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Menstrual and reproductive risk factors and risk for gastric adenocarcinoma in women: findings from the canadian national enhanced cancer surveillance system.

https://arctichealth.org/en/permalink/ahliterature168311
Source
Ann Epidemiol. 2006 Dec;16(12):908-16
Publication Type
Article
Date
Dec-2006
Author
Sarah Frise
Nancy Kreiger
Steven Gallinger
George Tomlinson
Michelle Cotterchio
Author Affiliation
Drug Safety Department, AstraZeneca, Mississauga, Toronto, Ontario, Canada.
Source
Ann Epidemiol. 2006 Dec;16(12):908-16
Date
Dec-2006
Language
English
Publication Type
Article
Keywords
Adenocarcinoma - epidemiology - etiology
Adult
Aged
Canada - epidemiology
Case-Control Studies
Contraceptives, Oral, Hormonal - adverse effects
Female
Hormone Replacement Therapy - adverse effects
Humans
Logistic Models
Menarche
Menopause
Menstrual Cycle
Middle Aged
Parity
Pregnancy
Risk factors
Stomach Neoplasms - epidemiology - etiology
Abstract
The role of menstrual and reproductive risk factors for gastric cancer has not been well studied.
This population-based case-control study included 326 women aged 20 to 74 years with gastric adenocarcinoma. Controls were 326 women frequency matched on age. Data for reproductive and/or hormonal exposure and gastric cancer risk factors were captured through self-administered questionnaire.
Later age at menarche was associated with increased risk for adenocarcinoma compared with menarche onset at younger than 13 years of age (13 to 14 years: odds ratio [OR], 1.45; 95% confidence interval [CI], 1.00-2.10; > or =15 years: OR, 1.93; 95% CI, 1.19-3.13). Compared with premenopause, natural menopause was associated with increased risk for adenocarcinoma (OR, 1.99; 95% CI, 0.98-4.05). Compared with nulliparity, 4 or more births were associated with decreased risk for gastric cancer, as was being pregnant for 5 months or longer if the first pregnancy occurred at younger than 24 years (OR, 0.55; 95% CI, 0.31-0.96) or 25 years or older (OR, 0.67; 95% CI, 0.38-1.18). Oral contraceptives and hormone replacement therapy were associated with a non-statistically significant decreased risk.
These findings suggest that hormonal factors associated with greater exposure to estrogen and/or progesterone may be associated with decreased risk for gastric cancer.
Notes
Comment In: Ann Epidemiol. 2007 Sep;17(9):721-217553698
PubMed ID
16843679 View in PubMed
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Psychiatric disorders and use of mental health services by Ontario women.

https://arctichealth.org/en/permalink/ahliterature187248
Source
Can J Psychiatry. 2002 Nov;47(9):849-56
Publication Type
Article
Date
Nov-2002
Author
Sarah Frise
Allan Steingart
Margaret Sloan
Michelle Cotterchio
Nancy Kreiger
Author Affiliation
Department of Public Health Sciences, University of Toronto, Toronto, Ontario.
Source
Can J Psychiatry. 2002 Nov;47(9):849-56
Date
Nov-2002
Language
English
Publication Type
Article
Keywords
Adult
Aged
Case-Control Studies
Female
Humans
Mental Disorders - epidemiology
Mental Health Services - utilization
Middle Aged
Ontario - epidemiology
Prevalence
Abstract
To describe the lifetime prevalence of selected psychiatric disorders in Ontario women and to compare these estimates with use of mental health resources.
We obtained data from a survey of 3062 Ontario women, aged 25 to 74 years, who participated in the Women's Health Study. A 5-item scale assessed lifetime prevalence of 5 psychiatric disorders (anxiety, depression, posttraumatic stress disorder [PTSD], obsessive-compulsive disorder [OCD], and anorexia [AN] or bulimia [BN]). We assessed use of mental health services by comorbidity. We employed stratified random sampling to select study subjects. Prevalence estimates were weighted and 95%CIs were obtained using Taylor linearization techniques (1).
Nearly 30% of those surveyed reported at least 1 of the disorders studied. The most common were depression (27%) and anxiety (21%). Lifetime prevalence of PTSD, OCD, and AN or BN were 10.7%, 6.1%, and 3.9%, respectively. Successively younger birth cohorts displayed an increase in prevalence and a decrease in onset-age for all disorders. "Ever" use of mental health services was higher for women with 3 or more comorbid disorders (65%) than for those with no disorder (9.8%), or only 1 disorder (51.4%).
The results of this study highlight the need to conduct more research into the reasons for the low rates of professional service use, especially for women with high comorbidity. They also highlight the need to understand the phenomenon underlying the possibly increasing rates of disorders in younger birth cohorts, so that outreach strategies can be modified to accommodate differences in younger women.
PubMed ID
12500755 View in PubMed
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