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Maternal diet, prenatal exposure to dioxin-like compounds and birth outcomes in a European prospective mother-child study (NewGeneris).

https://arctichealth.org/en/permalink/ahliterature266778
Source
Sci Total Environ. 2014 Jun 15;484:121-8
Publication Type
Article
Date
Jun-15-2014
Author
Eleni Papadopoulou
Manolis Kogevinas
Maria Botsivali
Marie Pedersen
Harrie Besselink
Michelle A Mendez
Sarah Fleming
Laura J Hardie
Lisbeth E Knudsen
John Wright
Silvia Agramunt
Jordi Sunyer
Berit Granum
Kristine B Gutzkow
Gunnar Brunborg
Jan Alexander
Helle Margrete Meltzer
Anne Lise Brantsæter
Katerina Sarri
Leda Chatzi
Domenico F Merlo
Jos C Kleinjans
Margaretha Haugen
Source
Sci Total Environ. 2014 Jun 15;484:121-8
Date
Jun-15-2014
Language
English
Publication Type
Article
Keywords
Adult
Birth weight
Cohort Studies
Denmark - epidemiology
Diet - statistics & numerical data
Dioxins - blood
Environmental Policy
Environmental pollutants - blood
Female
Gestational Age
Great Britain - epidemiology
Greece - epidemiology
Health Policy
Humans
Infant, Newborn
Maternal Exposure - statistics & numerical data
Mothers
Pregnancy
Prenatal Exposure Delayed Effects - epidemiology
Spain - epidemiology
Abstract
Maternal diet can result in exposure to environmental contaminants including dioxins which may influence foetal growth. We investigated the association between maternal diet and birth outcomes by defining a dioxin-rich diet. We used validated food frequency questionnaires to assess the diet of pregnant women from Greece, Spain, United Kingdom, Denmark and Norway and estimated plasma dioxin-like activity by the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR-CALUX®) bioassay in 604 maternal blood samples collected at delivery. We applied reduced rank regression to identify a dioxin-rich dietary pattern based on dioxin-like activity (DR-CALUX®) levels in maternal plasma, and calculated a dioxin-diet score as an estimate of adherence to this dietary pattern. In the five country population, dioxin-diet score was characterised by high consumption of red and white meat, lean and fatty fish, low-fat dairy and low consumption of salty snacks and high-fat cheese, during pregnancy. The upper tertile of the dioxin-diet score was associated with a change in birth weight of -121g (95% confidence intervals: -232, -10g) compared to the lower tertile after adjustment for confounders. A small non-significant reduction in gestational age was also observed (-1.4days, 95% CI: -3.8, 1.0days). Our results suggest that maternal diet might contribute to the exposure of the foetus to dioxins and dioxin-like compounds and may be related to reduced birth weight. More studies are needed to develop updated dietary guidelines for women of reproductive age, aiming to the reduction of dietary exposure to persistent organic pollutants as dioxins and dioxin-like compounds.
PubMed ID
24691212 View in PubMed
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