Article
Author
G F Korytina
L Z Akhmadishina
D G Ianbaeva
T V Viktorova
Source
Mol Biol (Mosk). 2006 Mar-Apr;40(2):231-8
Language
Russian
Publication Type
Article
Keywords
Aged
Alleles
Bashkiria - ethnology
Female
Gene Frequency - genetics
Genotype
Humans
Male
Middle Aged
Polymorphism, Restriction Fragment Length
Pulmonary Disease, Chronic Obstructive - ethnology - genetics
Vitamin D-Binding Protein - genetics
Abstract
The distribution of alleles and genotypes of vitamin D-binding protein (DBP) gene has been studied in patients with Chronic Obstructive Pulmonary Disease (COPD, n = 298) and healthy individuals (n = 237) from two ethnic groups (Tatars and Russians) living in Republic Bashkortostan. Statistically significant differences in the distribution of DBP gene genotypes between Tatars and Russians (chi2 = 8.854, df = 5, P = 0.04) were revealed. The pattern of allele's distribution within DBP gene was similar in healthy control subjects of both ethnic groups, with gradient reduction in row GC*1S> GC*1F> GC*2. The most common genotypes were: GC*1F/1S in Tatars (36.79%) and GC*1S/2 in Russians (34.62%). It has been shown, that Tatars with genotype GC*1F/1S have a lower risk of COPD development: the frequency of GC*1F/1S genotype in COPD patients was significantly lower than in healthy individuals (19.85% versus 36.79%; chi2 = 7.622, P = 0.0067, Pcor = 0.0335; OR = 0.42 CI 95% 0.22-0.79). At the same time, COPD patients from the same group had higher frequency of GC* 1F/2 genotype than healthy individuals (19.08% versus 8.49%; chi2 = 4.52, P = 0.033, Pcor = 0.165; OR = 2.54 CI 95% 1.067-6.20). In Russian population the distribution of alleles and genotypes of DBP gene were similar in COPD patients and healthy individuals.
PubMed ID
16637263 View in PubMed
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18 records – page 1 of 2.