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Prenatal exposure to polychlorinated biphenyls and dioxins from the maternal diet may be associated with immunosuppressive effects that persist into early childhood.

https://arctichealth.org/en/permalink/ahliterature120128
Source
Food Chem Toxicol. 2013 Jan;51:165-72
Publication Type
Article
Date
Jan-2013
Author
Solvor Berntsen Stølevik
Unni Cecilie Nygaard
Ellen Namork
Margaretha Haugen
Helle Margrete Meltzer
Jan Alexander
Helle Katrine Knutsen
Ingeborg Aaberge
Kirsti Vainio
Henk van Loveren
Martinus Løvik
Berit Granum
Author Affiliation
Norwegian Institute of Public Health, NO-0403 Oslo, Norway. solvor.berntsen@fhi.no
Source
Food Chem Toxicol. 2013 Jan;51:165-72
Date
Jan-2013
Language
English
Publication Type
Article
Keywords
Antibody formation
Child, Preschool
Dioxins - toxicity
Environmental Pollutants - toxicity
Female
Food Contamination
Humans
Infant
Maternal Exposure
Measles Vaccine - immunology
Norway
Polychlorinated Biphenyls - toxicity
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced
Questionnaires
Regression Analysis
Respiratory Sounds - etiology
Respiratory Tract Infections - chemically induced - epidemiology
Abstract
We investigated whether prenatal exposure from the maternal diet to the toxicants polychlorinated biphenyls (PCBs) and dioxins is associated with the development of immune-related diseases in childhood. Children participating in BraMat, a sub-cohort of the Norwegian Mother and Child Cohort Study (MoBa), were followed in the three first years of life using annual questionnaires (0-3years; n=162, 2-3years; n=180), and blood parameters were examined at three years of age (n=114). The maternal intake of the toxicants was calculated using a validated food frequency questionnaire from MoBa. Maternal exposure to PCBs and dioxins was found to be associated with an increased risk of wheeze and more frequent upper respiratory tract infections. Furthermore, maternal exposure to PCBs and dioxins was found to be associated with reduced antibody response to a measles vaccine. No associations were found between prenatal exposure and immunophenotype data, allergic sensitization and vaccine-induced antibody responses other than measles. Our results suggest that prenatal dietary exposure to PCBs and dioxins may increase the risk of wheeze and the susceptibility to infectious diseases in early childhood.
PubMed ID
23036451 View in PubMed
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Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants.

https://arctichealth.org/en/permalink/ahliterature134515
Source
Food Chem Toxicol. 2011 Aug;49(8):1843-8
Publication Type
Article
Date
Aug-2011
Author
Solvor Berntsen Stølevik
Unni Cecilie Nygaard
Ellen Namork
Margaretha Haugen
Helen Engelstad Kvalem
Helle Margrete Meltzer
Jan Alexander
Joost H M van Delft
Henk van Loveren
Martinus Løvik
Berit Granum
Author Affiliation
Norwegian Institute of Public Health, NO-0403 Oslo, Norway. solvor.berntsen@fhi.no
Source
Food Chem Toxicol. 2011 Aug;49(8):1843-8
Date
Aug-2011
Language
English
Publication Type
Article
Keywords
Acrylamide - toxicity
Adult
Cohort Studies
Dioxins - toxicity
Eating
Environmental Pollutants - toxicity
Female
Humans
Infant
Maternal Exposure - adverse effects
Norway
Polychlorinated Biphenyls - toxicity
Pregnancy
Prenatal Exposure Delayed Effects
Questionnaires
Respiratory Sounds - physiopathology
Respiratory Tract Infections - chemically induced
Risk factors
Abstract
The birth cohort BraMat (n = 205; a sub-cohort of the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health) was established to study whether prenatal exposure to toxicants from the maternal diet affects immunological health outcomes in children. We here report on the environmental pollutants polychlorinated biphenyls (PCBs) and dioxins, as well as acrylamide generated in food during heat treatment. The frequency of common infections, eczema or itchiness, and periods of more than 10 days of dry cough, chest tightness or wheeze (called wheeze) in the children during the first year of life was assessed by questionnaire data (n = 195). Prenatal dietary exposure to the toxicants was estimated using a validated food frequency questionnaire from MoBa. Prenatal exposure to PCBs and dioxins was found to be associated with increased risk of wheeze and exanthema subitum, and also with increased frequency of upper respiratory tract infections. We found no associations between prenatal exposure to acrylamide and the health outcomes investigated. Our results suggest that prenatal dietary exposure to dioxins and PCBs may increase the risk of wheeze and infectious diseases during the first year of life.
PubMed ID
21571030 View in PubMed
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